Effectiveness of Integrative Therapy for Parkinson’s Disease Management

Woo, Yeonju,Hyun, Min Kyung Frontiers Media S.A. 2019 FRONTIERS IN AGING NEUROSCIENCE Vol.11 No.-

<P><B>Objectives:</B> To investigate the effectiveness of integrative therapy on prevalence and length of hospitalization and management of major complications of Parkinson’s disease (PD) in the South Korea.</P><P><B>Methods:</B> This study was a retrospective cohort analysis conducted using the National Health Insurance Service-National Sample Cohort in the South Korea. Patients over 65 years old who were newly diagnosed with PD during 2007–2011 were identified. The integrative therapy group was defined as patients treated with both Korean medicine (KM) and biomedicine, and the monotherapy group consisted of patients treated with biomedicine alone. From PD diagnosis to 2013, the prevalence and annual length of hospitalization because of PD and major complications (dementia, depression and pneumonia/sepsis) were analyzed using logistic regression, ANOVA and <I>t</I>-tests after propensity score (PS) matching with a 1:1 ratio.</P><P><B>Results:</B> After PS estimation and matching, the cohort used in the analysis included 228 subjects (114 integrative therapy group, 114 monotherapy group). Sex, age, index year, comorbidity, severity of disability, neurologic care, and anti-parkinsonism medication (levodopa, ropinirole, pramipexole, selegiline) were adjusted in both groups. The prevalence of hospitalization due to pneumonia/sepsis was 0.50 times (95% C.I.: 0.26–0.96) lower in the integrative therapy group than the monotherapy group, which was statistically significant (<I>p</I> = 0.038). The prevalence and annual length of total hospitalization and hospitalization because of PD, dementia, and depression in the integrative therapy group showed positive results compared to the monotherapy group, but these differences were not statistically significant.</P><P><B>Conclusion:</B> It has not been clearly identified that integrative therapy with KM and biomedicine for PD management is better treatment for patients compared to biomedicine monotherapy; however, we found a clue of better result in integrated therapy. Therefore, further investigation by increasing the number of subjects is needed to confirm the findings presented herein.</P>

비만환자의 펜터민 복용에 따른 체중과 심박수 변화에 대한 메타분석

우연주 ( Yeonju Woo ),정효미 ( Hyomi Jeong ) 한국보건정보통계학회(구 한국보건통계학회) 2018 보건정보통계학회지 Vol.43 No.4

목적: 식욕억제제인 펜터민의 투여에 따른 체중과 심박수 변화를 출판된 문헌을 토대로 메타분석을 시행하여 평가하고자 한다. 방법: 펜터민 투여군과 위약군의 체중과 심박수 변화를 측정한 무작위배정비교임상시험을 대상으로 PubMed, EMBASE, Cochrane library와 5개의 국내 전자데이터베이스 등 모두 8개의 전자데이터베이스로부터 검색전략에 따라 문헌들이 수집되었다. 메타분석에 따른 통합효과크기의 추정은 Mantel-Haenszel법에 의한 고정효과모델이 사용되었으며, 연구 간의 이질성이 존재하는 경우 변량효과모델이 사용되었다. 결과: 메타분석은 12개의 연구, 677명의 대상자에 대해 시행되었다. 펜터민의 투여에 따른 체중변화의 통합효과크기 추정치(SMD)는 -1.37 (95% 신뢰구간: -1.55, -1.19)로 통계적으로 유의하였으며, 출판연도, 국가, 펜터민의 용량, 추적관찰기간에 따른 하위그룹 분석에서 하위그룹 간 이질성은 나타나지 않았다. 펜터민의 투여에 따른 심박수 변화의 통합효과크기 추정치는 0.64 (95% 신뢰구간: 0.35, 0.92)로 통계적으로 유의하였다. 결론: 펜터민의 투여는 위약에 비해 유의하게 체중을 감소시키나, 심박수를 증가시킨다. Objectives: This study aimed to evaluate the change in weight and heart rate associated with the use of phentermine through meta-analysis based on the published literatures. Methods: Eight electronic databases, PubMed, EMBASE, Cochrane library, and five domestic databases were used to search the literature. Randomized controlled trials that evaluated the change in weight and heart rate with the use of phentermine compared with placebo were included in this study. The fixed-effect model weighted by the Mantel-Haenszel method was used in the meta-analysis, and the random-effects model was used when heterogeneity was present. Results: We included 12 studies comprising 677 patients. The change in weight observed with the use of phentermine (SMD=-1.37, 95% CI: -1.55, -1.19) was statistically significant compared with that observed with placebo. As per the subgroup analysis results, the change in weight by publication year, country, phentermine dosage, follow-up check was not heterogeneous. The change in heart rate observed with the use of phentermine (SMD=0.64, 95% CI: 0.35, 0.92) was significant compared with that observed with placebo. Conclusions: Weight loss and increased heart rate were confirmed in phentermine compared with placebo.

