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- 저자 : Kokue, Eiichi (검색결과 5 건)
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Active metabolites in rat bile after intravenous injection of [<sup>3</sup>H] pteroylglutamic acid
신호철,시모다 미노루,코쿠에 에이치,Shin, Ho-chul,Shimoda, Minoru,Kokue, Eiichi The Korean Society of Veterinary Science 1993 大韓獸醫學會誌 Vol.33 No.4
항암치료의 조절인자로서 중요시되는 활성엽산대사물의 장간(腸肝)순환동태를 규명하기 위해 랫드에 $[^3H]pteroylglutamic$ acid(PteGlu)를 정맥주사한 후 고성능 액체 크로마토그래피법(HPLC)을 이용해 담즙중 활성대사물에 관해 조사하였다. HPLC-liquid scintillation counting법의 분석결과, 현저한 다섯개의 방사활성 피크가 출현, 이들은 $H_4PteGlu$, $10-HCO-H_4PteGlu$, $5-CH_3-H_4PteGlu$와 paraaminobenzoyl glutamate(pABG), PteGlu로 각각 동정되었다. 전자 3물질의 활성엽산대사물의 동정은 표준물질과의 비교분석에 의해 HPLC-전기화학검출기를 이용한 retention time profile 및 hydrodynamic, Voltammogram의 일치성 그리고 HPLC-photodiode array분석에 의한 흡광스펙트럼의 일치성에 근거하였다. 후자 그 물질의(pABG 및 PteGlu) 동정은 흡광스펙트럼의 일치성에 근거하였다. 랫드 담즙중$[^3H]PteGlu$의 활성엽산대사물로서 $H_4PteGlu$의 존재가 처음으로 밝혀졌다. Active metabolites in rat bile after an intravenous injection of $[^3H]$ pteroylglutamic acid(PteGlu)were studies using high-performance liquid chromatography(HPLC). Predominant four radioactive metabolites and parent compound PteGlu were detected on the chromatogram of HPLC with liquid scintillation counting system. These metabolites were identified as tetrahydrofolate, 10-formyltetrahydrofolate, 5-methyltetrahydrofolate and para-aminobenzoyl glutamate. The identification of active folate metabolites was based on the consistency of retention time profiles and hydrodynamic voltammograms which were obtained by HPLC with the electrochemical detection system, and characteristics of UV absorbance spectra obtained by HPLC with photodiode array detection system.
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Koku, Oludolapo,Perry, Simon,Kim, Jin-Kuk Elsevier 2014 APPLIED ENERGY Vol.114 No.-
<P><B>Abstract</B></P> <P>This paper addresses a conceptual study investigating the techno-economic feasibility for the thermal Integration of LNG cold vaporisation energy in power generation applications. In conventional regasification systems, this valuable LNG cold energy is often being wasted to ambient heat sources, representing a thermodynamic inefficient process with a significant thermal impact on the local environment. A combined facility consisting of a non-integrated Combined Cycle Power Plant (CCPP) and an LNG receiving terminal employing traditional Open Rack Vaporisers (ORV) technology, has been modelled, as a base case. Retrofit strategies for the integration of LNG cold energy have been investigated, and their impacts on power production and system efficiency are systematically compared. Retrofit design options considered in this work include the use of a propane Rankine cycle coupled with the direct expansion of natural gas, the integration of a closed-loop water cycle or open-loop water circuit with a steam Rankine cycle, and the facilitation of integrated air cooling for a gas turbine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Development of thermal integration modelling framework for the utilisation of LNG cold energy. </LI> <LI> Feasibility study for various design options for the integration of low-temperature cold energy. </LI> <LI> Provision of a design approach for achieving efficient use of cold energy in LNG terminals. </LI> <LI> Understanding of techno-economic impacts associated with the thermal integration of LNG cold energy. </LI> </UL> </P>
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Suleyman Cuneyt Karakus,Huseyin Kilincaslan,Naim Koku,Idris Ertaskin 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.2
Purpose: Since laparoscopic appendectomy was first described, various modifications, such as single port incisionless-intracorporeal conventional equipmentendoscopic surgery (SPICES), have been described for reducing pain and improving cosmetic results. In the retrocecal and retrocolic positions, attachments to the lateral peritoneum and cecum may lead to difficulties during SPICES, which is performed with only one port. Here, we present the effects of variations in the position of the vermiform appendix in treating acute appendicitis with SPICES. Methods: We retrospectively reviewed 52 children who underwent SPICES for acute appendicitis between March 2010 and November 2011 in our institution. One group (group A) consisted of 30 patients (mean age, 10.5 ± 2.5 years) with retrocecal appendix, while the other group (group B) included 22 patients (mean age, 10.9 ± 2.3 years) with the appendix lying free in the peritoneal cavity. Results: There were no significant differences between groups in terms of patient age, gender, success rate of SPICES, mean operating time, mean follow-up period, overall complication rates or mean postoperative hospitalization period. Conclusion: These results suggest that SPICES is a safe and feasible approach even in patients with retrocecal acute appendicitis.
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A giant choledochal cyst in infancy: a case report
Nursel Yurttutan,Suleyman Cuneyt Karakus,Naim Koku,Mustafa Demirci,Ramazan Ucak 대한소아청소년과학회 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.5
Choledochal cyst is a dilation that encloses the intrahepatic or both extra- and intrahepatic portions of the biliary ducts. Postnatally, ultrasonography is the initial diagnostic modality of choice, allowing for precise measurements of intra- or extrahepatic duct dilatation and identification of stones and sludge. Symptoms depend on the age at presentation. Common bile duct malformations should be considered as a differential diagnosis of a cystic mass regardless of the cyst’s size or patient’s age, especially in children presenting with abdominal pain, jaundice, and palpable mass. To the best of our knowledge, we report the largest choledochal cyst in infancy.
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A giant choledochal cyst in infancy: a case report
Yurttutan, Nursel,Karakus, Suleyman Cuneyt,Koku, Naim,Demirci, Mustafa,Ucak, Ramazan The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.5
Choledochal cyst is a dilation that encloses the intrahepatic or both extra- and intrahepatic portions of the biliary ducts. Postnatally, ultrasonography is the initial diagnostic modality of choice, allowing for precise measurements of intra- or extrahepatic duct dilatation and identification of stones and sludge. Symptoms depend on the age at presentation. Common bile duct malformations should be considered as a differential diagnosis of a cystic mass regardless of the cyst's size or patient's age, especially in children presenting with abdominal pain, jaundice, and palpable mass. To the best of our knowledge, we report the largest choledochal cyst in infancy.
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