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Samantha E. Russell(Samantha E. Russell ),David R. Skvarc(David R. Skvarc ),Mohammadreza Mohebbi(Mohammadreza Mohebbi ),David Camfield(David Camfield ),Linda K. Byrne(Linda K. Byrne ),Alyna Turner(Aly 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: N -acetylcysteine (NAC) is a novel therapeutic agent with multiple mechanisms of action in the central nervous system and a favourable side effect profile. Clinical evidence indicates that adjunctive NAC may reduce the severity of depressive symptoms in individuals with major depressive disorder (MDD). Methods: A 12-week randomised controlled trial of 2,000 mg/day adjunctive NAC for MDD found no significant improvement at the primary endpoint (week 12) but did see improvements at the post-discontinuation interview (week 16). Within the context of patient-centered treatment, mixed-methods qualitative analysis was also included to explore factors that may determine individual responses to adjunctive NAC treatment. These data were drawn, under blinded conditions, from clinician notes recorded in the case report form. Using the DSM-5 symptom profile for MDD as the initial framework, themes were developed and explored. Frequencies were compared between placebo and NAC groups. Results: Per protocol analysis of individual themes across the six interviews revealed group differences in favour of NAC for overall depressive affect, optimism, relationships and reduced functional impairment. Conclusion: This study provides further evidence for the utility of the mixed methods approach complimenting the primary findings using traditional quantitative analyses, as well as being able to capture additional, often more subtle, evidence of individual symptom-level change that reflects improvement in functional abilities in response to NAC supplementation. The use of mixed methods to explore outcomes from psychiatric studies should be considered in future to work towards improved patient-centred care and both confirm quantitative findings and generate novel hypotheses.
Affect among Koreans: New Scales and their Structure
MichelleS.M.Yik,JamesA.Russell,Chang-KyuAhn 한국심리학회 2003 한국심리학회지 일반 Vol.22 No.1
이 논문은 한국사람이나 카나다 사람이나 순간적으로 느끼는 정서구조의 기본적 측면은 동일하다는 것을 보여준다. 순간정서를 평가하기 위해서 네 개 양식의 척도가 개발되었고, 각 척도는 Feldman, Barrett 및 Russell(1998)의 쾌, 불쾌, 활성화, 비활성화, Thayer(1996)의 에너지와 긴장, Larsen과 Diener(1992)의 쾌와 활성화의 여덟 개 조합, 그리고 Watson과 Tellegen(1985)의 긍정적 정서와 부정적 정서를 포함하고 있다. 365명의 한국인의 표집에서 새로운 척도는 심리 측정적으로 영어문화권의 카나다 인에서 나타난 것과 관련성이 있었다. 다시 말해서 새 척도의 정서차원은 이차원적 양극 정서 공간으로 통합될 수 있었다. This article shows that fundamental aspects of the structure of momentary affect are similar in Korean and Canadian societies. We developed questionnaire scales in Korean in four different formats for assessing momentary affect. Scales can be scored for Feldman Barrett and Russells (1998) Pleasant, Unpleasant, Activated, and Deactivated, Thayers (1996) energetic and tense arousal, Larsen and Dieners (1992) eight combinations of pleasantness and activation, and Watson and Tellegens (1985) Positive Affect and Negative Affect. In a sample of 365 Koreans, the new scales were found to be psychometrically sound and to be interrelated as found with English-speaking Canadians: Dimensions could be integrated into a two-dimensional bipolar affective space.
Russel J. Galanido,김동선,조정호 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.5
The separation of methanol-chloroform mixture, a minimum-boiling azeotrope, is performed using pressure- swing distillation process via process simulation. In this study, the steady-state optimization was carried out using PRO/II with PROVISION v.10. The two different column configurations (low-to-high pressure and high-to-low pressure) were compared wherein the positions of the low-pressure column and high-pressure column were operated interchangeably to attain an optimized design. Additionally, different heat-integration configurations (partial heat- and full heat-integration) were applied to lessen the overall utility consumption. It was determined that the low-to-high pressure column configuration provided a more optimized result for all heat-integrated systems as compared to high-tolow pressure column configuration. Application of heat-integration further decreases the cooling water and steam consumption by 38.86% and 35.74%, respectively, for partial heat-integrated system, and by 44.58% and 41.01%, respectively, for full heat-integrated system.
Russel Navarro Menchavez,하성호 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.6
Butanol fermentation has garnered renewed interest due to the search for renewable sources of energy. Although acetone-butanol-ethanol (ABE) fermentation has been studied for a long time, the methods utilized yield either a high butanol/ABE productivity and low titer or high butanol/ABE titer at a low productivity. In this work, we report the utilization of a highly dense calcium alginate immobilized Clostridium acetobutylicum cells in combination with fed-batch mode of fermentation to attain a high butanol/ABE productivity and concentration. A butanol concentration of up to 21.6 g/L was attained with a productivity of 0.40 g/L·hr, which is a 65% and 192% improvement to the conventional batch fermentation.
Russell L. Elsberry,Hsiao-Chung Tsai 한국기상학회 2014 Asia-Pacific Journal of Atmospheric Sciences Vol.50 No.3
A situation-dependent intensity prediction (SDIP) technique is developed for western North Pacific tropical cyclones that is based on the average of the intensity changes from the 10 best historical track analogs to the Joint Typhoon Warning Center best-tracks. The selection of the 10 best track analogs is also conditioned on the current intensity, and it is demonstrated that for a subsample of current intensities less than or equal to 35 kt the intensity mean absolute errors (MAEs) and biases are smaller than for the greater than 35 kt intensity subsample. The SDIP is demonstrated to have advantages as an intensity skill measure at forecast intervals beyond 36 h compared to the current climatology and persistence technique that uses only variables available at the initial time. The SDIP has significantly smaller intensity MAEs beyond 36 h with an almost 20% reduction at 120 h, has significantly smaller intensity biases than the present skill metric beyond 12 h, and explains 36% of the intensity variability at 120 h compared to 20% explained variance for the current technique. The probability distributions of intensities at 72 h and 120 h predicted by the SDIP are also a better match of the distribution of the verifying observations. Intensity spread guidance each 12 h to 120 h is developed from the intensity spread among the 10 best historical track analogs. The intensity spread is calibrated to ensure that the SDIP forecasts will have a probability of detection (PoD) of at least 68.26%. While this calibrated intensity spread is specifically for the SDIP technique, it would provide a first-order spread guidance for the PoD for the official intensity forecast, which would be useful intensity uncertainty information for forecasters and decision-makers.
Protection and Presentation : An Ongoing Battle of The American Civil War
Russell E,Brayley 세계문화관광학회 2011 Conference Proceedings Vol.12 No.-
Major battlefields from the American Civil War are protected in the National Park system and preserved as hallowed grounds. As places of interest and importance to the public battlefields are also presented for educational and interpretive purposes. Political and management conflict arises over the apparent contradiction between preservation as protection and preservation for presentation. Like other sacred sites the battlefields require formal designation protection and control to preserve their sanctity. However they also need to be understood appreciated and visited by those for whom the sites are an important part of their heritage. Interpretive activities such as large-scale battle re-enactments often emphasize the challenges of providing both protection and interpretive presentation.