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Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
Nguyen Huu Khanh Nhan,Tran Hoang Quang Minh,Tan N. Nguyen,Miroslav Voznak 한국광학회 2017 Current Optics and Photonics Vol.1 No.6
Due to optimal advances such as chromatic performance, durability, low power consumption, highefficiency, long-lifetime, and excellent environmental friendliness, white LEDs (WLEDs) are widely usedin vehicle front lighting, backlighting, decorative lighting, street lighting, and even general lighting. In thispaper, the remote packaging WLEDs (RP-WLEDs) with bi-layer red-emitting Sr2Si5N8: Eu2+ and yellowemittingYAG:Ce phosphor was proposed and investigated. The simulation results based on the MATLABsoftware and the commercial software Light Tools indicated that the color rendering index (CRI) of bi-layerphosphor RP-WLEDs had a significant increase. The CRI had a considerable increase from 72 to 94. Inconclusion, the results showed that bi-layer red-emitting Sr2Si5N8:Eu2+ and yellow-emitting YAG:Cephosphor could be a prospective approach for manufacturing RP-WLEDs with enhanced optical properties.
Khanh Nguyen-Huu(웡후칸),Seon-Woo Lee(이선우) 한국HCI학회 2019 한국HCI학회 학술대회 Vol.2019 No.2
Recently, in the field of indoor localization, wireless radio and dead reckoning techniques are two main branches that received much attention. The former one uses the wireless facility such as WiFi or Bluetooth to estimate the user position in two ways: triangulation and fingerprinting. The latter one uses the inertial sensors to estimate the displacement of the user based on the previous position. In this paper, from several experiments, we pointed out the effect of WiFi scanning interval and pedestrian walking speed to the positioning result. We also used the WiFi fingerprinting technique as a clue to compensate for the accumulated error of the pedestrian dead reckoning system which is implemented on a smartphone to analyze the effect of the two factors above.
A Heading Estimation based on Smartphone Holding Styles
Khanh Nguyen Huu,KyungHo Lee,Chang Geun Song,Seon-Woo Lee 한국HCI학회 2016 한국HCI학회 학술대회 Vol.2016 No.1
In this paper, based on four different holding styles of a smartphone, which is determined using a set of inertial sensors included in the smartphone, we suggest an effective method to estimate the heading direction of a user while he is walking. The four main holding styles are divided into thirty six sub-cases, which can cover a very free style of a user holding a smartphone. The classification of holding styles can support to get better performance of heading estimation. Further, the performance of the proposed methods is verified experimentally.
An Indoor/Outdoor Detection Method based on Smartphone
Khanh Nguyen-Huu,KyungHo Lee,Seon-Woo Lee 한국HCI학회 2017 한국HCI학회 학술대회 Vol.2017 No.2
In this paper, an effective method is suggested to detect whether a user is indoor or outdoor environment based on a set of sensors in a smartphone. There are not many tools or applications to detect the indoor/outdoor environment accurately but the environment information is useful for many location-based and context-aware applications such as indoor localization or activity recognition. The proposed methods attempts to classify current environment using a combination of six different types of sensors (Wifi module, the magnetometer, the status of battery charging, the GPS, the microphone, and the light sensor). The performance of the proposed methods is verified experimentally.
Advanced Magnetic Materials Produced by Using Rapid Quenching Technology
Nguyen Hoang Nghi,Nguyen Van Dung,Trinh Thi Thanh Nga,Bui Thi Khanh Nhung,Mai Thanh Tung,Nguyen Huu Tinh,Hoang Nhat Hieu,Bui Xuan Chien,Nguyen Thi Hong Tam 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.6
Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view. Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view.
Nguyen Huu Khanh Nhan,Tran Hoang Quang Minh,Nguyen Doan Quoc Anh 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.4
In this paper, a novel solution and application of the red Y2O3:Eu3+ dopant phosphor for enhancing color rendering index to more 86 for multi-chip white LED lamps (MCW-LEDs), which have correlated color temperature (CCT) of 7700 K, 6600 K, 5600 K, are presented. Then the effect of the concentration of Y2O3:Eu3+ phosphor on the color rendering index (CRI) is simulated, analyzed and demonstrated. After that the lumen output of MCW-LEDs depended on concentration Y2O3:Eu3+ phosphor is discovered. The lumen output has a decrease tendency at large weight range due to the enhancement extinction coefficient, according to Mie-scattering theory. Simulation results provided important conclusions for selecting and developing the phosphor materials in MCW-LEDs manufacturing.
Nguyen Doan Quoc Anh,Tran Hoang Quang Minh,Nguyen Huu,Khanh Nhan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.5
Recently, high-power light-emitting diodes (LEDs) have attracted great attention on the study and made remarkable progress. In this paper, method for enhancing uniform white light of a multi-chip white light LED by adding silicon dioxides in the phosphor layer is presented. Firstly, theory of study by using Mie theory and Monte Carlo ray-tracing is proposed. And then simulation and experimental results by using package LightTools software are performed. The experimental results and theory have the same direction: 1) the angular color temperature in narrow angles is much higher than that in wider angles for the non-SiO2 case and 2) in significantly reducing CCT deviation of a multi-chip white light LED by adding silicon dioxides in the phosphor layer.
랜드마크 및 층 감지 방법을 이용한 스마트폰 기반 실내 보행자 항법 시스템
이선우,Khanh Nguyen-Huu 제어·로봇·시스템학회 2020 제어·로봇·시스템학회 논문지 Vol.26 No.9
In this paper, an indoor PDR(Pedestrian Dead Reckoning) system using landmark and floor detection is proposed. The proposed method uses the PDR technique with error correction based on detecting the landmark. The system consists of an improved PDR, the landmark recognition, and the floor detection components. The improved PDR component is a PDR system with an improved capability using the recognition of holding styles. The landmark recognition component detects whether the user walks on the landmarks. Two kinds of landmarks are defined including the WiFi and the turning landmarks. The methods for recognizing each landmark are developed. Whenever the landmark is detected, the system updates the position with the given position of the landmark, which means to remove the cumulative position error. In addition, an adaptive floor detection method using a barometer and a WiFi fingerprinting technique is suggested for tracking a pedestrian in a multi-floor building. The experimental results on a three-floor building with three subjects show the superior performance of the proposed system. .