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Kuraś Renata,Stępnik Maciej,Grobelny Jarosław,Tomaszewska Emilia,Stanisławska Magdalena,Domeradzka-Gajda Katarzyna,Wąsowicz Wojciech,Janasik Beata 한국독성학회 2024 Toxicological Research Vol.40 No.1
There is still little literature data on the toxicity and safety of the commonly used molybdenum (Mo) disulfide which is present in the working as well as living environments. Thus, an experiment was carried out involving rats, with single and repeated intratracheal exposure (in the latter case, 7 administrations at 2-week intervals with the analysis performed after 90 days) to lower (1.5 mg Mo kg− 1 b.w.) and higher (5 mg Mo kg− 1 b.w.) doses of molybdenum(IV) sulfide nanoparticles ( MoS2-NPs) and microparticles ( MoS2-MPs). The analysis of Mo concentrations in the tail and heart blood as well as in soft tissues (lung, liver, spleen, brain), after mineralization and bioimaging, was meant to facilitate an assessment of its accumulation and potential effects on the body following short- and long-term exposure. The multi-compartment model with an exponential curve of Mo concentration over time with different half-lives for the distribution and elimination phases of MoS2- MPs and MoS2- NPs was observed. After 24 h of exposure, a slight increase in Mo concentration in blood was observed. Next, Mo concentration indicated a decrease in blood concentration from 24 h to day 14 (the Mo concentration before the second administration), below the pre-exposure concentration. The next phase was linear, less abrupt and practically flat, but with an increasing trend towards the end of the experiment. Significantly higher Mo concentrations in MoS2- NPs and MoS2- MPs was found in the lungs of repeatedly exposed rats compared to those exposed to a single dose. The analysis of Mo content in the liver and the spleen tissue showed a slightly higher concentration for MoS2- NPs compared to MoS2- MPs. The results for the brain were below the calculated detection limit. Results were consistent with results obtained by bioimaging technique.
Abel Adekanmi Adeyi,Nathan Kura Bitrus,Luqman Chuah Abdullah,Lekan Taofeek Popoola,Maureen Chijioke-Okere,Oluwagbenga Olawale Omotara,Shihab Ezzuldin M.Saber 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.1
Manganese dioxide was laden hooked on biochar sourced from chicken feather to obtain a biochar-supported manganese dioxide (BSM) composite. In order to reduce the costs of acquisition and minimise the disposal of adsorbents, prepared BSM composite were employed in the sequestration of Levofloxacin (LEVO) from aqueous environment. The physico-chemical features and the adsorption mechanisms of prepared BSM, prior and after the adsorption of LEVO molecules were revealed by Scanning Electron Microscopy and Fourier Transform Infrared spectroscopy techniques. The influence of adsorption parameters including BSM dose, initial concentration, temperature and residence time were studied. The removal of LEVO was significantly influenced by all parameters. Equilibrium data has its fitness in the following order: Redlich-Peterson ˃ Langmuir ˃ Freundlich models. The maximum adsorption capacity of BSM for LEVO was 104.13 mg/g. The kinetic analysis indicates best fittings for pseudo-second-order model suggesting chemisorption as controlled mechanism. Besides, liquid film and intra-particle diffusion had a vital influence on the LEVO sequestration process. Exothermic and spontaneous nature of LEVO uptake by BSM was revealed by thermodynamic analysis. The findings suggested that prepared BSM show high sorption capacity, and recyclability potential towards separation of LEVO from contaminated pharmaceutical wastewater.
T. Ogawa,K. Seto,D. Hasegawa,H. T. Yang,H. Kura,M. Doi,M. Takahashi 한국자기학회 2011 Journal of Magnetics Vol.16 No.3
In order to obtain mono-dispersed Fe NPs with high saturation magnetization, quantitative analysis method to investigate the growth dynamics of the Fe NPs synthesized by a conventional thermal decomposition method has been developed. As a result, fast nucleation process promotes formation of ~4 ㎚ of initial nucleus with a non-equilibrium phase, resulting in low saturation magnetization. And slow particle growth with atomic-scaled surface precipitation mode (< 100 atoms/(minㆍ㎚²)) can form the growth layer on the surface of initial nucleus with high saturation magnetization (~190 emu/gFe) as an equilibrium a phase of Fe. Therefore, higher stabilization of small initial nucleus generated just after the injection of Fe(CO)? should be one of the key issues to achieve much higher Ms of Fe NPs.
Conditional PTEN-deficient Mice as a Prostate Cancer Chemoprevention Model
Koike, Hiroyuki,Nozawa, Masahiro,De Velasco, Marco A,Kura, Yurie,Ando, Naomi,Fukushima, Emiko,Yamamoto, Yutaka,Hatanaka, Yuji,Yoshikawa, Kazuhiro,Nishio, Kazuto,Uemura, Hirotsugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: We generated a mouse model of prostate cancer based on the adult-prostate-specific inactivation of phosphatase and tensin homolog (PTEN) using the Cre-loxP system. The potential of our mice as a useful animal model was examined by evaluating the chemopreventive efficacy of the anti-androgen, chlormadinone acetate (CMA). Materials and Methods: Six-week-old mice were treated subcutaneously with $50{\mu}g/g$ of CMA three times a week for 9 or 14 weeks and sacrificed at weeks 15 and 20. Macroscopic change of the entire genitourinary tract (GUT) and histologically evident prostate gland tumor development were evaluated. Proliferation and apoptosis status in the prostate were examined by immunohistochemistry. Results: CMA triggered significant shrinkage of not only the GUT but also prostate glands at 15 weeks compared to the control (p=0.017 and p=0.010, respectively), and the trend became more marked after a further five-weeks of treatment. The onset of prostate adenocarcinoma was not prevented but the proliferation of cancer cells was inhibited by CMA, which suggested the androgen axis is critical for cancer growth in these mice. Conclusions: Conditional PTEN-deficient mice are useful as a preclinical model for chemoprevention studies and serve as a valuable tool for the future screening of potential chemopreventive agents.