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Mahmoud Nawwar,Nahla Ayoub,Sahar Hussein,Amani Hashim,Reham El-Sharawy,Kristian Wende,Manuela Harms,Ulrike Lindequist 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5
Chemical investigation on leaves of Annona muricata resulted in the isolation of the flavonol triglycoside, quercetin 3-O-α-rhamnosyl-(1'''' → 6'')-β-sophoroside, together with twelve known phenolics. The structures of these compounds were established by 1D- and 2D-nuclear magnetic resonance spectroscopic techniques and mass spectrometry data. The in vitro antioxidant studies of the investigated aqueous ethanol extract and its column fractions were accomplished using the oxygen radical absorbance capacity (ORAC) method. A stimulating effect on HaCaT human keratinocytes by the leaf extract was also assessed. Il-6 production after UV irradiation was not influenced by A. muricata leaf extract.
Deuteromycols A and B, Two Benzofuranoids from a Red Sea Marine-derived Deuteromycete sp.
Mahmoud Nawwar,Sahar Hussein,Nahla A Ayoub,Amani Hashim,Gudrun Mernitz,Beate Cuypers,Michael Linscheid,Ulrike Lindequist 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
Two benzofuranoids, deuteromycol A, 6,7-dihydroxy-2-[1'-hydroxy-(1'→5'')-2'',3'',4''-trihydroxy-2'',3''-dihydropyran]benzofuran and deuteromycol B, 1-(6,7-dihydroxy benzofuran-2-yl)methylacetate have been isolated from the ethanol extract of the marine-derived fungal strain MF003 (Deuteromycete) obtained from Red Sea mangrove drift wood. Deuteromycols A and B contain a catecholic nucleus that to the best of our knowledge is unusual in association with marine fungi secondary metabolites. Structures were established on the basis of extensive 1Dand 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. Besides, the extracts exhibited in vitro antibacterial activity.
Ahmed Esmat,Fahad A. Al-Abbasi,Mardi M. Algandaby,Ashaimaa Y. Moussa,Rola M. Labib,Nahla A. Ayoub,Ashraf B. Abdel-Naim 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
The present study aimed at isolating and elucidating the structure of the main components of Pistacia khinjuk L. and exploring its potential anti-inflammatory effect in different experimental models. The extract was evaluated for antiinflammatory activity by measuring paw volume in three experimental models. Then, prostaglandin E2 (PGE2) level, ear edema, tissue myeloperoxidase (MPO) activity, histopathology, nitric oxide (NO) level, and tumor necrosis factor-a (TNF-a) level were assessed. Seven phenolic compounds, mainly flavonoids and galloylated compounds, were isolated from the aqueous methanol extract: gallic acid (1), methyl gallate (2), quercetin-3-O-b-d-4C1-galactopyranoside (hyperin) (3), myricetin- 3-O-a-l-1C4-rhamnopyranoside (myricitrin) (4), 1,6-digalloyl-b-d-glucose (5), 1,4-digalloyl-b-d-glucopyranoside (6), and 2,3-di-O-galloyl-(a/b)-4C1-glucopyranose (nilocitin) (7). The anti-inflammatory activity was evidenced by decreased carrageenan-induced rat paw edema and PGE2 elevation. In the croton oil–induced ear edema model, MPO activity was significantly inhibited, and inflammatory histopathological changes were ameliorated. In the rat air pouch model, NO generation and TNF-a release were significantly inhibited. The isolation and nuclear magnetic resonance spectral data of compound 6 from the genus Pistacia are revealed for the first time. Also, P. khinjuk L. aqueous methanol extract possesses anti-inflammatory activity in several experimental models.