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Kwon, Ka Hee,Hwang, Sun Young,Moon, Bo Youn,Park, Young Kyung,Shin, Sook,Hwang, Cheol-Yong,Park, Yong Ho AAVLD 2012 Journal of veterinary diagnostic investigation Vol.24 No.5
<P>Enterococci are major zoonotic bacteria that cause opportunistic infections in human beings and animals. Moreover, pathogenic strains can be disseminated between human beings and animals, particularly companion animals that come into frequent contact with people. Recently, Enterococcus faecium clonal complex 17 (CC17) has emerged as a pandemic clone. Most CC17 strains are ampicillin resistant and possess virulence genes such as esp and hyl. Despite the possible dissemination of CC17 between human beings and animals, prevalence data about CC17 in animals is limited. In the present study, the phenotypes and genotypes of antimicrobial resistance were compared, as well as virulence gene profiles from 184 enterococci strains isolated from chickens, pigs, companion animals, and human patients in Korea. Ampicillin-resistant E. faecium (AREF) strains were selected, and multilocus sequence typing was performed to investigate the dispersion of CC17 among animals and human beings. The companion animal and human isolates showed high resistance rates to ampicillin and ciprofloxacin, whereas food animal isolates showed high tetracycline and erythromycin resistance rates. Ampicillin-resistant E. faecium was only detected in human (21/21 E. faecium, 100%) and companion animal (3/5 E. faecium, 60%) isolates, and all human AREF strains and 1 canine AREF strain were confirmed as CC17. In conclusion, the occurrence of antimicrobial resistance and virulence genes, and the distribution of enterococcal CC17 in companion animal enterococcal strains were similar to those of human strains rather than to those of food animal strains.</P>
아스파라거스(Asparagus officinalis L.) 뿌리 추출물의 항염증 및 항통풍 효과
이현주(Hyeon Ju Lee),한준희(Joon-Hee Han),홍민(Min Hong),최다혜(Da-Hye Choi),김종희(Jong-Hui Kim),박가희(Ka-Hee Park),박연희(Yeon-Hee Park),이재희(Jae Hee Lee),강해주(Hae Ju Kang),권태형(Tae-Hyung Kwon),안용조(Yong Jo Ahn) 한국식품과학회 2022 한국식품과학회지 Vol.54 No.6
본 연구에서는 ARW의 항염증 및 항통풍 효능을 평가하였다. LPS가 처리된 RAW 264.7 대식 세포에서 독성을 보이지 않았으며, ARW는 NO 생성 비율을 250 μg/mL 농도에서 87.3±3.3%, 500 μg/mL 농도에서 73.5±4.7%으로 NO 생성을 억제하였다. 또한 LPS를 단독 처리한 군의 경우 iNOS, COX-2 mRNA 발현이 증가하였고 LPS 및 ARW 500 μg/mL 처리한 농도군에서 COX-2 및 iNOS의 mRNA와 단백질 발현 수준이 감소함을 확인할 수 있었다. MSU를 주입하여 통풍을 유도한 마우스 발 부종은 ARW를 섭취한 군과 비교하여 감소하였다. 통풍 유도 마우스의 혈중요산, creatinine 및 BUN의 농도를 측정한 결과 ARW 투여군에서 creatinine과 요산이 감소하였으며, 마우스 신장에서 URAT1과 GLUT9의 mRNA와 단백질 발현 분석 결과 또한 감소하였다. HLPC를 이용하여 ARW의 지표성분 분석 결과 caffeic acid 함량은 1.25 mg/g, 루틴 함량은 0.08 mg/g으로 측정되었다. 국내에서 아스파라거스는 순 부위만 식용으로 사용하고 뿌리 등은 식품 원료로 등록되지 않아 모두 폐기되고 있다. 따라서 본 연구를 통해 ARW의 기능성 소재로서의 개발 가능성을 확인하였고, 향후 독성 평가 및 원료의 특성 분석 등을 통하여 한시적식품원료 등록 및 기능성 소재로서의 개발에 도움이 될 것으로 사료된다. This study aimed to evaluate the anti-inflammatory and anti-gout effects of asparagus root water extract (ARW). ARW was not cytotoxic up to 500 μg/mL and effectively inhibited nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages. It was confirmed that the mRNA and protein expression levels of COX-2 and iNOS decreased at an ARW concentration of 500 μg/mL. We also explored the anti-gout effects using a monosodium urate-induced mouse model. Decreased concentrations of uric acid, creatinine, and blood urea nitrogen were observed at an ARW concentration of 400 μg/mL. The mRNA and protein expression of URAT1 and GLUT9 in the mouse kidney decreased to the level of the positive control (allopurinol 50 μg/mL) at an ARW concentration of 400 μg/mL. We analyzed the caffeic acid and rutin contents in the ARW using HLPC; the results obtained were 1.25 and 0.08 mg/g, respectively. We suggest that ARW can be used as a functional materials agent, for its anti-inflammatory and anti-gout properties.
Ka-Hee Moon,Soon-Kwon Kim,Ji-Young Yoon,Don-Ho Gang,Win Win Nwe,Chang-Suk Huh 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
We studied on the diallel cross analysis of three different types of corn(Zea mays L.); supersweet(ss), sticky waxy and normal field corn in Korea and China. Four inbred lines each of three different types were crossed in a full diallel. Testing of 66 F1 crosses were made at two locations in Korea and China, respectively, in 2009. The objectives of the experiment was first to study different levels of heterosis among three types. In Korea, average ear length of 16 F1 crosses was the longest in N x wx (197mm), followed by wx x ss (193mm) and N x ss (191mm). Average of ss, wx and N were 135mm, 171 mm and 155mm. The relatively high level of N might be location specific breeding results, where the testing was done at the center of waxy corn breeding. Trends of three F1 crosses in China were similar with normal and supersweet corn. The result of this study has supported for breeding of high quality sticky-supersweet and high yield potential of normal -supersweet corn hybrids in the developing world to provide nutrition, sugar and other minerals such as Vitamin A and anthocyanin, simultaneously as a high quality food.