Investor Sentiment, Product Features, and Advertising Investment Sensitivities

Miao Luo,Daniel X. Jiang,Jun Cai 한국증권학회 2014 Asia-Pacific Journal of Financial Studies Vol.43 No.6

Investor sentiment plays an important role, affecting firm level advertising expenditures. Weprovide evidence that financially constrained firms exhibit lower advertising investment-cashflow sensitivity and higher advertising investment-q sensitivity during high sentiment periods. The patterns are driven mainly by those firms facing financial constraints. More importantly, weidentify several product features that also affect advertising investment sensitivities. Sorting onproduct features generates investment sensitivities that closely resemble those of sorting onfinancial constraint measures. We design empirical analyses to provide clean tests of the cost-of-external-financing-based and product-feature-based explanations underlying the variation inadvertising investment sensitivities.

Facile Preparation of Water Dispersible Red Fluorescent Organic Nanoparticles for Cell Imaging

Luo, Miao Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6

Red fluorescent organic nanopaticles (FONs) based on a diarylacrylonitrile derivative conjugated molecule were facilely prepared by surfactant modification. Such red FONs showed excellent water solubility and biocompatibility, making them promising for cell imaging applications.

Effect of Media Components and Morphology of Bacillus natto on Menaquinone-7 Synthesis in Submerged Fermentation

Miao-miao Luo,Lu-jing Ren,Sheng-lan Chen,Xiao-jun Ji,He Huang 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.6

Vitamin K2 (menaquinone or MK) plays an important role in blood clotting, cardiovascular disease, and anti-osteoporosis. A novel bacterial strain was isolated and identified as Bacillus natto based on 16SrDNA sequencing and LC-MS analysis. The objective of this study was to improve the extraction efficiency and productivity of MK-7 from B. natto. Acid-heating method efficiently disrupted B. natto cells for MK-7 extraction. Bacillus natto had a wide range of pH (5.0 ~ 9.0) for optimal growth. Its MK-7 yield was increased when rotation speed was increased to 200 rpm. The highest MK-7 yield was obtained when glycerol and soy peptone were used in the growth media. Batch fermentation was subsequently tested in 5 L bioreactor, which gave a high productivity of MK-7 (at 0.60 mg/L/h). A positive correlation between MK-7 yield and sporulation ratio was also found. This study provides valuable information on the extraction and production of menaquinone-7 from B. natto under submerged fermentation condition.

Facile Preparation of Water Dispersible Red Fluorescent Organic Nanoparticles for Cell Imaging

Miao Luo 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.6

Red fluorescent organic nanopaticles (FONs) based on a diarylacrylonitrile derivative conjugated molecule were facilely prepared by surfactant modification. Such red FONs showed excellent water solubility and biocompatibility, making them promising for cell imaging applications.

Research on the Resource Scheduling of the Improved SFLA in Cloud Computing

Yue Miao,Fu Rao,Luo Yu 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.1

It has always been a key topic in the current research how to make rational resource scheduling in the cloud computing environment. In this paper, the status of cloud computing resources is first analyzed, to point out the existing problems, and then combined with the characteristics of resource scheduling in cloud computing, the Shuffled Frog Leaping Algorithm is introduced. First, in its stage of subgroups classification, the chaos strategy is introduced and in the internal search the positive learning strategy is introduced, which makes the improved frog leaping algorithm gain good convergence, reduces the time of global search and optimization. Through the CloudSim platform, it shows that this algorithm can improve the efficiency of task processing and make the resource scheduling in cloud computing rational and effective.

Expression and Regulation of Transcription Factor FoxA2 in Chronic Rhinosinusitis With and Without Nasal Polyps

Qing Luo,Jia Zhang,Hongtian Wang,Fenghong Chen,Xi Luo,Beiping Miao,Xingmei Wu,Renqiang Ma,Xiangqian Luo,Geng Xu,Jianbo Shi,Huabin Li 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.5

Purpose: Chronic rhinosinusitis (CRS) is characterized by the excessive production of mucus. However, the molecular mechanism underlying mucin overproduction in CRS with or without nasal polyps (CRSwNP and CRSsNP, respectively) is poorly understood. This study was conducted to assess the importance of the transcription factor FoxA2 in mucin production and to investigate the targeting of FoxA2 as a potential therapeutic strategy for mucus hypersecretion in CRS patients. Methods: We enrolled 15 CRSwNP patients, 15 CRSsNP patients, and 10 normal controls in this study. The expression levels of FoxA2, MUC5AC, and MUC5B in inflamed and healthy nasal tissues were examined via immunohistochemistry and quantitative reverse transcription-polymerase chain reaction, and the levels of several proinflammatory cytokines in nasal secretions were measured via FlowCytomix analysis. In addition, the expression of MUC5AC and FoxA2 was determined in polyp-derived epithelial cells and NCI-H292 cells after in vitro stimulation. Results: FoxA2 was significantly down-regulated, and MUC5AC and MUC5B were significantly up-regulated in both the CRSwNP and CRSsNP patients compared to the controls (P<0.05), and the protein level of FoxA2 was negatively associated with the IL-6 level in the CRS patients (P<0.05). IL-6 significantly increased MUC5AC expression but inhibited FoxA2 expression in vitro (P<0.05). Transfection with a FoxA2 expression plasmid significantly decreased MUC5AC promoter activity (P<0.05) and inhibited IL-6-induced MUC5AC production (P<0.05). In addition, clarithromycin significantly alleviated IL-6-induced FoxA2 suppression and decreased MUC5AC expression in vitro (P<0.05). Conclusions: Our findings suggest that FoxA2 may be considered a therapeutic target for the modulation of mucus hypersecretion in CRS patients.

