Pratensein glycoside attenuates respiratory syncytial virus infection-induced oxidative and inflammatory injury via TGF-β signaling pathway

Zhang Qiong,Li Si,Huang Qiong 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.3

Background Respiratory syncytial virus (RSV)-induced oxidative stress and inflammation are the leading causes of many severe diseases, especially in infants and children. Although many studies focused on the mechanism during RSV infection, an effective therapy is still urgently needed. Objectives In our study, we examined the function of pratensein glycoside (PG) in the progression of RSV-induced infection in vitro. Results PG treatment significantly inhibited RSV-induced oxidative stress and inflammation in a dose-dependent manner. We found that 40 μM of PG had no signifi cant cytotoxicity and exerted an anti-viral eff ect. RSV infection led to the activation of the TGF-β signaling pathway, which in turn promoted RSV infection. We hyperactivated the TGF-β signaling pathway by TGF-β and found that PG treatment can repress the pro-inflammation eff ect of TGF-β, suggesting that PG inhibits RSV infection through inhibiting TGF-β signaling pathway. Conclusions PG attenuated RSV infection-induced oxidative stress and inflammation through inhibiting the TGF-β signaling pathway. This study provides evidence for the application of traditional Chinese herbal medicine in the treatment of viral infection.

Meta-analysis of the CYP1A2 -163C>A Polymorphism and Lung Cancer Risk

Deng, Sheng-Qiong,Zeng, Xian-Tao,Wang, Yun,Ke, Qing,Xu, Qiong-Li Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Many published studies have concerned associations between the CYP1A2 -163 C>A polymorphism and risk of lung cancer, but the results have been inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimate. We searched the PubMed database up to March 1, 2013 for relevant cohort and case-control studies. Supplementary search was conducted manually by searching the references of the included studies and relevant meta-analyses. A meta-analysis was performed using RevMan 5.2 software for calculation of pooled odds ratios (ORs) and relevant 95% confidence intervals (CIs) after data extraction. Finally, seven case-control studies and one nested case-control study involving 1,675 lung cancer patients and 2,393 controls were included. The meta-analysis showed that there was no association of CYP1A2 -163 C>A polymorphism with risk of lung cancer overall [(OR=0.89, 95%CI= 0.74-1.07) for C vs. A; (OR=0.73, 95%CI= 0.50-1.07) for AA vs. CC ; (OR=0.82, 95%CI= 0.62-1.09) for AC vs. CC; (OR=0.79, 95%CI= 0.58-1.07) for (AC+AA) vs. CC; and (OR=0.87, 95%CI= 0.67-1.13) for AA vs. (CC+AC)]. Subgroup analysis indicated that there was an associationbetween CYP1A2 -163C>A polymorphism and lung cancer risk for population-based controls, a trend risk for SCCL (squamous cell carcinoma of lung) and Caucasians. These results suggested that -163 C>A polymorphism is likely to be associated with risk of lung cancer compared with population-based controls.

Weight Gain during Neoadjuvant Chemotherapy is Associated with Worse Outcome among the Patients with Operable Breast Cancer

Qiong Fang,Jiahui Huang,Lu Gan,Kunwei Shen,Xiaosong Chen,Beiwen Wu 한국유방암학회 2019 Journal of breast cancer Vol.22 No.3

