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      • Strength enhancement of concrete incorporating alccofine and SNF based admixture

        Reddy, Panga Narasimha,Jindal, Bharat Bhushan,Kavyateja, Bode Venkata,Reddy, A. Narender Techno-Press 2020 Advances in concrete construction Vol.9 No.4

        Cement is the most significant component in concrete. Large scale manufacturing of cement consumes more energy and release harmful products (Carbon dioxide) into the atmosphere that adversely affect the environment and depletes the natural resources. A lot of research is going on in globally concentrating on the recycling and reuse of waste materials from many industries. A major share of research is focused on finding cementitious materials alternatives to ordinary Portland cement. Many industrial waste by-products such as quartz powder, metakaolin, ground granulated blast furnace slag, silica fume, and fly ash etc. are under investigations for replacement of cement in concrete to minimize greenhouse gases and improve the sustainable construction. In current research, the effects of a new generation, ultra-fine material i.e., alccofine which is obtained from ground granulated blast furnace slag are studied as partial replacement by 25% and with varying amounts of sulfonated naphthalene formaldehyde (i.e., 0.3%, 0.35% and 0.40%) on mechanical, water absorption, thermal and microstructural properties of concrete. The results showed moderate improvement in all concrete properties. Addition of SNF with combination of alccofine showed a significant enhancement in fresh, hardened properties and water absorption test as well as thermal and microstructural properties of concrete.

      • KCI등재

        Treatment of millet crop plant (Sorghum bicolor) with the entomopathogenic fungus (Beauveria bassiana) to combat infestation by the stem borer, Chilo partellus Swinhoe (Lepidoptera: Pyralidae)

        Narasimha P. Reddy,Akbar P. Ali Khan,Uma K. Devi,Hari C. Sharma,Annette Reineke 한국응용곤충학회 2009 Journal of Asia-Pacific Entomology Vol.12 No.4

        Experiments were done to test if Beauveria bassiana can become an endophyte in sorghum and confer protection from stem borer. Four-week-old sorghum seedlings were treated with B. bassiana. The plants were examined for endophytic presence of B. bassiana, 30 and 60 days after treatment. Stem cultures from treated plants showed growth of B. bassiana. PCR amplification using fungal specific primers for a conserved region of β tubulin gene yielded identical 360 bp products from both B. bassiana and treated sorghum plants. In a subsequent experiment, B. bassiana treated and untreated (control) sorghum plants were artificially infested with stem borer (Chilo partellus) larvae 15 days post treatment and the extent of damage was compared. About 40% of the control plants developed dead heart while no plant in the B. bassiana treated plot did. In the surviving control plants, stem tunneling by shoot borer was significantly higher compared to B. bassiana treated sorghum plants. Experiments were done to test if Beauveria bassiana can become an endophyte in sorghum and confer protection from stem borer. Four-week-old sorghum seedlings were treated with B. bassiana. The plants were examined for endophytic presence of B. bassiana, 30 and 60 days after treatment. Stem cultures from treated plants showed growth of B. bassiana. PCR amplification using fungal specific primers for a conserved region of β tubulin gene yielded identical 360 bp products from both B. bassiana and treated sorghum plants. In a subsequent experiment, B. bassiana treated and untreated (control) sorghum plants were artificially infested with stem borer (Chilo partellus) larvae 15 days post treatment and the extent of damage was compared. About 40% of the control plants developed dead heart while no plant in the B. bassiana treated plot did. In the surviving control plants, stem tunneling by shoot borer was significantly higher compared to B. bassiana treated sorghum plants.

      • SCISCIESCOPUS
      • DNA Repair Gene Polymorphisms at XRCC1, XRCC3, XPD, and OGG1 Loci in the Hyderabad Population of India

        Parine, Narasimha Reddy,Pathan, Akbar Ali Khan,Bobbarala, Varaprasad,Abduljaleel, Zainularifeen,Khan, Wajahatullah,Alanazi, Mohammed Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

        Background: DNA repair is one of the crucial defense mechanism against mutagenic exposure. Inherited SNPs of DNA repair genes may contribute to variation in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. India harbors enormous genetic and cultural diversity. Materials and Methods: In the present study we aimed to determine the genotypes and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 186 healthy individuals residing in the Hyderabad region of India and to compare them with HapMap and other populations. Results and Conclusions: The genotype and allele frequency distribution at the four DNA repair gene loci among Hyderabad population of India revealed a characteristic pattern. Comparison of these gene polymorphisms with other populations revealed a distinctiveness of Hyderabad population from the Deccan region of India. To the best of our knowledge, this is the first report of such DNA repair gene polymorphisms in the Deccan Indian population.

