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A Case Study of Applying Automated Essay Scoring Programs within a Military English Context
( Kyeongmin Woo ) 한국ESP학회 2022 ESP REVIEW Vol.4 No.1
The present study discusses the feasibility of implementing automated essay scoring (AES) software and explores its ability to analyze essays that deal with topics related to the military. Since the teaching of English to military personnel plays a pivotal role in a country’s defense and national security, there is a need to teach military-related terms and expressions. To help learners improve their English writing skills with the support of timely and proper feedback, the researcher explored the possibility of utilizing two types of AES software and their feedback functions. After collecting three student essays written on a military-related topic, the collected essays were edited by three different groups: Grammarly, e-rater, and three human raters. Analysis was completed by comparing the accuracy of the corrective feedback provided by Grammarly and e-rater as opposed to the native English-speaking raters. The error analysis was conducted using a qualitative approach and showed that there were some differences in categories such as verbs, and symbolmechanics among the three feedback groups. These findings suggest that these AES programs can be adapted to an EFL classroom designed to teach military English but are limited in assuring the same degree of linguistic accuracy as human raters.
( Kyeongmin Kim ),( Songmi Noh ),( Jae-ho Cheong ),( Hyunki Kim ) 대한소화기학회 2021 Gut and Liver Vol.15 No.5
Background/Aims: Caudal type homeobox (CDX)-1 and -2 are reportedly involved in the development and progression of gastric cancer (GC). Although there are several reports on the prognostic significance of CDX-2 expression in GC, it remains controversial. In this study, we sought to validate the prognostic value of CDX-1 and -2 expression according to the histologic and molecular subtypes of GC. Methods: In total, 1,158 cases of advanced GC were investigated using immunohistochemical staining and tissue microarrays for CDX-1 and -2 expression, and survival analysis was performed according to different histological and molecular subtypes. Results: Of the 915 GCs with CDX-1 expression, 163 (17.8%) were Epstein-Barr virus (EBV)- positive or mismatch repair deficient (MMR-d), and the remaining 752 (82.2%) were EBV-negative or MMR-proficient (MMR-p). Of the 1,008 GCs with CDX-2 expression, 177 (17.5%) were EBV-positive or MMR-d, and the remaining 831 (82.5%) were EBV-negative or MMR-p. In the EBV-positive and MMR-d groups, CDX expression had no relationship with patient outcomes. In the EBV-negative and MMR-p groups, 404 (53.7%) and 523 (62.9%) samples were positive for CDX-1 and CDX-2 expression, respectively. Survival analysis demonstrated that CDX-1 and CDX-2 expression in all patients was correlated with favorable outcomes in terms of overall survival (multivariate analysis; p=0.018 and p=0.028, respectively). In the subgroup analysis, CDX-1 expression and CDX-2 expression were associated with favorable outcomes in EBV-negative and MMR-p intestinal (p=0.015 and p=0.010), and mixed and diffuse-type (p=0.019 and p=0.042) GCs, respectively. Conclusions: The expression of CDX-1 and CDX-2 is a favorable prognostic factor in EBVnegative, MMR-p advanced GC. (Gut Liver 2021;15:694-704)
( Kyeongmin Han ),( Jaejoon Lee ),( Gnanendra Shanmugam ),( Sun Keun Lee ),( Junhyun Jeon ) 한국미생물·생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.7
Control of pine wilt disease, which is caused by pine wilt nematode Bursaphelenchus xylophilus, is heavily dependent on the use of chemicals such as abamectin. Although such chemicals are highly effective, demands for alternatives that are derived preferentially from natural sources, are increasing out of environmental concerns. One of the challenges to discovery of alternative control agents is lack of fast and efficient screening method that can be used in a high-throughput manner. Here we described the development of colorimetric assay for the rapid and accurate screening of candidate nematicidal compounds/biologics targeting B. xylophilus. Contrary to the conventional method, which relies on laborious visual inspection and counting of nematode population under microscope, our method utilizes a redox dye that changes its color in response to metabolic activity of nematode population in a given sample. In this work, we optimized parameters of our colorimetric assay including number of nematodes and amount of redox dye, and tested applicability of our assay for screening of chemicals and biologics. We demonstrated that our colorimetric assay can be applied to rapid and accurate quantification of nematode viability/mortality in a nematode population treated with candidate chemicals/biologics. Application of our method would facilitate high-throughput endeavors aiming at finding environment-friendly control agents for deadly disease of pine trees.
Kyeongmin Kim,Se Hoon Kim,Jung-Yun Lee,Yoo-Na Kim,Seung-Tae Lee,Eunhyang Park 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4
Objective: The RAD51 assay is a recently developed functional assay for homologous recombination deficiency (HRD) that reflects real-time HRD status. We aimed to identify the applicability and predictive value of RAD51 immunohistochemical expression in pre- and post-neoadjuvant chemotherapy (NAC) samples of ovarian high-grade serous carcinoma (HGSC). Methods: We evaluated the immunohistochemical expression of RAD51/geminin/γH2AX in ovarian HGSC before and after NAC. Results: In pre-NAC tumors (n=51), 74.5% (39/51) showed at least 25% of γH2AX-positive tumor cells, suggesting endogenous DNA damage. The RAD51-high group (41.0%, 16/39) showed significantly worse progression-free survival (PFS) compared to the RAD51-low group (51.3%, 20/39) (p=0.032). In post-NAC tumors (n=50), the RAD51-high group (36.0%, 18/50) showed worse PFS (p=0.013) and tended to present worse overall survival (p=0.067) compared to the RAD51-low group (64.0%, 32/50). RAD51-high cases were more likely to progress than RAD51-low cases at both 6 months and 12 months (p=0.046 and p=0.019, respectively). Of 34 patients with matched pre- and post-NAC RAD51 results, 44% (15/34) of pre-NAC RAD51 results were changed in the post-NAC tissue, and the RAD51 high-to-high group showed the worst PFS, while the low-to-low group showed the best PFS (p=0.031). Conclusion: High RAD51 expression was significantly associated with worse PFS in HGSC, and post-NAC RAD51 status showed higher association than pre-NAC RAD51 status. Moreover, RAD51 status can be evaluated in a significant proportion of treatment-naïve HGSC samples. As RAD51 status dynamically changes, sequential follow-up of RAD51 status might reflect the biological behavior of HGSCs.
A New Low-voltage Tunable CMOS VDTA-based 10MHz LP/BP Filter
Kyeongmin Park,Junho Bang,Jeho Song 한국산학기술학회 2014 SmartCR Vol.4 No.4
In this paper, a new low-voltage complementary metal oxide semiconductor voltage differencing transconductance amplifier is proposed, and its performance is demonstrated by comparing its theory and simulated results with conventional versions. The main advantage of the proposed voltage differencing transconductance amplifier is that there are only two transistors composing a path from Vdd to Vss. A secondary advantage is that it can operate at very low voltages of less than ± 0.6V, which is superior to that of conventional models that require ± 0.9V and ± 2V. Additionally, a 10MHz multifunction filter is designed with the proposed complementary metal oxide semiconductor voltage differencing transconductance amplifier, which works both as a lowpass filter and a bandpass filter. The performance of the proposed voltage differencing transconductance amplifier and filter is verified using an HSPICE simulation with complementary metal oxide semiconductor 0.18㎛ process parameters.