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In situ Diagnosis of Helicobacter pylori Infection Using the Endoscopic Kyoto Scoring System
Lim Eunsun,Jo Ik Hyun,Kim Yeon-Ji,Chung Woo Chul 대한상부위장관ㆍ헬리코박터학회 2021 Korean Journal of Helicobacter Upper Gastrointesti Vol.21 No.4
Background/Aims: This study aimed to investigate the possibility of in situ diagnosis of Helicobacter pylori (H. pylori) infection during endoscopic examination. The predictive infection value was estimated using the endoscopic Kyoto scoring system (EKSS), and specific endoscopic findings were evaluated for diagnosing H. pylori infection in H. pylori naïve patients and those with a eradication history.Materials and Methods: A total of 836 patients with H. pylori infection were analyzed. The state of the infection was predicted using the EKSS and specific endoscopic findings.Results: Patients were classified into two groups: the H. pylori naïve group and the group with a the bacterial eradication history. The area under the curve (AUC) on receiver operating characteristics analysis was 0.90 for EKSS in H. pylori naïve patients and 0.83 for the other group patients. For patients with open type atrophy and/or intestinal metaplasia, EKSS (24.4%; 95% CI, 12.4~0.3%) and regular arrangement of collecting venules (RAC) (46.3%; 95% CI, 30.7~62.9%) showed low specificities. Mucosal swelling (66.2%; 95% CI, 62.5~69.7%) and sticky mucus (80.5%; 95% CI, 74.8~85.2%) presented relatively high positive predictive values for H. pylori infection in naïve patients, whereas reflux esophagitis, hematin, red streak, and duodenitis exhibited high negative predictive values in patients with a H. pylori eradication history (98.0%; 95% CI, 96.4~99.1%).Conclusions: EKSS and RAC are excellent tools for predicting H. pylori infection. However, they have a limited role in patients with open type atrophy and/or intestinal metaplasia. Specific endoscopic findings could help predict the infection state.
한국 제약업계의 실사용데이터 활용 현황 및 발전 방향에 대한 설문조사 연구
조해린(Haerin Cho), 임은선(Eunsun Lim), 박수빈(Suvin Park), 조혜인(Haein Cho), 고하나(Hana Go), 조민정(Minjung Cho), 최남경(Nam-Kyong Choi) 한국보건사회약료경영학회 2023 한국보건사회약료경영학회지 Vol.11 No.1
Backgrounds: Real-world data (RWD) are drawing ever-increasing attention in the pharmaceutical industry. We survey to understand the current status of RWD utilization and gather opinions on improving its usage. Methods: We surveyed RWD utilization related to pharmaceutical companies' conducting and planning RWD studies. A survey was distributed to 181 members of the Korea Pharmaceutical and Bio-Pharma Manufacturers Association and 47 members of the Korean Research-based Pharma Industry Association on November 10, 2021. The questionnaire consisted of closedended and open-ended questions and was divided into three main parts: 1) experience of RWD studies, 2) plan of RWD studies, and 3) future of RWD development. Results: A total of 16 replies were received. Five of the respondents (31.2%) reported having experience conducting RWD studies, and eleven of the respondents (68.8%) reported having a plan for RWD studies. Most companies (81.3%) responded that no experts or departments were in charge of using RWD. Among them, 93.7% indicated that needed an education program to foster experts conducting RWD studies. Opinions on RWD utilization included resolving legal issues, expanding RWD acceptance by regulatory agencies, revising related regulations, and securing professional personnel. Conclusion: Although the low response rate, this study is meaningful in that only those currently interested in using RWD who are aware of the challenges responded. The survey indicates that most pharmaceutical companies have little experience conducting RWD studies but plan to conduct RWD studies. Therefore, we suggest establishing relevant guidelines for using RWD and nurturing infrastructures that can professionally handle RWD.
