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수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향
김미경 ( Kim¸ Mikyung ),한혜숙 ( Han¸ Hyesook ) 한국수학교육학회 2021 수학교육논문집 Vol.35 No.3
본 연구는 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향을 파악하기 위하여 대학 연계 자유학기제 융합수학탐구 수업에 신청한 49명의 학생들을 대상으로 단일집단 사전-사후 검사 설계를 통해 한 학기동안 이루어졌다. 본 연구의 주요 결과는 다음과 같다. 첫째, 사전, 사후 수학적 모델링 능력 검사 결과에 의하면, 사전 검사에 비해서 사후 수학적 모델링 검사의 평균 점수가 향상되었고, 사전, 사후 검사 간에 통계적으로 유의미한 차이가 있는 것으로 나타나 본 연구에서 제공한 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력을 향상시키는데 긍정적인 영향을 준다는 것을 확인하였다. 둘째, 각 문항별 분석 결과에 의하면 STEAM 수업 경험은 학생들의 창의적 사고 및 열린 사고를 요구하는 개방성이 높은 수학적 모델링 문항의 해결에 더욱 효과적인 것으로 나타났다. 셋째, 하위문항별 학생 응답 내용 분석 결과에 의하면, STEAM 수업 경험이 특히 학생들의 수학적 모델 구성 및 결과에 대한 타당성 검토 과정을 더욱 활성화시킨 것으로 나타났다. This study was conducted for one semester through one group pretest-posttest design with 49 first-year middle school students to explore the effects of mathematics-centered STEAM class experiences on students’ mathematical modeling abilities. The main results of this study are as follows: First, the results of the pre and post-mathematical modeling ability tests showed that the average score of posttest was improved compared to the pretest, and that the experiences of mathematics-centered STEAM classes provided in this study had a positive effect on improving the mathematical modeling ability of first-year middle school students. Second, STEAM classes were more effective in solving mathematical modeling problems that require students’ creative and divergent thinking. Third, the content analysis of student responses for each subquestion showed that STEAM classes were especially more helpful in activating students' mathematical model construction and validating steps.
Effect of fermented porcine placenta on physical fatigue in mice
Kim, Hee-Yun,Han, Na-Ra,Kim, Na-Rae,Lee, Mikyung,Kim, Jongbae,Kim, Chang-Ju,Jeong, Hyun-Ja,Kim, Hyung-Min SAGE Publications 2016 Experimental biology and medicine Vol.241 No.17
<P>The fatigue spreads among the people who live under stressful life and brings about a negative impact on physical function. Here we evaluated the anti-fatigue effects of fermented porcine placenta (FPP) and main constituents, lysine (Lys) and leucine (Leu) with treadmill stress test and forced swimming test (FST) in animal models. The mice were administrated with FPP, Lys, and Leu for 21 days. After treadmill exercise, FPP, Lys, and Leu significantly reduced fatigue-related biochemical parameters, including lactate, lactate dehydrogenase, glucose, creatine kinase, urea nitrogen, cortisol, and pro-inflammatory cytokines, whereas superoxide dismutase activity and glycogen levels were significantly increased by FPP, Lys, and Leu. In the FST, FPP, Lys, and Leu significantly decreased immobility times and up-regulated brain-derived neurotrophic factor expression in brain. Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-kappa B, interleukin (IL)-6, IL-1, and IL-4 through blockade of caspase-1/nuclear factor-B pathway in stimulated splenocytes. In addition, FPP, Lys, and Leu significantly promoted proliferation of splenocytes. In conclusion, these findings suggest the potential of FPP as a novel functional food for the regulation of fatigue.</P>
A Profile of Serum Mineral Parameters in Korean CKD Patients on Maintenance Hemodialysis
( Gheunho Kim ),( Bumsoon Choi ),( Daeryong Cha ),( Eunah Hwang ),( Hyungwuk Kim ),( Jaehyun Chang ),( Joohak Lee ),( Joongkyung Kim ),( Kwonwook Joo ),( Mikyung Kim ),( Sangchoel Lee ),( Sangwoong Ha 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
Lim, Soo,Han, Kyung Ah,Yu, JaeMyung,Chamnan, Parinya,Kim, Eun Sook,Yoon, Kun‐,Ho,Kwon, Sam,Moon, Min Kyong,Lee, Kwan Woo,Kim, Dong‐,Jun,Kim, Mikyung,Wongtanate, Manaj,Kim, Eun Young,Kim, S Blackwell Publishing Ltd 2017 Diabetes, obesity & metabolism Vol.19 No.1
<P><B>Background</B></P><P>Gemigliptin is a new dipeptidyl peptidase‐IV inhibitor. We investigated the efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes (T2D).</P><P><B>Methods</B></P><P>A total of 433 T2D patients with a glycosylated haemoglobin (HbA1c) level of 7.5% to 11.0% and a fasting plasma glucose (FPG) concentration <270 mg/dL were randomly assigned to 3 groups: (1) gemigliptin 50 mg qd + metformin 1000 to 2000 mg qd (titrated individually), (2) gemigliptin 50 mg qd, or (3) metformin 1000 to 2000 mg qd. The primary end‐point was the change in HbA1c level after 24 weeks. Secondary end‐points were the changes in FPG, insulin, proinsulin and C‐peptide levels. The percentages of responders who achieved an HbA1c level <7% (or <6.5%) were compared between treatment groups.