A DC Transformer Based on MMC and Full-Bridge Structure with Control Method

Sheng Cheng,Shuhuai Shi,Fang Zhuo,Feng Wang,Yanlin Zhu,Nan Zhang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

With the deterioration of environmental problems and the shortage of fossil energy, DC distribution net with convenient access to distributed energy has a bright prospect. To connect DC buses with different voltage level, DC/DC converter becomes the focus of research. This paper focuses on the modulation strategy of dc-dc converter based on the modular multilevel converter (MMC) and Full-bridge, which is suitable for medium-low voltage and high-power transmission. On this structure, a quasi-square wave modulation strategy with voltage conversion ability is adopted to improve the performance of the dc-dc converter. This modulation strategy can flexibly alter the AC voltage peak value and limit the dv/dt on the edge of square wave. Simulation results in MATLAB/Simulink verified the proposed modulation strategy.

Prediction of postoperative pancreatic fistula using a nomogram based on the updated definition

Cheng-Xiang Guo,Yi-Nan Shen,Qi Zhang,Xiao-Zhen Zhang,Jun-Li Wang,Shun-Liang Gao,Jian-Ying Lou,Ri-Sheng Que,Tao Ma,Ting-Bo Liang,Xue-Li Bai 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.98 No.2

Purpose: The International Study Group on Pancreatic Fistula’s definition of postoperative pancreatic fistula (POPF) has recently been updated. This study aimed to identify risk factors for POPF in patients having pancreaticoduodenectomy (PD) and to generate a nomogram to predict POPF. Methods: Data on 298 patients who underwent PD from March 2012 to October 2017 was retrospectively reviewed and POPF statuses were redefined. A nomogram was constructed using data from 220 patients and validated using the remaining 78 patients. Independent risk factors for POPF were identified using univariate and multivariate analyses. A predictive nomogram was established based on the independent risk factors and was compared with existing models. Results: Texture of the pancreas, size of the main pancreatic duct, portal vein invasion, and definitive pathology were the identified risk factors. The nomogram had a C-index of 0.793 and was internally validated. The nomogram performed better (C-index of 0.816) than the other most cited models (C-indexes of 0.728 and 0.735) in the validation cohort. In addition, the nomogram can assign patients into low- (less than 10%), intermediate- (10% to 30%), and high-risk (equal or higher than 30%) groups to facilitate personalized management. Conclusion: The nomogram accurately predicted POPF in patients having PD.

DNA methylation and mRNA expression of COL6A3 in antler mesenchyme of female and male reindeer

Jian‑Cheng Zhai,Ruo‑Bing Han,Sheng‑Nan Wang,Qiang‑Hui Wang,Yan‑Ling Xia,Wei‑Shi Liu,Ya‑Jie Yin,He‑Ping Li 한국유전학회 2019 Genes & Genomics Vol.41 No.9

Backgroud Reindeer is the only deer species that both male and female produce antlers, which provides a particularly interesting case in studying the differences between antlers of the two sexes. Alpha 3(VI) Collagen Gene (COL6A3), forms a microfibrillar network associated with the structural integrity and biomechanical properties, has been found to be one of the differentially expressed genes in antler mesenchyme of female and male reindeer. Objective and Methods The promoter sequence of reindeer COL6A3 gene was obtained using the cloning technology and analyzed by the bioinformatics methods. Bisulfite sequencing PCR (BSP) was used to detect the methylation status of the COL6A3 promoter in reindeer antler mesenchyme. Real-time quantitative PCR was used to detect COL6A3 expression in the antler mesenchyme of female and male reindeer. Results Sequence analysis revealed that the reindeer COL6A3 partial promoter sequence was 983 bp including the possible promoter region at + 105 bp to + 155 bp. Homology and phylogenetic analysis indicated that the COL6A3 promoter of reindeer had the closest genetic distance with Bos taurus, Capra hircus and Ovis aries. BSP results indicated that the methylation level of COL6A3 promoter in the female reindeer antler mesenchyme was significantly higher than in the male. Correlating with increased methylation status, we also found that COL6A3 mRNA expression in female reindeer antler mesenchyme was significantly lower than in the male. Conclusion The higher methylation level of the COL6A3 gene in female reindeer antler mesenchyme coincides with decreased COL6A3 mRNA expression, thereby affecting the transposon silencing mechanism and possibly contributing to apparent differences of antlers in female and male reindeer.

