Morin Protects Acute Liver Damage by Carbon Tetrachloride ($CCl_4$) in Rat

Lee, Hee-Seung,Jung, Kyung-Hee,Hong, Sang-Won,Park, In-Sub,Lee, Chong-Mu,Han, Hyo-Kyung,Lee, Don-Haeng,Hong, Soon-Sun 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9

The purpose of this study was to investigate possible beneficial effects of morin on $CCl_4$-induced acute hepatotoxicity in rats. Rats received a single dose of $CCl_4$ ($150{\mu}L$/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before $CCl_4$ administration. $CCl_4$ challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in $CCl_4$-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-$\alpha$), interleukin-$1{\beta}$ (IL-$1{\beta}$), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-$\alpha$, IL-$1{\beta}$, IL-6, and iNOS were increased by $CCl_4$ treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-$\alpha$, IL-$1{\beta}$, IL-6, and iNOS.

Control of IPMC-based Artificial Muscle for Myoelectric Hand Prosthesis

Lee Myoung-Joon,Jung Sung-Hee,Moon Inhyuk,Lee Sukmin,Mun Mu-Seong The Korean Society of Medical and Biological Engin 2005 의공학회지 Vol.26 No.5

This paper proposes an ionic polymer metal composite (IPMC) based artificial muscle to be applicable to the Myoelectric hand prosthesis. The IPMC consists of a thin polymer membrane with metal electrodes plated chemically on both faces, and it is widely applying to the artificial muscle because it is driven by relatively low input voltage. The control commands for the IPMC-based artificial muscle is given by electromyographic (EMG) signals obtained from human forearm. By an intended contraction of the human flexor carpi ulnaris and extensor carpi ulnaris muscles, we investigated the actuation behavior of the IPMC-based artificial muscle. To obtain higher actuation force of the IPMC, the single layered as thick as $800[{\mu}m]$ or multi-layered IPMC of which each layer can be as thick as $178[{\mu}m]$ are prepared. As a result, the bending force was up to the maximum 12[gf] from 1[gf] by actuating the single layered IPMC with $178[{\mu}m]$, but the bending displacement was reduced to 6[mm] from 30[mm]. The experimental results using an implemented IPMC control system show a possibility and a usability of the bio-mimetic artificial muscle.

Characterization of Inkjet-Printed Silver Patterns for Application to Printed Circuit Board (PCB)

Shin, Kwon-Yong,Lee, Minsu,Kang, Heuiseok,Kang, Kyungtae,Hwang, Jun Young,Kim, Jung-Mu,Lee, Sang-Ho The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.3

In this paper, we describe the analysis of inkjet-printed silver (Ag) patterns on epoxy-coated substrates according to several reliability evaluation test method guidelines for conventional printed circuit boards (PCB). To prepare patterns for the reliability analysis, various regular test patterns were created by Ag inkjet printing on flame retardant 4 (FR4) and polyimide (PI) substrates coated with epoxy for each test method. We coated the substrates with an epoxy primer layer to control the surface energy during printing of the patterns. The contact angle of the ink to the coated epoxy primer was $69^{\circ}$, and its surface energy was 18.6 $mJ/m^2$. Also, the substrate temperature was set at $70^{\circ}C$. We were able to obtain continuous line patterns by inkjet printing with a droplet spacing of $60{\mu}m$. The reliability evaluation tests included the dielectric withstanding voltage, adhesive strength, thermal shock, pressure cooker, bending, uniformity of line-width and spacing, and high-frequency transmission loss tests.

UHF RFID 태그 칩용 저전력, 저면적 비동기식 EEPROM 설계

백승면,이재형,송성영,김종희,박문훈,하판봉,김영희,Baek, Seung-Myun,Lee, Jae-Hyung,Song, Sung-Young,Kim, Jong-Hee,Park, Mu-Hun,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.12

