Patterns of Impaired Neurocognitive Performance on the Global Neuropsychological Assessment, and Their Brain Structural Correlates in Recent-onset and Chronic Schizophrenia

Vineeth Mohan(Vineeth Mohan ),Pravesh Parekh(Pravesh Parekh ),Ammu Lukose(Ammu Lukose ),Sydney Moirangthem(Sydney Moirangthem ),Jitender Saini(Jitender Saini ),David J. Schretlen(David J. Schretlen ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Schizophrenia is associated with impairment in multiple cognitive domains. There is a paucity of research on the effect of prolonged illness duration (≥ 15 years) on cognitive performance along multiple domains. In this pilot study, we used the Global Neuropsychological Assessment (GNA), a brief cognitive battery, to explore the patterns of cognitive impairment in recent-onset (≤ 2 years) compared to chronic schizophrenia (≥ 15 years), and correlate cognitive performance with brain morphometry in patients and healthy adults. Methods: We assessed cognitive performance in patients with recent-onset (n = 17, illness duration ≤ 2 years) and chronic schizophrenia (n = 14, duration ≥ 15 years), and healthy adults (n = 16) using the GNA and examined correlations between cognitive scores and gray matter volumes computed from T1-weighted magnetic resonance imaging images. Results: We observed cognitive deficits affecting multiple domains in the schizophrenia samples. Selectively greater impairment of perceptual comparison speed was found in adults with chronic schizophrenia (p = 0.009, η2 partial = 0.25). In the full sample (n = 47), perceptual comparison speed correlated significantly with gray matter volumes in the anterior and medial temporal lobes (TFCE, FWE p < 0.01). Conclusion: Along with generalized deficit across multiple cognitive domains, selectively greater impairment of perceptual comparison speed appears to characterize chronic schizophrenia. This pattern might indicate an accelerated or premature cognitive aging. Anterior-medial temporal gray matter volumes especially of the left hemisphere might underlie the impairment noted in this domain in schizophrenia.

Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells

Mohan, Chaya,Lee, Gyun Min Wiley Subscription Services, Inc., A Wiley Company 2010 Biotechnology and bioengineering Vol.107 No.2

<P>To enhance specific antibody (Ab) productivity (q<SUB>Ab</SUB>) of recombinant Chinese hamster ovary (rCHO) cells, post-translational limitations in the endoplasmic reticulum during antibody production should be relieved. Previously, we reported that overexpression of protein disulfide isomerase (PDI), which catalyzes disulfide bond exchanges and assists in protein folding of newly synthesized proteins, enhanced q<SUB>Ab</SUB> of rCHO cells by about 27% (Mohan et al., 2007, Biotechnol Bioeng 98:611–615) . Since the rate limiting step in disulfide bond formation is found to be the regeneration of oxidized PDI, the oxidation state of PDI, as well as the amount of PDI, might be important. Endoplasmic reticulum oxidoreductase (ERO1L) maintains PDI in an oxidized state so that disulfide bond formation occurs. Here, PDI and its helper protein, ERO1L were overexpressed in rCHO cells producing an Ab in an attempt to ease the bottleneck in disulfide bond formation, and hence, Ab folding and secretion. Transient expression of ERO1L alone and with PDI resulted in enhanced q<SUB>Ab</SUB> by 37% and 55%, respectively. In contrast, under stable inducible co-overexpression of PDI and ERO1L, the q<SUB>Ab</SUB> was unaffected or negatively affected by varying degrees, depending on the individual expression levels of these genes. In stable clones with altered oxidation state of PDI due to co-overexpression of PDI and ERO1L, secretion of Ab was hindered and PDI-associated retention of Ab was seen in the cells. Under transient gene expression, secretion of Ab was not compromised. The data presented here suggests a possible mechanism of PDI/ERO1L interaction with the target Ab and shows how the expression levels of these proteins could affect the q<SUB>Ab</SUB> of this Ab-producing rCHO cell line. Biotechnol. Bioeng. 2010;107: 337–346. © 2010 Wiley Periodicals, Inc.</P>

Quantum Sensing Research: A Scientometric Assessment of Global Publications during 1991-2020