Lim, Seon Woo,So, Eunsun,Yun, Hye Joo,Karm, Myong-Hwan,Chang, Juhea,Lee, Hanbin,Kim, Hyun Jeong,Seo, Kwang-Suk The Korean Dental Society of Anesthsiology 2018 Journal of Dental Anesthesia and Pain Medicine Vol.18 No.4
Background: When performing dental treatment under general anesthesia in adult patients who have difficulty cooperating due to intellectual disabilities, anesthesia induction may be difficult as well. In particular, patients who refuse to come into the dental office or sit in the dental chair may have to be forced to do so. However, for adult patients with a large physique, physical restraint may be difficult, while oral sedatives as premedication may be helpful. Here, a retrospective analysis was performed to investigate the effect of oral sedatives. Methods: A hospital-based medical information database was searched for patients who were prescribed oral midazolam or triazolam between January 2009 and December 2017. Pre-anesthesia evaluation, anesthesia, and anesthesia recovery records of all patients were analyzed, and information on disability type, reason for prescribing oral sedatives, prescribed medication and dose, cooperation level during anesthesia induction, anesthesia duration, length of recovery room stay, and complications was retrieved. Results: A total of 97 patients were identified, of whom 50 and 47 received midazolam and triazolam, respectively. The major types of disability were intellectual disabilities, autism, Down syndrome, blindness, cerebral palsy, and epilepsy. Analyses of changes in cooperation levels after drug administration showed that anesthesia induction without physical restraint was possible in 56.0% of patients in the midazolam group and in 46.8% of patients in the triazolam group (P = 0.312). Conclusions: With administration of oral midazolam or triazolam, general anesthesia induction without any physical restraint was possible in approximately 50% of patients, with no difference between the drugs.
Electronic Cigarette or Vaping Product Use-Associated Lung Injury: A Case Report
Lim Jiyun,남보다,황정화,Kim Yang-Ki,Oh Eunsun,Lee Eun Ji 대한영상의학회 2021 대한영상의학회지 Vol.82 No.6
Electronic cigarette (e-cigarette) or vaping product use-associated lung injury (EVALI) has emerged as a social issue as e-cigarette use is rapidly increasing worldwide and is related to many deaths in the United States. To our knowledge, this is the first case report of EVALI in South Korea of a 24-year-old man with acute respiratory symptoms and a history of e-cigarette use. Chest CT revealed diffuse bilateral ground-glass opacities with subpleural sparing, airspace consolidation, and centrilobular micronodules as typical patterns of EVALI with organizing pneumonia and diffuse alveolar damage. Infection was excluded with meticulous laboratory examinations, and the patients’ illnesses were not attributed to other causes. EVALI was diagnosed by meeting the diagnostic criteria with consistent clinico-radiologic findings through a multidisciplinary approach. Radiologists should have good knowledge of EVALI radiologic findings and play a cardinal role in the proper diagnosis and management of EVALI.
Lim, Yeong-Min,Yang, Pil-Sung,Jang, Eunsun,Yu, Hee Tae,Kim, Tae-Hoon,Uhm, Jae-Sun,Kim, Jong-Youn,Pak, Hui-Nam,Lee, Moon-Hyoung,Joung, Boyoung,Lip, Gregory Y.H. Elsevier 2019 Mayo Clinic proceedings Vol.94 No.2
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>To assess the effects of body mass index (BMI) variability on the incidence of new-onset atrial fibrillation (AF), stroke, cardiovascular (CV) risk factors, and CV outcomes in a general Asian population.</P> <P><B>Patients and Methods</B></P> <P>Data from the National Health Insurance Service–Health Screening cohort in Korea were used: 171,324 patients without AF were included, and BMI measurements occurred biennially from January 1, 2002, through December 31, 2009. Patient outcomes were followed through 2013. The BMI intraindividual variability between visits was measured.</P> <P><B>Results</B></P> <P>During mean ± SD follow-up of 47.4±3.9 months, 1959 patients (1.1%) developed new-onset AF. Overweight or obesity (BMI ≥25) had a greater risk of new-onset AF compared with BMI of 20 to 22.5, with a hazard ratio (HR) of 1.24 (95% CI, 1.10-1.41; <I>P</I><.001). In underweight or normal-weight participants (initial BMI <25), a 1-kg/m<SUP>2</SUP> increase of BMI variability increased the risk of new-onset AF, with an adjusted HR (aHR) of 1.13 (95% CI, 1.01-1.25; <I>P</I>=.02). Weight gain increased the risk of new-onset AF (aHR, 1.32; 95% CI, 1.01-1.71; <I>P</I>=.04) and myocardial infarction (aHR, 1.52; 95% CI, 1.06-2.18; <I>P</I>=.02) but not stroke. In this group, blood pressure, glucose level, and total cholesterol level were higher in individuals with the greatest BMI variability compared with those with stable BMI.</P> <P><B>Conclusion</B></P> <P>In the underweight and normal-weight Asian population, BMI variability, especially weight gain, was related to increased risk of new-onset AF and myocardial infarction. Avoiding weight gain is important to improve CV outcomes.</P>