Novel Deadlock Control for Smartphone Manufacturing Systems Using Petri Nets

Yi-Nan Lin,Sheng-Kuan Wang,Gwo-Jen Chiou,Cheng-Ying Yang,Victor R. L. Shen,Tony Tong-Ying Juang,Ting-Jui Huang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.3

Currently, the marketing strategy in the manufacturing industry is becoming more and more competitive. Thus, the production efficiency becomes the main developing trend, which many people are now pursuing. However, the automatic production might cause resource conflicts and system deadlocks. In this study, Petri net models and analysis were used to effectively avoid deadlocks and to achieve the goal of lean production. The iPhone XS device developed by Apple is now a popular product. Consequently, this paper aims to describe its manufacturing system by using Petri net models. Meanwhile, the siphon property of Petri nets can be used to detect the deadlock in the manufacturing processes and to avoid it from occurring. Two simulation software tools, WoPeD and PIPE, were applied to conduct the experiments. The experimental results have indicated that our proposed approach is more feasible and acceptable than other existing ones.

Patterning-Induced Ferromagnetism of Fe₃GeTe₂ van der Waals Materials beyond Room Temperature

Li, Qian,Yang, Mengmeng,Gong, Cheng,Chopdekar, Rajesh V.,N’Diaye, Alpha T.,Turner, John,Chen, Gong,Scholl, Andreas,Shafer, Padraic,Arenholz, Elke,Schmid, Andreas K.,Wang, Sheng,Liu, Kai,Gao, Nan,Admas American Chemical Society 2018 NANO LETTERS Vol.18 No.9

<P>Magnetic van der Waals (vdW) materials have emerged as promising candidates for spintronics applications, especially after the recent discovery of intrinsic ferromagnetism in monolayer vdW materials. There has been a critical need for tunable ferromagnetic vdW materials beyond room temperature. Here, we report a real-space imaging study of itinerant ferromagnet Fe<SUB>3</SUB>GeTe<SUB>2</SUB> and the enhancement of its Curie temperature well above ambient temperature. We find that the magnetic long-range order in Fe<SUB>3</SUB>GeTe<SUB>2</SUB> is characterized by an unconventional out-of-plane stripe-domain phase. In Fe<SUB>3</SUB>GeTe<SUB>2</SUB> microstructures patterned by a focused ion beam, the out-of-plane stripe domain phase undergoes a surprising transition at 230 K to an in-plane vortex phase that persists beyond room temperature. The discovery of tunable ferromagnetism in Fe<SUB>3</SUB>GeTe<SUB>2</SUB> materials opens up vast opportunities for utilizing vdW magnets in room-temperature spintronics devices.</P> [FIG OMISSION]</BR>

Safety and Efficacy of Elbasvir/Grazoprevir in Asian Participants with Hepatitis C Virus Genotypes 1 and 4 Infection

