Is Surgical Resection Justified for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus? (A Systematic Review and Meta-Analysis)

( Liang Lei ),( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Zhen-li Li ),( Jun Han ),( Han Zhang ),( Hao Xing ),( Han Wu ),( Ming-da Wang ),( Chao Li ),( Zheng Wang ),( Feng Shen ),( Meng-chao Wu ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is very poor. According to the BCLC treatment recommendations, sorafenib or other palliative treatment (PT) is recommended as the first-line therapy when it happens. In real world, however, a significant number of selected patients with HCC and PVTT suffered from surgical resection (SR). Methods: PubMed, Embase, Medline and Cochrane library were searched for studies comparing SR with PT (including TACE, sorafenib, etc.) for HCC with PVTT, which were published before September 2017. Results: 4,810 patients from 7 studies were enrolled in this meta-analysis, which divided into the SR group (n = 2,344) and the PT group (n = 2476). When compared with the PT group, the pooled hazard ratio (HR) for the 1, 3 and 5-year OS rates of the SR group were 0.56 (95% CI 0.52-0.60, P=0.03), 0.56 (95% CI 0.53-0.59, P<0.001) and 0.55 (95% CI 0.54-0.57, P<0.001). For subgroup analysis, when compared with the mere TACE group, the pooled HR for the 1, 3 and 5-year OS rates of the SR group were 0.54 (95% CI 0.43-0.67, P=0.81), 0.75 (95% CI 0.65-0.87, P=0.25) and 0.76 (95% CI 0.67-0.88, P=0.25). Conclusions: This meta-analysis demonstrated SR had better OS than TACE or other palliative therapy for HCC with PVTT. SR may be suitable as the first-line treatment for selected patients with resectable HCC and removable PVTT.

The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China

Liang Tiebiao,Liang Anshan,Zhang Xianbo,Wang Qi,Wu Haiqing,He Jun,Jin Tianbo 한국유전학회 2022 Genes & Genomics Vol.44 No.9

Background: Coronary heart disease (CHD) is a disease that seriously harms human health. Genetic factors seriously affect the CHD susceptibility. The CYP20A1, CYP4F2 and CYP2D6 are important drug metabolism enzymes in the human body. Objective: We aimed to explore the association between CYP20A1, CYP4F2, CYP2D6 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese Southern Han population. Methods: Based on the 'case-control' experimental design (505 cases and 508 controls), we conducted an association study between 5 candidate SNPs selected from CYP20A1 (rs2043449), CYP4F2 (rs2108622, rs3093106, rs309310), CYP2D6 (rs1065852) and CHD risk. Logistic regression was used to analyze the CHD susceptibility under different genetic models. Multi-factor dimensionality reduction (MDR) was used to analyze the interaction of 'SNP-SNP' in CHD risk. Results: Our results showed that under multiple genetic models, CYP2D6 rs1065852 significantly increased the CHD risk in these participants who are ≤ 60 years old (OR 1.40, CI 1.07-1.82, p = 0.013), smokers (OR 1.40, CI 1.02-1.93, p = 0.039), or have family history (OR 1.24, CI 1.02-1.51, p = 0.035). CYP4F2 SNPs rs2108622 (OR 0.63, CI 0.43-0.93, p = 0.020), rs3093106 (OR 0.52, CI 0.29-0.92, p = 0.023), and rs309310 (OR 0.55, CI 0.31-0.96, p = 0.033) were potentially associated with the course of CHD patients. Conclusion: Our study found that CY2D6 rs1065852 has an outstanding and significant association with increased CHD risk. Our study provided data supplements for CHD genetic susceptibility loci, and also provided a new and valuable reference for CHD drug treatment.

