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( Makiko Tanaka ),( Kazuhiko Fukatsu ),( Ryota Shinohara ),( Koji Arizono ),( Hiroshi Ishibashi ),( Masataka Hanashima ),( Sotarou Higuchi ),( Keijirou Tomoda ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1
Our study aims to establish a practical monitoring system by using Japanese Medaka (Oryzias latipes) for drainage from a landfill site and the environment around it. The monitoring system consists of 2 phases. The first phase is water testes, and the second phase is ecological monitoring. In this paper, we reported the first phase. We carried out the first phase experiment using untreated leachate and treated leachate processed by 3 types of advanced processes (Electric dialysis, RO, and DT module system). Untreated and treated leachate from the processing plant, Wakamatsu-ku, Kitakyushu city, Japan was used. The test items were acute toxicity of embryo, juvenile and adult, fecundity, and vitellogenesis as an estrogenic activity. Toxicity of leachate increased according to TOC concentration. Juvenile of Medaka was a very useful indicator of the toxicity of the leachate. No vitellogenin was induced after 2 weeks exposure to untreated leachate, although suspected EDCs were detected by GC/MS or targeted analysis. HSI increased in the case of exposure to diluted leachate (TOC concentration, 107, 214 mg/1). As the leachate has strong complex toxicities, it is difficult to evaluate the leachate by vitellogenin inducing only. Fecundity and vitellogenesis ware not effected by exposure to 2% concentration of leachate for 1 and 2 weeks exposure. Advanced treated leachate induced no acute toxicity, vitelogenesis, and reproduction.
송사리(Oryzias latipes)를 이용한 매립지에서의 내분비 교란물질 모니터링 시스템
( Makiko Tanaka ),( Kazuhiko Fukatsu ),( Ryota Shinohara ),( Koji Arizono ),( Hiroshi Ishibashi ),( Masataka Hanashima ),( Sotarou Higuchi ),( Keijirou Tomoda ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2
본 논문의 목적은 매립지와 매립지 주변환경에 대해서 송사리를 사용하여 실제 내분비교란물질에 대한 모니터링 시스템을 수립하는데 있으며, 그 모니터링 시스템은 2개phase 구성되어 있다. 첫번째 phase는 물에 대한 실험이며, 두번째 phase는 생태적 모니터링이다. 본 논문에서는 첫번째 phase에 관해서 나타내었으며, 이 실험에서는 처리되지 않는 침출수와 고도 처리된3가지(전기투석, 역삼투압, DT module system)의 침출수를 사용하여 실험을 실시하였다. 이때의 침출수는 일본의 若 松區北九州市에 위치한 매립지의 침출수를 이용하였다. 실험항목은 송사리의 태아, 치어, 성어의 급성 독성, 송사리의 생산성, 에스트로젠 활성도로써의 vitellogenesis 실험을 실시하였으며, 침출수의 의독성은 TOC농도에 따라 증가하였다. 송사리의 치어는 침출수의 독성 지표로 유용하였다. 비록, GC/MS를 이용하여 EDCs로 의심되는 물질이 검출될지라도, 처리되지 않은 침출수로부터의 2주간 노출시 vitellogenin는 유도되지 않았다. HIS는 희석된 침출수 (TOC 농도 107, 214mg/l)에 노출시 증가하였다. 침출수는 강한 복합독성을 가지고 있으므로, 오직 vitellogenin 변형만으로 침출수를 평가하기에는 어려움을 가지고 있으며, 생상성과 vitellogenesis는 2%농도에서 1-2주일간의 노출시 어떤 영향도 없었다. 고도처리된 침출수는 급성독성, 생산성과 vitellogenesis의 변화가 없었다. Our study aims to establish a practical monitoring system by using Japanese Medaka (Oryzias latipes) for drainage from a landfill site and the environment around k. The monitoring system consists of 2 phases. The first phase is water testes, and the second phase is ecological monitoring. In this paper, we reported the first phase. We carried out the first phase experiment using untreated leachate and treated leachate processed by 3 types of advanced processes (Electric dialysis, RO, and DT module system). Untreated and treated leachate from the processing plant, Wakamatsu-ku, Kitakyushu city, Japan was used. The test items were acute toxicity of embryo, juvenile and adult, fecundity, and vitellogenesis as an estrogenic activity. Toxicity of leachate increased according to TOC concentration. Juvenile of Medaka was a very useful indicator of the toxicity of the leachate. No vitellogenin was induced after 2 weeks exposure to untreated leachate, although suspected EDCs were detected by GC/MS or targeted analysis. HSI increased in the case of exposure to diluted leachate (TOC concentration, 107, 214 mg/l). As the leachate has strong complex toxicities, it is difficult to evaluate the leachate by vitellogenin inducing only. Fecundity and vitellogenesis ware not effected by exposure to 2% concentration of leachate for 1 and 2 weeks exposure. Advanced treated leachate induced no acute toxicity, vitellogenesis, and reproduction.