Brij Mohan Gupta,Surinder Mohan Dhawan,Ghouse Modin Mamdapur 건국대학교 GLOCAL(글로컬)캠퍼스 지식콘텐츠연구소 2022 International Journal of Knowledge Content Develop Vol.12 No.3

The study presents a global research scenario in the domain of quantum sensing in quantitative and qualitative terms. The study is based on an analysis of 588 global publications in the field, sourced from the Scopus database for the period 1991-2020. The study identified key countries, organizations and authors, network collaborative linkages at national, institutional, and author level. In addition, it identified broad subject areas intersecting quantum sensing research, key journals for research communications, and broad characteristics of highly-cited papers. The study finds that the USA and Germany lead the world ranking in quantum sensing research with a combined share of 50% to the global output. The USA, Germany, and Italy are the home countries to 13 of the top 15 most productive organizations, and also the home countries to 14 of the top 15 most productive authors in the subject. The top journals publishing most research publications are Physical Review A, Physical Review Letters and New Journal of Physics. However, in the most cited journals list in the subject, Agriculture & Forest Meterology, Science and Physical Review A tops the list.

The role of rectal diclofenac and aggressive hydration with Ringer's lactate in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients

Sharma Vivek Mohan,Mathur Amit,Goyal Mohan Babu,Jat Shankar Lal 소화기인터벤션의학회 2023 International journal of gastrointestinal interven Vol.12 No.2

Background: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is a common complication of therapeutic endoscopy. The aim of this trial was to determine whether a combination of rectal diclofenac and vigorous hydration with Ringer’s lactate is superior to the correspond-ing individual treatments for preventing PEP in high-risk patients. Methods: This randomized, open-label, controlled trial was conducted from August 2020 to January 2022. We included patients who were at high risk of developing PEP. Three intervention groups were made: group A, diclofenac sodium suppository (100 mg); group B, aggressive hydration with Ringer’s lactate; group C, a combination of diclofenac and aggressive hydration. PEP was defined as a serum amylase level > 3 times the upper limit of normal with epigastric pain within 24 hours after endoscopic retrograde cholangiopancreatography.Results: A total of 144 patients were included and 48 cases were randomized to each intervention group. The incidence of PEP was 8.3%, 10.4%, and 8.3% in groups A, B, and C, respectively. A personal history of alcohol consumption and more than one pancreatic duct guidewire cannulation were significantly associated with the development of PEP.Conclusion: No difference in the incidence of PEP was observed with or without the use of aggressive hydration. Combining aggressive hydration with a rectal nonsteroidal anti-inflammatory drug for preventing PEP cannot be recommended.

Integrating Software Product Line Engineering and Agile Development

Mohan, Kannan,Ramesh, Balasubramaniam,Sugumaran, Vijayan IEEE 2010 IEEE software Vol.27 No.3

<P>A software product line is a set of software-intensive systems sharing a common, managed set of features, developed from reusable core assets and incorporating variations to derive product variants. This involves identifying commonality and variability in the product family and implementing shared artifacts while preserving the ability to implement required variability. Software development organizations that recognize market opportunities for products that share a significant number of common elements, but that also exhibit variations, can reap significant economic benefits with SPLE. Agile methods emphasize improvisation over conventional development approaches. These methods focus on quick development in an uncertain, ill-understood environment in which requirements rapidly evolve. These methods also view people, rather than formal documentation, as a project's most important element.</P>

Optimization of Various Cutting Parameters on the Surface Roughness of the Machinable Glass Ceramic with Two Flute Square End Mills of Micro Grain Solid Carbide

Mohan Reddy Moola,Alexander Gorin,Khaled Abou Hossein 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.

Due to brittle nature of advanced ceramics surface damage, cracks, and edge chips are common problems when machining them by using conventional methods. Selection of proper cutting parameters and cutting tool may help to minimize the above mentioned problems. Cutting process of Machinable glass ceramics in end milling operation has been carried out using two flute square end micro-grain solid carbide end mills under dry conditions. The development of surface roughness model in terms of cutting speed, feed rate and axial depth of cut using Design of experiments and the Response surface methodology is presented in the paper. ANOVA analysis has been carried out to identify the most significant factors affecting surface roughness and the optimal cutting combination has been determined.

