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( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.
Chaetoglobosin A, an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12,13-Dibutyrate
KO, HACK-RYONG,KIM, BO YEON,AHN, SOON-CHEOL,OH, WON KEUN,KIM, JIN-HEE,LEE, HYUN SUN,KIM, HWAN-MOOK,HAN, SANG-BAE,MHEEN, TAE0ICK,AHN, JONG-SEOG 한국미생물 · 생명공학회 1998 Journal of microbiology and biotechnology Vol.8 No.6
Microbial Communities of Food Waste Fermentation Process with Different Concentration of Nitrogen
( Sung-young Mo ),( Tae-jin Lee ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 춘계학술발표논문집 Vol.2015 No.-
I. Introduction Recently, the world focuses on the development of a clean energy for our environment because of shortage of fossil fuel and pollution problem. Hydrogen is one of the clean energy. Bio-hydrogen gas production has received a wide spread attention due to its potential as a powerful fuel. Although the biological production of hydrogen gas from organic matters has not been studied intensively, it has become an exciting new area of technology that offers a chance to use hydrogen from a variety of renewable resources. In this study, the effects of nitrogen concentration and microbial community were investigated in the fermentative hydrogen production of food waste. II. Materials and methods Hydrogen production experiments were conducted in a 1.5L batch reactor at 30℃. pH of the food waste was adjusted to 5.52) by the addition of 3N aqueous KOH. The produced gas was collected by the biogas collector filled with 2% aqueous H<sub>2</sub>SO<sub>4</sub> (v/v) solution. The batch reactor is shown at Fig. 1. To analyze the complexity of the hydrogen-producing microbial community, DNA was extracted from the microorganisms in the reactor. The 16s rDNA fragments were amplified by PCR using 341f and 518r as primers followed by separation of denaturing gradient gel electrophoresis (DGGE). Each band on the DGGE profile represented a gene fragment of unique 16s rDNA sequences, each of which was analyzed using the BLAST program for identification of each species in the microbial community. III. Result and discussion Hydrogen gas production(Ph) and maximum hydrogen production rate(Rh) of the food waste fermentation with deferent concentration of nitrogen were calculated using a modified Gompartz equation1) at Table 1. Peak hydrogen production potential value (1309.5mL) occurred at 600mg/L of nitrogen concentration with 1000 mg NaCl/L. R-square values for regression analysis were shown over 92% for this experiment. PCR-DGGE analysis on 16S rDNA was attempted to investigate the effects of nitrogen concentration on microbial community responsible for hydrogen production. PCR-DGGE profiles of the samples showed various band patterns in Fig. 2. Based on band intensities, Band 9 and 11 of the sample with 600 mg/L nitrogen concentration was distinctly observed. Band 9, 11 were confirmed as Clostiridium and Band 1, 7 were confirmed as Enterococcus and Hydrogenoanaerobacterium respectively. IV. Conclusion 1) Peak hydrogen production potential value (1309.5mL) occurred at 600mg/L of nitrogen concentration with 1000mg NaCl/L. 2) The analysis shows that most microbe were identified as clostridium and enterobacter. Especially clostridium was founded in 600 mg/L nitrogen concentration.
Undifferentiated pleomorphic sarcoma: Non-skin origin malignancy that dermatologists can meet
( Jin-hwa Son ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hoon-soo Ki 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Undifferentiated pleomorphic sarcoma (UPS) is a rare moderately aggressive mesenchymal neoplasm capable of invading soft tissue, skeletal, and retroperitoneal structures. It most commonly occurs in extremities and relatively few cases have been reported arising in the skin. Dermatologists could meet non-skin origin malignancy as skin tumor on extremities. Here, we report as case of UPS presented with subcutaneous mass on the forearm. A 70-year-old man had a large hard subcutaneous mass on the left forearm presented 3 years ago. The protruding mass was insidious at onset and increased in size progressively. On examination, 7cm-sized mass with pain was noted and it was fixed to underlying structures. Histopathological examination showed tumor composed of highly pleomorphic spindle-shaped cells arranged in sheets and irregular fascicles with myxoid stroma. Immunohistochemical stain showed that some tumor cells were focal positive for smooth muscle actin, desmin, epithelial membrane antigen and pan cytokeratin. These findings were suggestive of UPS. Necrotic soft tissue mass with adjacent muscle invasion was revealed but no metastatic lesions were detected on several imaging tests (CT, MRI and PET-CT). Therefore, skin tumor of extremities could be considered the possibility of non-skin origin malignancy such as UPS. If it is suspected, dermatologists should be able to perform further evaluation and refer to other specialists.
