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강예은,Yi Hyon-Seung,Yeo Min-Kyung,Kim Jung Tae,Park Danbit,Jung Yewon,Kim Ok Soon,이성은,Kim Ji Min,Joung Kyong Hye,Lee Ju Hee,Ku Bon Jeong,Lee Mina,Kim Hyun Jin 대한의학회 2022 Journal of Korean medical science Vol.37 No.48
Background: Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy. To define the altered pathway in GDM placenta, we investigated the transcriptomic profiles from human placenta between GDM and controls. Methods: Clinical parameters and postpartum complications were reviewed in all participants. Differentially expressed canonical pathways were analyzed between the GDM and control groups based on transcriptomic analysis. CD4+ T, CD8+ T, and senescent T cell subsets were determined by flow cytometry based on staining for specific intracellular cytokines. Results: Gene ontology analysis revealed that the placenta of GDM revealed upregulation of diverse mitochondria or DNA replication related pathways and downregulation of T-cell immunity related pathways. The maternal placenta of the GDM group had a higher proportion of CD4+ T and CD8+ T cells than the control group. Interestingly, senescent CD4+ T cells tended to increase and CD8+ T cells were significantly increased in GDM compared to controls, along with increased programmed cell death-1 (CD274+ ) expression. Programmed death-ligand 1 expression in syncytotrophoblasts was also significantly increased in patients with GDM. Conclusion: This study demonstrated increased proinflammatory T cells, senescent T cells and immune-check point molecules in GDM placentas, suggesting that changes in senescent T cells and immune-escape signaling might be related to the pathophysiology of GDM.
Helicobacter pylori 감염과 사회경제적 요인에 대한 연구
정민경,권영세,최현,최연호,홍윤철,Jung, Min-Kyong,Kwon, Young-Se,Choe, Hyon,Choe, Yon-Ho,Hong, Yun-Chul 대한소아소화기영양학회 2000 Pediatric gastroenterology, hepatology & nutrition Vol.3 No.1
목 적: 우리 나라 청소년기 소아의 H. pylori 감염 유병율을 조사하고, 사회경제적 요인이 청소년의 H. pylori 감염에 어떠한 영향을 미치는지 알아보고자 하였다. 대상 및 방법: 1996년 10월 부천시에 살고 있는 10~15세의 532명(남아 285명, 여아 247명)의 소아를 대상으로 채혈을 시행하여 혈청학적인 방법(serum IgG antibody)으로 H. pylori 감염을 진단하였다. 설문지를 통하여 성별, 연령, Hollingshead index에 따라 분류한 사회경제적 수준, 주거형태(전세 또는 자가), 혼잡지수(crowding index)를 조사하였는데, 532명 중 375명(70.5%, 남:여=205:170)의 설문이 회수되었다. Hollingshead index는 부모의 교육정도와 직업을 고려하여 구분하였고 crowding index는 식구수/방수로 구하였다. 각각 단변수 회귀분석 후 의미있는 결과를 모아 다중회귀분석을 시행하였다. 결 과: H. pylori 유병률은 남아에서 17.1% (32/205), 여아에서 16.5% (28/170)로 통계적으로 유의한 차이는 없었다(P=0.88). 10~11세, 12~13세, 14~15세의 세 연령군으로 나누어 비교한 결과, 연령이 증가할수록 H. pylori 유병률은 각각 10.3% (7/68), 15.9% (25/157), 20.7% (31/150)로 유의한 증가를 보였다(P=0.05). 사회경제적 수준을 Hollingshead index로 구하여 세 군으로 나누어 비교한 결과, 사회경제적 수준이 높을수록 H. pylori 양성은 각각 20.0% (23/115), 16.0% (39/244), 6.3% (1/16)로 감소하는 역비례 관계를 보였으나 통계적으로 유의한 차이는 아니었다(P=0.16). 전세와 자가를 비교했을 때 H. pylori 양성은 각각 15.7% (22/140), 17.5% (41/235)로 유의한 차이가 없었다(P=0.66). 혼잡지수(crowding index: 식구수/방수)가 1.5 미만일 때 H. pylori 양성은 16.0% (26/163), 1.5 이상일 때 17.5% (37/212)로 유의한 차이가 없었다(P=0.70). 다중회귀분석 결과 H. pylori 감염에 대해 연령은 odds ratio 2.2 (95% confidence interval 0.9~5.4), Hollingshead index에 의한 사회경제적 수준은 odds ratio 3.6 (95% confidence interval 0.5~28.9)이었다. 