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      • Polymer Light Emitting Diode의 발광특성 연구 : A study on electoluminescence properties of PLED with poly [2-(2'-ethylhexyloxy)-5-methoxy-1,4-phenylenevinylene]

        이상협;배형철;송석태;한찬수;채희백 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

        In order to know how the [2-(2'-ethylhexyloxy)-5-methoxy-1,4-phenylenevinylene] (MEH-PPV) layer works in organic light emitting diode, two different types of devices were fabricated, which are MEH-PPV single layer devices and MEH-PPV/tris (8-hydroxy-quinoline)aluminium(Alq3) bilayer devices. On the indium-tin-oxide(ITO) glass anode MEH-PPV layer was first spin-coated, and the Alq3 layer and the aluminium(Al) anode were vapor-deposited sequentially. The devices shows a trend that has lower current, luminous efficiency in case the thickness of the device is larger. Some bilayer devices, however, show more improved performance than other devices of smaller total thickness. This results were discussed on the basis of improved exciton formation resulting from balanced carrier transport.

      • 물 및 디메틸포름아마이드中에서 4-(2-Pyridylazo)-resorcinol의 分光電氣化學的 環元

        李興洛,裵俊雄,李在鶴,吳相協 慶北大學校 1988 論文集 Vol.45 No.-

        Spectroelectrochemistry involve the combination of an electrochemical technique with a spectroscopic techinque so that the two measurements may be performed simultaneously in an electrochemical cell. One of the most generally useful spectroelectrochemical technique involves spectral observation of a thin layer of solution. Thin-layer spectroelectrochemistry at the optically transparent thin-layer electrode(OTTLE) takes advantage of the rapid electrolysis (30∼60 sec.) and small volume features of thin-layer electrochemistry. This study has used controlled potential as the excitation signal. Potential control provides a facile means of presicely adjusting the redox potential of the thin solution layer as determined by the Nernst equation for reversible systems: E_applied=E^0'+0.059/n log (O)/(R) In experiment, the slopes of Nernstian plot were 28.3mV in aqeous solution and 53mV in N, N-dimethylformamide(DMF) solution. The results of this study showed that the reduction mechanisms of 4-(2-pyridylazo)-resorcinol(PAR) were one two-electron step in aqueous solution and two one-electrons steps in DMF solution. The formal reduction potentials(E^0') of the PAR were -0.574 volts vs. S.C.E. in aqueous soltion and -0.74 volts vs. Ag/AgClO_4 in DMF solution. These results were generally similar to the reduction mechanism of the other cyclic hydrocarbons in the aprotic solvent. In aprotic solvent, the product of the first electron transfer is expected to be a relatively stable anion radical. In this experiment tetraethylammonium perchlorate was used as a supporting electrolyte of the DMF solution.

      • 腦卒中後 腦萎縮에 대한 調經論的 接近

        윤상협,이종수 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

        Objective : The aim of this study was to investigate the neuroprotection effect of estrogen on brain atrophy following cerebral infarction. Method : All animals in this study were classified into 4 groups; ovariectomy group (OVXgroup), cerebral infarction group (INF group), combination ovariectomy and cerebral infarction group ( OVX + INF group), and naturally intact group for control data (NOR group ). Cerebral infarction was made by Chen's method with some modification. Ovariectomy was performed by Wayforth's method. Experimental data for each group was collected at 15days, 1 month, 3 months, and 6 months after starting observation. Serum 17β-estradiol(E2) was determined by radioimmunoassay. Brain volume was measured and calculated with image analysis. Each brain was sliced at intervals of 2mm in chamber after 30 min of freezing in refregerater. Cerebral volume was obtained by sum of volume of each slice level, which was mean area × 2mm. Results : Cerebral ischemia was fou8nd to decrease the serum concentration of 17β-estradiol and to inhibit the physiologically conpensatary function of the ovariectomized rats. Also we found that deprivation of estrogen have resulted in more severe cerebral atrophy followed by cerebral infarction. Conclusion : It is suggested that estrogen has a neuroprotection effect on cerebral atrophy following cerebral infarction.(J Korean Oriental Med 2000;21(4):9-15)

      • 혼파초지에서 질소시비수준과 방목율이 목초 및 육우생산에 미치는 영향

        현봉수,김문철,김영호,송성언,이승협 제주대학교 농과대학 제주도축산문제연구소 1986 畜産論叢 Vol.1 No.1

        Effects of N fertilizer levels and stocking rates on beef production in a mixed pastiire of orchard-grass, perennial ryegrass, tall fescue, red clover and alsike clover were studied using 3 levels of N fertilizer (50, 100 and 200 kg/ha) and 3 stocking rates (3,4 and 5 head /ha). The summarized results are the following; 1. Increasing nitrogen fertilizer on the mixed pasture increased dry matter yield and protein content(P<0.05) of the pasture species. The stocking rate did not influence either dry matter yield or protein content. 2. The percentage of pasture species increased and that of weeds decreased with increasing N fer-tilizer levels. lncreasing stocking rate from 3 to 5 heads/ha significantly influenced that of the other pastures and weeds. 3. Herhage intake per animal increased at the lower stocking rate, but total herbage intake per ha increased at the higher stocking rate, Increasing nitrogen fertilizer decreased herbage intake per animal , but slightly higher intake per animal was obserbed at 5 head stocking rate. 4. No significant difference in weight gain/ha was found among N levels and stocking rates ussd. Live weight gain per animal was greater at the higher N level and also at the louer stocking rate.

