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Jung-Hoon Pyun,Tae-Bong Shin,Joo-Hee Lee,Kang-Min Ahn,Tae-Hyung Kim,Hyun-Suk Cha 대한치과보철학회 2016 The Journal of Advanced Prosthodontics Vol.8 No.2
PURPOSE To evaluate the effects of hydrogen peroxide pretreatment and heat activation of silane on the shear bond strength of fiber-reinforced composite posts to resin cement. MATERIALS AND METHODS The specimens were prepared to evaluate the bond strength of epoxy resin-based fiber posts (D.T. Light-Post) to dual-curing resin cement (RelyX U200). The specimens were divided into four groups (n=18) according to different surface treatments: group 1, no treatment; group 2, silanization; group 3, silanization after hydrogen peroxide etching; group 4, silanization with warm drying at 80℃ after hydrogen peroxide etching. After storage of the specimens in distilled water at 37℃ for 24 hours, the shear bond strength (in MPa) between the fiber post and resin cement was measured using a universal testing machine. The fractured surface of the fiber post was examined using scanning electron microscopy. Data were analyzed using one-way ANOVA and post-hoc analysis with Tukey's HSD test (α=0.05). RESULTS Silanization of the fiber post (Group 2) significantly increased the bond strength in comparison with the non treated control (Group 1) (P<.05). Heat drying after silanization also significantly increased the bond strength (Group 3 and 4) (P<.05). However, no effect was determined for hydrogen peroxide etching before applying silane agent (Group 2 and 3) (P>.05). CONCLUSION Fiber post silanization and subsequent heat treatment (80℃) with warm air blower can be beneficial in clinical post cementation. However, hydrogen peroxide etching prior to silanization was not effective in this study.
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Pyun Jung-Hoon,Ahn Byeong-Yun,Vuong Tuan Anh,Kim Su Woo,조윤주,Jeon Jaehyung,Baek Seung Ho,Kim Jaewon,Park Sungsu,배규운,Choi Jun-Hyuk,Kim Jae-Ryong,Ryu Dongryeol,Lee Sang-Jin,강종순 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse environmental cues. Although these cells are versatile, chronic stress can trigger VSMC dysfunction, which ultimately leads to vascular diseases such as aortic aneurysm and atherosclerosis. Protein arginine methyltransferase 1 (Prmt1) is a major enzyme catalyzing asymmetric arginine dimethylation of proteins that are sources of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase. Although a potential role of Prmt1 in vascular pathogenesis has been proposed, its role in vascular function has yet to be clarified. Here, we investigated the role and underlying mechanism of Prmt1 in vascular smooth muscle contractility and function. The expression of PRMT1 and contractile-related genes was significantly decreased in the aortas of elderly humans and patients with aortic aneurysms. Mice with VSMC-specific Prmt1 ablation (smKO) exhibited partial lethality, low blood pressure and aortic dilation. The Prmt1-ablated aortas showed aortic dissection with elastic fiber degeneration and cell death. Ex vivo and in vitro analyses indicated that Prmt1 ablation significantly decreased the contractility of the aorta and traction forces of VSMCs. Prmt1 ablation downregulated the expression of contractile genes such as myocardin while upregulating the expression of synthetic genes, thus causing the contractile to synthetic phenotypic switch of VSMCs. In addition, mechanistic studies demonstrated that Prmt1 directly regulates myocardin gene activation by modulating epigenetic histone modifications in the myocardin promoter region. Thus, our study demonstrates that VSMC Prmt1 is essential for vascular homeostasis and that its ablation causes aortic dilation/dissection through impaired myocardin expression.
