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Pham,Ngoc Minh 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-
Scientific and technological activities are scientific research, experimental research and development, technology development, application of technologies and services in science and technology, promotion of inventions and creative activities. Science and technology increasingly play a very important role in the country s economic development as well as in the production and business of each enterprise, especially for advanced companies. Multinational Corporation, with the motto: To become a market leader is no other way than to always be one step ahead of the opponent on the development of products and technology to meet the maximum demand. In the period of 2011 to 2020, the Ministry of Science and Technology coordinates with relevant central ministries and localities to implement more than 10 national S&T Programs, including many S&T oriented programs. In addition to, the enterprises themselves invest resources and cooperate in research and application of science and technology for production and business, enjoy preferential policies of the State (tax, credit, etc.) need to access national and local S&T programs and support their S&T tasks to improve productivity, quality and efficiency and business production and business competitiveness as well as.
Lipoxygenase Inhibitory Constituents from Rhubarb
Ngoc, Tran Minh,Minh, Pham Thi Hong,Hung, Tran Manh,Thuong, Phuong Thien,Lee, Ik-Soo,Min, Byung-Sun,Bae, Ki-Hwan 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Phytochemical study on the ethanol extract of rhubarb led to the isolation of fifteen compounds, including five anthraquinones: chrysophanol (1), physcion (2), emodin (7), chrysophanol-8-O-$\beta$-D-glucopyranoside (9) and emodin-8-O-$\beta$-D-glucopyranoside (15), and ten stilbenes: desoxyrhaponticin (3), rhaponticin (4), resveratrol (5), desoxyrhapotigenin (6), rhapontigenin (8), piceatannol-3'-O-$\beta$-D-glucopyranoside (10), piceid (11), $\varepsilon$-viniferin (12), ampelopsin B (13) and isorhaponticin (14). Their structures were identified by comparing the physicochemical data with those of published papers. Among the isolated compounds, stilbene derivatives (3-6, 8 and 10-14) showed remarkable inhibitory effect on lipoxygenase with $IC_{50}$ values ranging from 6.7 to $74.1\;{\mu}M$. The inhibition kinetics analyzed by Lineweaver-Burk plots found that they were competitive inhibitors with the linoleic acid at the active site of lipoxygenase. In addition, stilbenes exhibited significantly free radical scavenging activity against $ABTS^{\bullet+}$ with trolox equivalent activity capacity (TEAC) values ranging from 1.16 to 4.64. Whereas, anthraquinone derivatives (1-2, 7, 9 and 15) neither inhibited lipoxygenase nor scavenged free radical $ABTS^{\bullet+}$. These results indicated that stilbene derivatives were considerate to be mainly lipoxygenase inhibitor and free radical scavenger constituents of rhubarb.
( Minh Hai Pham ),( Quan Anh Tuan Le ),( Hoang Bac Nguyen ),( Quang Hung Vu ),( Thai Ngoc Huy Tran ),( Hang Dang Khoa N Guyen ),( Thi Ngoc Sang Duong ),( Van Toan Tran ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Laparoscopic pancreaticoduodenectomy (LPD) is considered as a safe and effective procedure in well - selected patients and appropriate surgical technique. Our aim is to evaluate suitability of using protocol for LPD in treatment of periampullary cancer at a single team. Methods: case series Results: Indication for LPD included 37 cases with resectable tumors which were classified basing on NCCN. All witness evaluation risk of complications with PREPARE score, ASA and evaluation risk of postoperative pancreatic fistula (POPF) with FRS classification. There were 2 open conversions because of vein resections, accounting for 5.4%. Standard lymphadenectomy was performed in all of 37 cases. In term of PREPARE score, major complications (Clavien - Dindo >= III) were 17.8%, 0% and 0% (5/28, 0/5 and 0/2 cases) in low risk, intermediate risk and high risk group, respectively. All of cases had ASA I or II. POPF happened 11.1% (1/9), 4.1% (1/24) and 50% (1/2) in low risk, intermediate risk and high risk group, respectively. Frozen section was needed for R0 margin. Retrieved lymph nodes was 8 - 18 with 12 lymph nodes in average. Conclusions: Indication for LPD with resectable tumors is acceptable. ASA I or II is a safe measure to select patient for LPD. FRS classification shows appropriation to evaluate risk of POPF.
New Dibenzocyclooctadiene Lignan from Kadsura induta and Their Cytotoxic Activities
Pham, Thi Hong Minh,Do, Tien Lam,Nguyen, Quyet Tien,Nguyen, Ngoc Tuan,Vu, Phuong Nhung,Nong, Van Hai,Phan, Van Kiem,Nguyen, Xuan Nhiem,Chau, Van Minh,Park, SeonJu,Kim, Seung Hyun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6