Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

Xia, Ling-Yun,Zeng, Xian-Tao,Li, Cheng,Leng, Wei-Dong,Fan, Ming-Wen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

This study aimed to investigate the association between p53 Arg72Pro polymorphism and the risk of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) by conducting meta-analysis. The PubMed database was searched for relevant studies until May 30, 2013. Relevant studies were selected and data were extracted by two independent authors. Overall, subgroup, and sensitivity analyses were then conducted using the Comprehensive Meta-Analysis v2.2 software. Wild-genotype ArgArg was considered as reference [odds ratio (OR) = 1.00]. Nine studies involving 1071 HNSCC cases were obtained. Meta-analysis results indicated no association between p53 Arg72Pro polymorphism and the risk of HPV-related HNSCC: for Pro/Pro vs. Arg/Arg, OR = 1.17, 95% confidence interval (CI) = 0.70-1.98; for Arg/Pro vs. Arg/Arg, OR = 1.25, 95% CI = 0.97-1.72; and for (Pro/Pro + Arg/Pro) vs. Arg/Arg, OR = 1.28, 95% CI = 0.95-1.70. These meta-analysis results were supported by subgroup and sensitivity analysis results. In conclusions, p53 Arg72Pro polymorphism is a potential marker of HP infection-related HNSCC rather than a susceptibility gene polymorphism.

Analysis on Vegetation Restoration and Drifting-Sand Control on Sandy Degraded Grassland in Yanchi

Xia Ling,Zhi Dong,Guang Yang 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08

In this paper, by investigating soil, field vegetation, and surface wind erosion status, combining in2 door analysis, the effect of vegetation recovery on sandy degraded grassland in Yanchi is studied. The results show t㏊t : after the process of protective growth, grazing rest and reseeding, the plant species and vegetation coverage are increased, and biomasses are enhanced about 66. 3214, at the same time, the effect of the measure of combining protective growth, grazing rest and reseeding is better t㏊n t㏊t of single protective growth and grazing rest, the formers biomass is 1. 54 times more t㏊n the latter. With the fixing of drifting - sand and the recovering of vegetation in demonstration area, the content s of physical clay minerals, organic matter, total N, available P and available K are all increased compared with those on drifting - sand. The thickness of wind erosion in drifting - sand control area is reduced, and the thickness is different in different vegetation recovering area, in which Artemisia sphaerocephala planting area suffers slight wind erosion; Caragana korshinskii forest present s slightly accumulating status, the accumulating thickness in Tamarix and Salix psammophila forest is the most.

Diagnostic Value of Straight Head Hanging in Posterior Canal Benign Paroxysmal Positional Vertigo

Ling Xia,김효정,이종희,최정윤,Yang Xu,김지수 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.4

Background and Purpose To determine the diagnostic value of straight head hanging (SHH) in benign paroxysmal positional vertigo involving the posterior semicircular canal (PC-BPPV). Methods We retrospectively included 62 patients (age=56.2±15.0 years, 47 female) with unilateral PC-BPPV who underwent both the Dix-Hallpike maneuver and SHH before receiving canalith repositioning therapy (CRT) between September 2017 and July 2020 at the Dizziness Center of Seoul National University Bundang Hospital in South Korea (16 patients, 25.8%) or the Neurology Outpatient Clinic of Aerospace Central Hospital in China (46 patients, 74.2%). SHH was performed before (n=29, group A) or after (n=33, group B) the Dix- Hallpike maneuver. Results Torsional upbeat nystagmus typical of PC-BPPV was induced during SHH in 52 (83.9%) patients, and the incidence of this type of positional nystagmus did not differ between the groups A and B (79.3% vs. 87.9%, p=0.569). The maximum slow-phase velocity of the induced upbeat nystagmus was higher during SHH than during the Dix-Hallpike maneuver toward the lesion side [range=2.0–60.0°/s (median=18.5°/s) vs. range=2.7–40.0°/s (median= 13.4°/s), p<0.001]. Reversal of the positional nystagmus was observed upon resuming the sitting position after SHH in 47 (75.8%) patients and after the Dix-Hallpike maneuver in 54 (87.7%) patients, with no significant difference between the groups (p=0.082). Conclusions SHH is effective for diagnosing PC-BPPV. Given its simplicity, SHH may be performed before the Dix-Hallpike maneuver, and CRT may be attempted thereafter when the typical positional nystagmus for unilateral PC-BPPV is induced during SHH.

Foreign Equity Investors and Momentum Profits: Evidence from Korea

( Ling Xia Sun ) 한국금융학회 2016 금융연구 Vol.30 No.1

This paper examines the trading behavior of foreigner equity investors and its impact on momentum profits. The Korean stock market makes a good setting for this study because of its openness to foreign investors and the availability of a rich dataset that records foreignners’ holdings and trading of each individual stock on a daily basis. Following Grinblatt and Keloharju (2000)’s methodologies, we find strong evidence of positive feedback trading by foreign investors for the period of 1999~2014. We also find that momentum profits are more pronounced among stocks that undergo bigger increases of foreigners’ holdings. In addition, the big magnitude of momentum profits conditional on increases of foreigners’ holdings is not affected by stocks’ attributes, such as market capitalization, book-to-market ratio, beta, and turnover ratio. In our robustness checks, we construct momentum portfolios based on firm-specific returns and also observe significant firm-specific momentum profits for those stocks incurring increases in foreigners’ holdings. Finally, we offer both risk- and behavior- based interpretations for our findings.