본 논문에서는 $0.18{\mu}m$의 EEPROM cell을 사용하여 수동형 UHF RFID 태그 칩에 사용되는 저전력, 저면적의 1Kbits 비동기식 EEPROM IP를 설계하였다. 저면적 회로 설계 기술로는 $0.18{\mu}m$ EEPROM 공정을 이용하여 비동기식 EEPROM IP를 설계하므로 command buffer와 address buffer를 제거하였고 separate I/O 방식을 사용하므로 tri-state 데이터 출력 버퍼(data output buffer)를 제거하였다. 그리고 저전압(low voltage)의 VDD에서 EEPROM cell이 필요로 하는 고전압(high voltage)인 VPP와 VPPL 전압을 안정적으로 공급하기 위해 기존의 PN 접합 다이오드 대신 Schottky 다이오드를 사용한 Dickson 전하펌프를 설계하므로 전하펌프의 펌핑단(pumping stage)의 수를 줄여 전하펌프가 차지하는 면적을 줄였다. 저전력 회로 설계 기술로 Dickson 전하 펌프(charge pump)를 이용하여 VPP generator를 만들고 Dickson 전하펌프의 임의의 노드 전압을 이용하여 프로그램과 지우기 모드에서 각각 필요로 하는 VPPL 전압을 선택하도록 하게 해주는 VPPL 전원 스위칭 회로를 제안하여 쓰기전류(write current)를 줄이므로 저전력 EEPROM IP를 구현하였다. $0.18{\mu}m$ 공정을 이용하여 설계된 비동기식 EEPROM용 테스트 칩은 제작 중에 있으며, 비동기식 1Kbits EEPROM의 레이아웃 면적은 $554.8{\times}306.9{\mu}m2$로 동기식 1Kbits EEPROM에 비해 레이아웃면적을 11% 정도 줄였다. In this paper, a low-power and small-area asynchronous 1 kilobit EEPROM for passive UHF RFID tag chips is designed with $0.18{\mu}m$ EEPROM cells. As small area solutions, command and address buffers are removed since we design asynchronous I/O interface and data output buffer is also removed by using separate I/O. To supply stably high voltages VPP and VPPL used in the cell array from low voltage VDD, Dickson charge pump is designed with schottky diodes instead of a PN junction diodes. On that account, we can decrease the number of stages of the charge pump, which can decrease layout area of charge pump. As a low-power solution, we can reduce write current by using the proposed VPPL power switching circuit which selects each needed voltage at either program or write mode. A test chip of asynchronous 1 kilobit EEPROM is fabricated, and its layout area is $554.8{\times}306.9{\mu}m2$., 11% smaller than its synchronous counterpart.

DMBA로 유발한 Mouse 피부암에 대한 Astaxanthin이 함유된 난황의 항암효과

이상호,박철우,이영춘,최의성,김무남,하영래,Lee, Sang-Ho,Park, Cheol-U,Lee, Yeong-Chun,Choe, Ui-Seong,Kim, Mu-Nam,Ha, Yeong-Rae 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1

Anticarcinogenic activity of astaxanthin-containing egg yolks (designate AEY) was investigated for 7,12-dimethylbenz[a]anthracene (DMBA)-induced two stage mouse epidermal carcinogenesis. Female ICR mouse (6-7 weeks of age) were house in a humidity-and-temperature-controlled facility and subjected to feed and water ad libitum. AEY (10 mg/0.2 ml acetone) was painted on the back of mice 7 days, 3 days and 5 min before DMBA treatment (50 nmole/0.2 ml acetone). One week later after DMBA treatment, 6 ${\mu}g$ tetradecanoyl 12-phorbol 13-O-acetate (TPA) dissolved in 0.2 ml acetone was applied on the mouse twice weekly over a period of 22 weeks. No sample was given to control mice. Control egg yolk (CEY) and astaxanthin-containing oil (designate AO) from Phaffia rhodozyma were used as positive controls. Mouse treated with AEY exhibited 10 tumors per mouse whereas control mouse exhibited 15 tumors per mouse, the fact that 33% reduction of tumor per mouse by AEY treatment. Tumor incidence was also reduced to 15% by AEY treatment when compared to that of control group. Such effects were also seen in CEY and AO treatment groups, but leaser extent. AO gave reduction of food intake and body weights relative to those of AEY and CEY, indicating toxicity of AO. These results suggest that AEY exhibits anticarcinogenic activity for DMBA-induced mouse epidermal carcinogenesis.