Immediate effects of mandibular posterior displacement on the pharyngeal airway space: A preliminary study

Yeonju Choi,Yong-Il Kim,Seong-Sik Kim,Soo-Byung Park,Woo-Sung Son,김성훈 대한치과교정학회 2020 대한치과교정학회지 Vol.50 No.2

Objective: This study aimed to evaluate the immediate effects of mandibular posterior displacement on the pharyngeal airway space (PAS) by using cephalometric evaluations and to investigate how the surrounding structures are schematically involved. Methods: In this retrospective study, 38 subjects with functional Class III malocclusion and two lateral cephalograms were selected. The first lateral cephalogram was taken with the mandible in the habitual occlusal position, and the second in anterior edge-to-edge bite. Paired t -test was used to analyze changes in the PAS, hyoid bone, tongue, and soft palate, followed by mandibular posterior displacement. Pearson’s correlation analysis was used to determine the relationship between the amount of mandibular posterior displacement and other variables. Results: A statistically significant decrease was observed in the PAS following mandibular posterior displacement. Along with mandibular posterior displacement, the tongue decreased in length (p < 0.001) and increased in height (p < 0.05), while the soft palate increased in length, decreased in thickness, and was posteriorly displaced (p < 0.001). The hyoid bone was also posteriorly displaced (p < 0.05). There was no correlation between the amount of mandibular posterior displacement and the measured variables. Conclusions: The PAS showed a statistically significant decrease following mandibular posterior displacement, which was a consequence of retraction of the surrounding structures. However, there were individual variances between the amount of mandibular posterior displacement and the measured variables. [Korean J Orthod 2020;50(2):129-135]

Papain 유도 호흡기 염증모델에서 인삼패독산(人蔘敗毒散)의 항염증 효과

우연주, 유준상, 이동혁, 서진우, 김주희, 권보인 상지대학교 한의학연구소 2023 尙志韓醫論文集 Vol.11 No.1

Objectives: Insampaedok-san and its main components have been used for treatment of fever, joint pain, cough, headache and pain. Using a respiratory inflammation model, we intend to investigate the anti-inflammatory effect and its mechanism of Insampaedok-san. Methods: We induced the actue respiratory inflammatory mouse model by papain treatment. BALB/C mice (female, 8 weeks old) were divided into three groups as follows: saline control (SC): papain treated group (vehicle): papain and Insampaedok-san (200mg/kg) treated group (n=4). To demonstrate the ani-inflammatory effect of Insampaedok-san water extracts, inflammatory cell infiltration was evaluated in bronchoalveolar lavage fluid (BALF) and nasal lavage fluid (NALF). In addition, immunogloblin (Ig)-E level was measured by using ELISA. Results: Insampaedok-san extracts administration decreased inflammatory cell infiltration in BALF and NALF. Especially, eosinophil infiltration was dramatically reduced. Furthermore, total Ig-E level was diminished in BALF and serum by Insampaedok-san administration. Conclusions: Our findings revealed Insampaedok-san extracts have anti-inflammatory effects by inhibiting inflammatory cell, especially eosinophil infiltration and Ig-E level.

Enhanced properties of SnS films doped with Zn

Yeonju Shin,Boyeon Kim,Ignatius Andre Setiawan,Hyeseon Park,Dong Hyo Kim,Gedi Sreedevi,Vasudeva Reddy Minnam Reddy,Salh Alhammadi,Woo Kyoung Kim 한국에너지학회 2022 한국에너지공학회 학술발표회 Vol.2022 No.4

Study of the surface reaction kinetics of (La,Sr)MnO_3−δ oxygen carriers for solar thermochemical fuel production

Kim, YeonJu,Jeong, Seung Jin,Koo, Bonjae,Lee, Siwon,Kwak, No Woo,Jung, WooChul The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.27