조건부 변동성과 상관관계 전이모델을 이용한 산업별 주가동조화 현상연구

( Xia Sun Ling ),김명현 ( Myeong Hyeon Kim ) 한국금융학회 2015 금융연구 Vol.29 No.2

본 논문은 글로벌 중요지수와 12개의 국내 산업별 포트폴리오의 상관관계 전이효과를 Dynamic Conditional Correlation(DCC) 모델과 비대칭성을 고려한 Asymmetric Dynamic Conditional Correlation (ADCC) 모델을 사용하여 분석한다. 2008년 금융위기와 2010년 유럽위기에 방점을 두고 국내 주식시장에 중요한 영향을 미치는 미국, 일본, 유럽과 중국 시장의 대표지수를 활용해 글로벌 대표지수들로부터 산업별 포트폴리오에 전이되는 메커니즘을 분석하였다. 종합지수(Index)를 활용한 선행연구의 결과와 부합하게, 산업레벨의 지수에서도 위기시 상관관계의 증가를 확인할 수가 있었다. 또한, 시간가변 상관계수의 산업간 변이의 결정요인을 탐구하고자 기업변수들을 활용한 패널회귀 식을 통해, 국내 산업포트폴리오의 각국 마켓지수와의 조건부 상관계수를 설명하는 요인이 다르며, 국내 산업의 각국의 상관계수 변이에 대한 반응이 다르게 나타남을 밝혀냈다. This paper examines how the outside markets` shocks are propagated to the Korean sectors by employing the Dynamic Conditional Correlation (DCC) and the Asymmetric Dynamic Conditional Correlation (ADCC) methodologies. Our special interests are paid on the recent two crisis periods, namely, the 2008 Global Financial Crisis and the 2010 European Sovereign Debt Crisis. For this purpose, we focus on the 4 market indices outside of Korea, i.e., S&P500, STOXX Europe 600, TOPIX,and Shanghai Stock Exchange A-share Index, which are widely used to present for the overall stock markets of America, Europe, Japan, and China. To construct the Korean sector indices, we follow the Fama and French`s classification of the 12 industries that are based on the 4-digit SIC codes. The 12 industries are consumer nondurables, consumer durables, manufacturing, oil, gas, and coal extraction and products, chemicals and allied products, business equipment, telephone and television transmission, utilities, whole sale, retail, and some services (shops), healthcare, medical equipment, and drugs, finance and Other. Our main findings based on the DCC and ADCC methodologies are summarized as follows. The first finding is that we have verified the stylized fact that conditional correlations between the market indices tend to increase during the crisis periods. This finding has been confirmed by the sectoral conditional correlations and also by the panel regression results. Our second finding is that conditional correlation dynamics exhibit significant differences among country-level indices, among sector-level indices, as well as between the two crises. Specifically, the Korean sectors` conditional correlations with the American S&P 500 index capture the well-known financial crisis stories such as the Lehman Brothers collapse however, the Korean sectors` conditional correlations with the STOXX Europe 600 index and the Japanese TOPIX show some puzzling patterns. To be specific, the Korean sectors` conditional correlations with the STOXX Europe 600 and the TOPIX keep decreasing after the Lehman Brothers shock. This pattern to some extent may contradict to the argument that the financial crisis has been a global common factor. In addition, variations among sectoral conditional correlations differ significantly. Variations among sectoral conditional correlations with the American and Chinese indices are larger than those with the European and Japanese during both crisis periods. Also, the absolute magnitude of the conditional correlations with the TOPIX is the largest during both crises. We further investigate the determinants of the sector-level correlations by conducting a panel regression analysis. Specifically, we associate the sector-level correlations with the crisis dummies and several sectorlevel corporate finance variables. Our finding is that crisis dummies and industry-specific variables, such as Tobin`s Q, PPE, Debt ratio, and ROAare significantly associated with the magnitude of conditional correlations. To our best knowledge, this is the first study to examine the determinants that drive a positive co-movement among conditional correlations during the crisis periods by analyzing the Korean sector-level data. Our findings thus contribute to the existing literature by figuring out what microdeterminants drive co-movement among the sector-level correlations and by associating the conditional correlations dynamics with the corporate investment and financing activities.

