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A Case of Short-chain Acyl-CoA Dehydrogenase Deficiency Detected by Newborn Screening
Park, Kyungwon,Ko, Jung Min,Jung, Goun,Lee, Hee Chul,Yoon, So Young,Ko, Sun Young,Lee, Yeon Kyung,Shin, Son Moon,Park, Sung Won The Korea Society of Inherited Metabolic Disease 2015 대한유전성대사질환학회지 Vol.15 No.1
Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is an autosomal recessive mitochondrial disorder of fatty acid oxidation associated with mutations in the ACADS gene. While patients diagnosed clinically have a variable clinical presentation, patients diagnosed by newborn screening are largely asymptomatic. We describe here the case of a 1-year-old male patient who was detected by newborn screening and diagnosed as SCAD deficiency. Spectrometric screening for inborn errors of metabolism at 72hrs after birth showed elevated butyrylcarnitine (C4) level of 1.69 mol/L (normal, <0.83 mol/L), C4/C2 ration of 0.26 (normal, <0.09), C5DC+C60H level of 39 mol/L (normal, <0.28 mol/L), and C5DC/C8 ration of 7.36 (normal, <4.45). The follow-up testing at 18 days of age were performed: liquid chromatography tandem mass spectrometry (LC-MS/MS), urine organic acids, and quantitative acylcarnitine profile. C4 carnitine was elevated as 0.91; urine organic acid analysis showed elevated ethylmalonic acid as 62.87 nmol/molCr (normal, <6.5), methylsuccinate 6.81 nmol/molCr (normal, not detected). Sequence analysis of ACADS revealed a homozygous missense mutation, c.164C>T (p.Pro55Leu). He is growing well and no episodes of seizures or growth retardation had occurred.
Ko, Min Jung,Yun, Sungha,Oh, Kyungwon,Kim, Kirang Cambridge University Press 2015 The British journal of nutrition Vol.114 No.11
<B>Abstract</B><P>The objective of this study was to examine whether high serum 25-hydroxyvitamin D (25(OH)D) concentration was associated with high skeletal muscle mass, taking into account the effects of sex and age among the participants of the Korea National Health and Nutrition Examination Survey (KNHANES) aged 40 years or older. This was a cross-sectional study using data from the 2009 to 2010 KNHANES; a total of 8406 subjects (3671 men and 4735 women) were included. The appendicular skeletal muscle mass index (ASMMI, kg/m<SUP>2</SUP>) was estimated to measure the skeletal muscle mass. Hypovitaminosis was classified when the level of serum 25(OH)D was <20 ng/ml. The general linear model adjusted for confounding factors was used to determine differences in means of ASMMI by 25(OH)D status. The mean values of ASMMI were higher for men when compared with women. Women had a greater proportion of hypovitaminosis (71·1 %) compared with men (53·2 %). After adjusting for multiple factors, men were seen to have significant differences in ASMMI based on 25(OH)D status regardless of age, showing a lower mean value of ASSMI in those with hypovitaminosis. However, there was no difference in ASMMI by 25(OH)D status among women in both younger and older age groups. In conclusion, we found that there might be a positive relationship between 25(OH)D and skeletal muscle mass in men, indicating that interventions to improve 25(OH)D levels that are aimed at increasing muscle mass could be beneficial for men with more rapid decreased rate of skeletal muscle mass.</P>
고수일(Ko, Sooil),장경원(Chang, Kyungwon) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.23
이 연구는 프로젝트학습에서 학생들이 팀 프로젝트를 수행하면서 프로젝트를 성공적으로 수행하기 위해 어떠한 노력과 행동을 수행하고 있는지 파악하기 위한 것으로, 학생들의 인식과 행동을 잡크래프팅의 개념으로 접근하여 분석하였다. 연구대상 이 된 학생들은 J대학교의 경영학과 학생들로 프로젝트학습에 참여한 37명의 학생들에게 프로젝트가 종료된 후에 프로젝트학습 참여 경험을 묻는 개방형 질문지를 제시하여 자신의 생각과 경험을 작성하도록 하였다. 이들의 답변 내용을 분석한 결과, 학생들은 프로젝트학습을 위한 과제해결과정에서 겪는 어려움을 극복하기 위해 다양한 잡크래프팅 전략을 활용한 것으로 나타났다. 학생들이 활용한 주요 잡크래프팅 전략은 인지, 관계, 과업 수준에서 모두 이루어졌다. 즉, 학생들은 팀 프로젝트의 과 정과 결과를 자신의 성장과 연계하는 인지 수준의 전략, 서로 좋은 관계를 형성하기 위한 관계수준의 전략, 팀 프로젝트가 이루어지는 데 필요한 과업 수준의 전략을 활용하였으며, 이러한 과정을 거쳐 프로젝트 결과물을 산출하였다. 프로젝트학습에서 학생들이 사용한 잡크래프팅 전략은 학생들이 자발적으로 실천한 것이지만, 이러한 결과를 토대로 향후에는 프로젝트학습을 운영하는 교수자가 학생들에게 잡크래프팅의 의미와 구체적인 전략을 안내하는 것이 필요하다는 시사점을 도출할 수 있었다. This study approached the concept of job crafting as to what kind of job crafting, and what kind of voluntary behaviors the learner is doing while performing a team project. The results of the questionnaire survey on the students who performed the team project showed that the students utilized various job crafting strategies to overcome the difficulties in the project learning process. Cognitive strategies that link the process and outcomes of a team project to their own growth are expanded to a relationship level strategy to build a good relationship with each other, and ultimately, through a task level strategy needed to achieve a team project. Although the students practical use of the job crafting strategy used in the project learning was based on the students themselves, this study provided useful information and suggestions for the educator to consider in order for the team project to be successful.