      • KCI등재

        Influence of rapid thermal annealing on electrical and structural properties of double metal structure Au/Ni/n-InP (1 1 1) diodes

        M. Bhaskar Reddy,V. Janardhanam,A. Ashok Kumar,V. Rajagopal Reddy,P. Narasimha Reddy 한국물리학회 2010 Current Applied Physics Vol.10 No.2

        The effect of rapid thermal annealing on the electrical and structural properties of Ni/Au Schottky contacts on n-InP have been investigated by current–voltage (I–V), capacitance–voltage (C–V), auger electron spectroscopy (AES) and X-ray diffraction (XRD) techniques. The Au/Ni/n-InP Schottky contacts are rapid thermally annealed in the temperature range of 200–500 ℃ for a duration of 1 min. The Schottky barrier height of as-deposited Ni/Au Schottky contact has been found to be 0.50 eV (I–V) and 0.86 eV (C–V),respectively. It has been found that the Schottky barrier height decreased with increasing annealing temperature as compared to as-deposited sample. The barrier height values obtained are 0.43 eV (I–V),0.72 eV (C–V) for the samples annealed at 200 ℃, 0.45 eV (I–V) and 0.73 eV (C–V) for those at 400 ℃. Further increase in annealing temperature to 500 ℃ the barrier height slightly increased to 0.46 eV (I–V) and 0.78 eV (C–V) compared to the values obtained for the samples annealed at 200 ℃ and 400 ℃. AES and XRD studies showed the formation of indium phases at the Ni/Au and InP interface and may be the reason for the increase in barrier height. The AFM results showed that there is no significant degradation in the surface morphology (rms roughness of 1.56 nm) of the contact even after annealing at 500 ℃.

      • KCI등재

        Current–voltage–temperature (I–V–T) characteristics of Pd/Au Schottky contacts on n-InP (111)

        M. Bhaskar Reddy,A. Ashok Kumar,V. Janardhanam,V. Rajagopal Reddy,P. Narasimha Reddy 한국물리학회 2009 Current Applied Physics Vol.9 No.5

        We have investigated the current–voltage–temperature (I–V–T) characteristics of Pd/Au/InP Schottky barrier diodes in the temperature range of 220–400 K. The I–V analysis based on thermionic emission (TE) theory shows an abnormal decrease of apparent barrier height and increase of ideality factor at low temperatures. The conventional Richardson plot exhibits nonlinearity with activation energy of 0.17 eV and the Richardson constant value of 5.63 × 10-6 A cm-2 K-2. The nonlinearity in the Richardson plot and strong dependence of Schottky barrier parameters on temperature may be attributed to the spatial inhomogeneity in the interface. Further, the homogeneous barrier height has been obtained from the linear relationship between experimentally obtained effective barrier heights and ideality factors. Φb versus (2kT)-1 plot has been drawn to obtain the mean barrier height [Φbo(T = 0 K)] and the standard deviation (σs) at zero-bias which are found to be 0.84 eV, 138 meV, respectively. The series resistance is also estimated from the forward current–voltage characteristics of Pd/Au/InP Schottky contacts using Cheung’s method and found that it is strongly dependent on temperature and also decreases with increase in temperature. We have investigated the current–voltage–temperature (I–V–T) characteristics of Pd/Au/InP Schottky barrier diodes in the temperature range of 220–400 K. The I–V analysis based on thermionic emission (TE) theory shows an abnormal decrease of apparent barrier height and increase of ideality factor at low temperatures. The conventional Richardson plot exhibits nonlinearity with activation energy of 0.17 eV and the Richardson constant value of 5.63 × 10-6 A cm-2 K-2. The nonlinearity in the Richardson plot and strong dependence of Schottky barrier parameters on temperature may be attributed to the spatial inhomogeneity in the interface. Further, the homogeneous barrier height has been obtained from the linear relationship between experimentally obtained effective barrier heights and ideality factors. Φb versus (2kT)-1 plot has been drawn to obtain the mean barrier height [Φbo(T = 0 K)] and the standard deviation (σs) at zero-bias which are found to be 0.84 eV, 138 meV, respectively. The series resistance is also estimated from the forward current–voltage characteristics of Pd/Au/InP Schottky contacts using Cheung’s method and found that it is strongly dependent on temperature and also decreases with increase in temperature.

