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Zhu (祝伟,), Wei,Udalski, A.,Gould, A.,Dominik, M.,Bozza, V.,Han, C.,Yee, J. C.,Novati, S. Calchi,Beichman, C. A.,Carey, S.,Poleski, R.,Skowron, J.,Kozłowski, S.,Mró,z, P.,Pietrukowicz, P.,P IOP Publishing 2015 The Astrophysical journal Vol.805 No.1
<P>We report the first mass and distance measurements of a caustic-crossing binary system OGLE-2014-BLG-1050 L using the space-based microlens parallax method. Spitzer captured the second caustic. crossing of the event, which occurred similar to 10 days before that seen from Earth. Due to the coincidence that the source-lens relative motion was almost parallel to the direction of the binary-lens axis, the fourfold degeneracy, which was known before only to occur in single-lens events, persists in this case, leading to either a lower-mass (0.2 and 0.07 M-circle dot) binary at similar to 1.1 kpc or a higher-mass (0.9 and 0.35 M-circle dot) binary at similar to 3.5 kpc. However, the latter solution is strongly preferred for reasons including blending and lensing probability. OGLE-2014-BLG-1050 L demonstrates the power of microlens parallax in probing stellar and substellar binaries.</P>
Han, C.,Udalski, A.,Gould, A.,Zhu, Wei,Street, R. A.,Yee, J. C.,Beichman, C.,Bryden, C.,Novati, S. Calchi,Carey, S.,Fausnaugh, M.,Gaudi, B. S.,Henderson, Calen B.,Shvartzvald, Y.,Wibking, B.,Szyma American Astronomical Society 2016 The Astrophysical journal Vol.828 No.1
<P>We present a combined analysis of the observations of the gravitational microlensing event OGLE-2015-BLG-0479 taken both from the ground and by the Spitzer Space Telescope. The light curves seen from the ground and from space exhibit a time offset of similar to 13 days between the caustic spikes, indicating that the relative lens-source positions seen from the two places are displaced by parallax effects. From modeling the light curves, we measure the space-based microlens parallax. Combined with the angular Einstein radius measured by analyzing the caustic crossings, we determine the mass and distance of the lens. We find that the lens is a binary composed of two G-type stars with masses of similar to 1.0 M-circle dot and similar to 0.9 M-circle dot located at a distance. of similar to 3 kpc. In addition, we are able to constrain the complete orbital parameters of the lens thanks to the precise measurement of the microlens parallax derived from the joint analysis. In contrast to the binary event OGLE-2014-BLG-1050, which was also observed by Spitzer, we find that the interpretation of OGLE-2015-BLG-0479 does not suffer from the degeneracy between (+/-, +/-) and (+/-, -/+) solutions, confirming that the four-fold parallax degeneracy in single-lens events collapses into the two-fold degeneracy for the general case of binary-lens events. The location of the blend in the color-magnitude diagram is consistent with the lens properties, suggesting that the blend is the lens itself. The blend is bright enough for spectroscopy and thus this possibility can be checked from future follow-up observations.</P>
OGLE-2016-BLG-1266: A Probable Brown Dwarf/Planet Binary at the Deuterium Fusion Limit
Albrow, M. D.,Yee, J. C.,Udalski, A.,Novati, S. Calchi,Carey, S.,Henderson, C. B.,Beichman, C.,Bryden, G.,Gaudi, B. S.,Shvartzvald, Y.,Szymań,ski, M. K.,Mró,z, P.,Skowron, J.,Poleski, R.,So American Astronomical Society 2018 The Astrophysical journal Vol.858 No.2
Amin, A.R.M.R.,Karpowicz, P.A.,Carey, T.E.,Arbiser, J.,Nahta, R.,Chen, Z.G.,Dong, J.T.,Kucuk, O.,Khan, G.N.,Huang, G.S.,Mi, S.,Lee, H.Y.,Reichrath, J.,Honoki, K.,Georgakilas, A.G.,Amedei, A.,Amin, A. Saunders Scientific Publications ; Academic Press 2015 SEMINARS IN CANCER BIOLOGY Vol.35 No.suppl
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Kruppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting.
