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Deuteromycols A and B, Two Benzofuranoids from a Red Sea Marine-derived Deuteromycete sp.
Mahmoud Nawwar,Sahar Hussein,Nahla A Ayoub,Amani Hashim,Gudrun Mernitz,Beate Cuypers,Michael Linscheid,Ulrike Lindequist 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
Two benzofuranoids, deuteromycol A, 6,7-dihydroxy-2-[1'-hydroxy-(1'→5'')-2'',3'',4''-trihydroxy-2'',3''-dihydropyran]benzofuran and deuteromycol B, 1-(6,7-dihydroxy benzofuran-2-yl)methylacetate have been isolated from the ethanol extract of the marine-derived fungal strain MF003 (Deuteromycete) obtained from Red Sea mangrove drift wood. Deuteromycols A and B contain a catecholic nucleus that to the best of our knowledge is unusual in association with marine fungi secondary metabolites. Structures were established on the basis of extensive 1Dand 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. Besides, the extracts exhibited in vitro antibacterial activity.
Mahmoud Nawwar,Nahla Ayoub,Sahar Hussein,Amani Hashim,Reham El-Sharawy,Kristian Wende,Manuela Harms,Ulrike Lindequist 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5
Chemical investigation on leaves of Annona muricata resulted in the isolation of the flavonol triglycoside, quercetin 3-O-α-rhamnosyl-(1'''' → 6'')-β-sophoroside, together with twelve known phenolics. The structures of these compounds were established by 1D- and 2D-nuclear magnetic resonance spectroscopic techniques and mass spectrometry data. The in vitro antioxidant studies of the investigated aqueous ethanol extract and its column fractions were accomplished using the oxygen radical absorbance capacity (ORAC) method. A stimulating effect on HaCaT human keratinocytes by the leaf extract was also assessed. Il-6 production after UV irradiation was not influenced by A. muricata leaf extract.