Purpose: This study was aimed at identifying the influence of initial weight and weight change during neoadjuvant chemotherapy (NAC) on pathologic complete response (pCR) and long-term survival in Chinese patients with operable breast cancer. Methods: We conducted a retrospective study using data from 409 female patients who received NAC for stage II or III breast cancer and had complete record of body mass index (BMI) before and after NAC. BMI of < 25 kg/m2 was categorized as normal weight/underweight (NW/UW); 25.0–29.9 kg/m2 was categorized as overweight (OW); ≥30 kg/m2 was categorized as obese (OB). BMI change was defined as the difference in BMI between day 1 of the first cycle of NAC and the day before surgery. A BMI gain or loss of > 2 kg/m2 following NAC was considered to be significant, else was considered stable. The study end points included pCR rates, disease-free survival (DFS), and overall survival (OS). Results: The median follow-up time was 43.2 (8.9–93.6) months. The average BMI was 23.40 ± 3.04 kg/m2 before NAC and 23.66 ± 3.02 kg/m2 after NAC (t = −3.604, p < 0.001). The pCR rate was 25.3% in the NW/UW group and 24.1% in the OW/OB group (p = 0.811), and was similar between the BMI-gain (23.3%) and the BMI-stable/loss (25.1%) groups (p = 0.787). Initial BMI was an independent prognostic factor for DFS (hazard ratio, 1.69; 95% confidence interval [CI], 1.13–2.53; p = 0.011) but not for OS, while BMI-gain was an independent prognostic factor for both DFS (hazard ratio, 2.09; 95% CI, 1.28–3.42; p = 0.003) and OS (hazard ratio, 1.97; 95% CI, 1.04–3.74; p = 0.039). Conclusion: BMI increased after NAC in Chinese breast cancer patients. Initial BMI and BMI change during NAC were not associated with pCR but were reversely associated with survival.

Port four: Others : Estimation of the effect for the Chinese Version of WHO Quality of Life Scale when used to measure the quality of life for the minority in Yunnan

( Qiong Meng ),( Chong Hua Wan ),( Mei Hua Guo ),( Zhi Hou Gao ),( Rui Xue Yang ) 한국환경보건학회(구-한국환경위생학회) 2004 Current Challenges and Advances in Environmental H Vol.- No.-

Construction of a Streptomyces lydicus A01 Transformant with a chit42 Gene from Trichoderma harzianum P1 and Evaluation of Its Biocontrol Activity against Botrytis cinerea

Qiong Wu,Linquan Bai,Weicheng Liu,Yingying Li,Caige Lu,Yaqian Li,Kehe Fu,Chuanjin Yu,Jie Chen 한국미생물학회 2013 The journal of microbiology Vol.51 No.2

Streptomyces lydicus A01 and Trichoderma harzianum P1are potential biocontrol agents of fungal diseases in plants. S. lydicus A01 produces natamycin to bind the ergosterol of the fungal cell membrane and inhibits the growth of Botrytis cinerea. T. harzianum P1, on the other hand, features high chitinase activity and decomposes the chitin in the cell wall of B. cinerea. To obtain the synergistic biocontrol effects of chitinase and natamycin on Botrytis cinerea, this study transformed the chit42 gene from T. harzianum P1 to S. lydicus A01. The conjugal transformant (CT) of S. lydicus A01 with the chit42 gene was detected using polymerase chain reaction (PCR). Associated chitinase activity and natamycin production were examined using the 3, 5-dinitrosalicylic acid (DNS)method and ultraviolet spectrophotometry, respectively. The S. lydicus A01-chit42 CT showed substantially higher chitinase activity and natamycin production than its wild type strain (WT). Consequently, the biocontrol effects of S. lydicus A01-chit42 CT on B. cinerea, including inhibition to spore germination and mycelial growth, were highly improved compared with those of the WT. Our research indicates that the biocontrol effect of Streptomyces can be highly improved by transforming the exogenous resistance gene, i.e. chit42from Trichoderma, which not only enhances the production of antibiotics, but also provides a supplementary function by degrading the cell walls of the pathogens.

A Vegetable Dietary Pattern Is Associated with Lowered Risk of Gestational Diabetes Mellitus in Chinese Women

Qiong Chen,Weiwei Wu,Hailan Yang,Ping Zhang,Yongliang Feng,Keke Wang,Ying Wang,Suping Wang,Yawei Zhang 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.6