The Study of Apomixis Traits and New Strains Selecting in Walnut

Wu Guo-liang,Wang Yong,Song Yu-qin,Yang Junqiang 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Automatic Polygonization Algorithm on Parallel and Graph Model

Liang Wu,Zhanlong Chen,Min Hao,Zhong Xie 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.5

The polygon construction is the emphasis and difficulty for constructing the topological relationship of spatial data. Many scholars continuous study and innovate for the algorithm. The traditional computational process mainly involves three steps in algorithms: (1) Determining the relationship between adjacent arcs. (2) Searching polygons. (3) Determining the topological relationship between arcs and polygons. With the increase of the number of data and the need to improve the automatization, speed and complexity of algorithm, the serial algorithm has become more and more difficult in polygon construction and is often more time consuming. The algorithm of polygon construction is meeting challenge with the development of computer technology. When processing the large-scale linear data, an efficient strategy to reduce the time of complex operations in algorithm has not been proposed in spatial data field. We propose a novel algorithm to construct polygons automatically in the parallel environment base on the new IT technology. The key of the algorithm is paralleling the more time consuming operation (search, sort. etc.) and improving the speed of polygon construction. According to the characteristics of directed rings in graph model, we construct topological polygons. The experimental results on multicore computers show that the algorithm is efficient parallel performance for polygon construction.

Potential Biomarker of L-type Amino Acid Transporter 1 in Breast Cancer Progression

Liang, Zhongxing,Cho, Heidi T.,Williams, Larry,Zhu, Aizhi,Liang, Ke,Huang, Ke,Wu, Hui,Jiang, Chunsu,Hong, Samuel,Crowe, Ronald,Goodman, Mark M.,Shim, Hyun-Suk The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.2

Purpose L-type amino acid transporter 1 (LAT1) is essential for the transport of large neutral amino acids. However, its role in breast cancer growth remains largely unknown. The purpose of the study is to investigate whether LAT1 is a potential biomarker for the diagnosis and treatment of breast cancer. Methods LAT1 mRNA and protein levels in breast cancer cell lines and tissues were analyzed. In addition, the effects of targeting LAT1 for the inhibition of breast cancer cell tumorigenesis were assessed with soft agar assay. The imaging of xenograft with anti-1-amino-3-[$^{18}F$]fluorocyclobutane-1-carboxylic acid (anti-[$^{18}F$]FACBC) PET was assessed for its diagnostic biomarker potential. Results Normal breast tissue or low malignant cell lines expressed low levels of LAT1 mRNA and protein, while highly malignant cancer cell lines and high-grade breast cancer tissue expressed high levels of LAT1. In addition, higher expression levels of LAT1 in breast cancer tissues were consistent with advanced-stage breast cancer. Furthermore, the blockade of LAT1 with its inhibitor, 2-aminobicyclo[ 2.2.1]heptane-2-carboxylic acid (BCH), or the knockdown of LAT1 with siRNA, inhibited proliferation and tumorigenesis of breast cancer cells. A leucine analog, anti-[$^{18}F$]FACBC, has been demonstrated to be an excellent PET tracer for the non-invasive imaging of malignant breast cancer using an orthotopic animal model. Conclusions The overexpression of LAT1 is required for the progression of breast cancer. LAT1 represents a potential biomarker for therapy and diagnosis of breast cancer. Anti-[$^{18}F$]FACBC that correlates with LAT1 function is a potential PET tracer for malignant breast tumor imaging.

Probabilistic Reliability Evaluation of Power Systems Including Wind Turbine Generators Considering Wind Speed Correlation

Wu, Liang,Park, Jeong-Je,Choi, Jae-Seok,Ei-Keib, A.A. The Korean Institute of Electrical Engineers 2009 Journal of Electrical Engineering & Technology Vol.4 No.4

The importance of renewable energy sources has been growing at a high rate as a result of being environment friendly. In particular, wind power is one of the most successfully utilized of such sources to produce electrical energy. Because of the randomness of wind speed, the reliability impact on this highly variable energy power is important aspect that needs to be assessed. In this paper, the impact on the reliability indices of wind speed correlation between two farms is considered.