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편창훈(Pyun Chang Hoon),오양래(Oh Yang Rae),최정은(Choi Jung Eun),표국종(Pyo Guk Jong) 연세대학교 사회복지연구소 2014 한국사회복지조사연구 Vol.41 No.-
본 연구는 여유자원이론에 근거하여 기업의 사회공헌규모와 기업의 재무적 성과가 어떤 관계를 가지는지를 검증하고자 한다. 이와 더불어 기업의 재무적 성과와 상호작용할 수 있는 변수로 기업의 전년도 사회공헌규모를 설정하고 기업 사회공헌규모에 이들이 가지는 영향력을 검증한다. 또한, 기업사회공헌에 대한 다각적인 이해를 위해 분석모형을 절대규모와 상대규모로 나누어 살펴보았다. KISVALUE의 자료를 바탕으로 구성된 매출액 순위 국내 1,000대 기업의 자료를 활용하여 OLS 회귀분석을 통하여 변수간의 관계를 검증하였다. 연구결과, 기업의 재무적 성과와 기업의 전년도 사회공헌 규모는 절대규모와 상대규모 모두에서 양(+)의 방향으로 통계적으로 유의한 결과를 확인하여 여유자원이론이 지지되고 있음을 실증적으로 확인하였다. 또한, 기업의 재무적 성과와 기업의 전년도 사회공헌규모의 상호작용효과를 확인하여 음(-)의 방향으로 통계적으로 유의한 결과를 확인하였다. This study attempts to examine the influence of corporate financial performance(CFP) on corporate philanthropy(CP). Moreover, we examine an interaction effect of previous corporate philanthropy (PCP) and CFP by using OLS(Ordinary Least Square) regression analysis method. The data stems from KISVALUE; This database is made by The Korea Chamber of Commerce & Industry(KCCI). We used 806 samples of data for analysis. This study confirms two interesting results: First of all, a major result of this study showed that CFP and PCP have positive effects on CP in a model(by using amount) 1 and a model 2(by using ratio). These results support discussion of slack resources theory. Second, though its power is minuscule, the interaction term(PCP×CFP) has negative effects on CP in both models.
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소아 아토피피부염에서 아토피성과 비아토피성의 중증도와 검사소견의 비교
신정은 ( Jung Eun Shin ),전유훈 ( You Hoon Jeon ),양현종 ( Hyeon Jong Yang ),편복양 ( Bok Yang Pyun ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2008 소아알레르기 및 호흡기학회지 Vol.18 No.3
목적: 아토피피부염의 발생기전에 있어 IgE와 호산구 및 ECP가 아토피피부염의 발생기전에 중요한 역할을 하리라 생각되고 있으나 이러한 검사결과와 임상적 중증도와의 상관관계에 대해서는 논란이 있다. 본 저자들은 아토피피부염 소아에서 아토피성과 비아토피성의 임상양상을 비교해보고 총 혈청 IgE, 혈중 호산구수, ECP 농도 등의 실험실 검사소견과 아토피피부염의 임상적 중증도의 상관관계를 밝혀 이의 임상적 유용성을 알아보고자 하였다. 방법: 2005년 10월부터 2008년 3월까지 순천향대학교병원 소아알레르기 호흡기센터에서 아토피피부염으로 진단받은 환아 271명을 대상으로 하였고 대상 환아에서 혈청 총 IgE치와 원인 항원 특이 IgE치, 말초 혈액 내 총 호산구수, ECP를 측정하였으며, 피부단자 시험을 시행하였다. SCORAD 점수를 통해 임상적 중증도를 반영하는 지표로 사용하였으며 천식과 알레르기비염의 동반여부와 알레르기 질환에 대한 가족력을 조사했다. 전체 환아는 특이 IgE가 한 가지 이상 양성이거나 피부단자시험에서 양성을 보인 아토피군과 특이 IgE가 모두 음성이며 피부 단자시험에서도 음성을 보인 비아토피군으로 분류하여 두 군에서 임상적 중증도를 반영하는 SCORAD 점수와 혈청 총 IgE치, 말초 혈액 내 호산구수, ECP의 상관관계를 조사하였다. 결과: 총 271명의 대상 환아중 아토피군은 162명, 비아토피군은 109명이었다. 총 IgE치, 말초 혈액내 호산구수, ECP, 아토피피부염의 가족력이 아토피군에서 비아토피군보다 더 높은 수치를 보였으며, 아토피군에서 SCORAD 점수가 더 높아 임상적 중증도가 더 높은 것으로 나타났다. 아토피군에서는 혈청 총 IgE치, 말초 혈액 내 호산구수, ECP 모두 SCORAD 점수와 통계적으로 유의한 상관관계를 보였으며, 이중 말초 혈액 내 호산구수의 상관계수가 가장 높았으며, 비아토피군에서는 말초 혈액내 호산구수만 SCORAD 점수와 통계적으로 유의한 상관관계를 보였으며 혈청 총 IgE치와 ECP는 상관관계를 보이지 않았다. 결론: 혈청 총 IgE치, 말초혈액 내 호산구수, ECP농도를 아토피성 아토피피부염 환아에서 중증도의 평가 지표로 사용할 수 있으며 호산구수는 비아토피성 환아에서도 중증도 판정에 역할을 할 수 있겠다. Purpose: We aim to compare clinical severity of atopic and non-atopic eczema in children and examine the relationship between total-IgE, eosinophil counts, Eosinophil, Eosinophil cationic protein (ECP) and clinical severity of atopic dermatitis (AD). Methods: A total of 271 children diagnosed with AD at the Pediatric Allergy Respiratory Center in Soonchunhyang University Hospital from October 2005 to March 2008 were enrolled for this study and divided into 2 groups: atopic and non-atopic eczema. Serum concentrations of total- and specific-IgE, eosinophil counts and ECP were measured. Allergy skin tests were also performed and the SCORAD index was used to evaluate clinical severity. Comparisons the SCORAD index and serum total-IgE, eosinophil count and ECP between the 2 groups were made. Results: Of the 271 patients, 162 (59.8%) were included in the atopic eczema group, while 109 (40.2%) were included in the non-atopic group according to the laboratory results. Serum total-IgE, eosinophil