      • 消化器癌의 症候와 治療에 관한 文獻的 考察

        김현아,임성우,윤상협,이원철 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.6 No.2

        근래 들어 악성종양의 발병률은 점점 상승하고 있으며 소화기암은 전체 악성종양중 높은 발생빈도를 보이는 질병으로 한의학계에서도 치료를 위해 많은 연구를 하고 있다. 소화기암의 증후와 치료에 관하여 ??膈, 反胃, 積聚, 臟毒을 위주로 明ㆍ淸代까지의 歷代 文獻을 통해 考票한 결과 이는 복강내 악성종양과 증후에 있어서 유사성을 나타내며 치료는 초기에는 祛邪法을, 중기에는 攻補兼施를, 후기에는 扶正法을 위주로 하는 것으로 나타났다. 역대 문헌에서는 이에 대한 처방구성을 다양하게 언급하여 향후 소화기암 치료에 응용할 수 있을 것으로 思料된다. In these days, the outbreak rate of a malignant tumor is gradually increasing, and the frequency of digestive organ's cancer is so high that the remedy is being studied in the Oriental Medicine Worid. I made a consideration the Erlgyuk(?膈), the Panwue(反胃), the Juckchui(績聚), the Jangdok(臟毒), on the symptom and treatment of gastrointestinal cancer, with the successsive literatures of the Myung and Chung Dynasty. In consequence, these are similar to the symtom of malignant tumor in abdominal cabity, and the the treatment is divided into three stages by each period. The Geosa-method(祛邪決) is used in the early stage, and in the middle the Gongbokyumsi-me��攻補兼施), and in the latter stage the Pujung-method(扶正法) is used. The successiv literatures shows the prescription of gastrointestinal cancer in variety. Therefore, I thinf the various prescription will be applied to gastrointestinal cancer on forward.

      • SCISCIESCOPUS

        Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir.

        Lee, Jung Min,Kim, Hyung Joon,Park, Jun Yong,Lee, Chun Kyon,Kim, Do Young,Kim, Ja Kyung,Lee, Hyun Woong,Paik, Yong Han,Lee, Kwan Sik,Han, Kwang-Hyub,Chon, Chae Yoon,Hong, Sun Pyo,Nguyen, Tin,Ahn, Sang International Medical Press 2009 ANTIVIRAL THERAPY Vol.14 No.5

        <P>BACKGROUND: The efficacy of adefovir dipivoxil (ADV) or entecavir (ETV) rescue monotherapy has not been directly compared in hepatitis B e antigen (HBeAg)-positive patients with lamivudine (3TC)-resistant chronic hepatitis B (CHB). We compared the efficacy of ADV and ETV rescue monotherapy in HBeAg-positive patients with confirmed genotypic 3TC resistance. METHODS: A total of 160 HBeAg-positive patients with confirmed 3TC resistance underwent switch therapy (91 ADV and 59 ETV). Parameters assessed included alanine aminotransferase (ALT) normalization, HBeAg seroconversion, undetectable serum hepatitis B virus (HBV) DNA by PCR (lower detection limit <300 copies/ml), virological breakthrough and initial virological response (IVR) at 3 (IVR-3) and 6 (IVR-6) months. RESULTS: Following 52 weeks of treatment in the ADV and ETV groups, serum HBV DNA became undetectable in 25 (27.5%) and 21 (35.6%; P=0.292) patients, ALT normalization occurred in 67/78 (85.9%) and 43/47 (91.5%; P=0.351), HBeAg seroconversion in 4 (4.4%) and 1 (1.7%; P=1.000), IVR-3 in 19 (20.9%) and 18 (30.5%), IVR-6 in 40 (44.0%) and 25 (42.4%) and virological breakthrough in 2 (2.2%) and 1 (1.7%; P=1.000) patients, respectively. CONCLUSIONS: ADV and ETV revealed comparable efficacy after 52 weeks of treatment in HBeAg-positive patients with 3TC resistance. Undetectable HBV DNA in serum following 52 weeks of treatment was predictable with IVR-3 and IVR-6 in both groups.</P>

      • SCIESCOPUSKCI등재
      • HCC : Transient Elastography can Predict Recurrence after Radiofrequency Ablation for Hepatocellular Carcinoma

        ( Sang Hoon Lee ),( Sang Hun Lee ),( Seung Up Kim ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang Hyub Han ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

        Background/ Aims: Liver stiffness (LS) values measured using transient elastography (TE) can accurately assess the degree of liver fibrosis. The degree of liver fibrosis is significantly associated with the risk of hepatocellular carcinoma (HCC) development. Thus, this study investigated whether LS values at radiofrequency ablation (RFA) can predict HCC recurrence after RFA. Methods: Between May 2005 and April 2011, a total of 56 patients with HCC who underwent RFA and LS value measurement at the same day were analyzed in this retrospective study. All were followed up for monitoring the development of HCC recurrence until March 2013. Results: The mean age of the patients (40 men, 16 women) was 62.1 years, and the median LS value was 23.0 kPa. During the follow-up period (median 27.9 [range, 1.1-77.3] months), 33 (58.9%) patients experienced HCC recurrence and 18 (32.1%) were dead. Median time to recurrence was 17.1 (range, 2.5-67.8) months and median time to mortality was 27.9 (range, 1.1-77.3) months. Patients with recurrence showed significantly higher prevalence of liver cirrhosis, spleen size, multiple tumors, and LS values, whereas they had significantly lower platelet count than patients without recurrence (all P<0.05). On multivariate analysis, together with previous anti- HCC treatment history, patients with a higher LS value >13.0 kPa were at a significant greater risk for HCC recurrence after RFA with a hazard ratio of 6.981 (P<0.05; 95% confidence interval, 1.650-28.782) compared with those with LS value ≤13.0 kPa. However, LS values were not predictive for overall survival (P=0.237). Conclusions: Our data suggest that LS values measured using TE can be a useful predictor of HCC recurrence after RFA. Further studies with large sample size are warranted for the validation of our results.

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