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신장과 비장에 다발성 경색을 동반한 렙토스피라병 1 예 보고
백진기,김종봉,양동호,송옥평,문수남,김표년,홍세용,추원석,봉형근,임헌관,차미경,조무식 대한내과학회 1994 대한내과학회지 Vol.46 No.2
Leptospirosis is an acute disease characterized by the symptoms of fever, myalgia, headache, and blood-tinged sputum. One of the prominent features in leptospirosis is hemorrhagic diasthesis, which is attributed to capillary injury of uncertain nature. Pathogenically the vascular damage has been elucidated to begin with increased permeability prior to endothelial necrosis. However, as different from the previously reported hemorrhagic complications there have been reported a few cases of leptospirosis complicated by infarction of the organs. We experienced a case of leptospirosis which was confirmed by passive hemagglutination antibody test, with multiple renal and splenic infarctions in a 17-year-old school girl. The diagnosis of the infarction was made by abdominal sonography, abdominal CT (computed tomography), and selective renal angiography which revealed multiple well defined lesions and hypovascularity on both kidneys. In this case the mechanism of infarction of the kidneys and spleen is uncertain. The serum levels of FDP and fibrinogen on admission were slightly increased, but not significant. The total fibrinolytic activity in euglobulin fraction was found to be decreased during the progression of the disease. There were no positive findings suggesting diffuse intravascular coagulation except for the slightly increased level of serum FDP. Her symptoms and laboratory findings were nearly normalized 2 weeks after treatment. And she was discharged with favorahle condition. We present one case of leptospirosis which showed decreased fibrinolytic activity throughout the progression of the disease, and complicated by infarction of the kidneys and spleen.
A 5.8-Gb/s Adaptive Integrating Duobinary DFE Receiver for Multi-Drop Memory Interface
Lim, Hyun-Wook,Choi, Sung-Won,Ahn, Jeong-Keun,Min, Woong-Ki,Lee, Sang-Kyu,Baek, Chang-Hoon,Lee, Jae-Youl,Hwang, Gyoo-Cheol,Jun, Young-Hyun,Kong, Bai-Sun Institute of Electrical and Electronics Engineers 2017 IEEE journal of solid-state circuits Vol. No.
<P>This paper describes a 5.8 Gb/s adaptive integrating duobinary decision-feedback equalizer (DFE) for use in next-generation multi-drop memory interface. The proposed receiver combines traditional interface techniques like the integrated signaling and the duobinary signaling, in which the duobinary signal is generated by current integration in the receiver. It can address issues such as input data dependence during integration, need for precursor equalization, high equalizer gain boosting, and sensitivity to high-frequency noise. The proposed receiver also alleviates DFE critical timing to provide gain in speed, and embed DFE taps in duobinary decoding to provide gain in power and area. The adaptation for adjusting the equalizer common-mode level, duobinary zero level, tap coefficient values, and timing recovery is incorporated. The proposed DFE receiver was fabricated in a 45 nm CMOS process, whose measurement results indicated that it worked at 5.8 Gb/s speed in a four-drop channel configuration with seven slave ICs, and the bathtub curve shows 36% open for 10(-10) bit error rate.</P>
Lim, Sang-Soon,Kim, Ju-Heon,Kwon, Beomjin,Kim, Seong Keun,Park, Hyung-Ho,Lee, Ki-Suk,Baik, Jeong Min,Choi, Won Jun,Kim, Dong-Ik,Hyun, Dow-Bin,Kim, Jin-Sang,Baek, Seung-Hyub Elsevier 2016 JOURNAL OF ALLOYS AND COMPOUNDS Vol.678 No.-
<P><B>Abstract</B></P> <P>As a field-assisted technique, spark plasma sintering (SPS) enables densification of specimens in a very short period of time compared to other sintering techniques. For high performance thermoelectric material synthesis, SPS is widely used to fabricate nanograin-structured thermoelectric materials by rapidly densifying the nanopowders suppressing grain growth. However, the microstructural evolution behavior of thermoelectric materials by SPS, another important process during sintering, has been rarely studied. Here, we explore SPS as a tool to control the microstructure by long-time SPS. Using p-type (Bi<SUB>0.25</SUB>Sb<SUB>0.75</SUB>)<SUB>2</SUB>Te<SUB>3</SUB> thermoelectric materials as a model system, we systematically vary SPS temperature and time to understand the correlations between SPS conditions, microstructural evolution, and the thermoelectric properties. Our results show that the relatively low eutectic temperature (∼420 °C) and the existence of volatile tellurium (Te) are critical factors to determine both microstructure and thermoelectric property. In the liquid-phase sintering regime, rapid evaporation of Te leads to a strong dependence of thermoelectric property on SPS time. On the other hand, in the solid-phase sintering regime, there is a weak dependence on SPS time. The optimum thermoelectric figure-of-merit (Z) of 2.93 × 10<SUP>−3</SUP>/K is achieved by SPS at 500 °C for 30 min. Our results will provide an insight on the optimization of SPS conditions for materials containing volatile elements with low eutectic temperature.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Spark plasma sintering (SPS) is used to synthesize the thermoelectric (Bi<SUB>0.25</SUB>Sb<SUB>0.75</SUB>)<SUB>2</SUB>Te<SUB>3</SUB>. </LI> <LI> Liquid phase and volatile element are a key for the microstructure and thermoelectric property. </LI> <LI> Thermoelectric figure-of-merit of 2.9 × 10<SUP>−3</SUP>/K is achieved at 500 °C for 30 min. </LI> </UL> </P>
