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Seo, S.U.,Kamada, N.,Munoz-Planillo, R.,Kim, Y.G.,Kim, D.,Koizumi, Y.,Hasegawa, M.,Himpsl, Stephanie D.,Browne, Hilary P.,Lawley, Trevor D.,Mobley, Harry L.T.,Inohara, N.,Nunez, G. Cell Press 2015 Immunity Vol.42 No.4
The microbiota stimulates inflammation, but the signaling pathways and the members of the microbiota involved remain poorly understood. We found that the microbiota induces interleukin-1β (IL-1β) release upon intestinal injury and that this is mediated via the NLRP3 inflammasome. Enterobacteriaceae and in particular the pathobiont Proteus mirabilis, induced robust IL-1β release that was comparable to that induced by the pathogen Salmonella. Upon epithelial injury, production of IL-1β in the intestine was largely mediated by intestinal Ly6C<SUP>high</SUP> monocytes, required chemokine receptor CCR2 and was abolished by deletion of IL-1β in CCR2<SUP>+</SUP> blood monocytes. Furthermore, colonization with P. mirabilis promoted intestinal inflammation upon intestinal injury via the production of hemolysin, which required NLRP3 and IL-1 receptor signaling in vivo. Thus, upon intestinal injury, selective members of the microbiota stimulate newly recruited monocytes to induce NLRP3-dependent IL-1β release, which promotes inflammation in the intestine.
Lightcurve survey of V-type asteroids in the inner asteroid belt
Hasegawa, S.,Miyasaka, S.,Mito, H.,Sarugaku, Y.,Ozawa, T.,Kuroda, D.,Nishihara, S.,Harada, A.,Yoshida, M.,Yanagisawa, K.,Shimizu, Y.,Nagayama, S.,Toda, H.,Okita, K.,Kawai, N.,Mori, M.,Sekiguchi, T.,Is Astronomical Society of Japan 2014 Publications of the Astronomical Society of Japan Vol.66 No.3
Hasegawa, K.,Yoshikawa, A.,Durbin, S.D.,Epellbaum, B.M.,Fukuda, T.,Waku, Y. The Korea Association of Crystal Growth 1999 韓國結晶成長學會誌 Vol.9 No.4
Fiber growth of $Al_{2}O_{3}/R-Al-O$ (R = Y, Gd, Dy, Ho, Er) eutectic by the micro-pulling down method is described. The thermal stability and strength at elevated temperature of each materials is evaluated in relation to the microstructure.
Visible-wavelength spectroscopy of subkilometer-sized near-Earth asteroids with a low delta-v
Kuroda, D.,Ishiguro, M.,Takato, N.,Hasegawa, S.,Abe, M.,Tsuda, Y.,Sugita, S.,Usui, F.,Hattori, T.,Iwata, I.,Imanishi, M.,Terada, H.,Choi, Y.-J.,Watanabe, S.-i.,Yoshikawa, M. Astronomical Society of Japan 2014 Publications of the Astronomical Society of Japan Vol.66 No.3
Interference Effect betweenϕandΛ(1520)Production Channels in theγp→K+K−pReaction near Threshold
Ryu, S. Y.,Ahn, J. K.,Nakano, T.,Ahn, D. S.,Ajimura, S.,Akimune, H.,Asano, Y.,Chang, W. C.,Chen, J. Y.,Daté,, S.,Ejiri, H.,Fujimura, H.,Fujiwara, M.,Fukui, S.,Hasegawa, S.,Hicks, K.,Horie, K.,Ho American Physical Society 2016 Physical Review Letters Vol.116 No.23
<P>The phi-Lambda(1520) interference effect in the gamma p -> K(+)K(-)p reaction has been measured for the first time in the energy range from 1.673 to 2.173 GeV. The relative phases between phi and Lambda(1520) production amplitudes were obtained in the kinematic region where the two resonances overlap. The measurement results support strong constructive interference when K+K- pairs are observed at forward angles but destructive interference for proton emission at forward angles. Furthermore, the observed interference effect does not account for the root s = 2.1 GeV bump structure in forward differential cross sections for phi photoproduction. This fact suggests possible exotic structures such as a hidden-strangeness pentaquark state, a new Pomeron exchange, or rescattering processes via other hyperon states.</P>