Background Identification of modifiable dietary factors, which are involved in the development of gestational diabetes mellitus (GDM), could inform strategies to prevent GDM. Methods We examined the dietary patterns in a Chinese population and evaluated their relationship with GDM risk using a case-control study including 1,464 cases and 8,092 control subjects. Propensity score matching was used to reduce the imbalance of covariates between cases and controls. Dietary patterns were identified using factor analysis while their associations with GDM risk were evaluated using logistic regression models. Results A “vegetable” dietary pattern was characterized as the consumption of green leafy vegetables (Chinese little greens and bean seedling), other vegetables (cabbages, carrots, tomatoes, eggplants, potatoes, mushrooms, peppers, bamboo shoots, agarics, and garlic), and bean products (soybean milk, tofu, kidney beans, and cowpea). For every quartile increase in the vegetables factor score during 1 year prior to conception, the first trimester, and the second trimester of pregnancy, the GDM risk lowered by 6% (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.89 to 0.99), 7% (OR, 0.94; 95% CI, 0.88 to 0.99), and 9% (OR, 0.91; 95% CI, 0.86 to 0.96). Conclusion In conclusion, our study suggests that the vegetable dietary pattern is associated with lower GDM risk; however, the interpretation of the result should with caution due to the limitations in our study, and additional studies are necessary to explore the underlying mechanism of this relationship.

The Oldies but Goodies: Cittaslow Community as the Base of Slow Tourism

Qiong Wu 융합관광콘텐츠학회 2023 융합관광콘텐츠학회 학술대회 발표집 Vol.2023 No.7

Research Motion Blurred Image Restoration Algorithms

Qiong Li,Junhui Rao,Xiaofeng Yang 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.9

Subject in the process of image acquisition and the relative games between the camera or camera image fuzzy, it seriously affected the further image feature extraction, target recognition and image analysis. In order to meet the needs of reality, get high quality image, we must be used image restoration techniques for fuzzy image restoration. Based on the detailed study on the basis of the theory of wavelet transform, we confirmed by experiments in motion blurred image of wavelet and decomposition level .The method to identify the fuzzy parameters, under the condition of without noise and with noise on the four classic image restoration algorithm, the simulation experiment using the peak signal-to-noise ratio, mean square error, average gray level gradient method and Laplace operator method of four kinds of image quality evaluation index to evaluate the healing effect and recovery result diagram and its quality evaluation. Through the scene shooting motion blurred image point spread function of parameter identification and image restoration, it demonstrates that the proposed point spread function’s parameters identification method is sound and effective.

Prediction of steel corrosion in magnesium cement concrete based on two dimensional Copula function

Qiong Feng,Hongxia Qiao,Penghui Wang,Wei Gong 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.2

In order to solve the life prediction problem of damaged coating steel bar in magnesium cement concrete, this study tries to establish the marginal distribution function by using the corrosion current density as a single degradation factor. Representing the degree of steel corrosion, the corrosion current density were tested in electrochemical workstation. Then based on the Copula function, the joint distribution function of the damaged coating was established. Therefore, it is indicated that the corrosion current density of the bare steel and coated steel bar can be used as the boundary element to establish the marginal distribution function. By using the Frank-Copula function of Copula Archimedean function family, the joint distribution function of the damaged coating steel bar was successfully established. Finally, the life of the damaged coating steel bar has been lost in 7320d. As a new method for the corrosion of steel bar under the multi-dimensional factors, the two-dimensional Copula function has certain practical significance by putting forward some new ideas.

Korean Advanced EFL Learners’ Attentional Allocation during Task Planning and Its Influence on Speaking

Qiong Wang,Jin-Hwa Lee 한국영어어문교육학회 2014 영어어문교육 Vol.20 No.3

This study investigated what advanced-level EFL learners pay attention to while planning and performing a speaking task, and how this cognitive process affects their subsequent task performance. A total of 21 English-major college students performed an oral presentation task after provided with 10-minute planning time. Their task performances were analyzed in terms of fluency, complexity and accuracy. Furthermore, in order to investigate the participants’ attentional allocation during task planning as well as task performance, retrospective interviews were conducted right after task performance. The analyses of the data showed that the learners placed most attention to conceptualization of ideas during pre-task planning and to fluency of speech while performing a task. On the other hand, little attention was paid to formulizing utterances and pursuing complexity and accuracy. It was also found that the learners’ attention to fluency, complexity or accuracy during task planning did not always lead to successful performance in the aspect. While speech rate and lexical diversity were more susceptible to attentional control, accuracy and syntactic complexity were not much affected by learners’ planning in advance. The findings are discussed in relation to the roles and limitations of pre-task planning in L2 performance and pedagogical implications.