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Conditional PTEN-deficient Mice as a Prostate Cancer Chemoprevention Model
Koike, Hiroyuki,Nozawa, Masahiro,De Velasco, Marco A,Kura, Yurie,Ando, Naomi,Fukushima, Emiko,Yamamoto, Yutaka,Hatanaka, Yuji,Yoshikawa, Kazuhiro,Nishio, Kazuto,Uemura, Hirotsugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: We generated a mouse model of prostate cancer based on the adult-prostate-specific inactivation of phosphatase and tensin homolog (PTEN) using the Cre-loxP system. The potential of our mice as a useful animal model was examined by evaluating the chemopreventive efficacy of the anti-androgen, chlormadinone acetate (CMA). Materials and Methods: Six-week-old mice were treated subcutaneously with $50{\mu}g/g$ of CMA three times a week for 9 or 14 weeks and sacrificed at weeks 15 and 20. Macroscopic change of the entire genitourinary tract (GUT) and histologically evident prostate gland tumor development were evaluated. Proliferation and apoptosis status in the prostate were examined by immunohistochemistry. Results: CMA triggered significant shrinkage of not only the GUT but also prostate glands at 15 weeks compared to the control (p=0.017 and p=0.010, respectively), and the trend became more marked after a further five-weeks of treatment. The onset of prostate adenocarcinoma was not prevented but the proliferation of cancer cells was inhibited by CMA, which suggested the androgen axis is critical for cancer growth in these mice. Conclusions: Conditional PTEN-deficient mice are useful as a preclinical model for chemoprevention studies and serve as a valuable tool for the future screening of potential chemopreventive agents.
Zouhair Boukha,Jonatan González-Prior,Beatriz de Rivas,Juan R. González-Velasco,Rubén López-Fonseca,José I. Gutiérrez-Ortiz 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.57 No.-
Hydroxyapatite (HAP) support has been synthesised and impregnated with different amounts of Pd. Theprepared Pd/HAP catalysts have been thoroughly characterised by BET, XRD, TEM, UV–visible–NIR, FTIR,XPS, CO2-TPD and NH3-TPD techniques and tested in the DCE oxidation reaction. The characterisation of the catalysts has revealed a clear evolution of the Pd species structure, byincreasing the Pd content, from highly dispersed tetrahedral coordinated Pd2+ to larger Pd2+ speciesparticles adopting square planar geometry. The latter seems to be partially encapsulated by the HAPsupport. In DCE oxidation reaction the Pd/HAP system has shown an activity comparable to that of conventionalsystem (Pd/alumina). However, the former has proved high selectivity towards the production ofoxygenated products (COx (CO2 and CO)). Notably, in contrast to Pd/alumina, the DCE oxidation does notyield vinyl chloride intermediate product over Pd/HAP. This catalytic behaviour has been related to themoderate acidity of HAP compared to that of alumina together with its interaction with the Pd activephase. This report, then, considers that Pd(x)/HAP could be presented as a good alternative to thosereported in the available literature.
E. E. Pérez‑Ramírez,M. de la Luz‑Asunción,A. L. Martínez‑Hernández,G. de la Rosa‑Álvarez,S. Fernández‑Tavizón,P. Salas,C. Velasco‑Santos 한국탄소학회 2019 Carbon Letters Vol.29 No.2
One- and two-dimensional carbon nanomaterials were tested as adsorbents for the elimination of two anionic dyes, reactive red 2 and methyl orange, and the cationic dye methylene blue from aqueous solutions under the same conditions. Carbon nanomaterials performed well in the removal of dyes. Surface oxygenated groups in the nanomaterials improved the cationic dyes’ adsorption, but not the adsorption of the anionic dye. The interactions between nanomaterials and dyes were verified by infrared and Raman spectroscopy. The pseudo-second order kinetic model was better fitted to the kinetic experimental data than the Elovich and pseudo-first order models. The equilibrium adsorption data were best fitted by the Langmuir model. The dimensions and morphology of the carbon nanomaterials play an important role in the adsorption of the three dyes. The main mechanism of adsorption of anionic dyes is by the interactions of the aromatic rings of the dye structures and π delocalized electrons on carbon nanostructures; the adsorption of cationic dye is mainly due to electrostatic interactions.
X-ray and gamma ray shielding behavior of concrete blocks
Hernandez-Murillo Christian Geovanni,Molina Contreras J. Rafael,Escalera-Velasco Luis Alberto,de Leon-Martínez Héctor Asael,Rodriguez-Rodriguez José Antonio,Vega-Carrillo Héctor Rene 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.8
The shielding characteristics of two concrete blocks, widely used in the building industry in Mexico have been determined. These characteristics include the mass interaction coefficients, the linear attenuation coefficients and the half-value layers. The energy-dispersed X-ray fluorescence shows that the percentage mass content of each atom in the sample, and the atomic volume of the constituent elements of a material, plays an important role in its shielding capabilities. The total linear attenuation coefficients and the half-value layers were analyzed for a set of photon energies related to X-rays for diagnosis and cancer treatment with linear accelerators. Our results show that the concrete blocks have similar photon attenuation coefficients than the Portland concrete and better features than gypsum
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Zhang, Yiqun,Kwok-Shing Ng, Patrick,Kucherlapati, Melanie,Chen, Fengju,Liu, Yuexin,Tsang, Yiu Huen,de Velasco, Guillermo,Jeong, Kang Jin,Akbani, Rehan,Hadjipanayis, Angela,Pantazi, Angeliki,Bristow, C Elsevier Science B.V., Amsterdam 2017 CANCER CELL Vol.31 No.6