Does maxillomandibular fixation affect skeletal stability following mandibular advancement? A single-blind clinical trial

Reza Tabrizi,Arash Sarrafzadeh,Shervin Shafiei,Hamidreza Moslemi,Ramtin Dastgir 대한악안면성형재건외과학회 2022 Maxillofacial Plastic Reconstructive Surgery Vol.44 No.-

Background: The stability of the results remains a significant concern in orthognathic surgeries. This study aimed to assess the amount of relapse following mandibular advancement with/without maxillomandibular fixation (MMF). Materials and methods: A single-blind clinical trial was conducted on patients with mandibular retrognathism who underwent BSSO for mandibular advancement and Lefort I maxillary superior repositioning. Patients were randomly divided into two groups of treatment (MMF) and control (no MMF). In the treatment group, MMF was performed for 2 weeks; meanwhile, MMF was not performed in the control group, and only guiding elastics were applied postoperatively. Lateral cephalograms were obtained preoperatively (T1), immediately after surgery (T2), and at 1 year postoperatively (T3). The distance from points A and B to the X and Y plane were measured to identify the amount of vertical and horizontal relapse in 1 year as a primary outcome. An independent t-test was applied in order to find differences in outcomes between the control and treatment groups. Results: Fifty-eight patients were evaluated in two groups (28 patients in the MMF group and 30 in the no-MMF group). The magnitude of mandibular advancement following BSSO was 7.68±1.39 mm and 7.53±1.28, respectively, without significant difference among the groups (p= 0.68). The mean sagittal and vertical changes (relapse) at point B were significantly different between the two groups at 1-year follow-up after the osteotomy (p=0.001 and p=0.05, respectively). Conclusion: According to the results of this study, patients with short-term MMF following BSSO for mandibular advancement benefit from significantly greater skeletal stability in the sagittal and vertical dimensions.

Skeletal stability following mandibular advancement: is it influenced by the magnitude of advancement or changes of the mandibular plane angle?

Reza Tabrizi,Mahsa Nili,Ehsan Aliabadi,Fereydoun Pourdanesh 대한구강악안면외과학회 2017 대한구강악안면외과학회지 Vol.43 No.3

Objectives: The aim of this study was to investigate the effects of advancement magnitude and changes in mandibular plane angle on the stability of mandibular advancement. Materials and Methods: This retrospective cohort study evaluated the postoperative stability of mandibular advancement in class II skeletal subjects who underwent bilateral sagittal split osteotomy. Radiographs taken preoperatively, immediately postoperatively and 1 year postoperatively were traced and analyzed using linear and angular measurements. To determine horizontal and vertical relapse, an X-Y coordinate system was established in which the X-axis was constructed by rotating S-N downward by 7° (approximation of the Frankfort horizontal plane) and the Y-axis was defined as a line perpendicular to the X-axis and passing through the point Sella. For certain reference points including point A, point B, pogonion and menton, the perpendicular distance between each point and both axes was determined and cephalometric variables were recorded as X and Y coordinates. Results: Twenty-five subjects were studied. A significant correlation between the amount of mandibular advancement and relapse in the B point (vertical and horizontal) and the pogonion point was observed (vertical and horizontal, P<0.001). Evaluation of data demonstrated a positive correlation between the mandibular plane angle (SN/ML) change and vertical relapse in the B point (P<0.05). A simple regression model demonstrated that 74% of horizontal relapse and 42.3% of vertical relapse in the B point was related to the amount of mandibular advancement. The receiver operating characteristic test showed that 8.5 mm mandibular advancement is related to a relapse rate of 1 mm or more in the pogonion, vertically or horizontally. Conclusion: The magnitude of mandibular advancement is a stronger surgical predictor for horizontal rather than vertical relapse at the B point. Changes in mandibular plane angle (SN/ML) during surgery affect vertical, but not horizontal relapse at the B point.