Subjective Experience on Virtual Reality-Assisted Mental Health Promotion Program
Hyebin Ko,Hyun Ju Lim,Jeonghyun Park,Kyungwon Kim,Hwagyu Suh,Byung Dae Lee,Young Min Lee,Eunsoo Moon,Du-Ri Kim,Jong-Hwan Park,Myung-Jun Shin,Yean-Hwa Lee 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.4
Objective Mental health promotion programs using virtual reality (VR) technology have been developed in various forms. This study aimed to investigate the subjective experience of a VR-assisted mental health promotion program for the community population, which was provided in the form of VR experience on a bus to increase accessibility.Methods Ninety-six people participated in this study. The relationship between the subjective experience and mental health states such as depression, anxiety, perceived stress, and quality of life was explored. The subjective experience on depression and stress before and after VR program treatment was compared using the Wilcoxon signed-rank test. The satisfaction with the VR-assisted mental health promotion program was examined after using the VR program.Results The VR-assisted mental health promotion program on a bus significantly improved subjective symptoms such as depression (p=0.036) and perceived stress (p=0.010) among all the participants. Among the high-risk group, this VR program significantly relieved subjective depressive feeling score (p=0.033), and subjective stressful feeling score (p=0.035). In contrast, there were no significant changes in subjective depressive feelings (p=0.182) and subjective stressful feelings (p=0.058) among the healthy group. Seventy-two percent of the participants reported a high level of satisfaction, scoring 80 points or more.Conclusion The findings of this study suggest that the VR-assisted mental health promotion program may effectively improve the subjective depressive and stressful feelings. The use of VR programs on buses to increase of accessibility for the community could be a useful approach for promoting mental health among the population.
강경원(Kang Kyungwon),김노수(kim Nosoo),유종향(Yoo jonghyang),강병갑(Kang Byunggab),고미미(Ko Mimi),최선미(Choi Sunmi) 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.2
Background and Purpose: The purpose of this study was investigate statistical validities of previously reported articles that used various statistical techniques such as t r test and analysis of variance. Methods: To analyze the statistical procedures. 66 original articles using those statistical methods were selected from 『Korean Journal of Oriental Medicine(KJOM)』 published from 1995 to 2007. Results: Twenty-one articles(32%) did not report correct p-values, 33 articles(50%) used mean ± standard error(mean ± SE) and 11 articles(l7%) used mean ± standard deviation(mean ± SD). Fifty-two articles(95%) of 55 ones which were tested for normal distribution made an error in describing normal distribution. Seventeen articles misused t-test and 12 articles did not carry out the multiple comparison. Conclusions: The training of researchers with clinical statistics or the participation of statisticians in research design will reduce the significant errors in statistical interpretation of the results.
( Ji Wool Ko ),( Giho Moon ),( Jin Geun Kwon ),( Kyoung Eun Kim ),( Hankaram Jeon ),( Kyungwon Lee ) 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.4
Purpose: The Armed Forces Trauma Center of Korea was established in April 2022. This study was conducted to report our 1-year experience of treating soldiers with open fractures of the lower extremity. Methods: In this case series, we reviewed the medical records of 51 Korean soldiers with open fractures of the lower extremity between April 2022 and March 2023 at a trauma center. We analyzed patients with Gustilo-Anderson type II and III fractures and reported the duration of transportation, injury mechanisms, injured sites, and associated injuries. We also presented laboratory findings, surgery types, intensive care unit stays, hospital stays, rehabilitation results, and reasons for psychiatric consultation. Additionally, we described patients’ mode of transport. Results: This study enrolled nine male patients who were between 21 and 26 years old. Six patients had type II and three had type III fractures. Transport from the accident scene to the emergency room ranged from 75 to 455 minutes, and from the emergency room to the operating room ranged from 35 to 200 minutes. Injury mechanisms included gunshot wounds, landmine explosions, grenade explosions, and entrapment by ship mooring ropes. One case had serious associated injuries (inhalation burn, open facial bone fractures, and hemopneumothorax). No cases with serious blood loss or coagulopathies were found, but most cases had a significant elevation of creatinine kinase. Two patients underwent vascular reconstruction, whereas four patients received flap surgery. After rehabilitation, six patients could walk, one patient could move their joints actively, and two patients performed active assistive movement. Eight patients were referred to the psychiatry department due to suicidal attempts and posttraumatic stress disorder. Conclusions: This study provides insights into how to improve treatment for patients with military trauma, as well as medical services such as the transport system, by revising treatment protocols and systematizing treatment.