기업의 전략적 일탈과 이익조정

나묘(Luo, Miao),전경민(Jeon, Kyeongmin),박삼복(Park, Sambock) 한국경영교육학회 2023 경영교육연구 Vol.38 No.1

Adenovirus-mediated Double Suicide Gene Selectively Kills Gastric Cancer Cells

Luo, Xian-Run,Li, Jian-Sheng,Niu, Ying,Miao, Li Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

The aim of this study was to evaluate the effect of the adenovirus-mediated double suicide gene (CD/TK) for selective killing of gastric cancer cells. Gastric cancer cells SCG7901 and normal gastric epithelial cell lines were infected by adenoviruses Ad-survivin/GFP and Ad-survivin/CD/TK. GFP expression and CD-TK were detected by fluorescence microscopy and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. After treatment of the infected cells with the pro-drugs ganciclovir (GCV) and/or 5-FC, the cell growth status was evaluated by methyl thiazolyl tetrazolium assay. Cell cycle changes were detected using flow cytometry. In nude mice bearing human gastric cancer, the recombinant adenovirus vector was injected directly into the tumor followed by an intraperitoneal injection of GCV and/or 5-FC. The subsequent tumor growth was then observed. The GFP gene driven by survivin could be expressed within the gastric cancer line SCG7901, but not in normal gastric epithelial cells. RT-PCR demonstrated the presence of the CD/TK gene product in the infected SCG7901 cells, but not in the infected normal gastric epithelial cells. The infected gastric cancer SCG7901, but not the gastric cells, was highly sensitive to the pro-drugs. The CD/TK fusion gene system showed significantly greater efficiency than either of the single suicide genes in killing the target cells (P<0.01). Treatment of the infected cells with the pro-drugs resulted in increased cell percentage in G0-Gl phase and decreased percentage in S phase. In nude mice bearing SCG7901 cells, treatment with the double suicide gene system significantly inhibited tumor growth, showing much stronger effects than either of the single suicide genes (P<0.01). The adenovirus-mediated CD/TK double suicide gene driven by survivin promoter combined with GCV an 5-FC treatment could be an effective therapy against experimental gastric cancer with much greater efficacy than the single suicide gene CD/TK combined with GCV or 5-FC.

CORROSION BEHAVIOR OF AUSTENITIC AND FERRITIC STEELS IN SUPERCRITICAL WATER

Luo, Xin,Tang, Rui,Long, Chongsheng,Miao, Zhi,Peng, Qian,Li, Cong Korean Nuclear Society 2008 Nuclear Engineering and Technology Vol.40 No.2

The general corrosion behavior of austenitic and ferritic steels(316L, 304, N controlled 304L, and 410) in supercritical water is investigated in this paper. After exposure to deaerated supercritical water at $480^{\circ}C$/25 MPa for up to 500 h, the four steels studied were characterized using gravimetry, scanning electron microscopy/energy dispersive X-ray spectroscopy(SEM/EDS), X-ray photoelectron spectroscopy(XPS), and X-ray diffraction(XRD). The results show that the 316L steel with a higher Cr and Ni content has the best corrosion-resistance performance among the steels tested. In addition to the oxide layer mixed with $Fe_{3}O_{4}$ and $(Fe,Cr)_{3}O_{4}$ that formed on all the samples, a $Fe_{3}O_{4}$ loose outer layer was observed on the 410 steel. The corrosion mechanism of stainless steels in supercritical water is discussed based on the above results.

Super-Lift DC-DC Converters: Graphical Analysis and Modelling

Miao Zhu,Fang Lin Luo 전력전자학회 2009 JOURNAL OF POWER ELECTRONICS Vol.9 No.6

Super-lift dc-dc converters are a series of advanced step-up dc-dc topologies that provide high voltage transfer gains by super-lift techniques. This paper presents a developed graphical modelling method for super-lift converters and gives a thorough analysis with a consideration of the effects caused by parasitic parameters and diodes’ forward voltage drop. The general guidelines for constructing and deriving graphical models are provided for system analysis. By applying it to examples, the proposed method shows the advantages of high convenience and feasibility. Both the circuit simulation and experimental results are given to support the theoretical analysis.