Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

과일속의 蛋白質 分解酵素의 食肉軟化劑로서의 利用에 關한 硏究

許康七,韓基暎,崔一信 안성산업대학교 1992 論文集 Vol.24 No.-

Crude proteases were prepared from fig, pear, papaya, kiwifruit and pineapple. The percentage of recovery of these crude proteases were 0.092, 0.267, 0.145, 0.612 and 0.19%, and pH of final prepared solutions were 7.63, 8.11, 6.59, 3.20 and 3.99 respectively. The hydrolyzation of chicken pectoral myosin by every crude protease observed wit SDS-PAGE showed that crude protease of pineapple, fig and kiwifruit exibited strong hydrolyzation, comparatively.

보조금행정에 대한 법적통제

許康茂 전북대학교 법학연구소 2002 法學硏究 Vol.23 No.-

Recently the higher the political·economic importance of a subsidy, the more making a demand an administrative reform such as arrangement and rationalization of subsidy. Nevertheless a statue which is disciplined subsidy is exceedingly scanty , the management which is left to administration's discretion in actual fact don't practical expost facto control in that financial loss grows heavier, whereas the control of a national assembly gradually reduces. In this reality, it is necessary viewpoint that the legal issue of subsidization solves with focusing on legal control with usual discussion - a form of an act of subsidizaton and the existence·nonexistence of the necessity with legal reservation. That is to say, if we grasp the practical affairs of subsidization that is managed on a large scale extraordinarily without legal basis, we need to investgate 'regulative law' and 'the principal of control' which secured impartiality, such as the control of national assembly, administrative process and judical judgment. At this sense of sight, this paper examine the general discussion with subsidization in Chapter 2, I will descirbe the summary contents with legal control and a detaied control system in Chapter 3. In addition to I will argue about, necessities and problems with legal control of subsidization in Chapter 4 shortly.

멀티미디어 데이타를 위한 DMA 스케쥴링을 포함한 ULS의 설계

허미경,송태섭,이강두 진주여자전문대학 1994 論文集 Vol.17 No.-

Next generation computer will have hardware support for digital "Continuous Media"(CM) such as audio and video. CM applications handle at high rate, with strict timing requirment. To run effienciently such application, an operating system must provide scheduling and IPC mechanism that reflect these needs. We propose that lightweight process to run effienciently mutiple address space, that is, user level scheduling of split-leve scheduling combines DMA scheduling by analysing multimedia data. These mechanism reduce kernel interaction and CPU overhead.

Switched Gacitor 저역통과 여파기의 최적 설계에 관한 연구

許康仁 동아대학교 공과대학 부설 한국자원개발연구소 1983 硏究報告 Vol.7 No.2

In this paper, General techniques for realizing differential integrator transformation and reduced OP-Amp transformation in low pass SCF are presented. The results of experiment are as follows. 1. The realization of SCF by two transformation can be made satisfactorily. 2. Differents between theoretical values and measured ones are considered due to the tolerances of components. 3. The realization of SCF by reduced OP-Amp transformation has less than error than by conventional differential transformation. 4. It is concluded that error can be reduced siginificantly when we make these filters of MOS IC which has better temperature and linear characteristics.

都市計劃施設事業과 財政分權 : 10年 以上 未執行 都市計劃施設敷地 買受費用의 財源 確保를 中心으로 Centering around Securing Financial Resources of the Purchase Expense of Unexecuted Urban Planning Facilities Site more than ten years

許康茂 한국공법학회 2004 공법연구 Vol.32 No.4

Urban planning facilities which are determinded by urban management plan are needed to support urban economic activities and to offer agreeable life space to inhabitants. However owing to weak lack of finance local government delayed the execution of urban planning facilities, as occurs serious infringement of private property right and the enmity of the people by relevant local inhabitant. In the unexecuted urban planning facilities problem in long-term, the effort of relevant local government is important. But more fundamentally when a financial support of government is sure to be premised, it will be able to solve the problem. In addition to relevant local government is to show the will of the solution for unexecuted urban planning facilities through management such as adjustmentㆍannulment of nonessential urban planning facilities designation and financial securement by improvement of urban planning. Besides government is to recapture betterment to achieve urban planning facilities work smoothly and is to divide it between government and local government with impartiality. In conclusion it is necessary that government should enact「a special law」in order to find a solution to the problem of urban planning facilities accumulated for a large number of years effectively.