In-Process Measurement of Surface Roughness using Machine Vision with Sub-Pixel Edge Detection in Finish Turning

Mohan Kumar Balasundaram,Mani Maran Ratnam 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

Common methods of in-process surface roughness measurement are capable of providing a limited number of amplitude parametersfor roughness assessment. This is mainly due to the averaging effect of the sensors used. In this work, we measured the amplitude,spacing, hybrid as well as functional surface roughness parameters during dry turning of AISI 1035 carbon steel using machinevision. A commercial DSLR camera with high shutter speed was used to capture a blur-free image of the workpiece surface profilediametrically opposite the cutting tool. The edge of the surface profile was detected to sub-pixel accuracy using the grey level invariantmoment and the roughness parameters were determined from the profile. The tool nose wear and machining time were correlated withamplitude, hybrid, and spacing surface roughness parameters, as well as the bearing area curve parameters. Three new roughnessparameters, namely average slope of profile peaks (Φp), average slope of profile valleys (Φv), relative length of peaks (Rrl), wereintroduced to study the effect of changes in tool nose micro geometry due to wear on the surface roughness. Among these newparameters Φp and Rrl showed better correlation with machining time and nose wear compared to all other parameters.

An investigation into the motion and stability behaviour of a RO-RO vessel

Mohan, Poonam,Shashikala, A.P. Techno-Press 2019 Ocean systems engineering Vol.9 No.2

Studies on motion response of a vessel is of great interest to researchers, since a long time. But intensive researches on stability of vessel during motion under dynamic conditions are few. A numerical model of vessel is developed and responses are analyzed in head, beam and quartering sea conditions. Variation of response amplitude operator (RAO) of vessel based on Strip Theory for different wave heights is plotted. Validation of results was done experimentally and numerical results was considered to obtain effect of damping on vessel stability. A scale model ratio of 1:125 was used which is suitable for dimensions of wave flume at National Institute of Technology Calicut. Stability chart are developed based on Mathieu's equation of stability. Ince-Strutt chart developed can help to capture variations of stability with damping.

Business Driven Science and Technology Parks (STPs) for Accelerating Innovation: Cases from Malaysia and India

Mohan, Avvari V. World Technopolis Association 2014 World Technopolis Review Vol.3 No.3

This paper presents two cases of Science and Technology Parks (STPs), from Malaysia and India, that are driven by business organisations in partnership with governments. The need to locate the STP near to a university or a research institute has been considered crucial to attract firms to the STP - but in this paper, we illustrate the efforts to develop a locally relevant STP through the cases of Pahang Bio Science in Malaysia and the ICICI Knowledge Park (now known as IKP) in Hyderabad India. These two developments are anchored by business organisations that are playing a pivotal role in their development. The government plays a supporting role in terms of policy and supplying certain complementary resources. In addition, we note that the government support also provides legitimacy for the business organisation developing the STP. In the case of the Malaysian STP, we note the approach is towards inclusive development by developing linkages to local communities, and in the case of the Indian STP, one can see the development of the STP in a dynamic way changing according to the needs of the sector. Especially interesting is the foresight by the nodal business organisations in developing the STPs.

Entrepreneurial Ecosystem Developments in Malaysia - Existing Actors Moving from a Cluster to a Countrywide Role and the Emergence of New Actors

Mohan, Avvari V. World Technopolis Association 2019 World Technopolis Review Vol.8 No.1

This paper examine the changing ecosystems in Malaysia, starting with the government policy driven greenfield cluster of Cyberjaya, which is part of the Multimedia Super Corridor (MSC) mega project. In this context of an emerging economy, predominantly production oriented, the role of the government was crucial with respect to implementing policies and building infrastructure for the ecosystems. First, the roles played by the cluster development agency, universities, and industry are explained. As the cluster developed, this paper, taking an entrepreneurial ecosystem approach, explores how some actors evolved and changed their roles to become catalyst organisations established for the cluster now serving nationwide. This was followed by the emergence of new actors in the ecosystems, for example, knowledge intermediaries, and new roles for universities. In addition to actors such as universities and industry, this paper recognizes the emergence of media organisations as new actors in the entrepreneurial ecosystems in Malaysia.