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An intelligent method to design die profile for rubber forming of complex curved flange part
Ling‑Yun Zhang,Shuai Zhou,Tian‑Zhang Zhao,Yi‑Pan Zeng 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.1
Rubber forming is an important forming process for the manufacture of aircraft sheet metal parts. The springback is one of the main defects in rubber forming. Classical springback compensation by displacement adjustment method using finite simulation is not satisfactory. In this research, the algorithms of compensating the arc and flange surface of complex curved flange with correction formula are proposed by experiment. The correction formula was developed based on the CATIA V5 R19 using Component Application Architecture. Compensate profile is presented including surface pick up, line pick up, division, compensation, extending, and trimming. The die profile of part with complex curved flanges in aircraft could be designed rapidly. It was found that the forming pressure has a little effect on the springback. This is within the tolerance limits of the part. The results reveal the method can achieve the industrial part precisely. The method is demonstrated on an aircraft wing rib part.
Family History and Stroke Risk in China: Evidence from a Large Cohort Study
Tian Tian,Guangfu Jin,Canqing Yu,Jun Lv,Yu Guo,Zheng Bian,Ling Yang,Yiping Chen,Hongbing Shen,Zhengming Chen,Zhibin Hu,Liming Li 대한뇌졸중학회 2017 Journal of stroke Vol.19 No.2
Background and Purpose Large cohort studies on relationship between family history of stroke(FHS) and stroke risk are lacking in Asians. We aimed to systematically evaluate the association ofFHS with stroke risk in a cohort study of 0.5 million Chinese adults. Methods Information about FHS was self-reported. The median follow-up time was 7.16 years andthe end-point of follow-up was incident stroke, which was entered directly into the China KadoorieBiobank system. Multivariate analyses were performed with Cox proportional hazards model, andinteraction analyses were carried using likelihood-ratio tests. Results Compared with participants without FHS, the hazard ratio (HR) (95% confidence interval,CI) of stroke for participants with FHS was 1.50 (1.46-1.55). The HRs increased with the number offirst degree relatives with stroke (HRs=1.41, 1.98 and 2.47 for 1, 2 and ≥3 relatives, respectively,Ptrend <0.001). The HRs were 1.57 (95% CI: 1.50-1.66) and 1.49 (95% CI: 1.45-1.54) for siblinghistory and parental history, respectively. Similar associations with offspring stroke risk wereobserved between paternal history (HR=1.48, 95% CI: 1.43-1.54) and maternal history (HR=1.49,95% CI: 1.43-1.55). Moreover, significant interactions were detected between FHS and health-riskbehaviors (tobacco smoking and alcohol drinking). Conclusions FHS is an independent risk factor for stroke in Chinese. The more first degree relativesare affected by stroke, the higher are individuals’ risk of suffering from stroke. The management ofthe health-risk behaviors for reducing stroke should be highlighted, especially for the individualswith FHS.
Tian, Wen-Ling,Yang, Sheng-Qi Techno-Press 2017 Geomechanics & engineering Vol.12 No.3
In this research, experimental and numerical simulations were adopted to investigate the effects of ligament angle on compressive strength and failure mode of rock-like material specimens containing two non-coplanar filled fissures under uniaxial compression. The experimental results show that with the increase of ligament angle, the compressive strength decreases to a nadir at the ligament angle of $60^{\circ}$, before increasing to the maximum at the ligament angle of $120^{\circ}$, while the elastic modulus is not obviously related to the ligament angle. The shear coalescence type easily occurred when ${\alpha}$ < ${\beta}$, although having the same degree difference between the angle of ligament and fissure. Numerical simulations using $PFC^{2D}$ were performed for flawed specimens under uniaxial compression, and the results are in good consistency with the experimental results. By analyzing the crack evolution process and parallel bond force field of rock-like material specimen containing two non-coplanar filled fissures, we can conclude that the coalescence and propagation of crack are mainly derived from parallel bond force, and the crack initiation and propagation also affect the distribution of parallel bond force. Finally, the displacement vectors in ligament region were used to identify the type of coalescence, and the results coincided with that obtained by analyzing parallel bond force field. These experimental and numerical results are expected to improve the understanding of the mechanism of flawed rock engineering structures.