Clinical Features, Treatments, and Prognosis of Intramedullary Spinal Cord Metastases From Lung Cancer: A Case Series and Systematic Review

Liang Wu,Li’ao Wang,Jun Yang,Wenqing Jia,Yulun Xu 대한척추신경외과학회 2022 Neurospine Vol.19 No.1

Objective: Intramedullary spinal cord metastasis from lung cancer (ISCM-LC) are increasing in prevalence. We aim to investigate its clinical features, treatments and prognosis. Methods: We reported 6 ISCM-LC cases and conducted a systematic review. Descriptive summarization, survival analysis, and multivariate Cox regression analysis were performed to comprehensively study the disease. Results: All 6 patients had surgery. One used chemotherapy and the other had targeted drugs. Two patients died of ISCM-LC, 1 died of pulmonary embolism, 1 was alive, and 2 were lost to follow-up. We identified 197 ISCM-LC cases in literature with a mean age of 58 years and male preponderance. Small cell lung cancer accounted for 39.1%. The median interval from lung cancer to ISCM-LC was 7 months. Limb weakness was the most common symptom, and 45% cases progressed rapidly. Concomitant brain, leptomeningeal, and vertebral metastasis occurred to 55.8%, 20%, and 19.5%, respectively. Peritumoral edema appeared in 83.3%. Through survival analysis, we found sex, extraspinal metastasis, pathology, and improved symptoms affected the overall survival. Additionally, gross total resection (GTR) shared similar effectiveness with non-GTR, and other treatments following surgery hardly added extra effect. Surgery, improved symptoms, and sex were 3 independent prognostic factors after adjusting for confounding. The estimated median survival time was 5 months. Conclusion: The overall survival of ISCM-LC remains poor. Surgery is an independent protective factor for survival. Surgery should be considered once tolerated, and GTR might not be necessary. In addition, female patients with improved symptoms after intervention might have better overall survival.

Integration of Active Tilting Control and Full-Wheel Steering Control System on Vehicle Lateral Performance

Liang Wu,Ahmac Ejaz,KHAN MUHAMMAD ARSHAD,윤일중 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.4

This research presents an integration of two control systems, an active tilting controller and a full-wheel steering controller. This integration improves vehicle lateral performances by enhancing road-holding capability, lateral stability, and safety simultaneously. The active tilting controller utilizes an active mass shift to evenly distribute the vertical load at each suspension, and boost road-holding capability. On the other hand, the full-wheel steering controller adjusts rear steering angles to use lateral force at each ground-tyre contact point and amplify the vehicle’s ability to follow the desired yaw rate and global sideslip angle during cornering maneuvers. Considering the improved road-holding capability and the coupling effect of body attitude motion and yaw motion, the two controllers in combination produce a synergistic effect on ride comfort, maneuverability and safety, and improve overall lateral performance. A 7-degree-of-freedom (DOF) linear full car model is used in designing the active tilting controller, while a 2-DOF bicycle model considering the attitude motion of the car body is used in designing a full-wheel steering controller. A 14-DOF complex nonlinear full car model that can truly reflect 6-DOF car body motion is applied to verify the performance of the proposed collaborative system. The simulation results show that the system represents a better lateral stability and steering response in intense driving while ensuring the better heading directivity of the vehicle.

Effects of anionic polyacrylamide on maize growth: a short term 14C labeling study

Wu, Liang,Ok, Yong Sik,Xu, Xing Liang,Kuzyakov, Yakov Springer-Verlag 2012 Plant and soil Vol.350 No.1

Probabilistic Reliability Evaluation of Power Systems Including Wind Turbine Generators Considering Wind Speed Correlation

Liang Wu,Jeongje Park,Jaeseok Choi,A. A. EI-Keib 대한전기학회 2009 Journal of Electrical Engineering & Technology Vol.4 No.4

The importance of renewable energy sources has been growing at a high rate as a result of being environment friendly. In particular, wind power is one of the most successfully utilized of such sources to produce electrical energy. Because of the randomness of wind speed, the reliability impact on this highly variable energy power is important aspect that needs to be assessed. In this paper, the impact on the reliability indices of wind speed correlation between two farms is considered.