Comparison of postoperative paresthesia after sagittal split osteotomy among different fixation methods: a one year follow-up study

Reza Tabrizi,Kousha Bakrani,Farshid Bastami 대한구강악안면외과학회 2019 대한구강악안면외과학회지 Vol.45 No.4

Objectives: Postoperative paresthesia is a common complication after sagittal split osteotomy (SSO). This study aimed to compare paresthesia among different fixation methods one year postoperative. Materials and Methods: This prospective cohort study assessed subjects in four groups: class II with miniplate fixation (Group 1), class II with three-screw fixation (Group 2), class III with miniplate fixation (Group 3), and class III with three-screw fixation (Group 4). Paresthesia was evaluated one year postoperative based on a 0-10 visual analogue scale. Pearson correlation was used to evaluate associations of age and mandibular movement with paresthesia. ANOVA was used to compare paresthesia among groups. Results: A total of 80 subjects were enrolled, with 20 subjects in each of the four groups. The Pearson correlation test demonstrated a significant correlation between mandibular movement and paresthesia (P=0.001). Comparison of paresthesia among the groups showed significant differences among groups 1 and 2, 2 and 3, and 3 and 4 (P<0.05). Conclusion: The three-screw fixation method led to more paresthesia one year postoperative compared with miniplate fixation. In addition, the magnitude of mandibular movement had a positive correlation with paresthesia.

Genetic diversity revealed by phytochemical and molecular analyses among and within eight Trigonella sp.

Mirzahosein-Tabrizi Maryam,Ghanavati Farangis,Azizinezhad Reza,Etminan Alireza 한국작물학회 2023 Journal of crop science and biotechnology Vol.26 No.3

Genetic diversity is a key factor for breeding programs and provides opportunities for developing superior varieties with preferred traits. Trigonella is a large genus of plants that is important in culinary terms and for the food industry. The present research aimed to study genetic diversity and population structure in a set of 90 accessions from eight diferent species of Trigonella sp. using 20 URP and SCoT primers. Also, fve amino acids and Trigonelline content were determined in the plants. The average marker index was 3.43 and 3.73 for SCoT and URP primers, respectively. NJ clustering was based on combined data and classifed all 90 accessions clearly, based on their species. AMOVA revealed that the main part (68%) of total variation occurring within species and T. monantha was the most diverse population among all species. According to the phytochemical, there were signifcant diferences between all species in terms of trigonelline content and the amounts of amino acids. High levels of genetic diversity were identifed among and within the eight species which can be considered for breeding purposes. Furthermore, URP and SCoT were found useful markers for the analysis of genetic diversity and population structures in Trigonella sp. Meanwhile, Trigonella foenum-graecum showed the highest Trigonelline content. As a matter of the health benefts provided by this alkaloid, T. foenum-graecum can be used not only for medicinal purposes but also as a useful vegetable and food ingredient.

A comparative study of hydroxyapatite nanostructures produced under different milling conditions and thermal treatment of bovine bone

Bahman Nasiri-Tabrizi,Abbas Fahami,Reza Ebrahimi-Kahrizsangi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.1

In the present investigation the effects of milling parameters (time, atmosphere, and media) andchemical composition of raw materials on the mechanochemical synthesis of nanocrystallinehydroxyapatite (n-HAp) were studied. For a comparative study of the mechanically activated samplesversus thermally treated specimen (natural origin), n-HAp was also produced via annealing of bovinebone at 800℃ for 2 h. The gained powders exhibited average sizes about 32 and 27 nm under airatmosphere, and about 32 and 34 nm under argon atmosphere. TEM images confirmed the formation ofn-HAp with various morphologies under different experimental conditions.

Numerical study of gas-solid reactive flow in a cylinder

Ardeshir Bangian Tabrizi,Mehrzad Shams,Reza Ebrahimi 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.3

A theoretical model is described for the numerical simulation of unsteady gas-solid reactive flow in packed beds of granular propellants in a tubular geometry. The approach couples continuity, momentum and energy equations in each phase along with porosity and granular stresses. Propellant bed combustion process is neglected, but the mass flow rate due to the combustion is derived using a pressure-based burning rate correlation. As the burning of solid propellant begins, pressure, temperature, density and other gas parameters begin to change rapidly. To catch these changes, a CFD approach with explicit McCormack method is used to solve the coupled system of equations. A moving mesh is used to consider the moving boundary. Pressure history, moving boundary velocity and other parameters of the mixture are obtained and compared with other numerical data.

