心悸와 關聯된 經穴을 支配하는 神經元의 標識部位에 對한 硏究

김낙경,李光揆,李昌炫 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.1

最近에 많이 利用하는 神經解剖學的 追跡子인 WGA-HRP와 CTB를 使用하여 心悸와 關聯하여 臨床에서 利用되는 神門(H?) 內關(P?) 心兪(B?) 厥陰兪(B?) 및 단중(CV?)을 선택하여 흰쥐에서 이와 相應하는 經穴部位를 支配하는 神經細胞體 및 神經纖維의 標識部位를 中樞神經系內에서 形態學的으로 觀察하였다. 本 實驗 結果로서 心臟의 標識部位와 神門 內關 心兪 厥陰兪 단중의 標識部位 사이의 類似點을 볼 수 있었으며, 또한 心臟에서의 交感神經細胞體 領域의 별모양신경절, 神門에서의 脊髓神經節에 標識된 感覺神經細胞體의 領域과 脊髓에 投射되는 感覺神經纖維, 內關의 脊髓神經節에 標識된 感覺神經細胞體의 領域과 脊髓에 投射되는 感覺神經纖維에서는 左側이 右側보다 優勢하게 標識되는 것을 알 수 있었다. 이러한 것은 心臟疾患의 主要徵候의 하나인 心悸에 多用되는 神門 內關 心兪 厥陰兪 단중과 心臟의 神經解剖學的 聯關性을 보여주며, 經絡과 經穴의 機能的 實體를 짐작할 수 있게 해준다. 또한 心臟 및 神門 內關의 標識部位가 左側에서 優勢하게 標識되는 것은 心臟痛의 특징인 右側 上肢보다 左側 上肢에 優勢하게 나타나는 것과도 관련이 있을것으로 思料된다. The location and local arrangement of the motor, sensory neurons and the primary afferent fibers within the brain stem, the nodosal ganglia, the spinal ganglia, the spinal cord and the sympathetic ganglia projecting to the rat's heart and the acupoints B14, B5, CV17, H7 and P6 were investigated by the HRP histochemical staining methods and the CTB immunohistochemical methods following injection of 5% WGA-HRP and 1% CTB into the heart and the acupoints B14, B5, CV17, H7 and P6. 1. The parasympathetic motor neurons innervationg the rat's heart were founded within the nucleus ambiguus, rostoventral reticular neucleus of reticular formation, dorsal motor nucleus of vagus nerve in the brain stem. The sensory nerve fibers in the brain stem were founded in nucleus tractus solitalius in the caudal portion and area postrema of medulla oblongata. The sympathetic motor neurons innervating the rat's heart were labeled within the left and right stellate ganglia, the left and right T4-T9 sympathetic chain ganglia, left side was much more labeled than the right side. The sensory neurons projecting to the rat's heart were founded in the left and right nodosal ganglia, in the left and right C8-T5 spinal ganglia. The primary afferent fibers projecting to the rat's heart were labeled in the dorsolateral part, middle part and medial part of lamina I-V within the C8-T9 spinal cord segments. 2. The priamry afferent fibers projecting to the rat's acupoints B14, B15 were labeled in the left and right posterior horn of lamina I-V within the C8-T7 spinal cord segments, and motor neurons were observed in the left and right anterier horn within the C8-T7 spinal cord segments. The sympathetic motor neurons innervating the rat's acupoints B14, B15 were labeled within the left and right superior cervical ganglia, middle cervical ganglia, stellate ganglia and the left and right T4-T9 sympathetic chain ganglia. The sensory neurons were founded in the T1-6 spinal ganglia. 3. The primary afferent fibers projecting to the rat's acupoint CV17 were labeled in the left and right posterior horn of lamina II-VI within the C7-T6, and motor neurons were observed in the anterior horn within the C7-T6 spinal cord segments. The sympathetic motor neurons innervating the rat's acupoint CV17 were labeled within the left and right middle cervical ganglia, stellate ganglia and the left and right T4-T6 sympathetic chain ganglia. The sensory neurons were founded in the T2-5 spinal ganglia. 4. The primary afferent fibers projecting to the rat's acupoint H7 were labeled in the medial part, middle part of the left and right posterior horn of lamina II-VI within the C5-T2 spinal cord segments, and motor neurons were observed in the left and right anterior horn within the C8-T1 spinal cord segments. The sympathetic motor neurons innervating the rat's acupoint H7 were labeled within the left and right middle cervical ganglia, stellate ganglia. The sensory neurons were founded in the C6-T6 spinal ganglia, left side was much labelled than right side. 5. The primary afferent fibers projecting to the rat's acupoint P6 were labeled in the medial part, middle part of the left and right posterior horn of lamina II-VI within the C5-T2 spinal cord segments, left side was much more labelled than right side, and motor neurons were observed in the left and right anterier horn within the C5-T1 spinal cord segments. The sympathetic motor neurons innervating the rat's acupoint P6 were labeled within the left and right middle cervical ganglia, stellate ganglia. The sensory neurons were founded in the C6-T1 spinal ganglia, left side was much labelled than right side. This results were neuroanatomically suggested that the location of rat's motor and sensory neurons innervating the acupoints(B14, B15, CV17, H7 and P6) related to the palpitation were closely related to those innervating the heart.