<i>Yersinia pseudotuberculosis</i> Exploits CD209 Receptors for Promoting Host Dissemination and Infection

He, Ying-Xia,Ye, Cheng-Lin,Zhang, Pei,Li, Qiao,Park, Chae Gyu,Yang, Kun,Jiang, Ling-Yu,Lv, Yin,Ying, Xiao-Ling,Ding, Hong-Hui,Huang, Hong-Ping,Mambwe Tembo, John,Li, An-Yi,Cheng, Bing,Zhang, Shu-Sheng American Society for Microbiology 2019 Infection and immunity Vol.87 No.1

<P><I>Yersinia pseudotuberculosis</I> is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals.</P><P><I>Yersinia pseudotuberculosis</I> is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer’s patches to initiate dissemination. In this study, we demonstrate that <I>Y. pseudotuberculosis</I> utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These <I>Y. pseudotuberculosis</I>-CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer’s patch-deficient mice. The blocking of the <I>Y. pseudotuberculosis</I>-CD209 interactions by expression of O-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for <I>Y. pseudotuberculosis</I> where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the <I>Y. pseudotuberculosis</I>-CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers.</P>

Weather Recognition Based on 3C-CNN

( Ling Tan ),( Dawei Xuan ),( Jingming Xia ),( Chao Wang ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.8

Human activities are often affected by weather conditions. Automatic weather recognition is meaningful to traffic alerting, driving assistance, and intelligent traffic. With the boost of deep learning and AI, deep convolutional neural networks (CNN) are utilized to identify weather situations. In this paper, a three-channel convolutional neural network (3C-CNN) model is proposed on the basis of ResNet50.The model extracts global weather features from the whole image through the ResNet50 branch, and extracts the sky and ground features from the top and bottom regions by two CNN5 branches. Then the global features and the local features are merged by the Concat function. Finally, the weather image is classified by Softmax classifier and the identification result is output. In addition, a medium-scale dataset containing 6,185 outdoor weather images named WeatherDataset-6 is established. 3C-CNN is used to train and test both on the Two-class Weather Images and WeatherDataset-6. The experimental results show that 3C-CNN achieves best on both datasets, with the average recognition accuracy up to 94.35% and 95.81% respectively, which is superior to other classic convolutional neural networks such as AlexNet, VGG16, and ResNet50. It is prospected that our method can also work well for images taken at night with further improvement.

Fabrication of CeO2@MnO2 Core–Shell Nanospheres and Their Application in CO Oxidation

Ling Liu,Jingjing Shi,Hong-Xia Cao,Ruiyu Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.3

Rational design and fabrication of heterogeneous core–shell nanostructures is of great significance because their two-phase interface could render hybrid junctions with rich redox reactions, which are beneficial for improving catalytic performance. Herein, hierarchical CeO2 yolk-shell nanospheres@MnO2 nanosheets core–shell nanostructures were fabricated by a multistep wet chemical synthetic strategy. The resulting CeO2@MnO2 core–shell nanospheres exhibited high catalytic activity toward CO oxidation in comparison with pure CeO2 and MnO2 structures and their physical and chemical mixture. The enhanced catalytic performance should be attributed to the formation of core–shell structure and the possible synergistic effects between the two components of MnO2 and CeO2, which facilitates materials with promoted redox properties and enhanced oxidation activity. In addition, this synthetic method is expected to extend to fabricate other multi-composite core–shell structures for a broad range of technical applications.

Tissue Culture and Rapid Propagation of Hybrid Hazelnut (Corylus heterophylla × C.avellana)

Xia-Hong Gao,Jia-Ning Liu,Ling Qin 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Genes Regulating the ABORTED MICROSPORES (AMS)-Mediated Male Sterility Networks in Melon (Cucumis melo L.)

Ling Wang,Dong-yang Dai,Xia Wu,Yun-yan Sheng,Peng Ji,Dan-dan Li,Fan Zhang,Di Wang 한국원예학회 2021 원예과학기술지 Vol.39 No.5

The male sterile plants have higher heterosis in the production of hybrid seeds. The ABORTED MICROSPORES (AMS) gene has been demonstrated to be a candidate gene for ms-5. However, the genetic mechanism underlying AMS-mediated male sterility (MS) regulatory networks in melon (Cucumis melo L.) is still not clearly understood. In the present study, we used transcriptome sequencing analysis, yeast hybridization technology, quantitative real-time polymerase chain reaction (qRT-PCR), and bioinformatics analyzed to systematically investigate the AMS-mediated MS regulatory networks in melon. A set of 15 proteins interacting with AMS, including the C. melo L. Zinc Ribbon protein 1 (CmZR1) gene, was identified using the yeast one-hybrid (Y1H) system and further confirmed using the yeast two-hybrid (Y2H) assay. The interaction of the CmZR1 protein with the C. melo L. Pectin Methylesterase Inhibitor 1 (CmPMEI1) protein was identified and further verified by the glutathione S-transferase (GST) pull-down technique. Bioinformatics analyzed the physical and chemical properties, gene structure, and kinship of the melon PMEI family. We proposed a partial regulatory network for melon MS in which the interaction of CmPMEI1 protein with CmZR1 protein regulates the expression of the AMS gene for pollen abortion. These findings provide important information for increasing the understanding of the molecular mechanism of the MS regulatory network in melon.