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Kyungho Lee,Junseok Jeon,Jong Man Kim,Gaabsoo Kim,김경아,Hye Ryoun Jang,Jung Eun Lee,Jae-Won Joh,Suk-Koo Lee,Wooseong Huh 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.1
Purpose: The incidence of chronic kidney disease (CKD) has been increasing due to improved survival after liver transplantation (LT). Risk factors of kidney injury after LT, especially perioperative management factors, are potentially modifiable. We investigated the risk factors associated with progressive CKD for 10 years after LT. Methods: This retrospective cohort study included 292 adult patients who underwent LT at a tertiary referral hospital between 2000 and 2008. Renal function was assessed by the e stimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease formula. The area under the curve of serial eGFR (AUCeGFR) was calculated for each patient to assess the trajectory of eGFR over the 10 years. Low AUCeGFR was considered progressive CKD. Linear regression analyses were performed to examine the associations between the variables and AUCeGFR. Results: Multivariable analysis showed that older age (regression coefficient = -0.53, P < 0.001), diabetes mellitus (DM) (regression coefficient = -6.93, P = 0.007), preoperative proteinuria (regression coefficient = -16.11, P < 0.001), preoperative acute kidney injury (AKI) (regression coefficient = -14.35, P < 0.001), postoperative AKI (regression coefficient = -3.86, P = 0.007), and postoperative mean vasopressor score (regression coefficient = -0.45, P = 0.034) were independently associated with progressive CKD. Conclusion: More careful renoprotective management is required in elderly LT patients with DM or preexisting proteinuria. Postoperative AKI and vasopressor dose may be potentially modifiable risk factors for progressive CKD.
YOO, Kyungho,SUNG, Sangkyung,LEE, Eunsung,LEE, Sanguk,KIM, Jaehoon,LEE, Ho-Jin,LEE, Young Jae THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIEN 2009 Transactions of the Japan Society for Aeronautical Vol.52 No.177
<P>Today Global Navigation Satellite Systems (GNSS) are widely used for determining position. Within the city environment, however, in which there are many tall buildings, GNSS signals are frequently interrupted, making it difficult for users to obtain information on their exact position. This paper analyzed the availability and positioning performance of a GPS augmented system within the Seoul urban area using the Japanese QZSS (Quasi-Zenith Satellite System) and a geostationary satellite. A 3-dimensional reproduction of Seoul that was based on the 3D GIS (Geographic Information System) Digital Map and a satellite tracking algorithm using Ray-Triangle Intersection algorithm were discussed. A satellite tracking algorithm was verified through filed testing and the QZSS orbit simulator was realized using Keplerian parameter. DOP (Dilution of Precision) and availability in the urban area of Seoul were analyzed using a GPS/QZSS/geostationary satellite separately and simultaneously.</P>
Lee, Kyungho,Lee, Songhyun,Jun, Youngsun,Choi, Minkee Academic Press 2017 Journal of catalysis Vol.347 No.-
<P><B>Abstract</B></P> <P>The cooperative effects of secondary mesoporosity and defects on the coke formation and deactivation of zeolite were investigated in <I>n</I>-pentane aromatization using model Ga/ZSM-5 catalysts. Mesoporosity was introduced to a commercial ZSM-5 by alkaline desilication, while the defects sites (<I>i.e.</I>, internal silanols) in zeolites were annealed by the treatment with ammoniumhexafluorosilicate. Aromatization after supporting Ga showed that the mesopore generation retarded catalyst deactivation via the suppression of internal coke formation while facilitating the external coke formation due to the enhanced diffusion of coke precursors <I>(e.g</I>., alkylaromatics) out of zeolite micropores. Internal coke can cause a more severe deactivation than external coke because the acid sites are mainly located in the zeolite micropores. However, the mesopore generation alone could not efficiently reduce the total amount of coke deposition (it mainly changed the location of coke). In contrast, the annealing of internal silanols could suppress the overall coke formation. This phenomenon could be explained by the fact that coke precursors are initially generated at the zeolite internal defects, and then deposited as coke at either the internal or the external surfaces of the zeolite depending on the relative kinetics of coke precursor diffusion and its polymerization. Consequently, the catalyst with mesoporosity and annealed internal silanols exhibited the slowest catalyst deactivation due to the suppression of both internal and external coke depositions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of zeolite mesopore and internal defects on coke formation were studied. </LI> <LI> Mesopore mainly changes the location of coke deposition, not its overall quantity. </LI> <LI> Mesopore induces external coke deposition which is less harmful than internal coke. </LI> <LI> Annealing defects suppress coke formation by inhibiting coke precursor formation. </LI> <LI> Generating mesopore while minimizing defect is effective for retarding deactivation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Inae,Kim, Sunmi,Kim, Ki-Tae,Kim, Sungkyoon,Park, Suhyun,Lee, Hyojin,Jeong, Yunsun,Lim, Jae-Eun,Moon, Hyo-Bang,Choi, Kyungho Elsevier 2018 Environment international Vol.117 No.-