Difference between Right and Left Facial Surface Electromyography in Healthy People

Kim, Bo-Hyun,Kim, Kyeong Han,Kim, Lak-Hyung,Kim, Jong-Uk,Yook, Tae-Han Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-

<P><B>Introduction</B></P><P> The study was to see whether there were differences in values of facial surface electromyography in subjects of good heath by muscles, age, and sex.</P><P><B> Methods</B></P><P> It draws ratio between lower value and higher value (R-LV/HV) and asymmetry index (AI), based on root mean square (RMS) from measurement of facial surface electromyography (sEMG) in 154 people of healthy people (male:female = 70:84) aging between more than 20 and less than 70.</P><P><B> Results</B></P><P> For R-LV/HV, it averages 81.70±14.60% on frontalis muscle, 73.74±19.12% on zygomaticus muscle, and 79.72±14.77% on orbicularis oris muscle. With analysis of the AI average was 10.87±10.14% on frontalis muscle, 16.71±14.79% on zygomaticus muscle, and 12.10±10.05% on orbicularis oris muscle. Both values were statistically significant in three parts of muscles as shown. Both of R-LV/HV and AI show no statistically significant difference on age and sex (p>0.05).</P><P><B> Conclusions</B></P><P> It could provide basic data for the future diagnosis of facial nerve palsy patients by measuring facial sEMG values for healthy people.</P>

Analysis of sliding/Impacting Wear in T7be to Convex Spring Contact and Relevant Contact Problem

Kim, Hyung-Kyu,Lee, Young-Ho,Heo, Sung-Pil,Jung, Youn-Ho,Ha, Jae-Wook,Kim, Seock-Sam,Jeon, Kyeong-Lak Korean Tribology Society 2002 KSTLE International Journal Vol.3 No.1

Wear on the tube-to-spring contact is investigated experimentally, The vibration of the tube causes the wear while the springs support it As for the supporting conditions, the contacting normal farce of 5 N,0 N and the gap of 0.1 mm are applied. The gap condition is for considering the influence of simultaneous impacting and sliding on wear. The wear volume and depth decreases in the order of the 5 N,0 N and the gap conditions. This is explained from the contact geometry of the spring, which is convex of smooth contour, The contact shear force is regarded smaller in the case of the gap existence compared with the other conditions. The wear mechanism is considered from SEM observation of the worn surface. The variation of the normal contact traction is analysed using the finite element analysis to estimate the slip displacement range on the contact with consulting the fretting map.

Rheumatoid Arthritis and HLA Class II Genotypes in Korean

Kim, Jung-Man,Lee, Hee-Dai,Han, Chang-Whan,Kim, Jin-Young,Kim, Weon-Yoo,Sung, Jin-Hyung,Ryu, Jae Duk,Ko, Lak-Hyun 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-

To determine which HLA antigens are associated with rheumatoid arthritis in Korean, we studies the HLA class II genotypes in 40 patients with rheumatoid arthritis and 35 normal healthy persons by the two step polymerase chain reaction. At first we designed 20 pairs of group specific primers followed by the alleles which have the same nucleotide sequences in the exon 2 region. We performed amplification reaction with these 20 pairs of primers for 32 cycles. Recation products were electrophoresed and only specifically amplified products were reamplified for 15 cycles with total 76 pairs of allele specific primers. We typed the HLA class II genotypes with specific band patterns of each allele. The genotypes in patients were compared with those of normals. HLA-DR4 gave the highest relative risk for rheumatoid arthritis(RR=4), which was statistically significant(P<0.01). The frequency of HLA-DR4 was 75.0% in patient group and 42.9% in normal control group. Relative risk was also associated with HLA-DQw4 of DQB1 gene(RR=3.82), which was statistically significant(P<0.05). The frequency of HLA-DQw4 was 38.9% in patients group and 14.3% in normal control group. HLA-DR1 and DQw3 were not associated with rheumatoid arthritis(P>0.05), Among HLA-DR4 subtypes, the frequency of Dw14(0404) in patient group was relatively higher (19.2%) than that in normal control group(7.7%). The relative risk was high(2.85), although it was not statistically significant(P>0.05). From this study, HLA-DR4 was found to be highly associated while DRI was not associated with rheumatoid arthritis patients in Koreans. (The Journal of Korean Orthopaedic Research Society 2(1):61-67, 1999)

Synthesis of Methyl-substituted Bicyclic Carbanucleoside Analogs as Potential Antiherpetic Agents

Kim, Kyung-Ran,Park, Ah-Young,Lee, Hyung-Rock,Kang, Jin-Ah,Kim, Won-Hee,Chun, Pu-Soon,Bae, Jang-Ho,Jeong, Lak-Shin,Moon, Hyung-Ryong Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.10

Novel bicyclo[3.1.0]hexanyl purine nucleoside analogues were synthesized as potential antiherpetic agents via a bicyclo[3.1.0]hexanol (${\pm}$)-8, which was prepared using a highly efficient carbenoid cycloaddition reaction. A highly diastereoselective reduction of ketone and a Mitsunobu reaction for the condensation of glycosyl donor (${\pm}$)-12 with 6-chloropurine were employed.

