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Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer
Kai Xiong,Hejun Zhang,Yang Du,Jie Tian,Shigang Ding 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Histone deacetylase inhibitors (HDACis) are a new class of anticancer drugs confirmed to have good therapeutic effects against gastric cancer (GC) in preclinical experiments, but most HDACis are non-selective (pan-HDACis), with highly toxic side effects. Therefore, it is necessary to screen HDAC family members that play key roles in GC as therapeutic targets to reduce toxic side effects. In this study, we evaluated the targeting specificity of the HDACi suberoylanilide hydroxamic acid (SAHA) for GC via fluorescence molecular imaging (FMI). In vitro FMI results showed that SAHA had higher binding affinity for GC cells than for normal gastric cells. In vivo FMI of gastric tumor-bearing mice confirmed that SAHA can be enriched in GC tissues. However, there was also a high-concentration distribution in normal organs such as the stomach and lungs, suggesting potential side effects. In addition, we found that among the HDAC family members, HDAC9 was the most significantly upregulated in GC cells, and we verified this upregulation in GC tissues. Further experiments confirmed that knockdown of HDAC9 inhibits cell growth, reduces colony formation, and induces apoptosis and cell cycle arrest. These results suggest that HDAC9 has an oncogenic role in GC. Moreover, HDAC9 siRNA suppressed GC tumor growth and enhanced the antitumor efficacy of cisplatin in GC treatment by inhibiting the proliferation and inducing the apoptosis of GC cells in vitro and in vivo. Our findings suggest that the development of HDAC9-selective HDACis is a potential approach to improve the efficacy of chemotherapy and reduce systemic toxicity.
Kai Yang,Cheng FangWang,Chun Xue You,Zhu Feng Geng,Rui Qi Sun,Shan Shan Guo,Shu Shan Du,Zhi Long Liu,Zhi Wei Deng 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.3
During our screening program for agrochemicals from Chinese medicinal herbs and wild plants, the essential oilof Litsea cubeba fruits was found to possess strong contact toxicity against the cigarette beetle Lasiodermaserricorne adults and the booklouse Liposcelis bostrychophila, with LD50 values of 27.33 μg/adult and71.56 μg/cm2, respectively, and also showed strong fumigant toxicity against the two stored product insectswith LC50 values of 22.97 and 0.73 mg/L, respectively. The essential oil obtained by hydrodistillation wasinvestigated by GC MS. The main components of the essential oil were identified to be E-citral (geranial)(27.49%), Z-citral (neral) (23.57%) and D-limonene (18.82%) followed by β-thujene (3.34%), β-pinene (2.85%), α-pinene (2.57%), 6-methyl-5-hepten-2-one (2.40%) and linalool (2.36%). Citral (Z/E-citral), D-limonene, β-pinene,α-pinene and linalool were separated and purified by silica gel column chromatography and preparative thinlayer chromatography, and further identified by means of physicochemical and spectrometric analysis. Citral andlinalool showed strong contact toxicity against L. serricorne and L. bostrychophila (LD50 = 11.76, 12.74 μg/adultand 20.15, 99.97 μg/cm2, respectively) and fumigant toxicity against L. serricorne and L. bostrychophila (16.54,18.04 mg/L air and 0.14, 0.71 mg/L air, respectively). Otherwise, citral, D-limonene and linalool were strongly repellentagainst the cigarette beetle L. serricorne as the essential oil whereas β-pinene and α-pinene exhibited weakerrepellency against the cigarette beetle compared with the positive control, DEET. Moreover, except α-pinene andlinalool, the other three compounds as well as the essential oil exhibited comparable repellency against thebooklouse relative to DEET.
Online Adaptive Optimal Tracking Control of Nonholonomic Mobile Robot
Kai Wang,Yingmin Jia,Junping Du,Jun Zhang 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
A velocity control law is developed for the kinematic steering system of nonholonomic mobile robot to track a reference trajectory not only to make the posture error asymptotically stable but also considered optimality based on a pre-defined cost function. In order to make the cost function finite, we transformed the tracking problem into a regulation problem by redefining system states and inputs. The proposed online and forward-in-time policy iteration (PI) algorithm based on approximate dynamic programming (ADP) to solve the continuous-time(CT) optimal control problem with infinite horizon cost by solving of Hamilton-Jacobi-Bellman (HJB) equation. This method learns online in real-time to approximate the cost function by using a single neural networks (NNs), and then the near optimal control policy can be computed directly according to the cost function, which removes the action network appearing in the ordinary ADP methods. Simulation results are provided to demonstrate the effectiveness of the proposed approach.
( Kai Wang ),( Xiao Dong Du ),( Kuk Tae Youn ),( Yasunori Hayashi ),( Chan Gyu Lee ),( Bon Heun Koo ) 대한금속재료학회 ( 구 대한금속학회 ) 2008 METALS AND MATERIALS International Vol.14 No.6
The impact-wear properties of low carbon high manganese alloy steel were tested under three different impact energies (0.7 J, 1.2 J and 1.7 J) using a modified MLD-10 wear tester. SEM inspection of the wear surface and subsurface optical metallographic analysis reveal the impact wear mechanism. Under corrosive conditions we observe a shift from single micro-cutting to impact-flaking, after the appearance of vertical section micro-cracks, while at higher impact energies fatigue corrosion and abrasion are observed.