Purification of the Human Tumor Nerosis Factor alpha Receptor in the Milk of Transgenic Pig
Keun Jung Kim,Ji Hye Lee,Eun Young Kim,Kang Sun Park,Kil Woo Han,Jeong Yu,Jun Jong Baek,Jae Sam Lim,Hong Ju Kim,Hong Kyun Kim,Min Kyu Kim 한국동물생명공학회(구 한국동물번식학회) 2014 Reproductive & Developmental Biology(Supplement) Vol.38 No.2s
Lim, Sang-Soon,Baek, In-Hwan,Kim, Kwang-Chon,Baek, Seung-Hyub,Park, Hyung-Ho,Kim, Jin-Sang,Kim, Seong Keun Elsevier 2019 CERAMICS INTERNATIONAL Vol.45 No.16
<P><B>Abstract</B></P> <P>The atomic layer deposition (ALD) of SnO<SUB>2</SUB> films has drawn interest from many researchers as a way to enhance the performance of functional materials for emerging applications such as transistors, sensors, and transparent electrodes. Among the critical issues in the exploitation of SnO<SUB>2</SUB> ALD in industrial applications is the lack of commercially available Sn precursors. Here, we demonstrate an ALD process for SnO<SUB>2</SUB> films using commercially available tetraethyltin (TET) as a precursor. H<SUB>2</SUB>O<SUB>2</SUB> is used as the oxygen source to overcome the lack of reactivity between TET and H<SUB>2</SUB>O, consequently the reaction of TET and H<SUB>2</SUB>O<SUB>2</SUB> results in the growth of SnO<SUB>2</SUB> films. The ALD process has a wide ALD window of 250–400 °C. In the range of the growth temperature, the grown films show a high density of ~6.2 g/cm<SUP>3</SUP> and an optical band gap of 3.7–3.9 eV, which is comparable to that of bulk SnO<SUB>2</SUB>. Negligible impurities remained in the films grown over the entire temperature range. The crystallization behavior and electrical properties of the SnO<SUB>2</SUB> films were examined as well. The ability of this ALD process to produce high-quality SnO<SUB>2</SUB> films with a commercially available tin precursor will allow it to be exploited in various applications.</P>
Effects of Acteoside on Porcine Oocyte Meiotic Resumption and Development of Parthenogenic Embryo
Keun Jung Kim,Ji Hye Lee,Xiaoxia Li,Eun Young Kim,Youn Bae Park,Kang Sun Park,Yu-Na Ha,Maria Kim,Kil Woo Han,Jun Jong Baek,Jae Sam Lim,Jae Seok Woo,Min Kyu Kim 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
Acteoside acts as an anti-oxidative activity and anti-apoptosis in the cells. But, it has been not studied on maturation and development of porcine oocytes. The aims of the present study were to examine the effects of acteoside on the morphological progress of meiosis, developmental competence, and ROS in porcine oocytes. Oocytes were matured in tissue culture medium-199, supplemented with acteoside at various concentrations: 0 (control), 10, 30 and 50 μM. The oocytes maturation rates of groups supplemented with acteoside were no significantly different (81.13, 85.96, 82.95 and 83.68%, respectively). Level of ROS was significantly decreased in acteoside treated group. Furthermore, the parthenogenetic blastocyst rate was significantly improved in 10 μM acteoside treated group compared with control group (44.83 vs. 27.75%). And we investigated effect of acteoside on the oocytes condition represented by cytoplasmic maturation by homogeneous distribution and formation of cytoplasmic organelles and regulation of apoptosis-related genes. In the results. during IVM, 10 μM acteoside treated oocytes showed that the mitochondria and lipid droplet were smaller and homogeneous distribution in cytoplasm compare with control oocytes. And reverse transcription polymerase chain reaction (RTPCR) of parthenogenetic blstocysts revealed that acteoside increased the anti-apoptotic genes (Mcl-1, Bcl-2 and Bcl-xL), whereas reduced the expression of pro-apoptotic genes (Bax and Bak). In conclusion, based on the results, the effect of acteoside on IVM was not attractive. However, in acteoside treated group, cytoplasmic maturation seemed to be improved with morphologically uniform distribution of cytoplasmic organelles. Furthermore, embryonic development in acteoside treated group was significantly highly increased than that of non-treated group. Our results represents that addition of acteoside to the IVM medium has a beneficial effect in physiology of porcine oocytes, providing a improved method for porcine oocytes in vitro. * This work was supported by a grant (Code# PJ008148) from BioGreen21 Program, Rural Development Administration, Republic of Korea.