( Wei Lai ),( Hiromitsu Kumada ),( Ponni Perumalswami ),( Tawesak Tanwandee ),( Wendy Cheng ),( Jeong Heo ),( Pin Nan Cheng ),( Peggy Hwang ),( Sheng Mei Mu ),( Xu Min Zhao ),( Michael Robertson ),( B 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Clinical experience with direct-acting antiviral treatments for hepatitis C virus (HCV) infection is emerging in the Asia-Pacific region. We conducted an integrated analysis of the safety and efficacy of elbasvir (EBR)/grazoprevir (GZR) in self-identified Asian participants who were enrolled in 11 EBR/GZR phase 2/3 studies. Methods: All participants received EBR/GZR 50 mg/100 mg alone for 12 weeks or in combination with ribavirin (RBV) for 16 weeks. The primary endpoint of all studies was sustained virologic response (HCV RNA < 15 IU/mL) 12 weeks after end of therapy (SVR12). Results: A total of 780 Asian participants with HCV GT1 or 4 infection were included (GT1b, n=715; GT1non-b, n=63; GT4, n=2). Most participants were enrolled from Japan (n=366, 46.9%), mainland China (n=146, 18.7%), Taiwan (n=109, 14.0%) and South Korea (n=90, 11.5%). Overall, 12.4% of participants had cirrhosis, and 20.4% were treatment-experienced. SVR12 was achieved by 756/780 (96.9%, 95% CI 95.5-98.0) of all Asian participants, including 748/772 (96.9%, 95% CI 95.4- 98.0) who received EBR/GZR for 12 weeks and 8/8 (100%, 95% CI 63.1-100.0) who received EBR/GZR + RBV for 16 weeks. The frequency of safety events among Asian participants was: any adverse event (AE), 58.1% (453/780), drug-related AEs, 23.6% (184/780), serious AEs, 2.6% (20/780), and discontinuation due to an AE, 0.9% (7/780). Fifteen participants (1.9%) had elevated ALT/AST levels that met the criteria for an event of clinical interest (ALT/AST >3× baseline and >100 U/L), 3 of whom discontinued treatment. The efficacy and safety profile of EBR/GZR was comparable to that observed among non-Asians. Conclusions: The combination of EBR/GZR was safe and highly effective in this large population of Asian participants with primarily HCV GT1b infection. Late transaminase elevations were reported in approximately 2% of participants, which is consistent with the safety profile of EBR/GZR in non-Asians.

Efficacy and Safety Profile of Combining Sorafenib with Chemotherapy in Patients with HER2-Negative Advanced Breast Cancer: A Meta-analysis

Jie Chen,Chun-Xiang Tian,Miao Yu,Qing Lv,Nan-Sheng Cheng,Zu Wang,Xi Wu 한국유방암학회 2014 Journal of breast cancer Vol.17 No.1

Purpose: The aim of the study was to evaluate the efficacy andsafety of combining sorafenib with chemotherapy in patients withhuman epidermal growth factor receptor 2 (HER2)-negative advancedbreast cancer. Methods: MEDLINE, EMBASE, CochraneCentral Register of Controlled Trials, American Society for ClinicalOncology abstracts, and European Society for Medical Oncologyabstracts were searched. Randomized clinical trials that comparedthe efficacy and safety of sorafenib plus chemotherapy inpatients with HER2-negative advanced breast cancer with placeboplus chemotherapy were eligible. The endpoints were progression-free survival (PFS), overall survival (OS), time to progression(TTP), duration of response (DOR), overall response rate(ORR), clinical benefits, and adverse effects. The meta-analysiswas performed using Review Manager 5.2.6 (The Nordic CochraneCentre), and the fixed-effect model weighted by the Mantel-Haenszel method was used. When considerable heterogeneitywas found (p<0.1), further analysis (subgroup analysis, sensitivityanalysis, or random-effect model) was performed to identifythe potential cause. The results are expressed as hazard ratios orrisk ratios, with their corresponding 95% confidence intervals. Results: The final analysis included four trials comprising 844 patients. The results revealed longer PFS and TTP, and higher ORRand clinical benefit rates in patients receiving sorafenib combinedwith chemotherapy compared to those receiving chemotherapyand placebo. OS and DOR were similar in the two groups. Meanwhile,the incidence of some adverse effects, including hand-footskin reaction/hand-foot syndrome, diarrhea, rash, and hypertension,were significantly higher in the sorafenib arm. Conclusion:Sorafenib combined with chemotherapy may prolong PFS andTTP. This treatment was associated with manageable toxicities,but frequent dose interruptions and reductions were required.