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Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
NGUYEN, Dang Huy,HA, Son Tung,TRAN, Manh Linh,NGUYEN, Duc Thang,NGUYEN, Thi Xuan Hong,NGUYEN, Dieu Linh,DO, Duc Tai Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.4
The research aims to investigate the impact levels of determinants on the loyalty of accountants to FDI firms underlying investment management in Thanglong Industrial Park in Hanoi, Vietnam. We conducted a questionnaire consisting of 31 observation variables with a 5-point Likert scale. Independent variables were measured from 1 "without effect" to 5 "strongly". The method of data collection was done through the survey and subjects are accountants in FDI firms doing business in Thanglong Industrial Park in Hanoi. After checking the information on the votes, there are 120 questionnaires with full information for data entry and analysis, This study employs Cronbach's Alpha test, and regression model. The results show that seven determinants including Working environment, The characteristics of working; Training, promotion prospects and development; Income, Personal characteristic, Collective work together and The method of leading had positive relationships with the loyalty of accountants. Based on the findings, some recommendations are given related to such determinants to improve the loyalty of accountants of FDI firms in general and FDI firms in Thanglong Industrial Park in Hanoi in particular. With which, those firms can enhance performance, reduce financial strain, saving on investment in the recruiting process of new staff, increase profitability to ensure investment management.
A review on the oil-soluble dispersed catalyst for slurry-phase hydrocracking of heavy oil
Manh Tung Nguyen,Ngoc Thuy Nguyen,조정모,박철우,박선영,정진환,이철위 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.43 No.-
Nowadays, unconventional-oil becomes a potential candidate for satisfying the world's energy demandsdue to the scarcity of other energy sources. However, it contains many impurities, such as heavy metal,sulfur-compounds, and nitrogen-compounds, and leads to quick deactivation of catalyst, high cokeformation, and large pressure drop during the operation of afixed bed or E-bed. Slurry phasehydrocracking (SHC) with the presence of oil-dispersed catalyst has been proven to be the best solution toovercome those problems. In oil-dispersed, the metal precursor, dispersion ability, and additive stronglyaffect the catalyst performance, and are all reviewed in this paper.
Effect of Polymer surfactant on size and shape of crystal in cooling crystallization
( Nguyen Manh Tung ),김광주 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
In this research, N-Guarnylurea dinitramide (GUDN) crystal was gotten by cooling crystallization process. The initial solution contains Dimethylformamide, water, GUDN and polymer. The ratio between DMF and water was maintained at 4:6 in mass, GUDN was loaded enough to make saturated solution at 70°C. The effects of some factors like concentration of polymer and polymer types on crystal size and shape will be discussed.The results indicate that polymer has strong effects on crystal size and especially crystal shape, crystal tends to be thin and flat in case using Methyl cellulose 4000, and big and rough when Span 80 was used as surfactant. In addition, using sufficient amount of polymer can minimize the number of oligomeric crystals, and narrow crystal size distribution.
Heterogeneous dispersed catalyst for a slurry-phase hydrocracking of heavy residual hydrocarbon
박철우,( Manh Tung Nguyen ),정진환,조정모,이철위 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
In this talk, we discuss the synthetic route of mesoporous hematite using a soft template. The successful synthetic methods for consistent mesoporous hematite nanoparticles using non-ionic soft template in an aqueous medium has not been fully explored, mainly because the strong gelation tendency inhibits the appropriate control of morphology during the synthetic step. In our study, we proved that 3-D hematite nanostructures can be obtained only when precursor solutions are controlled to a very narrow window of synthetic conditions. The synthesized worm-like nanocrystal has a relatively uniform pore size distribution and the average pore size about 20nm. The material could be a suitable for the catalytic conversion of heavy oil because the targeting molecules have molecular sizes of 10-20nm. The hydrocracking performance over the material is compared with other hematite structures to demonstrate the feasibility as a dispersed catalyst.
Reduction of Coke Formation in Slurry-Phase Hydrocracking
조정모,( Nguyen Manh Tung ),서필원,김성호,강기혁,박선영,서휘민,김규태 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Development of heavy hydrocarbon into toluene insoluble organic residue (TIOR; or coke) is not a favored reaction pathway in an upgrading process of petrolium residue. In many commercial catalytic hydrocrackers, a small amount of coke formation can cause a serious operating problem of clogging and unexpected instability due to its continuous accumulation on the process units including reactors. In general, a high hydrogen partial presssure or a low reaction temperature below 400C, which requires a high CAPEX and/or OPEX, is favored to reduce coke formation. In the presentation we will discuss the reaction behaviors of coke formation and an effective strategy to suppress the pathway to coke during the slurry-phase hydrocracking.
Synthesis of noble molybdenum and tungsten complexes for hydrocracking catalyst of heavy oil
신선영,이지훈,조윤경,Manh Tung Nguyen,박보근,박선영,이철위,김창균,정택모 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.72 No.-
This paper reports the synthesis of six potential catalyst precursors for hydrocracking reactions forvacuum residue refinement. New group 6 transition metal complexes, (LM(CO)3) (M = Mo or W, L1 = 3-phenyl-1-propyne, L2 = 4-phenyl-1-butyne, and L3 = 5-phenyl-1-pentyne) were prepared by simplystirring M(CO)3(RCN)3 in THF solution. New compounds were applied as a catalyst precursor forhydrocracking of vacuum residue and the catalytic activity was compared to the commercially availablematerial, Mo-octoate. LMo(CO)3 showed similar activities to Mo-octoate. Among all, L3Mo(CO)3 whichhad the longest alkyl chain showed a comparable result of low yield for coke and gas products.