( Sang Soo Lee ),( Ra Ri Cha ),( Chang Min Lee ),( Wan Soo Kim ),( Hyun Chin Cho ),( Jin Joo Kim ),( Jae Min Lee ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims:HepaticCvirus(HCV)genotype3infectionisthemostdifficultformofHCVtotreat,withamorerapidprogressiontofibrosisandcirrhosiscomparedwithothergenotypes.Theaimsofthisretrospectiveobservationalstudyweretoelucidatetheimpactofgenotype3infectiononhepatocellularcarcinoma(HCC)developmentandoverallmortalityinpatientswithHCV-relatedcirrhosis,comparedtoHCVgenotype1and2intheGyeongnamProvince,locatedonthesoutheastcoastofKorea.Methods:Atotal153patientswithHCV-relatedcirrhosiswereincludedbetweenJanuary2005andDecember2014.Amongthese,74hadgenotype1,55genotype2,and24patientshadgenotype3infection.Results:Theprevalenceofgenotype3inHCV-relatedcirrhosiswas16%.Individualsatriskforgenotype3infectionwereyoung,malegender,andpeoplewhoinjectdrugs.Duringmedianamedianfollow-up40.1months,38patientsdevelopedHCC,and23patientsdied.TheincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithgenotype1and2inthelogranktest.Despitebeingyounger,HCVgenotype3wasaindependentriskfactorforHCCdevelopment(adjustedhazardratio[HR〕=2.55)andoverallmortality(adjustedHR=3.69)onmultivariateanlalysis.Afterexclusionofpatientswithachievedsustainedvirologicresponse,theincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithnogenotype3.Conclusions:HCVgenotype3infectionisassociatedwithanincreasedriskofHCCandoverallmortalityinpatientswithcirrhosisafteradjustingwithconfoundingfactors.
A non-pigmented superficial basal cell carcinoma misdiagnosed as eczematous dermatitis
( Jin-hwa Son ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Gun-wook Ki 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Superficial basal cell carcinoma (BCC) typically present as a well-circumscribed, erythematous patch or plaque involving the trunk and extremities. Additional findings include focal scale or crust, a thin rolled border, and variable amounts of melanin. Especially, superficial BCC without pigmentation might be difficulty in early detection even for experienced dermatologists. We report a case of superficial BCC misdiagnosed as chronic eczematous dermatitis. A solitary erythematous plaque with long durations should be considered as malignant skin tumor in the differential diagnosis. A 48-year-old woman presented with 38 X 43 mm erythematous oozy plaque without pigmentation on her left arm that she had recognized 5 years previously. A dermoscopic examination revealed multiple small erosions on a homogenous pink background. Interestingly, multiple scars were found on face, extremities and she remembered that her father had applied chemical material for treatment of previous unknown dermatitis. The erythematous plaque had previously been diagnosed as eczema on another hospital after histologic examination. However, there was no improvement in the lesion after steroid therapy and re-biopsy was performed. The histopathologic findings revealed multifocal nests of atypical basaloid epithelium arising as buds from the basal layer of the epidermis. The diagnosis was confirmed of superficial BCC. She has been treated with Photodynamic therapy.