Diagnostic Value of Protein Ki67 (MIB-1) in Atypical Pap Smears of Postmenopausal Women

Fakhrjou, Ashraf,Dastranj-Tabrizi, Ali,Ghojazadeh, Morteza,Ghorashi, Sona,Velayati, Atefeh,Piri, Reza,Vahedi, Amir,Sayyah-Melli, Manizhe,Smaeili, Heydar-Ali,Bonakdari, Amir,Halimi, Monireh,Naghavi-Beh Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Background: Atrophic epithelium of cervix sampled from postmenopausal women may mimic high-grade cervical intraepithelial neoplasia in Papanicolaou-stained (Pap) smears. Ki-67 (MIB-1) protein presents on proliferating cells, and percentage of cells with positive nuclei provides a reliable tool for rapid evaluation of the growth fraction. The aim of this study was to determine the diagnostic value of protein Ki67 staining in atypical pap smears of postmenopausal women. Methods: In a case-control setting, pap smears of 75 women with an atypical pap smear (case group) and 75 with normal pap smears (controls) were obtained before and after estrogen treatment. Afterward, samples were exposed to the monoclonal antibody Ki-67 (MIB-1) and the immunohistochemically demonstrated Ki-67+ cells were compared. Results: Mean ages of cases and controls were $60.4{\pm}4.5$ and $59.9{\pm}4.3$ years respectively (P=0.50). There was one (2.7%) positive Ki-67 specimen in the case group, without any positive Ki-67 specimen in the control group (P=0.50). Conclusions: Measurement of proliferative activity index in Pap smears restrained with MIB1 is a simple, reliable, and cost-effective method for excluding negatives. This would imply that it might allow a substantial reduction of diagnostic estrogen courses and subsequent Pap smears in postmenopausal women with atypical findings.

Clinical Findings and Results of Surgical Resection of Thoracolumbar Osteoid Osteoma

Hojjat Hossein Pourfeizi,Ali Tabrizi,Mohammad Reza Bazavar,Jafar Ganjpour Sales 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.2

Study Design: Descriptive, cases series study. Purpose: To evaluate clinical findings and results of treatment of patients with spinal osteoid osteoma who underwent surgery. Overview of Literature: Osteoid osteoma is a benign tumor with spinal involvement rate of about 10%. It is manifested during adolescence with symptoms such as painful scoliosis. To treat the problem, operation on the patients and excising the nidus are suggested. Methods: This descriptive study was conducted on 11 patients with spinal osteoid osteoma at our orthopedic educational center. All patients were treated through open surgery and nidus curettage. All samples were pathologically confirmed. Imaging methods (spiral computed tomography-scan) was used in preoperative planning. Scoliosis and other clinical findings were studied. Results: The study was conducted on 11 patients comprising 6 females (54.5%) and 5 males (45.5%) with the mean age of 14.6 years. Mean deviation of scoliosis resulting from spinal osteoid osteoma was 22.8 degrees. There was more scoliosis in the involvement of the lumbar vertebra. In comparison with adults, scoliosis was more severe in youths. There was one case of vertebra body involvement with manifestation of painful scoliosis. Due to lack of careful preoperative examination, the surgery was repeated for this case. No sign of recurrence was observed in patients who underwent open surgery and all scoliosis in the follow-up had improved. Conclusions: Based on our findings, surgical excision of spinal ostoeid osteoma was successful and complete recovery was achieved in spinal deformity in the course of follow-up. Scoliosis is often seen during adolescence and lumbar involvement is more severe.