농촌지역 주민의 우울 수준과 양생실천 정도

김락형 ( Lak Hyung Kim ),김영희 ( Young Hee Kim ),안옥희 ( Ok Hee Ahn ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.4

Objectives: Yangseng is a traditional healthcare regimen on the promotion of health and prevention of illnesses by means of specific principles and methods for the purpose of living a long and healthy life. The purpose of this study was to investigate the relationship of depression level and Yangseng in rural residents for the promotion of health and prevention of illness. Methods: The subjects of this study were 1205 rural residents who live in Wanju, Cheonbuk, Korea. Beck depression inventory and the Yangseng were assessed by survey personnels. Results: The total score of Yangsaeng was 102.70±14.03, and the BDI score was 2.80±4.96. Mild depression group was 5.03%, depression and severe depression group was 3.86%. Normal group in depression showed higher Yangsaeng score, and the high Yangsaeng score group showed lower BDI score. Conclusions: Above results suggest that there are signigicant relations between depression and Yangsaeng. These results could be used for planning the public healthcare programs and Yangseng promoting program based on Korean traditional medicine.

절식요법에 참가한 여성들의 섭식태도와 우울에 대한 연구

김락형 ( Lak Hyung Kim ),김수연 ( Su Yeon Kim ),장인수 ( In Soo Jang ),권보형 ( Bo Hyung Kwon ) 대한한방신경정신과학회 2001 동의신경정신과학회지 Vol.12 No.2

중국에서의 파킨슨병 침치료 임상연구 동향

김락형 ( Lak Hyung Kim ),장인수 ( In Soo Jang ),강세영 ( Sei Young Kang ) 경락경혈학회 2011 Korean Journal of Acupuncture Vol.28 No.4

Objectives: The purpose of this study was to obtain some knowledge about the acupuncture treatments on Parkinson`s disease for the future practice and the research from the clinical studies in China. Methods: The literatures were searched using the data base-China Academic Journals (CAJ) (1994-2011). Clinical studies of acupuncture for Parkinson`s disease such as randomized controlled trial (RCT), non-randomized controlled trial (NRCT), case series, case report were included. Results: Of 145 articles, 52 Clinical studies met our inclusion criteria: 20 RCTs, 7 NRCTs, 22 case series and 3 case reports. Various kinds of acupuncture treatments such as scalp acupuncture, body acupuncture, abdominal acupuncture, acupoint injection, eye acupuncture and thick needle acupuncture (粗鍼) were used in the clinical studies. The treatment and control groups take Madopa Tablet (Levodopa + Benserazide HCl) in the same time in many studies, and Madopa treatment was used as a comparative treatment in the most of studies. Acupuncture treatment was done daily or 2~3 times a week for 2~20 weeks. All of studies reported high effective rate in the treatment group compared to control group. Conclusions: The results of this study could be used for the future study about the acupuncture therapy for Parkinson`s disease.

농촌지역 노인의 건강실태와 양생실천 조사연구 -전북 고창군 65세 이상 노인 설문조사 분석-

김락형 ( Lak Hyung Kim ),김영희 ( Young Hee Kim ),안옥희 ( Ok Hee Ahn ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.4

Objectives: Yangseng is a traditional healthcare regimen on the promotion of health and prevention of illnesses by means of specific principles and methods for the purpose of living a long and healthy life. The purpose of this study was to investigate the relationship of actual health and Yangseng in urban elderly for the promotion of health and prevention of illness. Methods: The subjects of this study were 393 elderly (male 139, female 254) who lives in Kochang, Cheonbuk, Korea. The questions about their health and Yangseng was asked by survey personnels. Results: In this survey, many of the urban elderly have osteoarthritis 54.45%, Herniated nucleus pulposus 45.04%, osteoporosis 32.06%, hypertention 37.40%, diabetes 17.05%. Most of them had pain in the body 82.7%, and reported fatigues 78.63%, stress 18.32%, and depression and anxiety 49.11%. The score of Yangeng was significantly higher in the group who don`t have osteoarthirtis, fatigue, depression and anxiety than in the group who have those. The average of the total score of Yangsen was 100.61±16.08. There was significant difference in Yangseng score according to osteoarthritis, fatigues, and depression and anxiety, while the score of Yangsen in the diabetes group was higher than that in the non-diabetes group. Conclusions: Above results could be used for planning the public healthcare programs and Yangseng promoting program based on Korean traditional medicine.

Synthesis and Biological Evaluation of Halo-neplanocin A as Novel Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase

Jeong, Lak Shin,Moon, Hyung Ryong,Park, Jae Gyu,Shin, Dae Hong,Choi, Won Jun,Lee, Kang Man,Kim, Hea Ok,Chun, Moon Woo,Kim, Hee-Doo,Kim, Joong Hyup 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12

Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.