최루가스(o-Chlorobenzylidene Malononitrile)가 흰쥐의 각막과 결막에 미치는 영향

이군자 서울보건대학 1995 서울보건대학 부설 한국보건과학연구소 논문집 Vol.2 No.1

Two groups of rats were exposed to the o-chlorobenzylidine malononitrile(CS) being used in the control of riots, and sacrificed to examine histological and histochemical changes of the cornea and conjunctiva. 1. In animals exposed to the CS gas (50mg/min./㎥) for 20min., reversible histological changes were observed in the cornea. Epithelial and endothelial Na,^(+) K^(+) -ATPase activity were reduced, wing cells of the epithelium were transformed to the squamous shape and mitotic activity occurred actively in the basal layer. 2. In animals exposed repeatedly to the CS gas (50mg/min./㎥) for 20min. once a day for 10 days, Na^(+), K^(+)-ATPase, Mg^(2+)-ATPase and alkaline phosphatase activities of the corneal epithelium and endothelium were reduced. And there was epithelial shrinkage, irregular basement membrane and irregularly arranged collagen fibers were also observed in the stroma. 3. In animals exposed to the CS gas (50mg/min./㎥) for 20min., reversible histological changes were observed in the conjunctiva. Mucin secreting activity of the goblet cells was reduced and lymphocytes, eosinophils were infiltrated. 4. In animals exposed repeatedly to the CS gas (50mg/min./㎥) for 20min. once a day for 10 days, irreversible changes were observed. Desquamation with oedema and shrinkage of the epithelial cells, and loss of some basement membrane were observed. Mucin secreting activity of the goblet cells was reduced and lymphocytes, eosinophils were infiltrated significantly. As a result when eyes are temporally exposed to the CS gas reversible degenerative changes, desquamation with oedema of the epithelium and infiltration are produced. And when eyes are repeatedly exposed to the CS gas histopathologic changes such as desquamation with oedema of the epithelium, infiltration, and reduced mucin secreting activity are occurred.

뇌졸중 자연유발증 고혈압 쥐(SHRSP)의 골밀도 및 골성분의 변화

임순길,이근일 龍仁大學校 體育科學硏究所 2003 體育科學硏究論叢 Vol.13 No.1

The results of the present study on the comparison of the characteristics of BMD and BMC between the SHRSP and WKY were as follows: 1. There was a significant difference between WKY and SHRSP by bcdy weight, blood pressure, total-BMD and bone-salt(p <.0l). 2. There was a significant difference between WKY and SHRSP by Femorld-BMD, Femoral-salt, Femoral Breaking Force(p<.0l). 3. There was a significant difference between WKY and SHRSP by Femorld Wet Mass, Femoral-Organic content and bone ashes(p<.0l). 4. There was a significant difference between WKY and SHRSP by Femorld-Ca and Femoral-P 9p(p<.01). In conclusions, the SHRSP group tended to have a symptom of the osteoporosis by decreased BMD and Femoral Breaking Force with hypertensions as compared with the WKY group. The reason for decreased bone mass is possibly due to a deficiency of the composition of bone and an abnormality of the mineral deposition.

도서관학(圖書館學)과 정보과학분야(情報科學分野)에 있어서 색인지(索引誌) 6종(種)의 검색비교(檢索比較) (2)

Keen, E. Michael 한국과학기술정보연구원 과학기술정보센터 1978 Journal of Information Science Theory and Practice Vol.11 No.3

Trade Cycles in a Re-export Economy: The Case of Singapore

Keen Meng Choy 한국국제경제학회 2012 International Economic Journal Vol.26 No.2

This article uses econometric methods to test the hypothesis that Singapore is a ‘re-export economy’. If the hypothesis is true, merchandize exports and imports would co-move together over the course of trade cycles while exports would be insensitive to the exchange rate due to their high import content. Impulse response analysis of a monthly structural vector error correction model incorporating these trade aggregates, proxies for external demand and relative prices affirms the empirical validity of the re-export hypothesis. Innovation accounting also suggests that growth in the worldwide semiconductor industry rather than price competitiveness is the most important factor behind's Singapore's trade expansion in the long run.

