Age-related Autoimmune Changes in Lacrimal Glands

Rodrigo G. de Souza,Cintia S. de Paiva,Milton R. Alves 대한면역학회 2019 Immune Network Vol.19 No.1

Age-related Autoimmune Changes in Lacrimal Glands

Rodrigo G. de Souza,Cintia S. de Paiva,Milton R. Alves 대한면역학회 2019 Immune Network Vol.19 No.1

Aging is a complex process associated with dysregulation of the immune system and low levels of inflammation, often associated with the onset of many pathologies. The lacrimal gland (LG) plays a vital role in the maintenance of ocular physiology and changes related to aging directly affect eye diseases. The dysregulation of the immune system in aging leads to quantitative and qualitative changes in antibodies and cytokines. While there is a gradual decline of the immune system, there is an increase in autoimmunity, with a reciprocal pathway between low levels of inflammation and aging mechanisms. Elderly C57BL/6J mice spontaneously show LGs infiltration that is characterized by Th1 but not Th17 cells. The aging of the LG is related to functional alterations, reduced innervation and decreased secretory activities. Lymphocytic infiltration, destruction, and atrophy of glandular parenchyma, ductal dilatation, and secretion of inflammatory mediators modify the volume and composition of tears. Oxidative stress, the capacity to metabolize and eliminate toxic substances decreased in aging, is also associated with the reduction of LG functionality and the pathogenesis of autoimmune diseases. Although further studies are required for a better understanding of autoimmunity and aging of the LG, we described anatomic and immunology aspects that have been described so far.

Comparative analysis of torsional and cyclic fatigue resistance of ProGlider, WaveOne Gold Glider, and TruNatomy Glider in simulated curved canal

Dias Pedro de Souza,Kato Augusto Shoji,Bueno Carlos Eduardo da Silveira,Vivan Rodrigo Ricci,Duarte Marco Antonio Hungaro,Calefi Pedro Henrique Souza,Pelegrine Rina Andréa 대한치과보존학회 2023 Restorative Dentistry & Endodontics Vol.48 No.1

Objectives This study aimed to compare the torsional and cyclic fatigue resistance of ProGlider (PG), WaveOne Gold Glider (WGG), and TruNatomy Glider (TNG). Materials and Methods A total of 15 instruments of each glide path system (n = 15) were used for each test. A custom-made device simulating an angle of 90° and a radius of 5 millimeters was used to assess cyclic fatigue resistance, with calculation of number of cycles to failure. Torsional fatigue resistance was assessed by maximum torque and angle of rotation. Fractured instruments were examined by scanning electron microscopy (SEM). Data were analyzed with Shapiro-Wilk and Kruskal-Wallis tests, and the significance level was set at 5%. Results The WGG group showed greater cyclic fatigue resistance than the PG and TNG groups (p < 0.05). In the torsional fatigue test, the TNG group showed a higher angle of rotation, followed by the PG and WGG groups (p < 0.05). The TNG group was superior to the PG group in torsional resistance (p < 0.05). SEM analysis revealed ductile morphology, typical of the 2 fracture modes: cyclic fatigue and torsional fatigue. Conclusions Reciprocating WGG instruments showed greater cyclic fatigue resistance, while TNG instruments were better in torsional fatigue resistance. The significance of these findings lies in the identification of the instruments’ clinical applicability to guide the choice of the most appropriate instrument and enable the clinician to provide a more predictable glide path preparation.

Incidence of frugivorous flies (Tephritidae and Lonchaeidae), fruit losses and the dispersal of flies through the transportation of fresh fruit

Louzeiro Leo Rodrigo Ferreira,Souza-Filho Miguel Francisco de,Raga Adalton,Gisloti Laura J. 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1

Frugivorous flies (Diptera: Tephritidae and Lonchaeidae) cause significant losses in horticultural crops. These losses are associated with the fruit damaged by frugivorous fly infestation occurring during all steps of the production and commercial sale. Pest monitoring is the main tool used to identify and avoid future losses in horticultural crops. In this study we monitor the population of frugivorous flies in a fruit orchard and a food supply centre (FSC) to assess fruit losses and examine the dispersal of flies. Six Anastrepha species, Ceratitis capitata (Wiedemann), five Neosilba species and Dasiops sp. were recovered from traps and fruit samples. The fruit losses were estimated for star fruit (26%), guava (17%), mango (4%), orange (1.9%), tangerine (0.9%) and apple (0.2%). The fruit collected at the FSC demonstrated that immature frugivorous flies can disperse for several kilometres through the transportation of fresh fruit. Due to the importance of frugivorous flies, this poses a threat to the production and commercial sale of fruit around the world. Our study presents information relevant to the pest management and risk mitigation for frugivorous flies.