정상인의 입각기에서 발바닥압력측정시 압력중심점의 위치

허재균,박시복,이상건,이강목,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

디지탈 시스템에서의 Sampling-Rate 변환을 위한 FIR구조의 구성에 관한 연구

金明起,許康仁 동아대학교 공과대학 부설 한국자원개발연구소 1986 硏究報告 Vol.10 No.1

In this paper, A general theory of multistage Interpolator and decimator for sampling rate reduction and sampling rate increase is presented. The use of classical interpolation methods in signal processing application is illustrated by a discussion of FIR interpolation filters derived from the Lagrange interpolation formula. Example is presented to compute the unit sample response of a sampling rate converter which converts data from a sampling rate of M to L.

PCM Voice CODEC의 Switched Capacitor Filter의 구성에 관한 연구

변건식,허강인 동아대학교 공과대학 부설 한국자원개발연구소 1984 硏究報告 Vol.8 No.2

Three Switched Capacitor decimation and interpolation circuits are described which perform all filtering functions in PCM Voice CODEC. The decimator can function as an input stage, the interpolator as an output stage in a filter system. The CODEC consists of 2 chips- the transmit chip includes the companding coder along with filtering functions, and the receive chip consists of the expanding decoder chip with its smoothing filter. Experimental results show the circuit to meet accepted requirements.

鷄糞의 飼料利用性에 關한 硏究 : 乾燥鷄糞의 採卵鷄育成에 있어서의 經濟性 Economic returns of Dried poultry waste in brooding of Laying hens

扈敬鎭,印致雄,한기영,許康七 안성산업대학교 1978 論文集 Vol.10 No.-

1. In order to decide a feasibility for partial substitution of dried poultry waste for complete formula feed and to decide an eligible levels for the substitution, growing trials were carried out under four treatments with three veplications in randomized block design, and the treatments were based upon the substitution rates such as 5%, 10%, 15% and check for two groups of chicks for Layer, namely, 7 to 12 weeks aged one and 13 to 20 weeks aged one. 2. While no significant differences were found in the increased body weight, feed consumption and egglaying rate among the treatments, partial substitution of the D. P. W, for complete formula feed seemed to be feasible, like as that of grain or grain bran, since no any interruptions were occurred in the way of the substitution. 3. The reason that the feeding efficiency of substitution of D. P. W. for complete formula feed to those of 13 to 20 weeks aged chicks, was shown far better than that of those of 7 to 12 weeks aged chicks, seemed to be attributable to the less nutrient deficlency derived from those substitutions. Therefore, such results might be reflected to those advantages for 13 to 20 weeks aged chicks over those of the other chicks. 4. While no significant differences were found in egg laying rate and egg weight among the treatments, 15% substitution plot showed a little over that of check plot, and this result might indicate that the egg laying may not be influenced by the substitution of feeding. 5. Refering to economic returns of substitution utilization of D. P. W for complete formula feed, while the advantages were shown top grade at 5% and in order of 10%, 15% of the substitution on 7 to 12 weeks aged chicks, advantages were also shown in order of 5%, 10%, 15% of the substitution on 13 to 20 weeks aged chicks. These results seemed to be feasible even in beyond of 15% of the substitution. 6. Since it was not able to find out the eligible levels of the substitution D. P. W. for complete formula feed for 13 to 20 weeks aged chicks in this study, the following studies shall be desirable in the future. (1) eligible substitution levels of D. P. W. for complete formula feed in those of 13 to 20 weeks aged chicks. (2) economic returns for Laying Hens through substitution D. P. W. for complete foumula feed in growing.