http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
Nakajima, Hiroshi,Hirose, Koichi The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.1
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing $CD4^+$ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.
Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
Hiroshi Nakajima,Koichi Hirose 대한면역학회 2010 Immune Network Vol.10 No.1
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction,and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing CD4+ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells,are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.
A Two-Dimensional Study of Transonic Flow Characteristics in Steam Control Valve for Power Plant
Yonezawa, Koichi,Terachi, Yoshinori,Nakajima, Toru,Tsujimoto, Yoshinobu,Tezuka, Kenichi,Mori, Michitsugu,Morita, Ryo,Inada, Fumio Korean Society for Fluid machinery 2010 International journal of fluid machinery and syste Vol.3 No.1
A steam control valve is used to control the flow from the steam generator to the steam turbine in thermal and nuclear power plants. During startup and shutdown of the plant, the steam control valve is operated under a partial flow conditions. In such conditions, the valve opening is small and the pressure deference across the valve is large. As a result, the flow downstream of the valve is composed of separated unsteady transonic jets. Such flow patterns often cause undesirable large unsteady fluid force on the valve head and downstream pipe system. In the present study, various flow patterns are investigated in order to understand the characteristics of the unsteady flow around the valve. Experiments are carried out with simplified two-dimensional valve models. Two-dimensional unsteady flow simulations are conducted in order to understand the experimental results in detail. Scale effects on the flow characteristics are also examined. Results show three types of oscillating flow pattern and three types of static flow patterns.
Neural Mechanisms of Discogenic Back Pain: How Does Nerve Growth Factor Play a Key Role?
Yasuchika Aoki,Seiji Ohtori,Koichi Nakagawa,Arata Nakajima,Gen Inoue,Masayuki Miyagi,Kazuhisa Takahashi 대한척추신경외과학회 2011 Neurospine Vol.8 No.2
It was reported that nerve fibers were present in the inner part of lumbar intervertebral discs from patients with discogenic pain. Because there are no nerve fibers in the inner part of annulus fibrosus in normal condition, this finding suggests nerve ingrowth into the disc may be a cause of discogenic pain. Disc degeneration is often asymptomatic, thus, to understand the differences between symptomatic and asymptomatic disc, it is necessary to understand the pathogenesis of discogenic pain. We recently revealed that over 90% of the nociceptive dorsal root ganglion (DRG) neurons innervating the disc are sensitive to nerve growth factor (NGF), which is related to inflammatory pain. This indicates that discogenic pain is closely related to inflammation and NGF may play a key role. The increase of inflammatory mediators in symptomatic discs has been reported; we therefore studied the effects of disc inflammation and found that it induces sensitization of disc-innervating neurons and nerve ingrowth into the disc. More recently, it was shown that annular rupture induces nerve ingrowth, an increase of inflammatory mediators in the disc, and upregulation of calcitonin gene-related peptide, a pain-related molecule in DRGs. These findings led us to believe that annular rupture triggers inflammation and nerve ingrowth, inflammatory mediators then further promote nerve ingrowth into the disc and sensitization of disc-innervating neurons, and discogenic pain finally becomes chronic. NGF, found in symptomatic discs, may act as a key factor in generating chronic discogenic pain by sensitizing disc-innervating neurons and stimulating nerve ingrowth into the disc.
ABO Blood Type and Risk of Peyronie’s Disease in Japanese Males
Mitsui Yozo,Kobayashi Hideyuki,Yamabe Fumito,Nakajima Koichi,Nagao Koichi 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.3
Purpose: Although multiple mechanisms associated with Peyronie’s disease (PD) have been proposed, details regarding etiologic factors, especially genetic, remain unclear. We examined the relationship of the ABO blood type system, known as a genetic factor associated with susceptibility to a number of diseases, with PD in Japanese males. Materials and Methods: We compared 202 Japanese PD patients treated with surgery at our hospital between March 2004 and December 2019 with 846 randomly selected non-PD male patients who underwent urological surgery during the same period regarding distribution of ABO blood types. In addition, we assessed the risk of PD according to blood type group among all study participants using odds ratio (OR) and 95% confidence interval (CI) calculations. Results: The distribution of individual blood types in the control group was nearly the same as that in the general Japanese population. In contrast, O, A, B, and AB blood types were noted in 37.6%, 36.1%, 14.9% and 11.4%, respectively, of the PD patients, which was significantly different from the control group, where blood type O was found in 29.1% and B in 23.2% (p<0.05). Our results showed that as compared with patients with blood group B, those with another blood type were more likely to develop PD, among which type O had a significantly increased OR of 2.018 (CI, 1.271–3.205). Conclusions: These are the first reported results showing that ABO blood type may be associated with risk of PD, though further investigations are needed.