임지희 ( Ji Hee Lim ),정광선 ( Kwang Seon Jung ),이종성 ( Jongsung Lee ),정은선 ( Eunsun Jung ),김대경 ( Dae Kyung Kim ),김영수 ( Youngsoo Kim ),김영우 ( Yong-woo Kim ),박덕훈 ( Deokhoon Park ) 대한화장품학회 2008 대한화장품학회지 Vol.34 No.3
본 연구에서는 제주도 해안에 자생하는 45종의 해양식물 추출물에 대한 항균 활성을 조사하였다. 해양식물 추출물은 80 % 메탄올에서 유효 성분을 추출하여 시료화 하였고 항균활성을 검증하였다. 그 결과, 45종의 해조류 중에서 넓패, 패, 구멍갈파래 등을 포함한 6종의 해양식물이 미생물 생육을 억제하는 결과를 보였다. 항균활성을 갖는 해양식물 중 패, 감태 2종은 항산화 효능도 동시에 가지고 있음을 확인하였다. 이러한 결과를 통해, 본 실험에서 확보된 추출물이 항균 물질로 사용될 수 있는 가능성을 확인하였다. In this study, we investigated the antimicrobial and antifungal activity from the wild seaweeds of Jeju island. The active ingredients of the seaweeds were prepared by 80 % methanol extraction. Antimicrobial and antifungal activity of seaweed extracts was examined. We found that 6 plant extracts among 45 plants, namely, Codium contractum, Undaria pinnatifida, Ishige sinicola, Ishige okamurai, Ishige okamurai, Ecklonia cava, Hizikia fusiformis, Ulva fasciata, Ulva pertusa, Sargassum siliquastrum, Ecklonia kurome, Gracilaria textorii, significantly inhibited growth of harmful microorganisms. Additionally, according to DPPH assay, 2 plant extracts were found to have antioxidant activities. Taken together, these results suggest the possibility that 11 plant extracts can be utilized as an antimicrobial agent.
Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Kim Kwangho,Ryu Tae Young,Jung Eunsun,Han Tae-Su,Lee Jinkwon,Kim Seon-Kyu,Roh Yu Na,Lee Moo-Seung,Jung Cho-Rok,Lim Jung Hwa,Hamamoto Ryuji,Lee Hye Won,Hur Keun,Son Mi-Young,Kim Dae-Soo,Cho Hyun-Soo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which histone methylation regulates metastasis has not been fully elucidated. Here, we found that the histone methyltransferase SMYD2 is overexpressed in lung cancer and that knockdown of SMYD2 could reduce the rates of cell migration and invasion in lung cancer cell lines via direct downregulation of SMAD3 via SMYD2-mediated epigenetic regulation. Furthermore, using an in vitro epithelial-mesenchymal transition (EMT) system with a Transwell system, we generated highly invasive H1299 (In-H1299) cell lines and observed the suppression of metastatic features by SMYD2 knockdown. Finally, two types of in vivo studies revealed that the formation of metastatic tumors by shSMYD2 was significantly suppressed. Thus, we suggest that SMYD2 is a potential metastasis regulator and that the development of SMYD2-specific inhibitors may help to increase the efficacy of lung cancer treatment.
사람유두종 바이러스 백신 미접종 관련 요인: 미국 국민건강영양조사 자료를 이용한 단면연구
김민주 ( Min-ju Kim ),임은선 ( Eunsun Lim ),박상신 ( Sangshin Park ),최남경 ( Nam-kyong Choi ) 한국보건정보통계학회(구 한국보건통계학회) 2021 보건정보통계학회지 Vol.46 No.1
The purpose of this study was to investigate the human papillomavirus (HPV) vaccination proportion and the factors associated with HPV non-vaccination according to the characteristics of Americans. Methods: The 2015-2018 National Health and Nutrition Survey (NHANES) data were analyzed. The subjects aged 9 to 26 were divided into subgroups according to age and sex. Results: The meaningful variables influencing HPV vaccination included birth country, health insurance, hepatitis A vaccine, hepatitis B vaccine, routine place to go for healthcare and times receive healthcare last year. The factors associated with HPV non-vaccination were income, hepatitis A vaccine, hepatitis B vaccine and times receive healthcare last year. Conclusions: This study was based on a survey of Americans, so the factors associated with HPV non-vaccination may differ from those of Koreans.
Melanogenesis Inhibitory Effect of Fatty Acid Alkyl Esters Isolated from <i>Oxalis triangularis</i>
Huh, Sungran,Kim, Young-Soo,Jung, Eunsun,Lim, Jihee,Jung, Kwang Sun,Kim, Myeong-Ok,Lee, Jongsung,Park, Deokhoon Pharmaceutical Society of Japan 2010 Biological & pharmaceutical bulletin Vol.33 No.7
<P>Ten fatty acid alkyl esters isolated from <I>Oxalis triangularis</I>, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from <I>Oxalis triangularis</I> have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.</P>