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Protective Effects of Syring Isolated from Kalopanax pictus on Galactosamine Induced Hepatotoxicity
LEE, KYUNGTAE,PARK, HEEJUHN,JUNG, WONTAE,CHOI, JONGWON,KADOTA, SHIGETOSHI WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1999 東西醫學硏究所 論文集 Vol.1999 No.-
Syringin, a phcnylpropanoid monoglycoside was isolated from the stem bark of Kalopanax pictus (Araliaccac). The isolated compound was tested for its hepato-protective activities in vivo, by using experimental hepatic intoxication in animals induced by intraperitoneal injection of galactosamine. Syringin recovered the be biochemical parameters such as the serum enzyme activities and microsomal oxidative enzyme activities and inhibited the lipid peroxidation. These antihepatotoxic effects of syringin were dependent on the dose and duration of administration.
Lee, Jin Wuk,Lee, Jae-Woo,Kim, Kyungtae,Shin, Yu-Jin,Kim, Jieun,Kim, Suhkmann,Kim, Heejung,Kim, Pilje,Park, Kyunghwa Elsevier 2017 Journal of hazardous materials Vol.340 No.-
<P><B>Abstract</B></P> <P>The aims of this study were to examine multi-generational reproductive toxicity and metabolism disturbances in <I>Oryzias latipes</I> exposed to 0.3, 3, and 30mg/L PFOA for 259-day. The highest concentration of PFOA suppressed fecundity over three generations from F0 to F2 and sac-fry survival rate in F2 generation, indicating that PFOA resulted in multi-generational reproductive toxicity <B>(<I>p<</I> </B> <B>0.05)</B>. Histologically, in F1 and F2 generations, <I>O. latipes</I> exposed to 30mg/L PFOA revealed accelerated gonad development, and the atrophy and degeneration of thyroid follicular cell. Glucose content showed the highest increase in both genders in all metabolites. However, alanine, glutamine, threonine, and lactate content, which are converted into glucose showed decline tendency, suggesting that PFOA led to gluconeogenesis. Change of osmolyte content affecting osmosis such as a decrease of male <I>myo</I>-inositol (<I>m</I>-Ino), an increase of female trimethylamine <I>N</I>-oxide (TMAO) and an increase of male dimethylamine (DMA) suggest that PFOA might affect osmoregulation of <I>O. latipes</I>. Oxaloacetate of male fish and succinate of female fish showed significant alterations, indicating that PFOA may affect energy metabolism differently by sex. These findings will help elucidate the toxicity of PFOA in diverse biological responses including metabolism change.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PFOA can affect carbohydrate metabolism and osmoregulation of <I>Oryzias latipes</I>. </LI> <LI> Glucose content can be used as a biomarker for PFOA exposure in <I>Oryzias latipes.</I> </LI> <LI> PFOA caused histological abnormality in gonad and thyroid follicular cell. </LI> <LI> PFOA caused multi-generational reproductive toxicity in <I>Oryzias latipes</I>. </LI> </UL> </P>
Facile solid-state synthesis of oxidation-resistant metal nanoparticles at ambient conditions
Lee, Kyu Hyung,Jung, Hyuk Joon,Lee, Ju Hee,Kim, Kyungtae,Lee, Byeongno,Nam, Dohyun,Kim, Chung Man,Jung, Myung-Hwa,Hur, Nam Hwi Elsevier 2018 SOLID STATE SCIENCES Vol.79 No.-
<P><B>Abstract</B></P> <P>A simple and scalable method for the synthesis of metal nanoparticles in the solid-state was developed, which can produce nanoparticles in the absence of solvents. Nanoparticles of coinage metals were synthesized by grinding solid hydrazine and the metal precursors in their acetates and oxides at 25 °C. The silver and gold acetates converted completely within 6 min into Ag and Au nanoparticles, respectively, while complete conversion of the copper acetate to the Cu sub-micrometer particles took about 2 h. Metal oxide precursors were also converted into metal nanoparticles by grinding alone. The resulting particles exhibit distinctive crystalline lattice fringes, indicating the formation of highly crystalline phases. The Cu sub-micrometer particles are better resistant to oxidation and exhibit higher conductivity compared to conventional Cu nanoparticles. This solid-state method was also applied for the synthesis of platinum group metals and intermetallic Cu<SUB>3</SUB>Au, which can be further extended to synthesize other metal nanoparticles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A simple and scalable method for the synthesis of metal nanoparticles in the solid state was developed. </LI> <LI> Nanoparticles of coinage and platinum group metals were synthesized from solid hydrazine and corresponding metal precursors. </LI> <LI> The Cunanoparticles are better resistant to oxidation and exhibit higher conductivity compared to conventional Cu ones. </LI> <LI> This solid-state method was successfully applied for the synthesis of intermetallic Cu<SUB>3</SUB>Au nanoparticles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Metal nanoparticles were synthesized in the solid-state by grinding solid hydrazine with metal precursors at ambient temperature. This facile method is easily scalable without the need for large reaction vessels.</P> <P>[DISPLAY OMISSION]</P>
Neurite Guidance on Laser-Scribed Reduced Graphene Oxide
Lee, Sang Hwa,Lee, Han Byeol,Kim, Yoonyoung,Jeong, Jae Ryeol,Lee, Min Hyung,Kang, Kyungtae American Chemical Society 2018 NANO LETTERS Vol.18 No.12
<P>This paper describes a one-step, chemical-free method to generate micropatterned in vitro neuronal networks on chemically unmodified reduced graphene oxide. The suggested method relies on infrared-based photothermal reduction of graphene oxide, which concurrently leads to the formation of submicrometer-scale surface roughness that promotes neuronal adhesion and guides neurite outgrowth. A commercially available laser source (LightScribe DVD drive) controlled by a computer software can be used to reduce graphene oxide (GO), and its repetitive scribing to a GO film brings about gradual increase and decrease in electrical conductivity and neurite guiding ability of the scribed regions, respectively. Our results also indicate that the observed adhesion-promoting and neurite guiding effect originate from the contrast in surface nanotopography, but not that in conductivity. This method is readily applicable to diverse graphene-based biomedical devices.</P> [FIG OMISSION]</BR>
Selective positioning of organic dyes in a mesoporous inorganic oxide film
Lee, Kyungtae,Park, Se Woong,Ko, Min Jae,Kim, Kyungkon,Park, Nam-Gyu Nature Publishing Group 2009 Nature materials Vol.8 No.8
Although sequential adsorption of dyes in a single TiO<SUB>2</SUB> electrode is ideal to extend the range of light absorption in dye-sensitized solar cells, high-temperature processing has so far limited its application. We report a method for selective positioning of organic dye molecules with different absorption ranges in a mesoporous TiO<SUB>2</SUB> film by mimicking the concept of the stationary phase and the mobile phase in column chromatography, where polystyrene-filled mesoporous TiO<SUB>2</SUB> film is explored for use as a stationary phase and a Brønsted-base-containing polymer solution is developed for use as a mobile phase for selective desorption of the adsorbed dye. By controlling the desorption and adsorption depth, yellow, red and green dyes were vertically aligned within a TiO<SUB>2</SUB> film, which is confirmed by an electron probe micro-analyser. The external quantum efficiency (EQE) spectrum from a solar cell with three selectively positioned dyes reveals the EQE characteristics of each single-dye cell.