      • KCI등재

        Characterization of degradation products of the Balsalazide by Mass spectrometry: Optimization of stability-indicating HPLC method for separation and quantification of process related impurities of Balsalazide

        Chilakabattina Naga Narasimha Babu,Ch. Srinivasa Reddy,Bhagya Kumar Tatavarti,M. Radha Madhavi,Venkateswara Rao Anna 한국분석과학회 2024 분석과학 Vol.37 No.1

        The study aimed to investigate a novel approach by utilizing liquid chromatography (LC) and liquidchromatography-mass spectrometry (LC–MS) to separate, identify and characterize very nominal quantities ofdegradation products (DPs) of balsalazide along with its process related impurities without isolation from theirreaction mixtures. The impurities along with balsalazide were resolved on spherisorb ODS2 (250×4.6 mm, 5.0 μm)column at room temperature using 0.2 M sodium acetate solution at pH 4.5 and methanol in the ratio of 55:45(v/v) as mobile phase pumped isocratically at 1.0 mL/min as mobile phase and UV detection at 255 nm. Themethod shows sensitive detection limit of 0.003 μg/mL, 0.015 μg/mL and 0.009 μg/mL respectively for impurity1, 2 and 3 with calibration curve liner in the range of 50-300 μg/mL for balsalazide and 0.05-0.30 for itsimpurities. The balsalazide pure compound was subjected to stress studies and a total of four degradation products(DPs) were formed during the stress study and all the DPs were characterized with the help of their fragmentationpattern and the masses obtained upon LC–MS/MS. The DPs were identified as 3-({4-[(E)-(4-hydroxyphenyl)diazenyl]benzoyl}amino)propanoic acid (DP 1), 4-[(E)-(4-hydroxyphenyl)diazenyl] benzamide (DP 2), 5-[(E)-(4-carbamoylphenyl)diazenyl]-2-hydroxybenzoic acid (DP 3) and 3-({4-[(E)-phenyldiazenyl]benzoyl}amino)propanoicacid (DP 4). Based on findings, it was concluded that, the proposed method was successfully applicable forroutine analysis of balsalazide and its process related impurities in pure drug and formulations and also applicablefor identification of known and unknown impurities of balsalazide.

      • Topography Optimization 기법을 활용한 브레이크 더스트커버 강건 설계

        김대훈(Daehun Kim),Vikas Vashisht,Narasimha Reddy Govindu 한국자동차공학회 2019 한국자동차공학회 부문종합 학술대회 Vol.2019 No.5

        Designers always struggle to find the best point in their trade off relationship of increased durability and weight lightening. Recently, with the growing voice of light weight to improve car fuel efficiency, Optimization is being studied in all automotive parts. Brake dust cover is also not an exception. Despite a thin plate structure of less than 1.0t, there are many requirements for additional thickness reduction or for the application of lightweight materials, structures and shapes. The brake dust cover is of a thin plate structure and is fastened to the axle parts of the vehicle and requires durability against vibration, such as road surface vibration. In this paper, the study of robust design is described by maximizing vibration durability within the required layout, structure and material by using the Topography Optimization technique.

      • KCI등재

        Rosa damascena Mill. L. attenuates myocardial lysosomal membrane destabilization in isoproterenol induced oxidative stress

        Chitikela P. Pullaiah,G. V. Narasimha Kumar,K. Jyothsna,K. Thyagaraju,Vinod K. Nelson,G. Dayanand Reddy 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4

        Lysosomal membrane damage suggests that it would be the major contributing factor of myocardial infarction followed by necrosis. The present investigation was carried out on the defensive effect of ethanolic extract of Rosa damascena Mill. L. extract on alterations in myocardial lysosomal enzyme activity and membrane bound Na+/K+ ATPases against isoproterenol induced myocardial infarction in rats. On treatment with isoproterenol (100 mg/kg body weight) for two consecutive days, animals have shown a significant increase in serum creatinine kinase-MB, lactate dehydrogenase and lysosomal enzyme activity; whereas membrane bound Na+/K+ ATPases and tissue antioxidants were decreased. Pre-treatment with Rosa damascena Mill. L. extracts 200 and 400 mg/kg body weight respectively, for 28 days, significantly prevented the alterations and restored the CK-MB, LDH, tissue antioxidants and lysosomal enzyme activity to near-normal status in rats. These findings demonstrate that Rosa damascena could preserve lysosomal integrity through increasing the antioxidant enzyme levels and membrane bound Na+/K+ ATPases integrity. The cardio protective activity of Rosa damascena was further supported by histopathological examination of heart sections. Hence all these findings confirm cardio protective potential of ethanolic extract of Rosa damascena.

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