An Iterative Algorithm for Solving the Least-Squares Problem of Matrix Equation AXB+CYD=E
Kai-juan Shen,Chuan-hua You,Yu-xia Du 한국전산응용수학회 2008 Journal of applied mathematics & informatics Vol.26 No.5
In this paper, an iterative method is proposed to solve the least-squares problem of matrix equation AXB + CY D = E over un-known matrix pair [X, Y ]. By this iterative method, for any initial matrix pair [X1, Y1], a solution pair or the least-norm least-squares solution pair of which can be obtained within finite iterative steps in the absence of roundoff errors. In addition, we also consider the optimal approximation problem for the given matrix pair [X0, Y0] in Frobenius norm. Given numerical examples show that the algorithm is efficient. In this paper, an iterative method is proposed to solve the least-squares problem of matrix equation AXB + CY D = E over un-known matrix pair [X, Y ]. By this iterative method, for any initial matrix pair [X1, Y1], a solution pair or the least-norm least-squares solution pair of which can be obtained within finite iterative steps in the absence of roundoff errors. In addition, we also consider the optimal approximation problem for the given matrix pair [X0, Y0] in Frobenius norm. Given numerical examples show that the algorithm is efficient.
Isolation and Characterization of a Putative Vacuolar Na+/H+ Antiporter Gene from Zoysia japonica L.
Yanhua Du,Qian Hei,Yaxin Liu,Hui Zhang,Kai Xu,Tao Xia 한국식물학회 2010 Journal of Plant Biology Vol.52 No.4
A Na+/H+ antiporter gene from Zoysia japonica (ZjNHX1) which is a member of plant NHX-genes family was cloned by reverse-transcription-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE)technology. The isolated cDNA is 2,421 bp in length and contains one open-reading frame (ORF) which comprises 540amino acid residues and shows higher homology with other plant Na+/H+ antiporters. ZjNHX1 could partially complement the salt-sensitive phenotypes of Δnhx1 and Δena1-4Δnhx1 yeast mutants in the presence of NaCl, KCl, and LiCl. The expression of ZjNHX1 in Z. japonica increased after NaCl treatment and this result accords with that of Na+contents determination under the same treatment. These results implied that ZjNHX1 functions as a vacuolar Na+/H+antiporter and plays an important role in salt tolerance and ion homeostasis in Z. japonica.
AN ITERATIVE ALGORITHM FOR SOLVING THE LEAST-SQUARES PROBLEM OF MATRIX EQUATION AXB+CYD=E
Shen, Kai-Juan,You, Chuan-Hua,Du, Yu-Xia Korean Society of Computational and Applied Mathem 2008 Journal of applied mathematics & informatics Vol.26 No.5
In this paper, an iterative method is proposed to solve the least-squares problem of matrix equation AXB+CYD=E over unknown matrix pair [X, Y]. By this iterative method, for any initial matrix pair [$X_1,\;Y_1$], a solution pair or the least-norm least-squares solution pair of which can be obtained within finite iterative steps in the absence of roundoff errors. In addition, we also consider the optimal approximation problem for the given matrix pair [$X_0,\;Y_0$] in Frobenius norm. Given numerical examples show that the algorithm is efficient.
Qi Chaoqi,Du Yang,Yang Ping,Liu Zhengwu,Lyu Hongya,Zhao Kai,Guo Lijie 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.12
The phase composition, microstructure, tensile properties of TC4 samples produced by laser melting deposition (LMD)and LMD followed by solution-aging treatment were investigated to explore a simpler approach to improve the mechanicalperformances and eliminate negative influences by post treatment. The as-deposited TC4 microstructure showed a combinationof α΄martensite and α-colony with various shapes, such as acicular, rod-like and lamellar. As a synergistic result ofsolution and aging treatment, the dispersion strengthening of secondary-α as well as optimization on length-width ratio ofprimary-α and volume fraction of β-phase cause an increase in the ductility and strength. Meanwhile, there is a differencebetween microstructure of water-quenched specimens and air-cooled specimens, subsequently playing a key role in properties. The solution with air-cooling and aging is comparatively found to significantly reduce the anisotropy and improvecomprehensive performance.
Synthesis and Solution Properties of Fluorinated Amphiphilic Polyacrylamide
Fangyuan Zhao,Kai Du,Zhuo Yi,Chao Du,Zhao Fang,Bingquan Mao 한국고분자학회 2015 폴리머 Vol.39 No.3
A series of hydrophobically associating fluorinated amphiphilic polyacrylamide copolymers with remarkably high heat resistance and salt tolerance were synthesized by free radical micellar copolymerization, using acrylamide (AM) and sodium 2-acrylamido-tetradecane sulfonate (AMC14S) as amphiphilic monomers, and 2-(perfluorooctyl) ethyl acrylate (PFHEA) as hydrophobic monomer. The structure of the terpolymer was characterized by FTIR, <SUP>1</SUP>H NMR and <SUP>19</SUP>F NMR. The solution properties of the terpolymers were investigated in details, and the results showed that the terpolymer solution had strong intermolecular hydrophobic association as the concentration exceeded the critical association concentration 1.5 g/L. The terpolymer solution possessed high surface activity, viscoelasticity, excellent heat resistance, salt tolerance and shearing resistance. The viscosity retention rate of copolymer solution was as high as 59.9% under the condition of fresh wastewater, 85℃ and a 60-days aging test.