Effects of Acteoside on Porcine Oocyte Meiotic Resumption and Development of Parthenogenic Embryo
Keun Jung Kim,Ji Hye Lee,Xiaoxia Li,Eun Young Kim,Youn Bae Park,Kang Sun Park,Yu-Na Ha,Maria Kim,Kil Woo Han,Jun Jong Baek,Jae Sam Lim,Jae Seok Woo,Min Kyu Kim 한국동물번식학회 2012 Reproductive & developmental biology Vol.36 No.2
Lim, Sang-Soon,Kim, Byung Kyu,Kim, Seong Keun,Park, Hyung-Ho,Kim, Dong-Ik,Hyun, Dow-Bin,Kim, Jin-Sang,Baek, Seung-Hyub Elsevier 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.727 No.-
<P><B>Abstract</B></P> <P>It is challenging to improve the thermoelectric figure-of-merit as its constituent terms such as Seebeck coefficient, electrical conductivity, and thermal conductivity, are inter-related in the way that the enhancement of one term leads to the degradation of others. Therefore, it is highly desirable to design a new synthesis process that allows us to independently control these terms. Here, we report a simple, two-step process combining spark plasma sintering (SPS) and post-annealing (PA) to separately control the carrier density and mobility in the p-type (Bi<SUB>0.2</SUB>Sb<SUB>0.8</SUB>)<SUB>2</SUB>Te<SUB>3</SUB>. High-temperature SPS enables enhancing the carrier mobility by reducing scattering sites such as grain boundaries. Then, the following PA at a lower temperature allows tailoring the carrier density without the degradation of mobility. Beyond bismuth telluride-based, room-temperature thermoelectric materials, we believe that our result will provide an insight for the performance enhancement of other thermoelectric materials such as oxide and skutterudite.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A two-step process is proposed to separately control the carrier density and the mobility. </LI> <LI> High-temperature spark plasma sintering is used to enhance the carrier mobility. </LI> <LI> The following low-temperature post-annealing can optimize the carrier density. </LI> </UL> </P>
Song, Keun Hong,Woo, Jun Sik,Kim, Ju Ri,Ryu, Gyeong Lim,Baek, Youl Chang,Oh, Young Kyoon,Kwak, Wan Sup,Park, Keun Kyu Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.6
Objective: This study was conducted to evaluate nutritional value and in situ degradability of fruit-vegetable byproducts and their feeding effects on performance of growing Hanwoo steers. Methods: Nutritional value and in situ degradability of cabbage, Chinese cabbage and fruit-vegetable byproducts were assessed. In vivo feeding trial was also performed for 12 weeks. Thirty-six growing steers were randomly allocated into three groups according to body weight (BW) and age in 12 pens (4 replications/treatment) and assigned to one of the three dietary treatments: control (byproduct 0%), FV-B (fruit-vegetable byproduct 20%), and CA-B (cabbage peel 15% plus Chinese cabbage peel 15%, total byproduct 30%). Results: The crude protein contents of cabbage, Chinese cabbage and fruit-vegetable byproducts were 18.69%, 20.20%, and 10.07%, respectively. Concentrations of neutral detergent fiber (NDF) were higher in cabbage (22.31%) and Chinese cabbage (28.83%) than fruit-vegetable (13.94%). Higher concentrations of non-fiber carbohydrate were observed for fruit-vegetable (66.72%) than cabbage (44.93%) and Chinese cabbage byproducts (24.69%). The effective degradability (ED) of both dry matter (DM) and NDF for fruit-vegetable byproduct (DM, 84.69%; NDF, 85.62%) was higher (p<0.05) than cabbage (DM, 68.47%; NDF, 55.97%) and Chinese cabbage byproducts (DM, 68.09%; NDF, 54.22%). The DM intake was not different among treatments because the amount of feed was kept constant according to the BW of growing steers to prevent overweight during the growing period. The average daily gain during the whole experimental period was not different among treatments (1.26, 1.25, and 1.34 kg/d for control, FV-B, and CA-B). The ED of both DM and NDF degradability of the total mixed ration (TMR) diets were very similar among treatments. Feed conversion ratio during the whole period showed no significant difference among treatments. Conclusion: This study demonstrates that fruit-vegetable and cabbage byproducts up to 20% and 30% (as fed basis), respectively can be included in TMR diets for growing beef cattle.