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Jia, Lina,Lee, Hun Seok,Wu, Chun Fu,Kundu, Juthika,Park, Sang Gyu,Kim, Ryong Nam,Wang, Li-Hui,Erkin, Ö,zgü,r Cem,Choi, Jong-Sun,Chae, Seoung Wan,Yang, Ho Bin,Choi, Yoon-La,Shin, Young Kee American Association for Cancer Research 2014 Molecular Cancer Research Vol.12 No.12
<P>SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin through the inhibition of GSK-3β. Here, SMAD4 modulated AURKA in a TGFβ-independent manner. Overexpression of SMAD4 significantly suppressed AURKA function, including colony formation, migration, and invasion of cell lines. In addition, SMAD4 bound to AURKA induced degradation of AURKA by the proteasome. A luciferase activity assay revealed that the transcriptional activity of the β-catenin/TCF complex was elevated by AURKA, but decreased by SMAD4 overexpression. Moreover, target gene analysis showed that SMAD4 abrogated the AURKA-mediated increase of β-catenin target genes. However, this inhibitory effect of SMAD4 was abolished by overexpression of AURKA or silencing of AURKA in SMAD4-overexpressed cells. Meanwhile, the SMAD4-mediated repression of AURKA and β-catenin was independent of TGFβ signaling because blockage of TGFβR1 or restoration of TGFβ signaling did not prevent suppression of AURKA and β-catenin signaling by SMAD4. These results indicate that the tumor-suppressive function of SMAD4 is mediated by downregulation of β-catenin transcriptional activity via AURKA degradation in a TGFβ-independent manner.</P><P><B>Implications:</B> SMAD4 interacts with AURKA and antagonizes its tumor-promoting potential, thus demonstrating a novel mechanism of tumor suppression. <I>Mol Cancer Res; 12(12); 1779–95. ©2014 AACR</I>.</P>
The hybrid energy spectrum of Telescope Array's Middle Drum Detector and surface array
Abbasi, R.U.,Abe, M.,Abu-Zayyad, T.,Allen, M.G.,Anderson, R.,Azuma, R.,Barcikowski, E.,Belz, J.W.,Bergman, D.R.,Blake, S.A.,Cady, R.,Chae, M.J.,Cheon, B.G.,Chiba, J.,Chikawa, M.,Cho, W.R.,Fujii, T.,Fu North-Holland ; Elsevier Science Ltd 2015 Astroparticle physics Vol.68 No.-
The Telescope Array experiment studies ultra high energy cosmic rays using a hybrid detector. Fluorescence telescopes measure the longitudinal development of the extensive air shower generated when a primary cosmic ray particle interacts with the atmosphere. Meanwhile, scintillator detectors measure the lateral distribution of secondary shower particles that hit the ground. The Middle Drum (MD) fluorescence telescope station consists of 14 telescopes from the High Resolution Fly's Eye (HiRes) experiment, providing a direct link back to the HiRes measurements. Using the scintillator detector data in conjunction with the telescope data improves the geometrical reconstruction of the showers significantly, and hence, provides a more accurate reconstruction of the energy of the primary particle. The Middle Drum hybrid spectrum is presented and compared to that measured by the Middle Drum station in monocular mode. Further, the hybrid data establishes a link between the Middle Drum data and the surface array. A comparison between the Middle Drum hybrid energy spectrum and scintillator Surface Detector (SD) spectrum is also shown.
R. L. Liu,Y. J. Qiao,M. F. Yan,Y. D. Fu 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.5
To study the effect of rare earth (RE) addition on low temperature plasma nitrocarburizing of martensitic precipitation hardening stainless steel, 17-4PH stainless steel was plasma nitrocarburized at 460 °C for different times with RE addition. The modified layers were tested by optical microscope, scanning electron microscope, X-ray diffraction, microhardness tester and pin-on-disc tribometer. The experimental results show that the layer depth of plasma RE nitrocarburized layer can be increased up to 56% compared with plasma nitrocarburizing without RE addition. Incorporation of RE element is beneficial to the formation of nitrogen and carbon expanded martensite (α'N). The surface microhardness of plasma RE nitrocarburized layer can be increased to 1286 HV and higher up to 80 HV than that obtained from the conventional treated one. The friction coefficient of martensitic stainless steel can be dramatically decreased by low temperature plasma nitrocarburizing with RE addition, and the friction coefficient of the modified specimens decrease gradually with increasing process time in the present test condition.
Fu, Y.L.,Zhang, B.R.,Wang, S.,Gao, X.X.,Wang, L.Y. Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
An improved method for the preparation of monomethine cyanine dyes with quinoline nucleus by one-pot three-component using 1-methyl-2-quinolinethione, quaternized 2- or 4-methylheterocyclic compounds and methyl p-toluenesulfonate as starting materials was described. Compared with the traditional methods, the new synthetic method reduced the reaction steps, shortened the reaction time, avoided the separation and purification of the intermediate and reduced cost. The dyes absorbed in the region 478.0-563.0 nm and had molar extinction coefficients of $1.3{\times}10^4-9.4 {\times}10^4L\;mol^{-1}\;cm^{-1}$. Their fluorescence maxima and Stokes shifts were in the range of 525.2-594.4 nm and 16.2-80.6 nm in different solvents, respectively. From the spectral properties of the dyes in different solvents, it could be found that the ${\lambda}_{max}$ of the dyes were shorter in protonic solvents, and showed hypsochromic shifts with the increase of polarity of the solvents.