Yi-Ling Du,Shi-Fei Chen,Liang-Ying Cheng,Xue-Ling Shen,Yuan Tian,Yong-Quan Li 한국미생물학회 2009 The journal of microbiology Vol.47 No.4
A novel Streptomyces strain, L10, which is capable of producing natamycin, was isolated from a soil sample collected from Zhejiang province, China. On the basis of phylogenetic analysis of rpoB gene and 16S rDNA sequences, as well as phenotypic comparison, strain L10 (CGMCC 2644) is proposed to be a previously uncharacterized strain of S. chattanoogensis. By screening a cosmid library of strain L10 and primer walking, a partial sequence of scnRI and the entire sequence of scnRII were obtained, which are orthologues to the pathway-specific positive regulator genes of natamycin biosynthesis in S. natalensis. The engineered S. chattanoogensis D1, generated by inserting an additional copy of scnRII into the chromosome of strain L10, increased its natamycin production by 3.3 fold in YSG medium and 4.6 fold in YEME medium without sucrose.
중국 중학생의 학업부력 및 학업 자기개념과 학업성취 간의 관계
능첨엽 ( Ling Tian-ye ),마서민 ( Ma Rui-min ),오혜림 ( Oh Hye-rim ),박병기 ( Bak Byung-gee ) 한국아동교육학회 2020 아동교육 Vol.29 No.4
본 연구의 목적은 학업부력, 학업 자기개념, 학업성취 간 관계구조를 수학-중국어의 영역 특수적 관점에서 분석하고 성별과 학년에 따라 어떠한 차이점을 보이는지 살펴볼 것이다. 434명의 중국 운남성(雲南省)의 중학생을 대상으로 학업부력, 학업 자기개념, 학업성취 간 관계구조를 구조 방정식 모형을 통해 분석하였다. 그 결과 첫째, 학업부력은 학업 자기개념을 매개로 학업성취와 연관성을 보이며 영역 특수적인 특성을 지녔다. 둘째, 성별에 따른 모형의 변인 간 직·간접 경로값에서 차이가 나타났다. 셋째, 학년에 따른 모형의 변인 간 직접 경로값에서 차이가 나타났다. 마지막으로, 본 연구의 교육적 시사점 및 제한점을 기술하고 몇 가지 후속 연구를 제시하였다. The purpose of this research is to analyze the structural relationship of academic buoyancy, academic self-concept, and academic performance with domain-specific perspective in the field of mathematics and Chinese. We also compared its relationship according to gender and grade. The sample consisted of 434 middle school students from Yunnan Province, China. The structural equation model was performed to examine the structural relationship of academic buoyancy, academic self-concept, and academic performance. As results, first, there existed the mediating effect of academic self-concept on the relationships between academic buoyancy and academic performance. Second, there was a difference in the direct and indirect path values between the variables of the model by gender. Third, there was a difference in the direct path value between the variables of the model according to the grade. Finally, the educational implications and limitations of this study, as well as some suggestions for the future research were presented.
Epigenetic Regulation of miR-129-2 Leads to Overexpression of PDGFRa and FoxP1 in Glioma Cells
Tian, Xiang-Yang,Zhang, Ling,Sun, Lai-Guang,Li, Ming Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
miR-129-2 is frequently downregulated in multiple cancers. However, how it is silenced in cancers remains unclear. Here we investigated the expression profile and potential biological function of miR-129-2 in glioblastoma (GBM), the most common and lethal form of brain tumors in adults. We showed that miR-129-2 is lost in GBM patient specimens and cultured cell lines. miR-129-2 expression could be restored upon treatment with a histone deadetylase inhibitor (trichostatin A) but not a DNA methylation inhibitor (5-Aza-2'-deoxycytidine), and more profound effect was observed with the treatment of these two drugs in combination. Furthermore, forced expression of miR-129-2 repressed the expression of major oncogenic genes such as PDGFRa and Foxp1 in GBMs. Consistently, expression of miR-129-2 significantly inhibits GBM cell proliferation in vitro. These results reveal that miR-129-2 is epigenetically regulated and functions as a tumor suppressor gene in GBMs, suggesting it may serve as a potential therapeutic target for GBM treatment.