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Muhammad Rizal Muhammad Asyraf,Mohamad Ridzwan Ishak,Mohd Nor Faiz Norrrahim,Abdul Latif Amir,Norizan Mohd Nurazzi,Rushdan Ahmad Ilyas,Mochamad Asrofi,Mazlan Rafidah,Muhammad Rizal Razman 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4
Man-made composites are vastly implemented in various engineering applications, particularly in cross-arm component of latticed transmission tower. However, their practice in this sector has increased pollutant emissions and landfill areas. Thus, scientists and engineers have been driven to look for other ‘greener’ alternative materials that have low-cost and renewable sources. Flax fibers and poly(lactic) acid (PLA) biopolymer have been extensively used to develop vast green composite structural products because of their great mechanical behaviours. A comprehensive understanding of properties of composite materials is essential to evaluate their applicability, especially in structural applications. This manuscript discusses the physic-mechanical properties and processing and manufacturability of flax fiber, PLA biopolymer and their composites. This review also comprehensively discovers the potential of fabric flax fiber-reinforced PLA composites for cross-arm application. The chemical composition, extraction, treatment and fabrications of these fiber and biopolymer are elaborated deeply given that these aspects are essential for the development of green composite cross-arm.
Effects of plant-derived smoke on the growth dynamics of Barnyard Grass (Echinochloa crus-galli)
Kamran, Muhammad,Khan, Abdul Latif,Waqas, Muhammad,Imran, Qari Muhammad,Hamayun, Muhammad,Kang, Sang-Mo,Kim, Yoon-Ha,Kim, Min-Ji,Lee, In-Jung Taylor Francis 2014 Acta agriculturæ Scandinavica. Section B, So Vol.64 No.2
Fungal endophyte Penicillium janthinellum LK5 improves growth of ABA-deficient tomato under salinity
Khan, Abdul Latif,Waqas, Muhammad,Khan, Abdur Rahim,Hussain, Javid,Kang, Sang-Mo,Gilani, Syed Abdullah,Hamayun, Muhammad,Shin, Jae-Ho,Kamran, Muhammad,Al-Harrasi, Ahmed,Yun, Byung-Wook,Adnan, Muhammad Springer-Verlag 2013 World journal of microbiology & biotechnology Vol.29 No.11
Biocompatibility of cobalt iron oxide magnetic nanoparticles in male rabbits
Furhan Iqbal,Tanveer Ahmad Tabish,Muhammad Naeem Ashiq,Muhammad Azeem Ullah,Shahid Iqbal,Muhammad Latif,Muhammad Ali,Muhammad Fahad Ehsan 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7
Present study was conducted to study the in vivo biocompatibility of cobalt iron oxide magnetic nano-particles (CoFe2O4 MNPs) in rabbits. CoFe2O4 MNPs were synthesized by the conventional micro emulsion technique in crystallite size range of 30 to 50 nm. The lattice constant (a) and cell volume were found to be 8.386 Å and 589.75 Å3, respectively, revealed by XRD. Subject animals were divided in three groups--low dose, high dose and control group without nanoparticles implantation for biocompatibility evaluation. CoFe2O4 was intraperitoneally implanted in rabbits: low dose (1mg CoFe2O4/Kg body weight) and high dose (10mg CoFe2O4/Kg body weight). Blood, serum and histological study of vital organs (liver, heart, kidney and spleen) were carried out in seven days of time protocol after sacrificing of animals. Results indicated that CoFe2O4 had drastically affected the blood chemistry in a dose-dependent manner as RDWa (P=0.01), Platelet (P<0.001) and Plateletcrit (P<0.001) concentrations reduced significantly in low dose and high dose CoFe2O4 treatments as compared to sham treated control group. Histological analysis revealed that CoFe2O4 exposure resulted in disordered and abnormal histology of liver, kidney and that of muscles at surgical site. It is concluded that CoFe2O4 has low biocompatibility and higher toxicity levels in living system at the applied doses.
Synthesis and Biological Evaluation of Tetrapeptide Ketones as Reversible 20S Proteasome Inhibitors
Latif, Muhammad,Jung, Myoung Eun,Lee, Kwangho,Choi, Gildon Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
Proteasome, a multicatalytic protease complex, has been validated as a promising therapeutic target in oncology. Carfilzomib (Kyprolis$^{(R)}$), a tetrapeptide epoxyketone, irreversibly inhibits the chymotrypsin-like (CT-L) activity of the proteasome and has been recently approved for multiple myeloma treatment by FDA. A chemistry effort was initiated to discover the compounds that are reversibly inhibit the proteasome by replacing the epoxyketone moiety of carfilzomib with a variety of ketones as reversible and covalent warheads at the C-terminus. The newly synthesized compounds exhibited significant inhibitory activity against CT-L activity of the human 20S proteasome. When the compounds were tested for cancer cell viability, 14-8 was found to be most potent in inhibiting Molt-4 acute lymphoblastic leukemia cell line with a $GI_{50}$ of $4.4{\mu}M$. Cytotoxic effects of 14-8 were further evaluated by cell cycle analysis and Western blotting, demonstrating activation of apoptotic pathways.
Latif, Muhammad,Yun, Jeong In,Seshadri, Kalapati,Kim, Hyoung Rae,Park, Chi Hoon,Park, Haeil,Kim, Hyoungsu,Lee, Jongkook American Chemical Society 2015 Journal of organic chemistry Vol.80 No.6
<P>A highly stereoselective construction of 2,6-cis-disubstituted tetrahydropyrans was achieved by using an intramolecular amide enolate alkylation with KHMDS. The efficiency and practicality of this methodology was successfully demonstrated in the total synthesis of (-)-centrolobine (1).</P>
Synthesis of 4-(3,4-dicarboxamido-1H-pyrrole)pyrimidines as Anaplastic Lymphoma Kinase Inhibitors
Muhammad Latif,변병진,LEEKWANGHO 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.2
To explore non-aniline aromatic substitution on the pyrimidine C4 position, novel 4-(N,N′-di-n-propyl-3,4-dicarboxamido-1H-pyrrole)pyrimidines are designed and synthesized as anaplastic lymphoma kinase inhibitors for non-small cell lung cancer treatment. To overcome the unexpected cleavage between the C-N linkage of pyrrole nitrogen and C4-pyrimidine during hydrolysis and inaccessibility of the desired diamide formation through coupling agent-mediated conditions, the 4-(N,N′-di-n-propyl-3,4-dicarboxamido-1H-pyrrole)pyrimidine was assembled through direct nucleophilic substitution under microwave irradiation. Thus prepared 4-(N,N′-di-n-propyl-3,4-dicarboxamido-1H-pyrrole)pyrimidines were measured both ALK binding and H3122 cell proliferation assay. Their weak ALK activities are explained with molecular modeling study.