Udalski, A.,Yee, J. C.,Gould, A.,Carey, S.,Zhu, W.,Skowron, J.,Kozłowski, S.,Poleski, R.,Pietrukowicz, P.,Pietrzyń,ski, G.,Szymań,ski, M. K.,Mró,z, P.,Soszyń,ski, I.,Ulaczyk, K.,W IOP Publishing 2015 The Astrophysical journal Vol.799 No.2
<P>We combine Spitzer and ground-based observations to measure the microlens parallax vector pi(E), and thus the mass and distance of OGLE-2014-BLG-0124L, making it the first microlensing planetary system with a space-based parallax measurement. The planet and star have masses of m similar to 0.5M(jup) and M similar to 0.7M(circle dot) and are separated by a(perpendicular to) similar to 3.1AU in projection. The main source of uncertainty in all of these numbers (approximately 30%, 30%, and 20%) is the relatively poor measurement of the Einstein radius theta(E), rather than uncertainty in pE, which is measured with 2.5% precision. This compares to 22% based on OGLE data alone, implying that the Spitzer data provide not only a substantial improvement in the precision of the pE measurement, but also the first independent test of a ground-based pE measurement.</P>
Shvartzvald, Y.,Li, Z.,Udalski, A.,Gould, A.,Sumi, T.,Street, R. A.,Novati, S. Calchi,Hundertmark, M.,Bozza, V.,Beichman, C.,Bryden, G.,Carey, S.,Drummond, J.,Fausnaugh, M.,Gaudi, B. S.,Henderson, C. American Astronomical Society 2016 The Astrophysical journal Vol.831 No.2
<P>Simultaneous observations of microlensing events from multiple locations allow for the breaking of degeneracies between the physical properties of the lensing system, specifically by exploring different regions of the lens plane and by directly measuring the 'microlens parallax.' We report the discovery of a 30-65M(J) brown dwarf orbiting a K dwarf in the microlensing event OGLE-2015-BLG-1319. The system is located at a distance of similar to 5 kpc toward the Galactic Bulge. The event was observed by several ground-based groups as well as by Spitzer and Swift, allowing a measurement of the physical properties. However, the event is still subject to an eight-fold degeneracy, in particular the well-known close-wide degeneracy, and thus the projected separation between the two lens components is either similar to 0.25 au or similar to 45 au. This is the first microlensing event observed by Swift, with the UVOT camera. We study the region of microlensing parameter space to which Swift is sensitive, finding that though Swift could not measure the microlens parallax with respect to ground-based observations for this event, it can be important for other events. Specifically, it is important for detecting nearby brown dwarfs and free-floating planets in high magnification events.</P>
An Earth-mass Planet in a 1 au Orbit around an Ultracool Dwarf
Shvartzvald, Y.,Yee, J. C.,Novati, S. Calchi,Gould, A.,Lee, C.-U.,Beichman, C.,Bryden, G.,Carey, S.,Gaudi, B. S.,Henderson, C. B.,Zhu, W.,Albrow, M. D.,Cha, S.-M.,Chung, S.-J.,Han, C.,Hwang, K.-H.,Jun American Astronomical Society 2017 ASTROPHYSICAL JOURNAL LETTERS - Vol.840 No.1
Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer
Stephen O Brien,Maria Twomey,Fiachra Moloney,Richard G. Kavanagh,Brian W. Carey,Derek Power,Michael M. Maher,Owen J. OConnor,Criostoir ÓSúilleabháin 대한위암학회 2018 Journal of gastric cancer Vol.18 No.3
Purpose: Surgical resection for gastric adenocarcinoma is associated with significant post-operative morbidity and mortality. The aim of this study was to assess the prognostic significance of sarcopenia in patients undergoing resection for gastric adenocarcinoma with respect to post-operative morbidity and survival. Materials and Methods: A retrospective analysis was conducted on a cohort of consecutive patients who underwent surgical resection for gastric adenocarcinoma between 2008 and 2014. Patient demographics, radiological parameters, and pathological data were collected. OsiriX software (Pixmeo) was used to measure skeletal muscle area, which was normalized for height to calculate skeletal muscle index. Results: A total of 56 patients (41 male, 15 female; mean age, 68.4 ± 11.9 years) met the inclusion criteria. Of these, 36% (20 of 56) of the patients were sarcopenic pre-operatively. Both sarcopenic and non-sarcopenic patient groups were equally matched with the exception of weight and body mass index (P=0.036 and 0.001, respectively). Sarcopenia was associated with a decreased overall survival (log-rank P=0.003) and was an adverse prognostic predictor of overall survival in multivariate analysis (hazard ratio, 10.915; P=0.001). Sarcopenia was a predictor of serious in-hospital complications in multivariate analysis (odds ratio, 3.508; P=0.042). Conclusions: In patients undergoing curative resection for gastric cancer, there was a statistically significant association between sarcopenia and both decreased overall survival and serious post-operative complications. The measurement and reporting of skeletal muscle index on pre-operative computed tomography should be considered.