( Drug Therapy ),( Kazuhiko Nakamura ),( Kazuya Akahoshi ),( Toshiaki Ochiai ),( Keishi Komori ),( Kazuhiro Haraguchi ),( Munehiro Tanaka ),( Norimoto Nakamura ),( Yoshimasa Tanaka ),( Kana Kakigao ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.4
Background/Aims: Antithrombotic/nonsteroidal antiinflammatory drug (NSAID) therapies increase the incidence of upper gastrointestinal bleeding. The features of hemorrhagic peptic ulcer disease in patients receiving antithrombotic/NSAID therapies were investigated. Methods: We investigated the medical records of 485 consecutive patients who underwent esophagogastroduodenoscopy and were diagnosed with hemorrhagic gastroduodenal ulcers. The patients treated with antithrombotic agents/NSAIDs were categorized as the antithrombotic therapy (AT) group (n=213). The patients who were not treated with antithrombotics/NSAIDs were categorized as the control (C) group (n=263). The clinical characteristics were compared between the groups. Results: The patients in the AT group were significantly older than those in the C group (p<0.0001). The hemoglobin levels before/without transfusion were significantly lower in the AT group (8.24±2.41 g/dL) than in the C group (9.44±2.95 g/dL) (p<0.0001). After adjusting for age, the difference in the hemoglobin levels between the two groups remained significant (p=0.0334). The transfusion rates were significantly higher in the AT group than in the C group (p=0.0002). However, the outcome of endoscopic hemostasis was similar in the AT and C groups. Conclusions: Patients with hemorrhagic peptic ulcers receiving antithrombotic/NSAID therapies were exposed to a greater risk of severe bleeding that required transfusion but were still treatable by endoscopy. (Gut Liver 2012;6:423-426)
Clinical Usefulness of Dual Red Imaging in Gastric Endoscopic Submucosal Dissection: A Pilot Study
Naoki Yorita,Shiro Oka,Shinji Tanaka,Takahiro Kotachi,Naoko Nagasaki,Kosaku Hata,Kazutaka Kuroki,Kazuhiko Masuda,Mio Kurihara,Mariko Kiso,Tomoyuki Boda,Masanori Ito,Kazuaki Chayama 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.1
Background/Aims: Dual red imaging (DRI) is a new, image-enhanced endoscopy technique. There are few reports about the usefulnessof DRI during gastric endoscopic submucosal dissection (ESD). We aimed to examine the usefulness of DRI in endoscopic hemostasisduring gastric ESD. Methods: We enrolled a total of 20 consecutive patients who underwent gastric ESD. Five endoscopists compared DRI with white lightimaging (WLI) for the visibility of blood vessels and bleeding points while performing endoscopic hemostasis. Results: The visibility of blood vessels was increased in 56% (19/34) of the cases, and the visibility of bleeding points was improved in55% (11/20) of the cases with the use of DRI compared with the use of WLI. Conclusions: DRI improved the visibility of blood vessels and bleeding points in cases with oozing bleeding, blood pooling around thebleeding points, and multiple bleeding points.