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New Dimeric Phenolic Conjugates from the Wood of Tamarix tetragyna
Hussein, Sahar A.M. The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.2
Two new dimeric phenolic conjugates, 2,3-di-O-dehydrodigallicmonocarboxyl-$({\alpha},{\beta})$-$^4C_1$-glucopyranose and ellagic acid 3,3'-dimethylether-4-0-$SO_3K$ were isolated from the debarked heart wood of Tamarix tetragyna (Tamaricaceae) along with the known phenolic compounds, isoferulic acid, ferulic acid, gallic acid, gallic acid 4-methyl ether, syringic acid, ellagic acid 3,3'-dimethyl ether and ellagic acid. All structures were determined mostly by ESI-MS, ID and 2D-NMR spectroscopy.
Polyphenolic Metabolites of the Flowers of Tamarix tetragyna
Sahar A. M. Hussein,Mahmoud A. M. Nawwar,Amani M. D. El Mousallami 한국생약학회 2000 Natural Product Sciences Vol.6 No.4
Phytochemical study of the constitutive polyphenolics of the flower aqueous alcohol extract of Tamarix tetragyna was carried out. The new sulphated flavonol, quercetin 3`,4`-dimethyl ether 3-O-KSO₃ as well as the new natural galloyl glucose, 2-O-galloyl-(α.β)⁴-⁴C₁-glucopyranose were isolated and characterised. The known sulphated flavonols, kaempferol 7,4-dimethyl ether 3,5-di-O-KSO₃, quercetin 7-methyl ether 3,3`,4`-tri-O-KSO₃, quercetin 7,4`-dimethyl ether 3-O-KSO₃ and quercetin 3-O-KSO₃ and the known sulphated phenolics, isoferulic acid 3-O-KSO₃ and ellagic acid 4,4`-dimethyl ether 3-O-KSO₃ were also separated and identified. The structures were established by conventional methods of analysis and confirmed by ¹H-, <sup>13</sup>C-NMR and negative ESI-mass spectrometry. 2D-homonuclear chemical shift correlation NMR experiment was applied for the new natural galloylglucose.
Unique Phenolic Sulphate Conjugates from the Flowers of Tamarix amplexicaulis
Sahar A. M. Hussein,Amani M. D. El-Mousallamy,Mahmoud A. M. Nawwar,Ahmed A. M. Souleman,Heba H. Barakat 한국생약학회 1998 Natural Product Sciences Vol.4 No.4
The unique sulphated phenolics, gallic acid 3-methyl ether 5-potassium sulphate, isoferulic acid 3-potassium sulphate, and ellagic acid 4,4`-dimethyl ether 3-potassium sulphate have been isolated from the flowers of Tamarix amplexicaulis Ehrenb. (Tamaricaceae). The hitherto unknown natural phenolic acid, gallic acid 3-methyl ether, together with the known phenolic, gallic acid, gallic acid 4-methyl ether, isoferulic acid, ferulic acid, ellagic acid, and ellagic acid 4,4`-dimethyl ether have been also separated and characterized. The structures were established by conventional methods, including electrophoretic analysis and confirmed by ESIMS, ¹H- and <sup>13</sup>C-NMR.
Deuteromycols A and B, Two Benzofuranoids from a Red Sea Marine-derived Deuteromycete sp.
Mahmoud Nawwar,Sahar Hussein,Nahla A Ayoub,Amani Hashim,Gudrun Mernitz,Beate Cuypers,Michael Linscheid,Ulrike Lindequist 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
Two benzofuranoids, deuteromycol A, 6,7-dihydroxy-2-[1'-hydroxy-(1'→5'')-2'',3'',4''-trihydroxy-2'',3''-dihydropyran]benzofuran and deuteromycol B, 1-(6,7-dihydroxy benzofuran-2-yl)methylacetate have been isolated from the ethanol extract of the marine-derived fungal strain MF003 (Deuteromycete) obtained from Red Sea mangrove drift wood. Deuteromycols A and B contain a catecholic nucleus that to the best of our knowledge is unusual in association with marine fungi secondary metabolites. Structures were established on the basis of extensive 1Dand 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. Besides, the extracts exhibited in vitro antibacterial activity.
Mahmoud Nawwar,Nahla Ayoub,Sahar Hussein,Amani Hashim,Reham El-Sharawy,Kristian Wende,Manuela Harms,Ulrike Lindequist 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5
Chemical investigation on leaves of Annona muricata resulted in the isolation of the flavonol triglycoside, quercetin 3-O-α-rhamnosyl-(1'''' → 6'')-β-sophoroside, together with twelve known phenolics. The structures of these compounds were established by 1D- and 2D-nuclear magnetic resonance spectroscopic techniques and mass spectrometry data. The in vitro antioxidant studies of the investigated aqueous ethanol extract and its column fractions were accomplished using the oxygen radical absorbance capacity (ORAC) method. A stimulating effect on HaCaT human keratinocytes by the leaf extract was also assessed. Il-6 production after UV irradiation was not influenced by A. muricata leaf extract.
E1/E2 of Hepatitis C Virus Genotype-4 and Apoptosis
Zekri, Abdel-Rahman N,Sobhy, Esraa,Hussein, Nehal,Ahmed, Ola S,Hussein, Amira,Shoman, Sahar,Soliman, Amira H,El-Din, Hanaa M Alam Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Several studies have addressed the possible role of hepatitis C virus genotype-4 (HCV GT4) in apoptosis. However, this still not fully understood. In the current study a re-constructed clone of E1/E2 polyprotein region of the HCV GT4 was transfected into the Huh7 cell line and a human apoptotic PCR array of 84 genes was used to investigate its possible significance for apoptosis. Out of the 84 genes, only 35 showed significant differential expression, 12 genes being up-regulated and 23 down-regulated. The highest-up regulated genes were APAF1 (apoptotic peptidase-activating factor 1), BID (BH3 interacting domain death agonist) and BCL 10 (B-cell CLL/lymphoma protein 10) with fold regulation of 33.2, 30.1 and 18.9, respectively. The most down-regulated were FAS (TNF receptor super family), TNFRSF10B (tumor necrosis factor receptor super-family member 10b) and FADD (FAS-associated death domain) with fold regulation of -30.2, -27.7 and -14.9, respectively. These results suggest that the E1/E2 proteins may be involved in HCV-induced pathogenesis by modulating apoptosis through the induction of the intrinsic apoptosis pathway and disruption of the BCL2 gene family.