<P><B>Abstract</B></P> <P>Bisphenol A (BPA) is one of the most widely used chemicals in various consumer products. In thermal papers such as receipts and tickets, BPA is used as a heat-activated developer. Cashiers are therefore suspected to be a vulnerable group of exposure to BPA, but neither contribution of receipt handling to the total body burden of BPA among cashiers, nor related health effects are well characterized. Female cashiers (n = 54) were recruited from seven retail shops of a major supermarket chain in Korea, and urinary levels of BPA and metabolic syndrome (MetS) related biomarkers were measured. In order to estimate the contribution of receipt handling to the body burden of BPA, an intervention was designed on the use of gloves: the subjects were asked not to wear gloves during the work for one week, and in the following week, to wear gloves. Urine samples were collected at pre-shift and post-shift for the first two consecutive days in each week, and urinary BPA concentrations were measured. In cashiers without gloves, about a two-fold increase in urinary BPA concentrations was observed after work-shift. When the cashiers wore gloves, however, urinary BPA levels showed no changes. Higher urinary BPA concentrations were associated with greater levels of fasting insulin and insulin resistance. Our observation shows that receipt handling among the cashiers could double the BPA exposure levels at post-shift compared to those at pre-shift, and use of simple protective equipment such as gloves could effectively reduce the BPA exposure levels.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Contribution of receipt handling to body burden of BPA was determined in cashiers. </LI> <LI> Without gloves, urinary BPA levels increased by two folds following work-shift. </LI> <LI> Use of gloves could efficiently prevent occupational exposure to BPA. </LI> <LI> Urinary BPA levels were associated with increased insulin levels and resistance. </LI> </UL> </P>
Lee, Gowoon,Lee, Sangwoo,Ha, Nayoung,Kho, Younglim,Park, Kyunghwa,Kim, Pilje,Ahn, Byeongwoo,Kim, Sunmi,Choi, Kyungho Academic Press 2019 Ecotoxicology and environmental safety Vol.173 No.-
<P><B>Abstract</B></P> <P>Gemfibrozil, a lipid-regulating pharmaceutical, has been widely used for treating dyslipidemia in humans and detected frequently in freshwater environments. Since plasma cholesterol is a precursor of steroid hormones, the use of gemfibrozil may influence the sex hormone balances. However, its endocrine toxicity following long-term exposure is not well understood. The purpose of the present study is to investigate the effects of gemfibrozil on sex hormones and reproductive outcomes in a freshwater fish, following a long-term (155 d) exposure. For this purpose, Japanese medaka embryos (F0) were exposed to a series of gemfibrozil concentrations, i.e., 0, 0.04, 0.4, 3.7, and 40 mg/L for 155 d, and reproductive parameters, sex hormones, and associated gene expressions were assessed. For comparison, a short-term exposure (21 d) was performed separately with adult medaka and measured for sex hormones and related gene expressions. Following the 155 d long-term exposure, the fecundity showed a decreasing pattern. In addition, at 3.7 mg/L gemfibrozil, testosterone (T) level in the female fish was significantly decreased, and the hatchability of F1 fish was significantly decreased. The <I>estrogen receptor</I> (<I>er)</I> or <I>vitellogenin</I> (<I>vtg)</I> genes in gonads and liver were up-regulated. However, plasma cholesterol levels did not show significant changes in both sexes. The observations from the short-term (21 d) exposure were different from those of the long-term exposure. Following the short-term exposure, decreased 17β-estradiol (E2), and 11-ketotestosterone (11-KT) levels along with decrease plasma cholesterol were observed in the male fish. The hormone disruption following the short-term exposure appears to be associated with the hypocholesterolemic activity of gemfibrozil. Our results show that the mechanisms of gemfibrozil toxicity may depend on the exposure duration. Consequences of long-term exposure to other fibrates in the water environment warrant further investigations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Exposure to gemfibrozil led to sex hormone and reproduction changes in fish. </LI> <LI> Changes in steroidogenesis and cholesterol levels were different by exposure duration. </LI> <LI> Long-term (155 d) exposure from embryo stage caused weak estrogenic responses. </LI> <LI> Short-term adult exposure caused decreased E2 levels. </LI> </UL> </P>