결 론: 부천시 청소년기 소아의 H. pylori 감염유병률은 16.8%이며, 부모의 교육정도와 직업에 따른 사회경제적 수준이 가족내 혼잡도, 주거형태보다 감염에 더욱 영향을 미치는 것으로 보인다. Purpose: This study was conducted to evaluate the association between H. pylori infection and socioeconomic status and to determine the current prevalence of H. pylori infection in Korean adolescents. Methods: A structured questionnaire was sent to the children's parents to obtain demographic information on the parents and environmental information. Of the 532 questionnaires sent out, 375 (70.5%; 170 girls and 205 boys) were returned. Their ages ranged from 10 to 15 years (mean, 12.9 years). After collecting blood samples, we measured serum IgG antibody to H. pylori using ELISA method. The association of risk factors such as age, sex, socioeconomic class, type of house, and crowding index with H. pylori infection were analyzed by multiple regression analysis. Socioeconomic status was estimated from the parents' education and occupation using a modified Hollingshead index. Results: The prevalence rate of H. pylori infection was 16.8% (63/375). It increased with age (10.3% at 10~11 years, 15.9% at 12~13 years, and 20.7% at 14~15 years). The H. pylori infection was inversely related to the socioeconomic class (6.3% for the upper class, 16.0% for the middle class, and 20.0% for the lower calss). Crowding condition and type of house did not affect significantly on seroprevalence of H. pylori infection. After logistic regression, we found that the odds ratio for age was 2.2 (95% confidence interval 0.9~5.4), and for socioeconomic status, 3.6 (95% confidence interval 0.5~28.9). Conclusion: The prevalence of H. pylori infection in Korean adolescents was 16.8%. It related inversely to socioeconomic status but was not statistically significant. Socioeconomic status based on parents' education and occupation seemed to affect more on H. pylori seroprevalence than crowding or type of house did.
진주연(Ju Youn Jin),양희경(Hee Kyoung Yang),김지민(Ji Min Kim),고문수(Mun Su Ko),홍현주(Hyun Ju Hong),진영건(Young Gun Jin),김동건(Dong Gun Kim),김상철(Sang Chul Kim),이일(Il Lee),현민경(Min Kyong Hyon),강상철(Sang Chul Kang),김재훈(Ja 한국독성학회 2006 Toxicological Research Vol.22 No.4
Aralia elata, a common medicinal and culinary herb, has been consumed for centuries without any reported adverse effects. However, due to its limited safety information, we decided to investigate the repeated-dose toxicity of ethanolic extract of Aralia elata. The test was administered once daily by the gavage to male and female rats at doses of 0, 250, 500 and 1,000 ㎎/㎏/day for four weeks. Throughout the study, no treatment-related deaths or clinical signs were observed. Also, no apparent changes were detected in ophthalmoscopy, urinalysis, serum biochemistry, hematology and gross necropsy. The test result showed a significant decrease in body and heart weight of males treated with 250 ㎎/㎏ of extract of Aralia elata compared to normal control, a significant increase in relative brain weight and adrenal weight in females treated with 250 ㎎/㎏ of extract compared to normal control. However, all these changes were not considered toxicologically important due to irrelevant dose-response relationship to gross and microscopic findings. Histopathologically, abnormal changes were not observed in any target organs. On the basis of these results, the NOAEL of extract of Aralia elata was estimated to be more than 1,000 ㎎/㎏/day under the tested conditions.