Characterization of Antimony Resistant Bacterial Strains Isolated from the Sb-contaminated Soil

Keen-Ju Moonk,Hyun-jung Kim,In-Hyun Nam 대한환경공학회 2017 대한환경공학회 학술발표논문집 Vol.2017 No.11

도서관학(圖書館學)과 정보과학분야(情報科學分野)에 있어서 색인지(索引誌) 6종(種)의 검색비교(檢索比較) (1)

Keen, E. Michael 한국과학기술정보연구원 과학기술정보센터 1978 Journal of Information Science Theory and Practice Vol.11 No.2

THE SOCIAL COST OF MONOPOLY WITH ASYMMETRIC LOBBYING ABILITIES

Keen, Jung Hoon 한국경제학회 1998 The Korean Economic Review Vol.14 No.2

How solute-membrane interaction influences foulant formation in polymeric catalytic membrane: Competitive and sequential reactions

Ian Keen Koo,Poh Teck Lim,Xiao Chen,K.B. Goh 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

Foulant-induced deactivation usually limits polymeric catalytic membrane performance, but the mechanismsgoverning foulant formation remain poorly understood. Recent research suggests that the interactionbetween solutes and the membrane plays a crucial role in foulant formation. This paper proposes amolecular theory to explain how reactant/product-membrane interactions influence foulant formation. This theoretical approach allows us to untangle the coupled competitive/sequential reaction–non-idealdiffusion phenomena in deactivating polymeric catalytic membranes. In other words, we include thereactant and product molecular information when describing their non-ideal reaction–diffusion behaviorin confined polymeric environments; that is, they can interact (i) catalytically and (ii) non-catalyticallywith the membranes. We demonstrate how the non-catalytic reactant/product-membrane interactionscontrol the partitioning process between the membranes and bulk solutions, allowing us to capturethe formation of foulant locally and the global deactivation process. In our observations, we have foundthat attractive reactant-membrane interactions can enhance diffusion within the membrane, but this cancome at the cost of reduced catalytic activity. Conversely, with the repulsive pair interaction, the reactantsmust overcome a more significant energy barrier to penetrate the membranes, simultaneously limitingthe polymeric catalytic membrane performance and hindering foulant formation. In conclusion, ourtheory establishes a detailed understanding of reaction–diffusion phenomena governing foulant formationin polymeric catalytic membranes, considering the direct interaction between active reactants/productsand reactive membranes.