</P><P><B>Results</B></P><P>Baseline HbA1c levels were 8.7% in all groups. The mean changes in HbA1c level from baseline to week 24 were −2.06%, −1.24% and −1.47% in the combination, gemigliptin monotherapy and metformin monotherapy groups, respectively. The 95% confidence intervals for between‐group differences in HbA1c changes were −1.02 to −0.63 in the combination group vs the gemigliptin group and −0.82 to −0.41 vs the metformin group, which confirmed the superiority of combination therapy. A significantly higher percentage of patients in the combination therapy group reached the target HbA1c level <7% (or <6.5%) compared with the monotherapy groups. No severe side effects were observed.</P><P><B>Conclusions</B></P><P>In T2D patients, the initial combination of gemigliptin and metformin had superior efficacy without safety concerns compared with monotherapy with either drug.</P>
Mikyung Kim,Chang-ho Han The Society of Korean Medicine 2023 대한한의학회지 Vol.44 No.2
Objectives: Cupping therapy (CT) has been widely used in traditional medicine worldwide for various indications, including stroke. The aim of this study was to systematically review the clinical evidence of CT for stroke. Methods: To identify randomized controlled trials (RCTs) reporting the effectiveness and/or safety of CT, seven databases including PubMed, EMBASE, and Cochrane Library were searched for articles published from January 2000 to February 2021 without language restrictions. Meta-analysis was performed using Review Manager 5.4 software and the results were presented as mean difference (MD) or standard mean difference (SMD) for continuous variables and odds ratio (OR) for diverse variables with 95% confidence intervals (CIs). Assessment of the methodological quality of the eligible trials was conducted using the Cochrane Collaboration tool for risk of bias in RCTs. Results: Twenty-two RCTs with 1653 participants were included in the final analysis. CT provided additional benefit in improving upper limb motor function (Fugl-Meyer assessment for upper limb motor function, MD 6.91, 95% CI 4.64 to 1.67, P<0.00001) and spasticity (response rate, OR 3.28, 95% CI 1.31 to 8.22, P=0.08) in stroke survivors receiving conventional medical treatment. These findings were supported with a moderate level of evidence. CT did not significantly increase the occurrence of adverse events. Conclusions: This study demonstrated the potential of CT to be beneficial in managing a variety of complications in stroke survivors. However, to compensate for the shortcomings of the existing evidence, rigorously designed large-scale RCTs are warranted in the future.
Mikyung Kim,Yeonju Woo,한창호 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.1
Background: While the use of herbal and traditional medicine (H&TM) has been extensive worldwide, the current status of H&TM management in pharmacovigilance remains to be investigated. To date, there is little information regarding the use of the classification/coding system (CCS) to detect signals for certain drugs within databases built on the basis of the spontaneous reporting system (SRS). The purpose of this study is to investigate the status of the SRS and CCS for H&TM in the pharmacovigilance systems of various countries around the world. Methods: An e-mail survey was performed from late December 2018 to early January 2019 with 54 experts in pharmacovigilance. The results based on the information provided by the respondents were summarized. Results: Fourteen experts from 13 countries responded to the survey. Eleven countries/regions were found to already include H&TM in their SRSs, managing only limited range of H&TM. Of the 9 countries/regions that provided the information on the status of CCS for H&TM in their domestic pharmacovigilance systems, only China had a separate CCS for H&TM. Conclusion: Revising the current pharmacovigilance systems to include or expand the range of H&TM, and developing an internationally harmonized system to classify and code H&TM suitable to the unique characteristics of H&TM are critical and overall beneficial.
Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2
Kim, Mikyung,Pena, June Bryan de la,Cheong, Jae Hoon,Kim, Hee Jin The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.4
Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the midbrain and forebrain. This indicates that Per2 may affect various neurobiological activities such as sleeping, depression, and addiction. In this review, we focus on the neurobiological functions of Per2, which could help to better understand its roles in the CNS.