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구성태,조명수,황재호,변기원,김경식,손인철 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1
In the present study, we aimed. to consider the name of twelve main Meridian in order to understand the concept of the Meridian system and to applicate acupuncture theory in the clinical field properly and fundamentally. We referred to several literatures on the matter and we found out that the name of present twelve Meridian was not settled until the period of Yellow Emperor's Classic. In the time of Yellow Emperor's Classic, the two theory of Internal Organ and Meridian system were combined and added new theory of 'WoonGi'. The general rule of combination is that the component of name of Meridian consist of 'Hand' or 'Foot', 'three Eum and Yang' and internal organ. The internal organ coupled with the root ki or middle ki of 'three Eum and Yang' and the 'Hand' or 'Foot' depend on the location of internal organ that belongs to meridian. The name of Twelve Meridian is a kind of system formed to analyze the two concepts organically and dynamically. One is material internal organ and the other is immaterial meridian system.
( Ki Cheul Sohn ),( Su Jin Kang ),( Joo Wan Kim ),( Ki Young Kim ),( Sae Kwang Ku ),( Young Joon Lee ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.4
This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved signifi cantly in the Ca gluconate- administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dosedependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-α, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-infl ammatory, anti-oxidative and immunomodulatory effects in CIA mice.
Sohn, Ki Cheul,Jung, Hyun-Jung,Lee, A-Jin,Kim, Sang-Gyung,Shin, ImHee,Kwak, Sang Gyu The Society of Korean Medicine 2013 대한한의학회지 Vol.34 No.4
Objectives: Classifying the pattern of jaundice during diagnosis will significantly improve the outcome of common KM interventions. This study aimed at determining an objective index for accurately diagnosing heat and dampness KM patterns in patients with jaundice. Methods: We systematically reviewed laboratory findings from case reports published in the scientific literature of Korean medicine. Cases were classified as following either the heat or dampness pattern. Biochemical indices were compared using a Bayesian factor (BF) analysis and standard t-tests. Results: The laboratory findings of 32 patients were evaluated. The heat pattern was observed in 17 patients and the dampness pattern in 15. No significant differences were observed between the 2 groups in terms of white blood cell count (BF=1.659); hemoglobin concentration (BF=2.627); platelet count (BF=1.019); or levels of direct bilirubin (BF=1.453), aspartate aminotransferase (BF=1.226), alanine aminotransferase (BF=1.340), alkaline phosphatase (BF=2.344), or gamma-glutamyl transpeptidase (BF=2.782). However, total bilirubin levels were significantly higher in the dampness pattern group (BF=0.854, P-value=0.070). Conclusions: Patients with high total bilirubin levels may predominantly follow the dampness pattern, while those with low levels may predominantly follow the heat pattern. These results are expected to be useful for the development of timely and efficient KM treatments as well as new integrative therapeutic approaches for jaundice. However, further studies are essential to fully validate the utility of total bilirubin as a biomarker for differentiating between heat and dampness patterns.
잭나이프 및 붓스트랩 방법을 이용한 임상자료의 회귀계수 타당성 확인
손기철,신임희,Sohn, Ki-Cheul,Shin, Im-Hee 한국데이터정보과학회 2012 한국데이터정보과학회지 Vol.23 No.4
여러 임상자료를 이용하여 반응변수와 설명변수간의 관계를 규명하는 분석이 많이 이루어지고 있다. 이를 위해서 회귀분석이 흔히 사용되고 있으며, 이를 통해 설명변수가 반응변수를 얼마나 설명하는지 또한 모형이 얼마나 자료에 적합한지에 대해 분석하고 있다. 그러나 임상자료로 분석된 회귀모형에 대한 타당성 확인은 대부분 분석된 회귀모형이 얼마나 자료를 설명하는가를 나타내는 결정계수만을 살펴보는 것에 그치고 있다. 결정계수 이외의 다른 방법으로도 분석된 회귀모형의 회귀계수에 대한 타당성을 확인할 필요가 있다. 따라서 본 논문에서는 잭나이프 회귀분석과 붓스트랩 회귀분석을 이용하여 임상자료로 분석한 회귀모형의 회귀계수에 대한 타당성을 확인하는 방법을 소개하고자 한다. There are lots of analysis to determine the relation between dependent variable and explanatory variables. Often the regression analysis is used to do this, and we can analyze the how much the explanatory variable can be related with dependent variable and how much the regression model can explain the data. But the validation check of regression model is usually determined by coefficient of determination. We should check the validation of regression coefficient with different methods. This paper introduces the method for validation check the regression coefficient using the jackknife regression and bootstrap regression in clinical data.