Carcass Composition and Cuts of Bulls and Steers Fed with Three Concentrate Levels in the Diets

Ivanor Nunes do Prado,Rodrigo Augusto Cortez Passetti,Dayane Cristina Rivaroli,Mariano Garcia Ornaghi,Kennyson Alves de Souza,Camila Barbosa Carvalho,Daniel Perotto,Jose Luiz Moletta 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.9

In this paper, weight, carcass dressing, weights of the primary cuts, weights of the physical components of the primary cuts, and weights of the main commercial cuts of 66 Purunã animals, of which 33 were bulls and 33 were steers were evaluated. These animals, with an average age of 19 months at the beginning of the experiment, were finished in a feedlot system during 116 days, and were fed with diets containing three levels of concentrate (0.8%, 1.1%, and 1.4% of body weight). The concentrate was formulated with 25% soybean meal, 73% ground corn grain, 1% of a mineral mix, and 1% of limestone. The interaction between sexual groups and the concentrate level was not significant for any of the variables. Likewise, no effect of the concentrate level was detected on the same variable traits. The bulls demonstrated higher hot carcass weights (265.1 vs 221.7 kg) and a higher proportion of forequarter (38.4% vs 36.1%) however the steers presented with higher proportions of side (19.7% vs 18.5%) and hindquarter (44.2% vs 43.1%). The bulls produced higher yields of muscle in the three primary cuts, there by resulting in higher yields of edible portions of the carcass. The bulls also produced higher weights of tenderloin, knuckle, topside, flat, eye round, rump, and rump cover. The finishing of young bulls in feedlot is to be recommended, since the animals produce carcasses with higher amounts of edible meat and higher yields of commercial cuts, thus allowing for a better price for the carcass. Low concentrate level could be used due to the lower cost of production for farmers.

Effect of medium or high concentrations of in-office dental bleaching gel on the human pulp response in the mandibular incisors

Roderjan Douglas Augusto,Stanislawczuk Rodrigo,Soares Diana Gabriela,de Souza Costa Carlos Alberto,Favoreto Michael Willian,Reis Alessandra,Loguercio Alessandro D. 대한치과보존학회 2023 Restorative Dentistry & Endodontics Vol.48 No.2

Objectives The present study evaluated the pulp response of human mandibular incisors subjected to in-office dental bleaching using gels with medium or high concentrations of hydrogen peroxide (HP). Materials and Methods The following groups were compared: 35% HP (HP35; n = 5) or 20% HP (HP20; n = 4). In the control group (CONT; n = 2), no dental bleaching was performed. The color change (CC) was registered at baseline and after 2 days using the Vita Classical shade guide. Tooth sensitivity (TS) was also recorded for 2 days post-bleaching. The teeth were extracted 2 days after the clinical procedure and subjected to histological analysis. The CC and overall scores for histological evaluation were evaluated by the Kruskal-Wallis and Mann-Whitney tests. The percentage of patients with TS was evaluated by the Fisher exact test (α = 0.05). Results The CC and TS of the HP35 group were significantly higher than those of the CONT group (p < 0.05) and the HP20 group showed an intermediate response, without significant differences from either the HP35 or CONT group (p > 0.05). In both experimental groups, the coronal pulp tissue exhibited partial necrosis associated with tertiary dentin deposition. Overall, the subjacent pulp tissue exhibited a mild inflammatory response. Conclusions In-office bleaching therapies using bleaching gels with 20% or 35% HP caused similar pulp damage to the mandibular incisors, characterized by partial necrosis, tertiary dentin deposition, and mild inflammation. Objectives The present study evaluated the pulp response of human mandibular incisors subjected to in-office dental bleaching using gels with medium or high concentrations of hydrogen peroxide (HP). Materials and Methods The following groups were compared: 35% HP (HP35; n = 5) or 20% HP (HP20; n = 4). In the control group (CONT; n = 2), no dental bleaching was performed. The color change (CC) was registered at baseline and after 2 days using the Vita Classical shade guide. Tooth sensitivity (TS) was also recorded for 2 days post-bleaching. The teeth were extracted 2 days after the clinical procedure and subjected to histological analysis. The CC and overall scores for histological evaluation were evaluated by the Kruskal-Wallis and Mann-Whitney tests. The percentage of patients with TS was evaluated by the Fisher exact test (α = 0.05). Results The CC and TS of the HP35 group were significantly higher than those of the CONT group (p < 0.05) and the HP20 group showed an intermediate response, without significant differences from either the HP35 or CONT group (p > 0.05). In both experimental groups, the coronal pulp tissue exhibited partial necrosis associated with tertiary dentin deposition. Overall, the subjacent pulp tissue exhibited a mild inflammatory response. Conclusions In-office bleaching therapies using bleaching gels with 20% or 35% HP caused similar pulp damage to the mandibular incisors, characterized by partial necrosis, tertiary dentin deposition, and mild inflammation.