Lactobacillus acidophilus and Lactobacillus crispatus Culture Supernatants Downregulate Expression of Cancer-testis Genes in the MDA-MB-231 Cell Line

Azam, Rosa,Ghafouri-Fard, Soudeh,Tabrizi, Mina,Modarressi, Mohammad-Hossein,Ebrahimzadeh-Vesal, Reza,Daneshvar, Maryam,Mobasheri, Maryam Beigom,Motevaseli, Elahe Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Lactobacilli are probiotics shown to have antitumor activities. In addition, they can regulate gene expression through epigenetic mechanisms. In this study, we aimed to assess anti tumor activities of Lactobacillus acidophilus and Lactobacillus crispatus on the MDA-MB-231 breast cancer cell line. The effects of culture supernatants were determined by MTT [3-(4,5-dimethylthiazol-2-y-2,5-diphenyltetrazolium bromide] assay. Changes in expression of 5 cancer-testis antigens (CTAs), namely AKAP4, ODF4, PIWIL2, RHOXF2 and TSGA10, were analyzed by quantitative real time RT-PCR. The culture supernatants of the 2 lactobacilli inhibited MDA-MB-231 cell proliferation. In addition, transcriptional activity of all mentioned CTAs except AKAP4 was significantly decreased after 24 hour treatment with culture supernatants. This study shows that Lactobacillus acidophilus and Lactobacillus crispatus have antiproliferative activity against MDA-MB-231 cells. In addition, these lactobacilli could decrease transcriptional activity of 4 CTAs. Previous studies have shown that expression of CTAs is epigenetically regulated, so it is possible that lactobacilli cause this expression downregulation through epigenetic mechanisms. As expression of CTAs in cancers is usually associated with higher grades and poor prognosis, downregulation of their expression by lactobacilli may have clinical implications.

Outcomes and influential factors in functional and dental rehabilitation following microvascular fibula flap reconstruction in the maxillomandibular region: a systematic review and meta-analysis

Elahe Tahmasebi,Elham Keykha,Samira Hajisadeghi,Hamidreza Moslemi,Shervin Shafiei,Mohammad Hosein Kalantar Motamedi,Arman Torabizadeh,Reza Tabrizi,Mostafa Alam 대한악안면성형재건외과학회 2023 Maxillofacial Plastic Reconstructive Surgery Vol.45 No.-

Background This systematic review and meta-analysis aimed to evaluate the factors influencing and success rates of dental implants for functional and dental rehabilitation following microvascular fibula flap reconstruction in the maxillomandibular region. Main text We conducted a comprehensive search of electronic databases, including MEDLINE, Web of Science, Embase, Scopus, and Cochrane’s CENTRAL, as well as gray literature sources and manual searches of notable journals. The search was performed from inception until February 2023. Studies were included if they examined functional and dental rehabilitation outcomes in patients receiving maxillofacial reconstruction using microvascular fibula flaps and were retrospective or prospective cohort studies involving human subjects. Case–control studies, research involving other reconstruction methods, and animal-based studies were excluded. Data was extracted and confirmed by two independent researchers, and risk of bias was assessed using the Newcastle–Ottawa Scale. Meta-analyses were conducted for dental implant and graft success rate, with separate analyses for different factors affecting the outcome. Heterogeneity was evaluated using Cochran’s Q test and the I2 test. The pooled success rate for implants was 92% and for grafts, 95%, with significant heterogeneity. Implants in fibular grafts had a 2.91 times higher failure rate than those in natural bones. Radiated bone and smoking were identified as factors influencing implant failure, with radiated bone having a 2.29 times higher risk and smokers having a 3.16 times higher risk compared to their respective counterparts. Patient-reported outcomes showed improvements in key areas such as dietary intake, mastication, speech, and esthetics. The success rates declined over time, emphasizing the importance of long-term follow-up. Conclusions Dental implants in free fibula grafts generally have favorable success rates, with minimal bone resorption, manageable probing depths, and limited bleeding on probing. Implant success is influenced by factors such as smoking and radiated bone.