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석병석(Suk, Byong-suk),민승용(Min, Seung-yong),권재욱(Kwon, Jae-wook),김창균(Kim, Chang-kyoon),문상만(Moon, Sang-man),최수진(Choi, Su-jin),구철회(Koo, Cheol-hea),김인규(Kim, In-kyu),류동영(Ryu, Dong-young) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.2
시험용 달 궤도선의 발사 요구조건 사전 분석 단계로 최근 외국에서 발사한 달 탐사선의 발사 요구조건을 분석하였다. 일반적으로 달 탐사선의 발사 요구조건은 달 임무 궤도를 결정하는 중요한 요소이며, 또한 지구, 달, 태양의 상대적인 운동으로 인해 임무궤도 요구조건을 만족하는 발사 가능 시간이 주기적으로 반복되는 경향이 있다. 분석 결과 설정된 발사 요구조건들로부터 달 궤도선의 주 임무가 달의 남/북극 지역의 광학 관측 임을 간접적으로 알 수 있었다. 향후 우리나라 달 궤도선 발사 요구 조건 설정에 본 논문이 도움이 되길 기대한다. In the preliminary study on launch window requirement for Korea Path-finder Lunar Orbiter(KPLO), the recent foreign lunar orbiter’s lauch window requirement was analyzed. Normally, the launch requirements depends on the mission orbit. Based on the relationship between Moon, Earth, and Sun, the launch time will be available periodically to meet requirements. In this paper, it is understood that the launch window requirements come from payload mission requirements to take picture each poles of Moon. This paper might be a practical example to derive KPLO launch requirements in the future.
Successful treatment in a patient with onychogryphosis associated with onychomycosis
( Sang Hyeon Won ),( Woo Il Kim ),( Min Young Yang ),( Won Ku Lee ),( Gun Wook Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Onychogryphosis is a disorder of nail plate growth that is clinically characterized by an opaque, yellow-brown thickening of the nail plate associated with gross hyperkeratosis, elongation, and increased curvature. There can be various causes of acquired onychogryphosis, and onychomycosis may be the one of them. So it should be noted that onychogryphosis and onychomycosis can coexist. We present the case of a 55-year-old man with a 6-year history of severe thickening, abnormal growth, and yellow discoloration of both great toenails, clinically consistent with onychogryphosis. Potassium hydroxide (KOH) examination was positive. It was necessary to treat both onychogryphosis and onychomycosis respectively. There are a wide variety of therapies according to the cause and patient comorbidities. As for onychogryphosis, nail grinding was done as a palliative therapy. And for onychomycosis, efinaconazole 10% topical solution was administered. After 9 months of these combination therapy, significant cosmetic improvements were achieved. To our knowledge, successful treatment for onychogryphosis associated with onychomycosis has rarely been reported in Korean dermatologic literature. Therefore, we suggest that nail grinding and efinaconazole 10% topical medication should be regarded as one of good treatment modalities in a patient with onychogryphosis associated with onychomycosis.
Inexplicable but real phenomenon: rapidly regressed
( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Kaposi’s sarcoma (KS) is a type of spindle cell malignancy that arises from the vascular endothelium, usually presenting as violaceous papules and plaques. KS development is invariably linked with human herpesvirus (HHV)-8 infection. Almost spontaneous regressions of KS have been previously described in the iatrogenic type. Herein, we present a classic KS in immunocompetent patient showing rapid regression after biopsy. A 78-year-old male presented with relatively well-defined erythematous patches on forehead, Rt. upper eyelid and chin, and violaceous papule on nose. His medical and family histories were noncontributory. The patient denied history of recent overseas travel, homosexual or unnatural sexual practices, and serum anti-HIV antibody was negative. A histopathologic examination from the nose revealed typical findings of KS and tumor cells showed positive staining for CD31, CD34, and factor VIII-related antigen. Polymerase chain reaction in a biopsy specimen was positive for HHV-8. Without specific treatment, the lesion rapidly regressed within 2 weeks. It is generally accepted that immune status plays an important role for KS. As viral wart disappear after biopsy occasionally, it is possible that the biopsy may have then exposed antigens and induced an immunologic reaction, which led to the rapid regression of KS.
( Sung-min Park ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo Kim ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.1
Background: Pruritus is a common symptom in psoriasis. However, few studies have assessed the characteristics of pruritus according to morphological phenotypes of psoriasis. Objective: To investigate the characteristics of pruritus according to morphological phenotypes of psoriasis and to assess the association with inflammatory mediators related to pruritus. Methods: Psoriasis patients were divided into 2 groups according to clinical phenotype: eruptive inflammatory (EI) and chronic stable (CS). Clinical data of pruritus were assessed by an itch questionnaire. Serum neuropeptides and cytokines including substance P, histamine, vasoactive intestinal peptide, neuropeptide Y, calcitonin gene-related peptide and interleukin-31 (IL-31) were quantitatively measured. Results: In total, 50 patients with psoriasis (30 male, 20 female; mean age, 45.7 years) were studied (EI, n=15 and CS, n=35). Pruritus was reported by 80% of EI and CS patients. There were no significant differences in prevalence of pruritus, pruritus intensity, severity of psoriasis, serum neuropeptides, or IL-31 between the 2 groups. Conclusion: The morphological phenotype does not seem to be an important factor affecting the prevalence and characteristics of pruritus in psoriasis. (Ann Dermatol 32(1) 1∼7, 2020)
Spontaneous intracerebral hemorrhage in a patient with severe psoriasis vulgaris
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Psoriasis is chronic immune-mediated inflammatory skin disorder of unknown etiology. Psoriasis was previously believed to affect only the skin, and in some patients, the joints. Recent evidence suggests that chronic psoriasis may lead to other comorbidities such as cardiovascular disease, obesity, and type 2 diabetes mellitus. However, the association between psoriasis and intracerebral hemorrhage (ICH) has rarely been reported. The patient was 43-years-old female with a history of severe chronic psoriasis vulgaris for 6 years refractory to conventional immunomodulatory treatments and phototherapy. She was unregularly followed-up and 2 month ago, she was treated with cyclosporine (2.5mg/kg), but the disease aggravated. Four days ago, abruptly, she started to notice weakness of right lower extremity and dysarthria. She denied any history of trauma. On magnetic resonance imaging study, bilateral ICH in basal ganglia was observed. She did not have any risk factors such as trauma, advanced age, and hypertension for ICH. Therefore, we suspected that severe chronic psoriasis vulgaris may have played an important role in occurrence of spontaneous ICH.