손기철,신임희,Sohn, Ki-Cheul,Shin, Im-Hee 한국데이터정보과학회 2012 한국데이터정보과학회지 Vol.23 No.4
많은 분야에서 수집된 자료 중 데이터의 범위에서 많이 벗어난 아주 작은 값이나 아주 큰 값인 이상치가 종종 존재한다. 이런 이상치의 발생원인은 자료의 입력과정에서의 오류 또는 응답 과정에서 응답자의 특이한 답변 때문이다. 만약 자료에서 이상치가 존재할 경우 자료의 요약값인 평균과 분산에 많은 영향을 미쳐서 잘못된 정보가 산출된다는 문제점이 있다. 따라서 연구자는 자료에서 이상치가 존재하는지를 주의깊게 살펴보아야 한다. 특히 사람을 대상으로 실시한 임상자료의 경우 자료의 비용측면에서나 결과의 일관성 측면에서 이상치의 판단은 더욱 중요한 문제이다. 따라서 본 논문에서는 이상치를 판단하는 방법인 Grubb 검정과 Cochran 검정을 이용하여 임상자료에서의 이상치를 판단하는 방법을 소개하고자 한다. There are very small values and/or very big values which get out of the normal range for survey data in various fields. The reasons of occurrence for outlier are two. One of them is the error in process of data input and the other is the strange response of the respondent. If the data has outliers, then the summary statistics such as the mean and the variance produce misleading information. Therefore, researcher should be careful in detecting the outlier in data. In particular, it is very important problem for clinical fields because the cost of experiment is very high. This article introduce the Grubb test and Cochran test to detect outliers in the data and we apply this method for clinical data.
손기철,김달호,Sohn, Ki-Cheul,Kim, Dal-Ho 한국데이터정보과학회 2012 한국데이터정보과학회지 Vol.23 No.4
여러 분야에서 자료를 수집하기 위하여 모집단에서 표본을 추출하는 표본설계를 하고 있다. 특히 실험군과 대조군이 존재하는 임상자료에서는 모집단에서 집단별 일반적 변수들의 특성이 표본에 잘 반영되어야 하므로 더욱더 표본설계가 중요한 문제이다. 즉 모집단에서 집단별로 일반적 변수들이 가지는 빈도, 중심척도 그리고 산포척도 등이 표본에서도 동일하게 나타나야 한다. 그러나 주로 이루어지는 표본설계는 매우 복잡하고 어려워 일반 연구자가 사용하는데 있어 어려움을 겪는다. 따라서 본 논문에서는 시뮬레이션을 이용하여 집단별로 일반적 특성을 유지할 수 있는 임상자료의 샘플링 방법을 연구하였다. 또한 중환자실에 있는 환자자료에 적용하여 모집단과 표본의 일반적 변수의 특성값을 계산하여 보았고 통계적 가설검정을 이용하여 모집단과 표본집단에서 일반적 변수들의 값의 차이 여부를 비교하여 보았다. There are lots of sampling design which is determined for sample survey in various fields. Especially, it is important problem for clinical data because basic characteristic variables by group which consist of experiment group and control group in population should be reflect to sample. Therefore, frequencies, center scales and dispersion scales of variables by group in population should be similar in sample. But usual sampling design is very complicate so it is difficult to use in practice for researcher. In this paper, we consider the sampling method using simulation. We applied the proposed method to colon cancer data from a hospital. We compare basic characteristic variables between population and sample with mean, frequency and statistic hypothesis test.