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Deuteromycols A and B, Two Benzofuranoids from a Red Sea Marine-derived Deuteromycete sp.
Mahmoud Nawwar,Sahar Hussein,Nahla A Ayoub,Amani Hashim,Gudrun Mernitz,Beate Cuypers,Michael Linscheid,Ulrike Lindequist 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
Two benzofuranoids, deuteromycol A, 6,7-dihydroxy-2-[1'-hydroxy-(1'→5'')-2'',3'',4''-trihydroxy-2'',3''-dihydropyran]benzofuran and deuteromycol B, 1-(6,7-dihydroxy benzofuran-2-yl)methylacetate have been isolated from the ethanol extract of the marine-derived fungal strain MF003 (Deuteromycete) obtained from Red Sea mangrove drift wood. Deuteromycols A and B contain a catecholic nucleus that to the best of our knowledge is unusual in association with marine fungi secondary metabolites. Structures were established on the basis of extensive 1Dand 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. Besides, the extracts exhibited in vitro antibacterial activity.