<P>(La,Sr)MnO3−δ has received a great deal of attention as an oxygen carrier that can replace the state-of-the-art carrier CeO2 for solar-driven thermochemical fuel production. Despite the many relevant studies, however, the redox reaction kinetics of this material, which determines the fuel production rate, has rarely been reported. Here, we investigate the surface reaction rate of reduced Sr-doped lanthanum manganite thin films, as a model for a gas/solid interface of a perovskite-structured oxygen carrier under a condition, in which carbon monoxide is produced from CO2 in a two-step thermochemical cycling process. Thin films of La1−xSrxMnO3−δ (<I>x</I> = 0.1, 0.2, 0.3, 0.4) with dense and flat surfaces are fabricated <I>via</I> pulsed laser deposition, and their surface oxygen exchange rates are then characterized <I>via</I> electrical conductivity relaxation under actual operating conditions (<I>T</I> = 650 to 800 °C and <I>p</I>O2 = 2.9 × 10<SUP>−19</SUP> to 9.0 × 10<SUP>−13</SUP> atm). As the Sr content increases, the oxygen exchange greatly decelerates. On the other hand, for a given Sr content, the oxygen exchange does not vary much over a wide range of <I>p</I>O2 near the target temperature of 800 °C. We also observe the surface oxygen exchange rate has a direct impact on the CO production rate. These observations can guide the selection of an ideal oxygen carrier composition for high-performance fuel production.</P>

Alteration of Sphingolipid Metabolism and pSTAT3 Expression by Dietary Cholesterol in the Gallbladder of Hamsters

Hyun-Woo Shin,Donghyun Kim,이윤선,유환수,이범재,Jae Seon Kim,Soyong Jang,Heena Lim,Yeonju Lee,오세관 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9

Cholesterol and sphingolipids are major lipid constituents of the plasma membrane and have been implicated in a number of human diseases, such as atherosclerosis, fatty liver, diabetes mellitus, coronary heart disease, and hypertension. However, the relationship between cholesterol and sphingolipid metabolism has not been investigated. The purpose of this study was to determine whether dietary cholesterol would induce the alteration of sphingolipid metabolism in hamsters. Hypercholesterolemia was induced in hamsters by placing them on an experimental diet containing 0.5% cholesterol plus 0.5% choline chloride for 8 and 12 weeks. The serum profile of the hamsters showed that the administration of cholesterol increased the levels of total cholesterol, LDL cholesterol, and triglycerides as well as the activities of GOT and GPT. The levels of ceramide and sphingosine-1-phosphate (So-1-P) were remarkably elevated by 6-fold, respectively, in the bile juice of cholesterol-fed hamsters. Interestingly, the levels of iNOS and GFAP were increased in the gallbladders of cholesterol-fed hamsters. In addition, the immunostaining of pSTAT3 was increased on the gallbladder epithelium after cholesterol feeding. These results suggest that sphingolipid metabolism may be regulated in the bile juice during cholesterol feeding and may be a potential target for the treatment of hypercholesterolemia-induced diseases.

멀티모드 eVTOL UAM 비행 시뮬레이션 공력 데이터베이스 구축을 위한 물리기반 Frequency Analysis 연구

최연주(Yeonju Choi),장막심(Maxim Tyan),이재우(Jae-Woo Lee) 한국항공우주학회 2022 한국항공우주학회 학술발표회 논문집 Vol.2022 No.11

우리나라의 한약 부작용 규모 추정

우연주,Woo, Yeonju 대한예방한의학회 2020 대한예방한의학회지 Vol.24 No.1

Objectives : The purpose of study was estimation of adverse events [AEs] scale relating herbal medicine in Korea using Korean Medicine Utilization and Herbal Medicine Consumption Survey (National statistics No. 117087). Methods : Using microdata of Korean Medicine Utilization and Herbal Medicine Consumption Survey 2017, the number of inpatients and outpatients who experienced AEs was calculated. The microdata included AEs of all treatment methods that have been performed by visiting Korean medical institutions for one year, so set up the data into three models; model A (in case all treatments were only herbal medicine for one year), model B (in case herbal medicines were a part of all treatment methods in 1 year), model C (in case herbal medicines were a part of treatment methods at least one time in 1 year). The proportion of patients who experienced AEs during the last 1 year was calculated and then, the number of AEs relating herbal medicine was estimated. Results : A total of 1,010 outpatients and 904 inpatients were included in Korean Medicine Utilization and Herbal Medicine Consumption Survey 2017. The number of patients who had experienced AEs in the past 1 year was 0 in the model A, 9 in the model B (5 for outpatients, 4 for inpatients), and 19 in the model C (10 for outpatients, 9 for inpatients). By consideration for the complex sample survey, estimating the number of AEs relating herbal medicine, the model A was 0, the model B was 36,457 patients (0 to 75,526 patients), and the model C was 84,830 patients (26,314 to 143,347 patients). Conclusion : From the results of this study, it was possible to estimate the scale of AEs relating herbal medicines in Korea, suggesting that it is necessary to understand the actual condition of AEs and establish its management system.

정확한 공력 데이터베이스를 위한 Space Mapping과 VFM 기반 다정밀도 외삽 기법 연구

최연주(Yeonju Choi),이치호(Chiho Lee),Vinh Pham,Maxim Tyan,이재우(Jae-Woo Lee) 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.7