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The seroprevalence of Bartonella henselae in healthy adults in Korea
( Hea Yoon Kwon ),( Jae Hyoung Im ),( Sun Myoung Lee ),( Ji Hyeon Baek ),( Areum Durey ),( Shin-goo Park ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.3
Background/Aims: Cat-scratch disease (CSD), caused by Bartonella henselae is one of the most common zoonosis. However, only several cases of B. henselae infection have been reported in Korea. This study investigated the seroprevalence of B. henselae in healthy adults and related risk factors. Methods: Serum samples from 300 healthy participants were analyzed using an immunoglobulin G immunof luorescence assay (IFA) for B. henselae isolated in Korea. Surveys on the risk factors for B. henselae infection were conducted simultaneously. Results: Of the participants, 47.7% and 15.0% raised dogs and cats, respectively. The overall seroprevalence of B. henselae was 15.0% (IFA titer ≥ 1:64). Participants who had raised cats showed 22.2% seropositivity against B. henselae, and those with no experience with cats showed 13.7% seroprevalence (p = 0.17). Participants who had cats as pets or been scratched by cats, showed 9.8% seropositivity against B. henselae (IFA titer ≥ 1:256). However, those who had not raised or been scratched by a cat showed 2.0% seropositivity (p = 0.015). Conclusions: In Korea, the seroprevalence of B. henselae is higher than expected, suggesting that Bartonella infection due to B. henselae is not uncommon. Cats are proposed to play a more important role than dogs in transmission of CSD.
( Hea Yoon Kwon ),( Yeon Sook Moon ),( Jun Hyeok Lim ),( Yeong Hoon Park ),( Ju Han Lim ),( Chul Soo Kim ),( Hyeong Gyu Yi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Before 1980s, the main cause of lead poisoning was associated to occupation such as building bridge, smelting and foundry. After 1980s, lead poisoning occurs from non-occupational causes such as from ingestion of herbal supplements. We encountered a 37-year-old male who visited the hospital for general weakness and abdominal pain. He had been taking Korean herbal medicine for two months to relieve anal fistula pain. Laboratory evaluation demonstrated hemoglobin 8. 3 g/dL hematocrit 24. 0%, retibulocyte 2. 91%, and peripheral blood smear showed normocytic michromic anemia with basophilic stippling. Also, serum aspartate aminotransferase and alaninetransaminase were elevated to 43 IU/L and 123 IU/L, respectively. Both duodenoscopy and colonoscopy were performed, which showed negative results except chronic superfi cial gastritis and anal fi stula. Initially, porphyria was suspected for because abdominal pain with persistent anemia, elevated reticulocyte count and abnormal liver function tests were not explained by evaluation for frequent diseases. Subsequent tests of porphyria, porphobilinogen and delta-aminolevulinic acid were elevated. However, history of herbal medication led us to measure the concentration of serum lead, which was increased to 54. 6 μg/dL. He was successfully treated with lead chelating agent. We report a case of lead poisoning with similar clinical manifestation to porphyria caused by ingestion of Korean herbal medicine, which implies the importance of evaluation of lead poisoning in certain clinical setting. Since both porphyria and lead poisoning usually manifest nonspecifi c symptoms such as anemia, hepatitis and acute abdomen pain, physicians` suspicion according to patient`s history is important in diagnosis such rare diseases.