아크릴계 점착제의 제조와 가교물성에 관한 연구

김판수 ( Pan Soo Kim ),이상무 ( Sang Mu Lee ),정신혜 ( Sin Hye Jung ),이원기 ( Won Ki Lee1 ) 한국접착및계면학회 2013 접착 및 계면 Vol.14 No.1

압력감응성 아크릴 점착제의 물성은 가교를 위한 관능성그룹을 가진 단량체를 이용하여 쉽게 물성을 조절할 수 있다. 본 연구에서는 두개의 다른 가교제, isocyanate 및 epoxy형 가교제에 따른 아크릴 점착제의 가교특성과 물성을 연구하였다. 2-Ethylhexyl acrylate, acrylic acid (AA)와 2-hydroxyethyl methacrylate를 주 단량체로 하여 이소시아네이트 또는 에폭시형 가교제로 가교한 점착제의 박리점착 특성, 볼텍, 유지력 및 수축성을 고찰하였다. 점착특성은 AA함량 증가와 더불어 증가하였고 가교점이 많고 ether와 같은 유연한 결합을 생성하는 에폭시형 가교제에서 우수한 물성을 나타내었다. The physical properties of the acrylic pressure sensitive adhesives (PSAs) can be easily controlled by a proper functional monomer which has functional groups for crosslinking. This study was to investigate the effect of crosslinking agents, isocyanate and epoxy types, of acrylic PSAs on adhesive properties. 2-Ethylhexyl acrylate, acrylic acid (AA), and 2-hydroxy ethyl methacrylate as monomer were used. The obtained samples with different AA contents were partially crosslinked with epoxy- or isocyanate-typed agent. Peel strength, balltack, holding power test and contraction percentage of the obtained PSA were evaluated. Most properties of acrylic PSAs were increased with AA content and acrylic PSAs with epoxy-typed crosslinking agent (4 crosslinking sites) which produces flexible link (ether), showed better properties than those of isocyanate-typed one (3 crosslinking sites).

넓은 전압 범위와 개선된 파워-업 특성을 가지는 밴드갭 기준전압 발생기의 스타트-업 회로

성관영,김종희,김태호,카오투안부,이재형,임규호,박무훈,하판봉,김영희,Sung, Kwang-Young,Kim, Jong-Hee,Kim, Tae-Ho,Vu, Cao Tuan,Lee, Jae-Hyung,Lim, Gyu-Ho,Park, Mu-Hum,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.8

본 논문에서는 넓은 동작전압 범위와 저소비 전력 그리고 개선된 파워-업 특성을 가지는 캐스코드 전류 거울형 CMOS 밴드갭 기준전압 발생기의 스타트-업 회로를 제안하였다. 새롭게 제안된 스타트-업 회로는 기존의 스타트-업 회로에 비해 안정적인 파워-업 특성을 가지며 공급전압(VDDA)이 높아지더라도 밴드갭 기준전압 발생기 회로의 동작에 영향을 미치지 않는 것을 모의실험을 통하여 확인하였고 $0.18{\mu}m$ tripple-well CMOS 공정을 이용하여 테스트 칩을 제작하고 측정하였다. 측정 된 기준전압 Vref는 평균값이 738mV이고 $3{\sigma}$는 29.88mV이다. A start-up circuit of the bandgap reference voltage generator of cascode current mirror type with wide operating voltage range and enhanced power-up characteristics is proposed in the paper. It is confirmed by simulation that the newly proposed start-up circuit does not affect the operation of the bandgap reference voltage generatory even though the supply voltage(VDDA) is higher and has more stable power-up characteristic than the conventional start-up circuit. Test chips are designed and fabricated with $0.18{\mu}m$ tripple well CMOS process and their test has been completed. The mean value of measured the reference voltage(Vref) is 738mV and The three sigma value($3{\sigma}$) is 29.88mV.

내장형 펌핑 커패시터를 사용한 TFT-LCD 구동 IC용 전하펌프 설계

임규호,송성영,박정훈,이용진,이천효,이태영,조규삼,박무훈,하판봉,김영희,Lim, Gyu-Ho,Song, Sung-Young,Park, Jeong-Hun,Li, Long-Zhen,Lee, Cheon-Hyo,Lee, Tae-Yeong,Cho, Gyu-Sam,Park, Mu-Hun,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.10

