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RISS 인기검색어
- 검색키워드
- 저자 : Ting-Jui Huang (검색결과 3 건)
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Lan Ting-Yuan,Lin Yen-Chun,Tseng Tai-Chung,Yang Hung-Chih,Kao Jui-Hung,Cheng Chiao-Feng,Lee Tai-Ju,Huang Shang-Chin,Lu Cheng-Hsun,Li Ko-Jen,Hsieh Song-Chou 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Rituximab is known to be associated with high hepatitis B virus (HBV) reactivation rate in patients with resolved HBV infection and hematologic malignancy. However, data regarding HBV reactivation (HBVr) in rheumatic patients receiving rituximab is limited. To assess the HBVr rate in hepatitis B surface antigen (HBsAg)-negative patients receiving rituximab for autoimmune diseases in a large real-world cohort. Methods: From March 2006 to December 2019, 900 patients with negative HBsAg receiving at least one cycle of rituximab for autoimmune diseases in a tertiary medical center in Taiwan were retrospectively reviewed. Clinical outcome and factors associated with HBVr were analyzed. Results: After a median follow-up period of 3.3 years, 21 patients developed HBVr, among whom 17 patients were positive for hepatitis B core antibody (anti-HBc) and four were negative. Thirteen patients had clinical hepatitis flare, while eight patients had HBsAg seroreversion without hepatitis. Old age, anti-HBc positivity, undetectable serum hepatitis B surface antibody level at rituximab initiation and a higher average rituximab dose were associated with a higher HBVr rate. There was no significant difference in the HBVr risk between rheumatoid arthritis and other autoimmune diseases. Among anti-HBc-negative patients, subjects without HBV vaccination at birth had an increased risk of HBVr (4/368, 1.1%) compared with those who received vaccination (0/126, 0%). Conclusions: In HBV endemic areas where occult HBV is prevalent, anti-HBc-negative patients, may still be at risk for HBVr after rituximab exposure. HBVr may still be considered in HBsAgnegative patients developing abnormal liver function after rituximab exposure, even in patients with negative anti-HBc.
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The Major Changes of Gilbert’s Syndrome and UGT1A1 Gene Abnormalities in Mongolians Are Western Type
( Nyam Biziya ),( Nyamaa Bayarmaa ),( Jui-ting Hu ),( May-jen Huang ),( Ching-shan Huang ),( Sien-sing Yang ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Hereditary abnormalities of uridinediphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene is the major cause of unconjugated hyper-bilirubinemia. The abnormalities of UGT1A1 gene in Mongolian population remain uninvestigated. Eight in 99 consecutive Mongolian adults developed indirect hyperbilirubinemia. We therefore studied Mongolian patients for GS and UGT1A1 abnormalities. Methods: Between 2007 and 2014, ninety-nine consecutive Mongolian adult patients of chronic liver disease from the Department of Gastroenterology, Mongolian National University of Medical Sciences were studied. Eight (8.1%) of them developed indirect hyperbilirubinemia. All patients were tests for blood chemistries, hemoglobin, international normalized ratio (INR), mean corpuscular volume (MCV), glucose-6-phosphate dehydrogenase (G6PD) levels as well as UGT1A1 genetic abnormalities. We genotyped the UGT1A1 gene for the A(TA)6TAA (6) or A(TA)7TAA (7) promoter variant, and the coding region for nucleotide mutations (nt)-211 G to A, nt-686 C to A, nt-1091 C to T and nt-1456 T to G. Results: Among the eight patients that developed indirect hyperbilirubinemia, six were male and two were female. All patients had hemoglobin, INR, MCV and G6PD levels within normal limit and we excluded possibility of anemia, decompensated liver function, thalassemia and G6PD deficiency. Our data confirms two variants of the UGT1A1 gene among the Mongolian patients. Two case were homozygous for nt-211G>A mutation, two case heterozygous for 6/7 promoter variants and nt-211G>A mutation, whereas four case were typical GS with homozygous 7/7 promoter genotype with no mutation in the coding region None of our Mongolian patients had mutations at nt-686, nt-1091 or nt-1456. Conclusions: Our pilot results show that GS and UGT1A1 abnormalities are common in Mongolians. Prevalence of the UGT1A1 promoter abnormalities in Mongolians are similar to the Western population; whereas the high prevalence of nt-211G>A variant is similar to the Asians. Further studies with much larger number of patients are necessary to confirm the genetic status of GS and UGT1A1 variants in Mongolians.
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Novel Deadlock Control for Smartphone Manufacturing Systems Using Petri Nets
Yi-Nan Lin,Sheng-Kuan Wang,Gwo-Jen Chiou,Cheng-Ying Yang,Victor R. L. Shen,Tony Tong-Ying Juang,Ting-Jui Huang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.3
Currently, the marketing strategy in the manufacturing industry is becoming more and more competitive. Thus, the production efficiency becomes the main developing trend, which many people are now pursuing. However, the automatic production might cause resource conflicts and system deadlocks. In this study, Petri net models and analysis were used to effectively avoid deadlocks and to achieve the goal of lean production. The iPhone XS device developed by Apple is now a popular product. Consequently, this paper aims to describe its manufacturing system by using Petri net models. Meanwhile, the siphon property of Petri nets can be used to detect the deadlock in the manufacturing processes and to avoid it from occurring. Two simulation software tools, WoPeD and PIPE, were applied to conduct the experiments. The experimental results have indicated that our proposed approach is more feasible and acceptable than other existing ones.
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