( Hea Yoon Kwon ),( Oh Hyun Lee ),( Min Joo Kim ),( Woo Chul Joo ),( Sun Young Lee ),( Moon Jae Kim ),( Joon Ho Song ),( Seoung Woo Lee ) 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.2
Background: The composite summary score (range, 0-24) of abdominal aorticcalcification (AAC) devised by Kauppila et al is a simple method of assessing AACseverity. However, few studies have been conducted to determine an optimal AACcutoff score for the prediction of mortality or to investigate the relation betweenmineral metabolism and AAC progression using the scoring system. Methods: The medical records of 112 patients on hemodialysis who had undergonesimple lateral lumbar radiography every 6 months from August 2009 werereviewed. Patients were followed until November 2012, and the relationshipbetween the degree of AAC at baseline and mortality was evaluated. In addition,the relationship between the progression of AAC and serum concentrations ofcalcium and phosphate was evaluated in the 75 patients who were successfullyfollowed until November 2012. Results: The mean AAC score at baseline was 5.574.8, and the cutoff calcificationscore for the prediction of mortality was 7.75 (sensitivity¼61%, specificity¼81%). Patients were allocated to Group A (baseline total calcification score r8.0, n¼85)or Group B (baseline total calcification score48.0, n¼27), and multivariate analysisshowed that Group B was an independent risk factor of all-cause mortality andcardiovascular events. Of the 75 patients successfully followed, 51 showed AACprogression (Group 1) and 24 showed no change or improvement (Group 2). Group1 was found to have significantly higher mean serum corrected calcium levelsduring the 2nd year and 3rd year of follow-up than Group 2. Furthermore, repeatedmeasuresanalysis of variance showed higher monthly corrected calcium concentrations(P¼0.099) and mean corrected calcium levels during the 1st year, 2nd year,and 3rd year of follow-up (P¼0.062) in Group 1, but without statistical significance. The cutoff values of mean corrected calcium of the 2nd year and 3rd year for theprediction of AAC progression during follow-up years were 8.96 mg/dL and9.45 mg/dL, respectively. Serum phosphate levels and corrected calcium phosphatevalues were similar in Groups 1 and 2. Conclusion: Patients with an AAC score of48 at baseline seem to be at higher riskof mortality during follow-up. Of the serum variables examined, such as correctedcalcium, phosphate, and corrected calcium phosphate, corrected calcium was found to be marginally associated with AAC progression. However, a larger-scaleprospective study is required to confirm our findings.
Kwon, Oran,Lee, Sunho,Ban, Soonhyun,Im, Jooyeon J.,Lee, Doo Suk,Lee, Eun Hee,Kim, Joohee,Lim, Soo Mee,Lee, Sang Gon,Kang, Ilhyang,Kim, Kyung-Hee,Yoon, Sujung,Lee, Sun Hea The Korean Society of Biological Psychiatry 2015 생물정신의학 Vol.22 No.2
Objectives The combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of this study was to investigate the efficacy and safety of the herbal mixture for improving working memory as well as microstructural changes in white matter integrity in individuals with subjective memory complaints. Methods Seventy-five individuals with subjective memory complaints were assigned to receive either placebo (n = 15) or herbal mixture (low-dose group, n = 30 and high-dose group, n = 30) supplementation in an 8-week, randomized, double-blind, placebo-controlled clinical trial. Changes in working memory performance and fractional anisotropy (FA) values reflecting white matter integrity from baseline to 8-week endpoint were assessed. Results The herbal mixture group showed an increase in working memory performance compared to the placebo group (p for interaction = 0.001). In addition, the herbal mixture group showed an increase in FA values in the temporo-parietal regions (corrected p < 0.05), which are crucially involved in working memory function and are among the most affected regions in patients with cognitive impairments. Conclusions Findings from this study indicate that the herbal mixture may be a promising therapeutic option for individuals with subjective memory complaints.
Oh, Hea-Young,Shin, Su-Kyung,Heo, Hyoung-Sam,Ahn, Ji-Sook,Kwon, Eun-Young,Park, Jung Han Yoon,Cho, Yun-Young,Park, Hae-Jin,Lee, Mi-Kyung,Kim, Eun Jung,Jung, Un-Ju,McGregor, Robin A,Hur, Cheol-Goo,Choi New Century Health Publishers 2013 GENES AND NUTRITION Vol.8 No.3
