http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ticks and Severe Fever with Thrombocytopenia Syndrome (SFTS)
Jungsang Ryou,Sun-Whan Park,Bong Gu Song,E-Hyun Shin,Seok-Min Yun,Myung-Guk Han,Ye-ji Lee,Mi Yeoun Park,Chan Park 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.04
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease, causing high fever, thromobocytopenia, leukopenia, gastrointestinal simptoms (vomiting, diarrhea), hemorrhage and multiorgan dysfunction. It was known that Haemaphysalis longicornis (H. longicornis), a major tick in Korea, is the principal vector for severe fever with thrombocytopenia syndrome virus (SFTSV). Firstly, to investigate the existence and prevalence of SFTSV in the country, we collected the ticks in 9 provinces in South Korea and detected SFTSV from H. longicornis ticks from 2011 to 2012. And we also investigated SFTSV infection in ticks collected from healthy humans without SFTS symptom and their residential areas. From the former study, we collected 13,053 ticks, and H. longicornis (90.8%, 11,856/13,053) was the most abundant among them. The minimum infection rate (MIR) of SFTSV in H. longicornis was 0.5% (59 pools). From the later study, totally 422 ticks of 8 species were collected from humans and at their neighborhood throughout the nation from May to October, 2013 and SFTSVs were detected from 12 pools (5.7% MIR) by RT-PCR. Finally, we diagnosed 35 patients by detecting SFTSV gene with their sera, and isolated 26 SFTSVs among them in 2013. These findings indicate that SFTSVs are prevalent and SFTS is probably endemic in Korea.
Park, Sun-Whan,Ryou, Jungsang,Choi, Woo-Young,Han, Myung-Guk,Lee, Won-Ja Allen Press, etc 2016 The American journal of tropical medicine and hygi Vol.95 No.6
<P>Since the first reported case of severe fever with thrombocytopenia syndrome (SFTS) in South Korea in 2013, between 2013 and 2015, we collected 1,697 serum samples from suspected patients who experienced symptoms of SFTS. We performed reverse transcriptase polymerase chain reaction using total RNA extracted from the patients' sera. When viral RNA was detected in the sera, SFTS was diagnosed. Among the 1,697 samples, 170 were positive for SFTS virus. We then analyzed the epidemiologic features of these 170 cases. As a result, we found that the annual number of cases increased steadily. However, the annual case fatality rate exhibited a downward trend. The majority of patients were aged ≥ 60 years, and most cases occurred during May–October in the eastern and southern parts of the country. These results may be useful for effective SFTS control by describing the clinical and epidemiologic features of the disease in South Korea.</P>
Seroprevalence of Anti-SARS-CoV-2 Antibodies among Outpatients in Southwestern Seoul, Korea
노지윤,서유빈,윤진구,성혜,현학준,이재갑,이누리,정세리,박민정,송원근,윤정,임채승,Jungsang Ryou,Lee Joo-Yeon,Kim Sung-Soon,정희진,김우주,윤수영,송준영 대한의학회 2020 Journal of Korean medical science Vol.35 No.33
Serosurveillance studies reveal the actual disease burden and herd immunity level in the population. In Seoul, Korea, a cross-sectional investigation showed 0.07% anti-severe acute respiratory syndrome coronavirus-2 antibody seropositivity among 1,500 outpatients of the university hospitals. Low seroprevalence reflects well-implemented social distancing. Serosurveillance should be repeated as the pandemic progresses.