Clinical Outcomes of Peroral Endoscopic Myotomy for Achalasia Depend on Manometric Subtype
( Tae Young Yang ),( Joo Young Cho ),( Weon Jin Ko ),( Ga Won Song ),( Sung Pyo Hong ),( Won Hee Kim ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background/Aims: Peroral endoscopic myotomy (POEM) is known to be safe and effective endoscopic surgery compared with surgical myotomy for achalasia patients. A higher percentage of patients with type II achalasia successfully treated with laparoscopic Heller myotomy than patients with types I and III achalasia. We evaluated whether manometric subtype was associated with response to treatment in a patients treated with POEM. Methods: Esophageal pre-treatment manometry data were collected from 53cases that was performed POEM from November 2011 to August 2014 at two tertiary referral centers. Manometric tracings were classified according to the 3 Chicago subtypes. Results: Among 53cases, 35 type 1, 8 type2 and 10 type3 achalasia were included. There was no difference in pre-POEM Eckardt score, basal LES pressure, and integrated relaxation pressure (IRP) between type 1, type 2 and type 3 group (6.1±3.9 vs. 8.4±3.6 vs. 6.6±3.4; p=0.215, 27.3±29.8 vs. 39.7±12.3 vs. 34.1±32.8 mmHg; p=0.089, and 23.4±29.6 vs. 30.1±14.9 vs. 19.2±28.8 mmHg; p=0.709). All patients showed a significant improvement in Eckardt score after POEM during median follow-up of 16 months (6.1±3.9 vs. 0.6±2.4; p<0.001, 8.4±3.6 vs. 0.6±1.4; p=0.008, 6.6±3.4 vs. 1.0±2.0; p<0.001). But there was difference in decreased degree of Eckardt score between type 1, type 2 and type 3 group (p=0.637), LES pressure was significant decrease only for type 2 group (23.5±16.3 vs. 16.1±12.4; p=0.113, 39.7±12.3 vs. 19.5±4.4; p=0.029, 34.1±32.8 vs. 16.8±17.2; p=0.421). IRP score was significant decrease only fortype 1 group (23.4±18.3 vs. 11.0±9.5; p=0.014, 30.1±14.9 vs. 12.50±7.5; p=0.057, 19.0±29.0 vs. 11.6±12.3; p=0.886). Conclusions: POEM showed good clinical outcomes in any manometric subtype. There was no difference among the manometric subtype. In the future, large prospective study is needed to confirm that POEM can be considered as standard treatment in any subtype of achalasia patients.
Laparoscopic and robotic pectopexy in pelvic organ prolapse: pilot study
( Tae Kyu Jang ),( Hye Won Chung ),( So Jin Shin ),( Chi Heum Cho ),( Sang Hoon Kwon ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Pelvic organ prolapse (POP) is one of the most prevalent gynecological conditions requiring surgical treatment. Pectopexy using minimal invasive surgery was developed to reduce the short-term morbidity and recurrence associated with the open abdominal approach, providing the same results. The aim of this study is to evaluate the feasibility and safety of laparoscopic and robotic pectopexy in POP. Methods: Data were retrospectively collected from database at Dongsan Medical Center, for POP patients who underwent laparoscopic or robotics pectopexy from January 2019 to December 2019. Laparoscopic pectopexy was performed through a standard multi-port (4 port) platform and robotic pectopexy was performed using the da Vinci Xi or X Surgical System (Intuitive Surgical, Sunnyvale, CA). Results: Total 6 POP patients who underwent laparoscopic and robotic pectopexy were identified. We performed 3 of laparoscopic pectopexy and 3 of robotic pectopexy each. All procedures were successfully performed, without complication and conversion to laparotomy. The mean operation time was 100 minutes in laparoscopic surgery and 150 minutes in robotic surgery. The patient returned to clinic at postoperative 10 days, and normal position of pelvic organ was confirmed by pelvic examination. The patient is currently follow-up state at postoperative 6 month without any recurrence or complication. Conclusion: Laparoscopic and robotic pectopexy is feasible and safe in patients with apical POP. Operative times were reasonable and surgical procedure was well tolerated by patients. Further evaluation should be performed in large-scale comparative studies with vaginal or abdominal approach to confirm the safety and benefits of laparoscopic and robotic pectopexy in apical POP.