연구논문 : 후쿠자와 유키치(福澤諭吉)의 "궁리(窮理)" 인식과 과학제국주의

김성근 ( Sung Keen Kim ) 한국동서철학회 2015 동서철학연구 Vol.76 No.-

본 논문은 메이지 일본의 개화사상가 후쿠자와 유키치(福澤諭吉, 1835-1901)의 ‘궁리(窮理)’ 개념을 중심으로 그의 과학사상과 문명론을 살펴본 것이다. ‘궁리’라는 어휘는 일찍이 ‘격물’과 함께 사물의 이치에 대한 탐구를 뜻하는 주자학의 대표적 어휘였다. 그러나 후쿠자와에 의해 이 ‘궁리’ 개념은 물리적 대상세계에 대한 법칙적 탐구로 한정되었다. 즉, 후쿠자와는 ‘궁리’를 자연철학(natural philosophy), 혹은 자연과학(natural science)의 뜻으로 사용했고, 그것은 인간의 삶의 환경을 개선하는데 중요한 실용적 학문이라고 보았다. 후쿠자와의 ‘궁리’가 문명 발달의 핵심적인 지식으로 규정된 것은 『학문의 권유』(1872년 초편), 『문명론의 개략』(1875년) 등을 통해서였다. 후쿠자와는 인류의 문명이란 애당초 ‘미개’, ‘반개’, ‘문명’이라는 3단계의 발전 과정을 거친다고 보았다. 아울러 당시 문명의 발달에서 가장 앞선 것은 서양문명으로, 그 근저에는 바로 궁리(궁리학)에 대한 탐구가 있다고 역설했다. 그러나 동시에 후쿠자와에게 있어 문명이란 국가의 독립이 없이는 가능한 것이 아니었다. 후쿠자와의 문명론에 놓인 이 같은 문명=국가의 논리는 1881년 『시사소언』의 집필 이후, 일본의 독립에 대한 위기감이 심화될수록, 후쿠자와의 문명론을 국가론 속에 매몰시켜간 요인이었다. 즉, 후쿠자와는 일본의 독립을 위해서라면 주변국인 중국, 조선을 문명의 세계로 이끌 필요가 있고, 불가피한 경우에는 위력의 사용 또한 용인될 수 있다고 주장했다. 그 같은 문명론의 국가주의적 경도는 일찍이 후쿠자와 스스로가 문명 발달의 핵심적 지식으로서 인간의 삶의 환경을 개선하는 학문으로 이해했던 ‘궁리’를 국가적 산업, 즉 식산을 위한 학문으로 재인식하게 만들었다. 즉, 후쿠자와에게 있어 문명의 발달이 국가 독립의 수단으로 인식되어갈 때, 문명 발달의 중요한 척도였던 궁리(물리)도 국가의 독립을 위한 수단으로 인식될 수밖에 없었던 것이다. 이 같은 후쿠자와의 궁리(물리) 이해는 메이지 계몽사상의 시대적 특징을 보여줌과 동시에, 20세기 초에 등장했던 일본의 ‘국가적 과학’의 모습을 미리 예견한 것이기도 했다. This article studies Fukuzawa Yukichi``s scientific thought and the theory of civilization, centering on his understanding of physics, which he called Kyuri(窮理). Kyuri was one of the most important concepts of Neo-confucianism, along with a concept of Kakubutsu(格物). However, Fukuzawa redefined the concept of kyuri in the meaning of the research against the physical world. He used the term kyuri as the same meaning with natural philosophy or natural science, and illustrated that kyuri was the most useful knowledge to advance human life and environment. In his books, Gakumon no Susume(1872-) and Bunmeiron no Kairyaku(1875), however, Fukuzawa insisted that kyuri was the main knowledge for the development of human civilization. He also insisted that civilization could be developed through three steps, which were the uncivilized stage(野蠻), the semicivilized stage(半開), and the civilized stage(文明). Moreover, he illustrated that the reason why Western countries were highly civilized at that time was because they had studied kyuri. After he published jijishogen(1881), however, Fukuzawa``s theory of civilization was obsessed by nationalistic thinking because he felt the crisis of independence of Japan. According to Fukuzawa, civilization of a nation could not develop unless the nation became independent first. This idea of civilizaion=nation supported Fukuzawa’s aggressive thinking that Meiji Japanese had to civilize China and Choseon to get over their national crisis, and if it was impossible, Japanese military power could be considered to those countries. Having a nationalistic understanding of the theory of civilization, Fukuzawa thought newly that kyuri should be not only the knowledge for advancing human life and environment, but also for the national increase of production. When Fukuzawa thought that the development of civilization was just a tool for national independence, butsuri was defined as the tool for national independence. Fukuzawa``s understanding of butsuri showed the properties of Meiji thinkers`` philosophy of enlightenment, and would also predict in advance Japan``s national science which was connected with Japanese imperialism in the early 20th century.

Effects of Flavonoid-Rich Beverages on Prostacyclin Synthesis in Humans and Human Aortic Endothelial Cells: Association with Ex Vivo Platelet Function

Carl L. Keen,John A. Polagruto,Derek D. Schramm,Janice F. Wang-Polagruto,Luke Lee 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4

Diets rich in flavonoids have been associated with reduced risk for cardiovascular disease. This may be due,in part, to flavonoid-induced alterations in eicosanoid synthesis. Our objective was to identify plant-derived beverages that al-ter synthesis of prostacyclin in cultured human aortic endothelial cells (HAEC), and to determine if these beverages could al-ter in vivo6-keto-prostaglandin F 1a (a stable metabolite of prostacyclin) synthesis and platelet function. HAEC were treatedwith nine commonly consumed beverages to determine their effects on prostacyclin synthesis under acute and chronic treat-ment regimens. Orange, purple grape, and pomegranate juices and coffee (6 9 mL/kg) were then provided to 28 fasted, healthyadult subjects (eight men and 20 women) on five separate days. Plasma samples were collected immediately following juiceconsumption (baseline), and at 2 and 6 hours post-consumption. On an acute basis, administration of HAEC with pomegran-ate juice increased media prostacyclin. Chronic exposure to purple grape and pomegranate juice increased aortic endothelialcell prostacyclin synthesis (38% and 61%, respectively; P, .05). The consumption of purple grape, pomegranate, and orangejuice prolonged epinephrine/collagen-induced clotting time (P, .05). Purple grape juice increased plasma 6-keto-prostaglandinF1a (20%; P, .05) at 2 hours; pomegranate and orange juice did not significantly influence plasma prostacyclin concentra-tions. Consistent with the in vitrodata, coffee consumption did not influence clotting time or plasma prostacyclin concentra-tions. These results indicate that the HAEC model system can provide a qualitative means to screen food and food-derivedproducts for biologic activity related to cardiovascular health.