<P>Prolonged high-fat diet leads to the development of obesity and multiple comorbidities including non-alcoholic steatohepatitis (NASH), but the underlying molecular basis is not fully understood. We combine molecular networks and time course gene expression profiles to reveal the dynamic changes in molecular networks underlying diet-induced obesity and NASH. We also identify hub genes associated with the development of NASH. Core diet-induced obesity networks were constructed using Ingenuity pathway analysis (IPA) based on 332 high-fat diet responsive genes identified in liver by time course microarray analysis (8 time points over 24?weeks) of high-fat diet-fed mice compared to normal diet-fed mice. IPA identified five core diet-induced obesity networks with time-dependent gene expression changes in liver. These networks were associated with cell-to-cell signaling and interaction (Network 1), lipid metabolism (Network 2), hepatic system disease (Network 3 and 5), and inflammatory response (Network 4). When we merged these core diet-induced obesity networks, Tlr2, Cd14, and Ccnd1 emerged as hub genes associated with both liver steatosis and inflammation and were altered in a time-dependent manner. Further, protein-protein interaction network analysis revealed Tlr2, Cd14, and Ccnd1 were interrelated through the ErbB/insulin signaling pathway. Dynamic changes occur in molecular networks underlying diet-induced obesity. Tlr2, Cd14, and Ccnd1 appear to be hub genes integrating molecular interactions associated with the development of NASH. Therapeutics targeting hub genes and core diet-induced obesity networks may help ameliorate diet-induced obesity and NASH.</P>
윤혜련(Hea Ryun Yoon),황민아(Min A Hwang),신명선(Myung Sun Shin),권순복(Soon Bok Kwon),김수진(Soo-Jin Kim),배소영(So Yeong Pae) 한국언어치료학회 2010 言語治療硏究 Vol.19 No.2
This study was conducted to identify the appropriate and necessary conditions for a speech pathology certification system in a department of speech therapy by collecting and analyzing data from relevant graduate schools, undergraduate schools and colleges through which speech pathologists are trained and reviewing treatment examples in other countries, while focusing on data from domestic departments of speech therapy and the educational environment. The research was carried out by first examining the actual educational situationincluding educational facilities and equipment, student evaluation systems, and information on relevant professors, and then, by suggesting the conditions for the most appropriate evaluation on the educational environment to cultivate outstanding speech pathologists. Research subjects were 23 schools in total, which granted our request for data on the educational environment for 2007. Regarding educational facilities and equipment, universities which had undergraduate schools and graduate schools were equipped with clinical laboratories and experimental laboratories, while universities which had only graduate schools rarely had clinical and experimental laboratories. Universities also differed in the condition of their experimental and practice equipment; the equipment they had was mostly instruments for voice analysis. Regarding the evaluation of students, universities which had relevant departments maintained 90% or higher rate in the recruitment and enrollment rate. Regarding the passing rate for the relevant qualification examination, around 40% was the prevailing percentage. Also, the employment rate for graduates from the relevant departments was 80% or higher,and thus, it can be said that most of the graduates can be employed in relevant occupations. Regarding professors, the number of full-time speech pathology professors was somewhat small. In fact, five universities with colleges and graduate schools, had no full-time professors who majored in speech language pathology.Finally, in respect of suggesting the conditions for the appropriate evaluation system on the educational environment, we would like to suggest the evaluation percentage to be 30% for educational facilities and equipment, 30% for student evaluation, and 40% for professor evaluation.
A caes of amniotic fluid embolism treated by multidisciplinary treatment
( Yeo Nyeong Yoon ),( Ji Hea Byun ),( Jeong Ha Wie ),( Ji Young Kwon ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
The emergency cesarean section was decided due to the minimal variability with fetal heart rate(FHR) 130-140. Dexamethasone was given prior surgery to support the newborn’s lung development. The cesarean section was performed at 32+6weeks under spinal anesthesia and living baby weighing 1540g was delivered with apgar score of 5 and 7 at 1 minute and 5 minuet. Suddenly 3 hours after surgery, the clinical symptoms were founded with spontaneous cough,sputum,dyspnea, cyanosis of finger tip, low blood pressure, spO2 63% and performed chest x-ray, suggesting pulmonary edema. The immediate management was required by respiratory and cardiac department and performed intubation, bed side echocardoigram, added inotropic agent to improve blood pressure. Subsequently, cardiothorathic department was ready to perform extracorporeal membreane oxygenation(ECMO). For further evaluation, enhanced computerd tomography(CT) lung mediastinum and bronchoscopy was performed. The CT showed pulmonary edema and pleural effusion,combined pnemonia, suggesting amniotic fluid embolism. Additionally, to prevent exacerbation of hemorrhage the evaluation of coagulation parameter was performed and indicated management of antithrombin therapy. The patient stabilized and discharged the day 6 without complication.
Preparation of biodegradable PLGA nanospheres employing a fast solvent evaporation method /
Jang, Jung Yoon,Kwon, Byung Soo,Lee, Hea Eun,Kim, Dong Hwan,Kang, Ho Kyung,Kang, Jae Seon,Lee, Snag Kil,Choi, Guang Jin The Korean Society of Industrial and Engineering C 2007 Journal of industrial and engineering chemistry Vol.13 No.6