Combination of Anterior and Posterior Subcutaneous Internal Fixation for Unstable Pelvic Ring Injuries: The “Hula Hoop Technique”

( Daniel Balbachevsky ),( Robinson Esteves Pires ),( Rodrigo Guerra Sabongi ),( Theophilo Asfora Lins ),( Geiser De Souza Carvalho ),( Helio Jorge Alvachian Fernandes ),( Fernando Baldy Dos Reis ) 대한외상학회 2019 大韓外傷學會誌 Vol.32 No.1

Unstable pelvic ring lesions are usually treated with internal fixation. In patients presenting clinical instability or soft tissue complication risk, external fixation is a safe treatment option. However, pin tract infection, insufficient biomechanical properties, difficulty sitting and changing decubitus are important drawbacks related to the treatment. The present study reports the association of anterior and posterior subcutaneous internal fixation by applying spine-designed implants on the pelvic ring disruption: supra- acetabular pedicle screws with an interconnecting rod (Infix), plus posterior transiliac fixation with the same system, which the authors have named the “Hula Hoop Technique”.

Effects of Passiflora edulis (Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Maricelma da Silva Soares de Souza,Sandra Maria Barbalho,De´bora Cristina Damasceno,Marilza Vieira Cunha Rudge,Kleber Eduardo de Campos,Ana Carolina Goyos Madi,Bruno Ribeiro Coelho,Rodrigo Ce´sar Oliv 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.1

The aim of this study was to evaluate the effects of Passiflora edulis f. flavicarpa Degener (yellow passion) juice on the lipid profile and oxidative stress status of Wistar rats. Adult male Wistar rats were divided in two groups (n = 8 animals per group): the control group, which received water, and the treated group, which was given P. edulis juice (1,000 mg/kg). Both groups received by gavage treatment twice a day for 28 days. The treated group showed an increased high-density lipoproteincholesterol level and decreased low-density lipoprotein-cholesterol and free fatty acid levels compared with the control group. Levels of triglycerides and and very low-density lipoprotein-cholesterol, superoxide dismutase activity, and total glutathione concentration were not statistically different between the two groups, but the thiobarbituric acid–reactive substances concentration (indicating lipid peroxidation) decreased in the treated group. These findings suggests that P. edulis juice in the experimental conditions used showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats.

Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease

Alice Barros Camara,Iara Dantas de Souza,Rodrigo Juliani Siqueira Dalmolin 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.9

Vitamin D (VD) deficiency is a growing problem, affecting a significant portion of the population in many countries. VD deficiency may be related to several diseases, including Alzheimer's disease (AD). This study aimed to review the relationship between VD deficiency and AD. We describe the proteins involved in AD pathogenesis and how those proteins can be influenced by VD deficiency. We also investigated a relationship between AD death rate and solar radiation and we found an increased AD death rate in countries with low sunlight. It was also observed that amyloid precursor protein, ryanodine receptor, mammalian target of rapamycin complex 1, and receptor for advanced glycation end products are associated with a worse prognosis in AD. While the Klotho protein, phosphatase and tensin homologue, and VD receptor are associated with a better prognosis in the disease. The literature suggests that decline in VD concentrations may be involved in the establishment and progression of AD. According to sunlight data, we can conclude that countries with low average sunlight have high AD death rate.

Carcass Composition and Cuts of Bulls and Steers Fed with Three Concentrate Levels in the Diets

do Prado, Ivanor Nunes,Passetti, Rodrigo Augusto Cortez,Rivaroli, Dayane Cristina,Ornaghi, Mariana Garcia,de Souza, Kennyson Alves,Carvalho, Camila Barbosa,Perotto, Daniel,Moletta, Jose Luiz Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.9

In this paper, weight, carcass dressing, weights of the primary cuts, weights of the physical components of the primary cuts, and weights of the main commercial cuts of 66 $Purun{\tilde{a}}$ animals, of which 33 were bulls and 33 were steers were evaluated. These animals, with an average age of 19 months at the beginning of the experiment, were finished in a feedlot system during 116 days, and were fed with diets containing three levels of concentrate (0.8%, 1.1%, and 1.4% of body weight). The concentrate was formulated with 25% soybean meal, 73% ground corn grain, 1% of a mineral mix, and 1% of limestone. The interaction between sexual groups and the concentrate level was not significant for any of the variables. Likewise, no effect of the concentrate level was detected on the same variable traits. The bulls demonstrated higher hot carcass weights (265.1 vs 221.7 kg) and a higher proportion of forequarter (38.4% vs 36.1%) however the steers presented with higher proportions of side (19.7% vs 18.5%) and hindquarter (44.2% vs 43.1%). The bulls produced higher yields of muscle in the three primary cuts, there by resulting in higher yields of edible portions of the carcass. The bulls also produced higher weights of tenderloin, knuckle, topside, flat, eye round, rump, and rump cover. The finishing of young bulls in feedlot is to be recommended, since the animals produce carcasses with higher amounts of edible meat and higher yields of commercial cuts, thus allowing for a better price for the carcass. Low concentrate level could be used due to the lower cost of production for farmers.