Fu, N.,Lv, R.,Guo, Z.,Guo, Y.,You, X.,Tang, B.,Han, D.,Yan, H.,Row, K.H. Elsevier 2017 Journal of chromatography Vol.1492 No.-
<P>In this work, choline chloride (ChCI) deep eutectic solvents (DESs) were evaluated for the pretreatment of palm samples in the analysis of polyphenols, such as protocatechuic acid, catechins, epicatechin, and caffeic acid. During the enrichment step of the pretreatment, eight DESs comprising ChCI with ethylene glycol (EG), glycerol (Gly), xylitol (Xyl), phenol (Ph), formic acid (FA), citric acid (CiA), oxalic acid (OA), or malonic acid (MA), were prepared and applied to the reflux extraction of polyphenols from palm samples. All the DESs exhibited higher polyphenol extraction efficiency than methanol, and the highest extraction efficiency was obtained using ChCI-FA (1:1, mole ratio). For the purification step of the pretreatment, eight ChCI DES-modified adsorbents were prepared by hydrothermal polymerization and packed into solid phase extraction (SPE) cartridges, and ChCI-Urea, ChCI-Gly, ChCI-FA, and water, were used as eluents. The ChCI DES-modified adsorbents were characterized by Fourier transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscopy, and Brunauer-Emmett-Teller surface analysis, and the polyphenols were analyzed by mass spectrometry and high-performance liquid chromatographultraviolet detection. The highest purification efficiency was obtained using the ChCI-Ph DES-modified adsorbent as the SPE packing material and ChCI-Urea-H2O (1:1:5, mole ratio), ChCI-Gly (1:1, mole ratio), ChCI-FA-H2O (1:1:5, mole ratio), and H2O as the eluents. Compared to conventional purification processes that employ commercial C-18 or C-8 SPE columns with organic solvents as eluents, the ChCI DES-based SPE purification process successfully avoided the use of expensive commercial SPE columns and organic solvents. Furthermore, it isolated a larger amount of the target compounds under the same experimental conditions, and could be applied over five cycles with good reversibility. This work indicates that DESs as green solvents have great potential for the totally green pretreatment of samples during the enrichment and purification processes. (C) 2017 Elsevier B.V. All rights reserved.</P>
Yuguang Fu,Tu Hoang,Kirill Mechitov,Jong R. Kim,Dichuan Zhang,Billie F. Spencer Jr 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.4
Seismic structural health monitoring (SHM) of structures is critical not only to detect earthquakes to send early warning, but also to enable rapid structural condition assessment to ensure safety. Traditional monitoring systems using wired sensors are expensive. Wireless sensors offer tremendous opportunity to reduce costs, which remains elusive for seismic structural monitoring due to two main obstacles. First, there are constraints on power resources. Most wireless sensors are dutycycled to preserve limited battery power; and hence, can miss an earthquake in power-saving sleep mode. Second, there is a lack of support for rapid post-event data collection and processing. Conventional data transmission after sensing can introduce significant delays, and real-time data acquisition that eliminates these delays has limited throughput. In this paper, an intelligent wireless monitoring system, <i>xShake</i>, is developed for cost-effective real-time seismic SHM. It consists of: 1) energy-efficient wireless sensor prototypes utilizing on-demand sensing technique, 2) live-streaming framework that supports high-throughput real-time data acquisition, and 3) a rapid condition assessment application, enabling real-time data visualization and processing for end users. The performance of the <i>xShake</i> is validated through lab tests, demonstrating that it can capture high-fidelity synchronized data under earthquakes and enable real-time structural condition assessment.
F. Fu,G. A. R. Parke 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.3
A double-layer grid space structure is a conventional long span structure used where large column-free areas are required. Due to its’ large indeterminacy and the redundancy of its structural confi guration, it is normally considered in design practice, that progressive collapse will not be triggered when the loss of an individual member occurs. However, research and several prior accidents have shown that progressive collapse could occur following the loss of some critical members when the structures are subject to abnormal loading such as heavy snow. To investigate the structural behavior of this type of structure, a 3D fi nite element model of a double-layer space structure grid was built by the authors, several collapse scenarios have been investigated using an implicit method which follows the alternative path method defi ned in GSA. In addition, case studies have been made using the explicit method which is to simulate the whole process of the structural collapse. In the analysis, diff erent members failure or support collapses were studied. The response of the structure was investigated and the correspondent potential of progressive collapse was discussed in detail. Methods to mitigate the progressive collapse of this type of space structure have also been recommended.
Y. L. Fu,B. R. Zhang,S. Wang,X. X. Gao,L. Y. Wang 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
An improved method for the preparation of monomethine cyanine dyes with quinoline nucleus by one-pot three-component using 1-methyl-2-quinolinethione, quaternized 2- or 4-methylheterocyclic compounds and methyl p-toluenesulfonate as starting materials was described. Compared with the traditional methods, the new synthetic method reduced the reaction steps, shortened the reaction time, avoided the separation and purification of the intermediate and reduced cost. The dyes absorbed in the region 478.0-563.0 nm and had molar extinction coefficients of 1.3 × 104 - 9.4 × 104 L mol−1 cm−1. Their fluorescence maxima and Stokes shifts were in the range of 525.2-594.4 nm and 16.2-80.6 nm in different solvents, respectively. From the spectral properties of the dyes in different solvents, it could be found that the λmax of the dyes were shorter in protonic solvents, and showed hypsochromic shifts with the increase of polarity of the solvents.