counts, ECP, the SCORAD index and the frequency of a family history of eczema were relatively higher in the atopic group. In the atopic group, serum total-IgE, eosinophil counts and ECP each had a statistically significant correlation with the SCORAD index with eosinophil counts showing the highest correlation. However, only eosinophil counts had a statistically significant correlation with the SCORAD index in the non-atopic group. Conclusion: Serum total-IgE, eosinophil counts, and ECP can be used as markers for clinical severity in patients with atopic eczema, while eosinophil counts be used as marker for clinical severity in those with non-atopic eczema. [Pediatr Allergy Respir Dis(Korea) 2008;18:219-227]
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You Hoon Jeon,Kangmo Ahn,김지현,Meeyong Shin,Soo-Jong Hong,So-Yeon Lee,Bok-Yang Pyun,Taek Ki Min,Minyoung Jung,Jeongmin Lee,송태원,Hye-Young Kim,Sooyoung Lee,Kyunguk Jeong,Yoon-Ha Hwang,Minji Kim,Yong Ju Le 대한의학회 2022 Journal of Korean medical science Vol.37 No.4
Background: Atopic dermatitis (AD) is a heterogeneous disease with different age of onset, disease course, clinical symptoms, severity, and risk of comorbidity. The characteristics of children with AD also vary by age or country. However, little is known about the clinical characteristics of AD in Korean school-aged children and adolescents. Furthermore, there are few studies on phenotypic differences according to onset age. This study aimed to explore the clinical characteristics and phenotypes according to onset age and severity of AD in children and adolescents in Korea. Methods: AD patients aged 6–18 years who presented to 18 hospitals nationwide were surveyed. The patients were examined for disease severity by pediatric allergy specialists, and data on history of other allergic diseases, familial allergy history, onset age, trigger factors, lesion sites, treatment history and quality of life were collected. The results of the patient’s allergy test were also analyzed. The patients were classified into infancy-onset (< 2 years of age), preschoolonset (2–5 years of age), and childhood-onset (≥ 6 years of age) groups. Study population was analyzed for clinical features according to onset-age groups and severity groups. Results: A total of 258 patients with a mean age of 10.62 ± 3.18 years were included in the study. Infancy-onset group accounted for about 60% of all patients and presented significantly more other allergic diseases, such as allergic rhinitis and asthma (P = 0.002 and P = 0.001, respectively). Food allergy symptoms and diagnoses were highly relevant to both earlier onset and more severe group. Inhalant allergen sensitization was significantly associated with both infancy-onset group and severe group (P = 0.012 and P = 0.024, respectively). A family history of food allergies was significantly associated with infancyonset group (P = 0.036). Severe group was significantly associated with a family history of AD, especially a paternal history of AD (P = 0.048 and P = 0.004, respectively). Facial (periorbital, ear, and cheek) lesions, periauricular fissures, hand/foot eczema, and xerosis were associated with infancy-onset group. The earlier the onset of AD, the poorer the quality of life (P = 0.038). Systemic immunosuppressants were used in only 9.6% of the patients in the severe group. Conclusion: This study analyzed the clinical features of AD in Korean children and adolescents through a multicenter nationwide study and demonstrated the phenotypic differences according to onset age and severity. Considering the findings that the early-onset group is more severe and accompanied by more systemic allergic diseases, early management should be emphasized in young children and infants.
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