A Case of Cervical Chondrocutaneous Branchial Remnant Comprised of Hyaline Cartilage
( Sang-jin Cheon ),( Tae-wook Kim ),( Seong-min Park ),( Hyun-ju Lee ),( Hyunju Jin ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyang- 대한피부과학회 2019 Annals of Dermatology Vol.31 No.1
Two cases of pigmented neurofibroma with hypertrichosis
( Sang Jin Cheon ),( Hyun Ju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Pigmented neurofibroma (PNF) is a rare variant of tumor consisting neurofibroma with melanin-laden pigmented cells. Rarely, there has been reported PNF with hypertrichosis. In that case, differential diagnoses of smooth muscle harmatoma and combined with Becker’s nevus are required. Case 1, a 29-year-old man presented with localized brownish plaque with hypertrichosis on the left side of forehead. In physical examination, 15x15cm size, well-defined brownish plaque with excessive terminal hair on the left side of forehead. On histopathologic finding, the hair follicles were abundant in the dermis and the spindle cell proliferation with wavy nuclei were detected within deep reticular dermis. Spindle cells were positive for S-100 and also showing positive to melan-A melanin-laden cells were scattered. Case 2, 7-year-girl presented with solitary palpable mass in subcutis and brownish patch with hypertrichosis on the left shin. Also on histologic exam, revealed prominent hair follicle, spindle cell proliferation and scattered melanin-laden cells were observed. Both patients, the diagnosis of PNF with hypertrichosis was made by distinctive histopathologic findings. Herein, we experience two cases of PNF with hypertrichosis. This will be helpful understanding distinctive histopathologic finding of PNF with hypertrichosis.
Leuprolide-induced foreign body granuloma in a patient with prostate cancer
( Sung Min Park ),( Jeong Min Kim ),( Gun Wook Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Leuprolide, an agonist of gonadotropin-releasing hormone (GnRH), is indicated in the treatment of sex hormone-responsive diseases including prostate cancer. To date, several cases of leuprolide-induced foreign body granuloma have been reported. We report a case of foreign body granuloma developing after injections of leuprolide 3-month depot formulation. A 80-year-old man presented with localized erythematous indurated plaqueand nodule on the left upper arm. The patient had been treated for metastatic prostate cancer with subcutaneous injections of leuprolide at 3-month intervals from 18 months ago. Skin biopsy from indurated plaque revealed granulomas with multinucleated giant cells from dermis to subcutaneous fat layer. The granuloma contained numerous round, translucent vacuoles. Cultures from the tissue for bacteria, fungi and mycobacteria were all negative. The diagnosis of leuprolide-induced foreign body granuloma was made by clinicopathologic findings. Various theories on the cause of local reactions to leuprolide have been suggested. The formation of such granulomas may be related to the Polylactic-co-glycolic acid (PLGA) polymers that allow slow release after injection, or leuprolide itself. The depth of injection could have also contributed, therefore, intramuscular injection is recommended to minimize granuloma formation. Dermatologists need to know that depot leuprolide may cause a granulomatous reaction.
The use of ingenol mebutate gel as adjuvant therapy for large or multiple Bowen disease
( Sang Jin Cheon ),( Hyun Ju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Bowen disease (BD) is squamous cell carcinoma in situ, which may progress to invasive carcinoma if not adequately managed. In single and small BD, many therapeutic options are available including excision, curettage, cryotherapy, and topical agents such as 5-fluorouracil and imiquimod. But in the case with large or multiple lesions, therapeutic choice is restrictive. Herein, we experienced two cases of large or multiple BD successfully managed with ingenol mebutate gel. A 81-year-old woman was diagnosed as BD for large lesion on the right calf measuring 7 x 10 cm. We applied ingenol mebutate gel 0.05% on the affected area once daily for 2 consecutive days. 1 month after treatment, crust fell out and only focal small lesion was remained. After additional cryotherapy was done twice and clinically resolved large BD during follow-up 6 months.. A 54-years-old woman was diagnosed as BD for multiple hyperkeratotic plaques on the both palms. We applied ingenol mebutate gel 0.05% once daily for 2 consecutive days. After 3 months, only a few lesions were remained. Following three times additional cryotherapy, the lesions were improved enough to be controlled cryotherapy. Through our experience, we suggest ingenol mebutate gel could be effective adjuvant therapy option for large or multiple BD.