Cho, Du-Hyong,Choi, Yoon Jung,Jo, Sangmee Ahn,Ryou, Jungsang,Kim, Jin Yi,Chung, Jongkyeong,Jo, Inho American Physiological Society 2006 American journal of physiology. Cell physiology Vol.291 No.2
<P>Thiazolidinediones (TZDs), synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligands, have been implicated in the inhibition of protein synthesis in a variety of cells, but the underlying mechanisms remain obscure. We report that troglitazone, the first TZD drug, acutely inhibited protein synthesis by decreasing p70 S6 kinase (p70S6K) activity in bovine aortic endothelial cells (BAEC). This inhibition was not accompanied by decreased phosphorylation status or in vitro kinase activity of mammalian target of rapamycin (mTOR). Furthermore, cotreatment with rapamycin, a specific mTOR inhibitor, and troglitazone additively inhibited both p70S6K activity and protein synthesis, suggesting that the inhibitory effects of troglitazone are not mediated by mTOR. Overexpression of the wild-type p70S6K gene significantly reversed the troglitazone-induced inhibition of protein synthesis, indicating an important role of p70S6K. Okadaic acid, a protein phosphatase 2A (PP2A) inhibitor, partially reversed the troglitazone-induced inhibition of p70S6K activity and protein synthesis. Although troglitazone did not alter total cellular PP2A activity, it increased the physical association between p70S6K and PP2A, suggesting an underlying molecular mechanism. GW9662, a PPARgamma antagonist, did not alter any of the observed inhibitory effects. Finally, we also found that the mTOR-independent inhibitory mechanism of troglitazone holds for the TZDs ciglitazone, pioglitazone, and rosiglitazone, in BAEC and other types of endothelial cells tested. In conclusion, our data demonstrate for the first time that troglitazone (and perhaps other TZDs) acutely decreases p70S6K activity through a PP2A-dependent mechanism that is independent of mTOR and PPARgamma, leading to the inhibition of protein synthesis in endothelial cells.</P>
Hantaan virus nucleocapsid protein stimulates MDM2-dependent p53 degradation
Park, Sun-Whan,Han, Myung-Guk,Park, Chan,Ju, Young Ran,Ahn, Byung-Yoon,Ryou, Jungsang Society for General Microbiology 2013 The Journal of general virology Vol.94 No.11
<P>Apoptosis has been shown to be induced and downregulated by the Hantaan virus (HTNV) nucleocapsid (N) protein. To address these conflicting data, expression of the p53 protein, one of the key molecules involved in apoptosis, was assessed in the presence of the N protein in A549 and HeLa cells. The amount of p53, increased by drug treatment, was reduced when cells were infected with HTNV or transfected with an expression vector of the HTNV N protein. When cells were treated with a proteasome inhibitor (MG132) or an MDM2 antagonist (Nutlin-3), <I>p53</I> expression was not reduced in N protein-overexpressed cells. We concluded that the HTNV N protein ubiquitinates and degrades p53 MDM2-dependently. Here we report downregulation of p53 expression through a post-translational mechanism: MDM2-dependent ubiquitination and degradation by the HTNV N protein. These results indicate that N protein-dependent p53 degradation through the ubiquitin proteasome system is one of the anti-apoptotic mechanisms employed by HTNV.</P>
Severe Fever with Thrombocytopenia Syndrome Virus, South Korea, 2013
Park, Sun-Whan,Han, Myung-Guk,Yun, Seok-Min,Park, Chan,Lee, Won-Ja,Ryou, Jungsang U.S. Department of Health and Human Services * Cen 2014 Emerging Infectious Diseases Vol.20 No.11
<P>During 2013, severe fever with thrombocytopenia syndrome was diagnosed in 35 persons in South Korea. Environmental temperature probably affected the monthly and regional distribution of case-patients within the country. Phylogenetic analysis indicated that the isolates from Korea were closely related to isolates from China and Japan.</P>
Geographical Distribution of Ixodid Ticks (Acari: Ixodidae) in Korea during 2011-12
Bong Gu Song,Jong Yul Roh,Won Il Park,Eun-hee Shin,Sun-Whan Park,Jungsang Ryou,Chan Park,Wook-Gyo LEE,E-hyun Shin,Mi-Yeoun Park 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
We investigated the prevalence of severe fever with thrombocytopenia- syndrome virus (SFTSV) and geographical distribution of ixodid ticks from 25 regions of the Korea during 2011-2012. We collected 25,940 ixodid ticks with 3 genera and 7 species using dry ice bait trap and flagging. Among them, Genus Haemaphysalis, Ixodes and Amblyomma counted 25,821 (99.5%), 118 (0.5%) and 1 (<0.0%). Genus Haemaphysalis consisted of 4 species, H. longicornis (90.4%), H. flava (9.2%), H. formosensis and H. hystricis (<0.1%). Genus Ixodes consisted of 2 species, I. nippoenesis (0.4%) and I. persulcatus (0.1%). Only one Amblyomma testudinarium was collected. The highly infested sites were grassland (50.1%) and mixed stand forest (20.3%). Minimum infection rate (MIR) of SFTSV in H. longicornis was 0.5% in Korea and this rate was similar to that in China (0.46%). Our results showed that H. longicornis is a major vector of SFTSV and its surveillance will be needed at high risk area.