본 논문에서는 TFT-LCD 구동 IC 모듈의 소형화 측면에서 유리한 DC-DC 변환기 회로인 펌핑 커패시터 내장형 크로스-커플드 전하펌프(Cross-Coupled Charge Pump with Internal Pumping Capacitor) 회로가 새롭게 제안되었다. VGH 및 VGL 전하펌프 각각의 입력단과 전하 펌핑 노드를 연결하는 NMOS 및 PMOS 다이오드를 두어, 초기 동작 시 전하 펌핑 노드를 서로 같은 값으로 프리차지하여 대칭 적으로 전하 펌핑을 하도록 하였다. 그리고 첫 번째 전하 펌프의 구조를 다르게 설계하여 펌핑된 전하가 입력단으로 역류되는 현상을 방지하였다. 또한, 펌핑 클럭 구동 드라이버의 위치를 펌핑 커패시터 바로 앞에 두어 기생 저항으로 인한 펌핑 클럭 라인의 전압강하를 방지하여 구동능력을 향상 시켰다. 마지막으로 내장형 펌핑 커패시터를 Stack-MIM 커패시터를 사용하여 기존의 크로스-커플드 전하펌프 보다 레이아웃 면적을 최소화하였다. 제안된 TFT-LCD 구동 IC 용 전하펌프 회로를 $0.13{\mu}m$ Triple-Well DDI 공정을 사용하여 설계하고, 테스트 칩을 제작하여 검증하였다. A cross-coupled charge pump with internal pumping capacitor, witch is advantages from a point of minimizing TFT-LCD driver IC module, is newly proposed in this paper. By using a NMOS and a PMOS diode connected to boosting node from VIN node, the pumping node is precharged to the same value each pumping node at start pumping operation. Since the lust-stage charge pump is designed differently from the other stage pumps, a back current of pumped charge from charge pumping node to input stage is prevented. As a pumping clock driver is located the font side of pumping capacitor, the driving capacity is improved by reducing a voltage drop of the pumping clock line from parasitic resistor. Finally, a layout area is decreased more compared with conventional cross-coupled charge pump by using a stack-MIM capacitors. A proposed charge pump for TFT-LCD driver IC is designed with $0.13{\mu}m$ triple-well DDI process, fabricated, and tested.

TFT -LCD 구동 IC용 커패시터 내장형 DC-DC 변환기 설계

임규호,강형근,이재형,손기성,조기석,백승면,성관영,이용진,박무훈,하판봉,김영희,Lim Gyu-Ho,Kang Hyung-Geun,Lee Jae-Hyung,Sohn Ki-Sung,Cho Ki-Seok,Baek Seung-Myun,Sung Kwan-Young,Li Long-Zhen,Park Mu-Hun,Ha Pan-Bong,Kim Young-Hee 한국정보통신학회 2006 한국정보통신학회논문지 Vol.10 No.7

A non-overlap boosted-clock charge pump(NBCCP) with internal pumping capacitor, an advantageous circuit from a minimizing point of TFT-LCD driver IC module, is proposed in this paper. By using the non-overlap boosted-clock swinging in 2VDC voltage, the number of pumping stages is reduced to half and a back current of pumping charge from charge pumping node to input stage is also prevented compared with conventional cross-coupled charge pump with internal pumping capacitor. As a result, pumping current of the proposed NBCCP circuit is increased more than conventional cross-coupled charge pump, and a layout area is decreased. A proposed DC-DC converter for TFT-LCD driver IC is designed with $0.18{\mu}m$ triple-well CMOS process and a test chip is in the marking. 본 논문에서는 TFT-LCD 구동 IC 모듈의 소형화측면에서 유리한 DC-DC 변환기 회로인 펌핑 커패시터 내장형 비중첩 부스트-클락 전하펌프 (Non-overlap Boosted-Clock Charge Pump: NBCCP) 회로가 제안되었다 .2VDC 전압으로 스윙하는 비중첩 부스트-클럭의 사용으로 기존의 펌핑 커패시터 내장형 크로스-커플드 전하펌프에 비해 펌핑 단의 수를 반으로 줄일 수 있었고, 전하 펌핑 노드의 펌핑된 전하가 입력 단으로 역류되는 현상을 방지하였다 . 그 결과 제안된 펌핑 커패시터 내장형 비중첩 부스트-클럭 전하펌프 회로는 기존의 펌핑 커패시터 내장형 크로스-커플드 전하펌프에 비해 펌핑 전류가 증가하였고, 레이아웃 면적은 감소되었다. 제안된 TFT-LCD 구동 IC용 DC-DC 변환기 회로를 $0.18{\mu}m$ Triple-Well CMOS 공정을 사용하여 설계하고, 테스트 칩을 제작 중에 있다.

Effect of Dioscorea Rhizoma powder on TNBS-induced IBD Model of Mice

Sung-Won Lim,Mee-Sun Hyun,Bong-Joon Song,Yong-Seo Shin,Jung-Mu Hur,Bon-Hee Gu,Sun-Hee Lee,Dae-Ki Kim 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.8